International Journal of Current Research and Review
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IJCRR - Vol 13 Issue 13, July, 2021

Pages: 24-27

Date of Publication: 05-Jul-2021


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Platelet-Rich Plasma in the Treatment of Dorsal Wrist Ganglion

Author: Prakasam N, Vasudevan A, Guru Prasad R, Prabakar M. S., Senguttuvan K, Palani V

Category: Healthcare

Abstract:Introduction: Ganglions are one of the commonest soft tissue lesions that arise from a joint capsule or tendon sheath. The gold standard treatment for this is excision biopsy. The other options are intra-lesional hyaluronidase injection or triamcinolone injection after aspiration. These techniques have drawbacks. Surgery has a formation of scar which sometimes has a chance of becoming an unsightly hypertrophic scar. Aim: To check the effectiveness of Platelet Rich Plasma (PRP) in dorsal wrist ganglion. Materials and Methods: A case-control study in adherence with the principles of the Declaration of Helsinki was conducted on 60 patients. 20 patients were given intra-lesional hyaluronidase injection after aspiration and 20 patients were given intralesional PRP injection after aspiration and another 20 patients were given triamcinolone injection after aspiration. Results: PRP group had lower recurrence rates compared to the other two groups. The Hyaluronidase group had recurrences and required a repeat injection, it was also noted that the capsule thickened after the treatment in these patients. Triamcinolone group had lower recurrence rates at 1 month follow up but this eventually increased over a 6 monthly follow up, they also required a second injection Conclusion: PRP is easy to obtain, safe and cost-effective in the management of dorsal wrist ganglion. More studies to be conducted in the future in a larger population with a larger observational period to confirm this.

Keywords: Protein-rich Plasma, Platelet Rich Plasma (PRP), Ganglion, Hyaluronidase, Triamcinolone

Full Text:

INTRODUCTION:

Ganglion cysts are cystic lesions arising from the soft tissues adjacent to joint capsules or tendon sheaths. These are most commonly seen in the wrists, hands and feet, but they do occur within muscles, menisci and tendons also. These are classified based on their site of origin: the tendon sheath, joint, bone or soft tissue. Of these, the most commonly occurring is the one arising from the tendon sheaths followed by the intratendinous ganglion cyst. Most of these arise from the extensor tendons of the wrist and hand.1

The intraneural ganglions are mostly benign and contain the mucinous substance. These are formed within the nerve sheath of the peripheral nerves. The symptoms of these include peripheral neuropathy. Their pathogenesis is unclear. There are different treatments but all of these have been disappointing and the recurrence rates are high.2

The aetiology of intratendinous ganglion cysts is controversial. One such aetiology is that recurrent injury to the tendon with subsequent cystic degeneration. And this theory holds good because tenosynovitis or associated tendon tears are present in the area adjacent to the ganglion cyst. 1 There are three possible explanations for these cysts so far. One is that they are formed from a capsular defect of a nearby joint, this allows joint fluid to egress and track along the epineurium of an innervating articular branch. The second is that the fluid follows the path of least resistance; and the third being that the cyst takes form due to pressure changes.2,3,4

Similarly, the aetiology of intraneural ganglion cysts has also been unclear. We have observed this from the very first known report (1809) described by Beauchêne till the newer ones. Although materials from these studies support evidence of an elbow joint connection2.

Intraneural recurrences are now becoming commonly recognized. This is probably because of increasing awareness, use of MRI’s and better follow-up by patients 5 with increasing imaging technologies, the joint connections are identified initially and/or postoperatively. 6,7 it is also observed that the intraneural recurrences decrease when the diagnosis is made early and treatments target the articular branch connection. 2

A surgical approach is still the gold standard and has a significantly lower recurrence rate when compared with aspiration and intra-lesional injections.4,8 Arthroscopic excision has limited data but has so far given good outcomes amongst patients and is not considered superior. 9 It was stated by Crijns et al. in 2019 that patients who have undergone hand surgeries have more tendencies toward depression and chronic pain along with an unsightly hypertrophic scar. 10

We wanted a scarless procedure for our patients and we also wanted a low recurrence rate. Hence, the aim of this study was directed to identify the effectiveness of PRP in patients with dorsal wrist ganglion.

METHODOLOGY:

In adherence to the principles of the Declaration of Helsinki, written informed consent was obtained from participants of this study. Permission from the Institutional Review Board was obtained (ACS-MCH/20/JAN/18/09). This was a case-control study conducted at ACS Medical College from 2018 to 2020. 60 patients were chosen for this study, of which, 20 were given PRP treatment, 20 were given the routine hyaluronidase injections and 20 other patients were given triamcinolone injection. An ultrasound was done before the study for all patients.11

Inclusion criteria:

  1. Above 18 years

  2. Patients with Dorsal wrist ganglion from all departments– single, size up to 2 cms

  3. No comorbidities

  4. No bone or joint pathologies

  5. Consenting for the study

Exclusion Criteria:

  1. Below 18 years of age

  2. Multiple ganglia

  3. Osteoporosis of the joint

  4. Comorbidities like Diabetes mellitus, generalised osteoporosis, blood disorders, bleeding or clotting disorders

  5. Patients with HIV, Hepatitis or any other infections

  6. Patients on any long-term medications

  7. Patients not consenting to the study

Group A patients received Intra lesional PRP injections after aspiration. Review after one week as a routine. Group B patients received intra-lesional hyaluronidase after aspiration. Group C patients were given intra-lesional triamcinolone after aspiration. An 18-gauge needle was used to aspirate the contents. The amount injected into the lesion was always equal to the amount withdrawn from the ganglion.

Following this, patients were asked to rest with a compression bandage or a crepe bandage which was removed after a day.

These patients were then followed up for one year. All three groups were asked to review at 15 days, then at one month, 3 months than at 6 months and then at one year. There was a total of 5 visits to the hospital including the first visit.

Parameters like pain, mobility, size of the swelling were noted during every visit.

PRP PREPARATION:12

PRP was prepared from the patient’s blood. About 5-10 ml of blood was withdrawn from the patient. This was then transferred to a container with an anticoagulant. An initial soft spin of the whole blood (3000 RPM for 5 min at 23°C). This separated the blood into two layers. The topmost layer was pipetted out and subjected to a hard spin (4500 RPM for 10 mins) (Figure 1 and 2). The lower one-third portion constitutes the PRP. This was aspirated in a syringe with an 18-Gauge needle and injected as per the above-mentioned protocol.13

 

RESULTS:

There were 40 patients, of which 20 were cases and 20 were controls. All the patients were 20-40 years of age. 30 patients were females and 10 were males. 36 of these patients were involved with activities involving fine hand movements.

Parameters compared:

The pain was slightly higher with the PRP group. The cost involved in the treatment was slightly higher with controls. Patients were able to do their routine activities by the second day in both groups. (Table 1)

The following observations were made:

  1. There was only one recurrence in the PRP group for the entire period of the study. The patient was given a repeat PRP injection and had no complaints in the follow-up.

  2. The hyaluronidase group had 5 recurrences at three-month follow-up and three recurrences at 6-month follow-up.

  3. The triamcinolone group had 4 recurrences at three-month follow-up and 4 recurrences at six-month follow-up.

  4. All the patients with recurrences were administered with a second dose of PRP / Hyaluronidase/triamcinolone injections depending on the group they were in.

  5. On follow-up, the hyaluronidase group had a thickening of the capsule and this mimicked a recurrence in some cases. Similarly, the triamcinolone group had slight hypopigmentation of the overlying skin. But this discolouration slowly vanished with time. This discolouration was probably due to the seepage of the injected steroid.

  6. A pain score of more than 3 was considered significant. These patients were managed with paracetamol.

  7. Long-term patient satisfaction was higher in the PRP group.

DISCUSSION:

Platelet-rich plasma also called PRP promotes physiological and pathological healing. PRP therapy is nowadays used in surgeries. It is also a treatment of choice for osteoarthritis (OA) and tendinopathies. 14

PRP therapies are used for disorders that have tissue regeneration. PRP Injections are used to treat tendinopathy and they have shown some clinical benefits with pain management.15 it is also known that PRP can reduce inflammatory and angiogenic status. 14

PRP, as we know is biological. Hence it can be used in both physiological and pathological conditions. But to know its importance is a necessity. 16 From chronic tendinopathy to acute traumatic rupture it is observed that multiple cytokines take part.14

PRP as the name suggests is known to contain large amounts of platelets. These are activated to form Prostaglandins (PG) and in turn release Platelet Growth Factor (PGF), this is of significant importance in therapy.12

As stated by Guo et al. exosomes that are released by PRP may lead to angiogenesis through activation of Erk and Akt signalling pathways. This suggests that PRP-induced re-epithelialization may be triggered by activation of Yes-Activated Protein (YAP). 17

The main advantages of PRP are that it is prepared from the patient’s blood and it does not need a high-tech lab for this purpose. The more important advantage being, PRP is autologous and hence there are no reactions to this treatment when compared to the commonly used cortico-hyaluronidases. 18,19,20 on the other hand, there are no pieces of evidence to regulate the formulation and composition of PRP and hence make it difficult for us to know the exact dosage that is to be given. 16-20

As stated by Prakasam et al. in the year 2018 and 2020, PRP is easy to obtain, can be cost-effective, safe and has a lot of healing properties. This can be used to heal ulcers of any origin. 13,21

Although the limitations of this study are its small size and a small follow up period, we conclude by saying that PRP can be used for dorsal wrist ganglion as it is safer, pain-free in the long term and has very minimal recurrences.

CONCLUSION:

PRP is easy to obtain, safe and cost-effective in the management of dorsal wrist ganglion. PRP also fares better in terms of recurrence and pain when compared to the regular Hyalase Injection and Triamcinolone injection. More studies to be conducted in the future in a larger population with a larger observational period to confirm this.

ACKNOWLEDGEMENTS:

We would like to acknowledge and thank our institute for allowing and encouraging us to conduct and write about this study. We would also like to take this opportunity to thank our staff and other members of our department who have helped us in crossing all the obstacles to make this article a successful one.

CONFLICT OF INTEREST:

None

SOURCE OF FUNDING:

None

AUTHOR CONTRIBUTIONS:

Dr. M. S. Prabakar, Dr. K. Senguttuvan, Dr. V. Palani – conceptualisation of the study, overview of the study, review of manuscript and results

Dr. Prakasam N, Dr. Vasudevan A, Dr. Guru Prasad R – Review of literature, conduction of the study, data analysis, manuscript writing,

References:

1.        Kim SK, Park JM. intratendinous ganglion cyst of the semimembranosus tendon. Br J Radiol. 2010;83(April):e79–82.

2.        Desy NM, Frcs C, Wang H, Ahmed M, Elshiekh I, Tanaka S, et al. Intraneural ganglion cysts: a systematic review and reinterpretation of the world’s literature. J Neurosurg. 2016;125(9):615–630.

3.        Lu H, Chen L, Jiang S, Shen H. A rapidly progressive foot drop caused by the posttraumatic Intraneural ganglion cyst of the deep peroneal nerve. BMC Musculoskelet Disord. 2018;19(298):1–5.

4.        Harsch I. Para-Articular Cysts in a 64-Year-Old Man. Dtsch Arztebl Int. 2018;115(249b).

5.        Mathoulin C, Gras M. Arthroscopic Management of Dorsal and Volar Wrist Ganglion Dorsal ganglion Volar ganglion Wrist arthroscopy Treatment. Hand Clin. 2017;33:769–777.

6.        Kodaira S, Nakajima T, Takahashi R, Moriya S, Nakagawa T. A case of intra-articular ganglion cysts of the knee joint?: correlation between arthroscopic and magnetic resonance imaging. BMC Med Imaging [Internet]. 2016;16(36):8–11. Available from: http://dx.doi.org/10.1186/s12880-016-0138-8

7.        Mao Y, Dong Q, Wang Y. Ganglion cysts of the cruciate ligaments?: a series of 31 cases and review of the literature. BMC Musculoskelet Disord [Internet]. 2012;13(137):1–4. Available from: BMC Musculoskeletal Disorders

8.        Miralles JR, Cisneros LN, Escolà A, Fallone JC, Cots M, Espiga X. Type A ganglion cysts of the radiocapitellar joint may involve compression of the superficial radial nerve. Orthop Traumatol Surg Res [Internet]. 2016;102(6):791–794. Available from: http://dx.doi.org/10.1016/j.otsr.2016.05.014

9.        Head L, Gencarelli JR, Allen M, Boyd KU. Wrist Ganglion Treatment: Systematic Review and Meta-Analysis. J Hand Surg Am [Internet]. 2015;40(3):546-553.e8. Available from: http://dx.doi.org/10.1016/j.jhsa.2014.12.014

10.      Crijns TJ, Bernstein DN, Ring D, Gonzalez RM, Wilbur DM, Hammert WC. Depression and Pain Interference Correlate With Physical Function in Patients Recovering From Hand Surgery. hand. 2019;14(6):830–835.

11.      Ting W, Ke W, Chang V, Özçakar L. Ultrasound facilitates the diagnosis of tarsal tunnel syndrome?: intraneural ganglion cyst of the tibial nerve. J Ultrasound [Internet]. 2019;22(1):95–98. Available from: https://doi.org/10.1007/s40477-018-0314-5

12.      Everts PAM, Knape JTA, Weibrich G, Schönberger JPAM, Hoffmann J, Overdevest EP, et al. Platelet-Rich Plasma and Platelet Gel?: A Review. J Am Soc Extra-Corporeal Technol. 2006;38:174–187.

13.      Prakasam N, Prabakar MS, Reshma S, Loganathan K, Senguttuvan K. A clinical study of platelet-rich plasma versus conventional dressing in the management of diabetic foot ulcers. Int Surg J. 2018;5(10):3210–3216.

14.      Andia I, Rubio-azpeitia E. Platelet-rich Plasma Modulates the Secretion of Inflammatory / Angiogenic Proteins by Inflamed Tenocytes. Clin Relat Res. 2015;473:1624–1634.

15.      Lacci KM, Dardik A. Platelet-Rich Plasma?: Support for Its Use in wound healing. YALE J Biol Med. 2010;83:1–9.

16.      Everts P, Onishi K, Jayaram P, Mautner K. Platelet-Rich Plasma?: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci. 2020;21(7794):1–36.

17.      Guo S, Tao S, Yin W, Qi X, Yuan T, Zhang C. Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model. Theranostics. 2017;7(1):81–96.

18.      Ma N. Blood-Derived Products for Tissue Repair / Regeneration. Int J Mol Sci. 2019;20(4581):3–5.

19.      Mariani E. Platelet Concentrates in Musculoskeletal Medicine. Int J Mol Sci. 2020;21(1328):1–43.

20.      Noh K, Liu XN, Zhuan Z, Yang C. Leukocyte-Poor Platelet-Rich Plasma-Derived Growth Factors Enhance Human Fibroblast Proliferation In Vitro. Orig Artic Clin Orthop Surg. 2018;10(2):240–247.

21.      Prakasam N, Vasudevan A, Prasad G, Bala V. New Age Treatment For An Age-Old Problem – PRP For Post - Surgery Non - Healing Venous Ulcers. Eur J Mol Clin Med ISSN. 2020;07(05):185–192.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

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A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
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A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
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A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
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A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
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A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
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A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
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A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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