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IJCRR - 2nd Wave of COVID-19: Role of Social Awareness, Health and Technology Sector, June, 2021

Pages: 81-85

Date of Publication: 11-Jun-2021


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Effet of COVID-19 Pandemic on the Diagnosis of Breast Lesions Compared with Breast Lesions in the Previous Five Years

Author: Rohi Wani, Sheema Sheikh, Josepheen Shahmiri, Abdul Maajed Jehangeer, Misbah Rashid, Salma Gull

Category: Healthcare

Abstract:Background: Covid-19 pandemic caused havoc in both people, the health care system and more so in patients with malignancies. Breast malignancies being one of the most common and relatively curable malignancies got hit a lot due to the impact of the Covid-19 pandemic. The multistep impact of pandemic delayed the diagnosis as also the treatment of this multidisciplinary approach disease. Objective: To determine the effect of the Covid-19 pandemic on the diagnosis of breast lesions. Methods: This is a descriptive type of histopathological study in which we have collected and studied the data of Breast lesions over the Five years (Jan 2015-Dec 2019) and compared it with the data of Breast lesions in the Covid-19 year (the year 2020). Results: The number of cases of breast specimens received for histopathology per year declined from an average of 224/year to 124/year in the Covid-19 year of 2020. Conclusion: The decrease in the number of cases alludes to the downfall in the number of patients coming for diagnosis and in turn getting treatment. This study also highlights the importance of anticipation of various cases which will cluster shortly.

Keywords: Breast Carcinoma, Covid-19, Pandemic

Full Text:

INTRODUCTION

As the Covid-19 started in Wuhan in early January 2020, significant disruptions occurred in the health care system. This pandemic has hit all the aspects of our life and among the malignancies, it has hit Breast carcinoma badly, not only by hampering both its primary and secondary prevention but also its treatment.1 Breast Carcinoma is the most common and feared malignancy of women globally, with 1.7 million women getting diagnosed every year with this disease and it kills one patient out of the three.1 It stands second in the list of frequently occurring newly diagnosed cancers worldwide. It is estimated that nearly 70% of malignant tumours are caused by environmental factors, whereas in breast cancer this percentage reaches 90–95%.2

The breast although being an accessory organ is quite vital in terms of its varied pathologies and more importantly its accessibility to diagnostic procedures and potential of cure to its various life-threatening diseases. Most of the breast lesions turn out to be benign, however, the malignancies are nonetheless quite common. Diagnosis of breast lesions occurs usually by palpation in younger age groups and by screening mammographic procedures in the elderly. Covid 19 Pandemic has affected every aspect of this deadly disease with a potential cure, whether it's self-examination, an appointment with a doctor, clinical facility accessible to the patients and ultimately the treatment also. 3-6

Breast Carcinoma is the most common malignancy of women worldwide (except for non-melanoma skin carcinoma) and causes the majority of cancer deaths in women. Breast stands out most of the organs of the body in terms of its commonality of lesions, both benign and malignant, the convenience of self-examination,  accessibility to diagnostic workup, better prognosis, and better cure rates.3,4

This article summarises the comparative data-driven impact on breast surgeries in the Covid-19 year 2020 and thus the diagnosis of breast lesions. We are presenting the data of breast lesions over the last five years in addition to the data of the last year of covid 19 the pandemic year 2020.

MATERIAL AND METHODS

All the breast specimens submitted for histopathological ex­amination over six years were studied which is from Jan 2015-Dec 2020 including the specimens of the Covid-19 year 2020. It is a descriptive and retrospective type of study. All the breast cases which included Lumpectomy, Exci­sion biopsies, Tru cut biopsies, Mastectomy specimens and Blocks for Review were included in the study irrespective of age and sex. There were no exclusion criteria. Only the specimens which had the pure diagnosis of dermal pathology were excluded.  Specimens were received in 10% formalin and were subjected to routine Hematoxylin and Eosin stains.

All the sections were studied in detail, clinical history was noted down and the morphological diagnosis was made. Cases were clustered as those of the previous five years (2015-2020) of the non-Covid period and those of the Covid era which is the year 2020. The data was tabulated as benign and malignant lesions. The average number of cases from the previous Five year period was calculated and compared to Covid 2020 year. The total number of cases received in the departments every year for all Six years was calculated. Nec­essary details and variations in histopathology were noted down.

RESULTS

The total number of breast specimens received in our department in the last six years was 1223.  Out of these total of 1099 breast specimens were received in the last five years from Jan 2015 to Dec 2019 with an average of 220 specimens in a year, whereas in the last year of the Covid 19 pandemic a total of only 124 specimens were received in our department. Among the total of 311 malignant specimens received in the last six years, 259 were received in the previous five years making an average of 52 (259/5) malignancies of breast reported per year. Interestingly we have reported a total of exactly 52 malignancies of the breast in the Covid 19 pandemic year (the year 2020). Among the benign breast cases were the total of 912 reports in all the six years, of which 840 were reported in the previous 5 years with an average of 168 (840/5) benign reports per year and an alarming number of only 72 benign reports in the Covid Pandemic year-2020year (Table 1).

When we compare the data of all the Six years individually (Table 2),  we can make out that we received a total of 191 Breast specimens in 2015, 193 in the year 2016, 241 in the year 2017, 238 in the year 2018, 238 in the year 2019 and only 124 in the year 2020. As our data suggest that the most significant impact of the Covid-19 pandemic was on the benign breast lesions, which dumped down from an average of 168 cases per year to less than its half, and turned out to be only 72 cases in Covid-19 year, directly alluding to the impact of  Covid -19 on the decreased number of surgeries performed on breast and in turn to the exponential decrease in the number of patients amenable to the medical amenities in the menace of Covid-19 (Table 1). Such an impact of the pandemic on this organ is quite distressing for such a disease which is accessible, amenable and even curable.

The total number of cases received in our department decreased to just 124 cases in the year 2020 from 238 cases of the year 2019, decreasing to almost half (Table 2). The decrease in the number of specimens occurred even though in addition to the routine breast specimens operated in our tertiary care, most of the surgeries done in the local surgical centres who used to sent these cases previously to the distant pathology labs landed in our department for histopathology, due travel restrictions.

DISCUSSION

There was a block at multiple levels for the diagnosis of this disease. It was not only multidisciplinary care algorithms that forced patients into delaying care but patients also self-selected to delay care. Almost 4 out of 10 patients revealed that the economic changes from the pandemic affected their ability to pay for medical care.3 Another survey by ACEP showed that almost one-third of patients (29%) delayed or avoided going to the medical facilities just to avoid COVID-19 exposures. And out of every Five patients Four were fearful of contracting the virus from a patient or health care worker if they did go. More than 81% of participants acknowledged practising social distancing.4,5  An Italian study, during the height of the outbreak, showed a significant increase in patients refusing to undergo diagnostic appointments and breast biopsies at a major cancer centre.5 In another study of 600 patients, almost four-fifth stated they had routine and follow up appointments delayed, two-thirds had reconstruction surgery delayed, and almost two-third had delayed diagnostic imaging. Therapies that require in-person visits to the hospital (radiation, chemotherapy infusion, and surgical lumpectomies) were more likely to be delayed than those that could be obtained through telehealth appointments or a prescription pick-up. On average, about 30% of patients experienced delays in the mainstays of breast cancer treatment including lumpectomies, radiation therapy, and chemotherapy.6

A survey conducted by Radiology reported that 97.4% of 228 radiology practices (urban, academic, and rural) experienced declines in imaging volume in March/April 2020, with a drop of greater than 90% of elective procedures and 60% of urgent procedures.7

A multidisciplinary group survey done by the European Breast Cancer Research Association of Surgical Trialists was distributed by breast cancer societies to 377 breast cancers in 41 countries. It was seen that the estimated time interval between the diagnosis and treatment initiation increased to almost 20% of institutions. There was a modification in 56% of cases for primary systemic therapy, with upfront surgery increasing from 33.7% to 42.2% and 39.8% to 50.7% in ER-negative/HER2-positive and T1cN0 triple-negative cases, respectively. Chemotherapy was considered as an increased risk for developing COVID-19 complications by 67% of responders and 51% reported modification in chemotherapy protocols. A large majority (68%) recommended endocrine treatment to postpone surgery in patients with luminal-A tumours. Even postoperative radiation therapy was postponed in 20% of cases. Thus breast cancer management was considerably modified during the COVID-19 pandemic.8,9

The full understanding of the implications of the delay in diagnosis and access to treatment of breast cancer cannot be done unless it is contextualised to the biology of this cancer itself and the patterns of clinical presentation, for example, the stage of the disease and the setting of care. Every patient presenting with a new breast lump that is highly suspicious of malignancy or the one who has already undergone a screening procedure with image findings highly suspicious for malignancy should be promptly referred for tissue diagnosis and/or imaging and should be designated as a high priority. So based on clinical and pathological criteria, priority must be given to the undeferrable cases in a multidisciplinary assessment. Histopathology diagnosis can have an immediate impact. For some, as with patients of symptomatic metastatic relapse, whenever the provision of treatment can be simply life-saving and/or can significantly modify the quality of life, a histopathology diagnosis should be simply included in a set of undeferrable health services.10

Pacino et al. stated very vividly that It is extremely important to maintain breast disease awareness and guarantee a safe health infrastructure of awareness for both the patients as well as the health workers.11 Assessing the data-driven delay in diagnosis we can make out approximately the burden of disease in the community which could not communicate to the medical centres. As of now when the vaccination has already started and we have been able to control the Covid-19 to some extent, we have to anticipate the number of cases that will increase to show up.12

This pandemic has led to a bid and sudden disruption in routine medical care, as also the treatment of cancer patient which is an especially vulnerable group, as here the outcome is strictly dependent on timely and high-quality multidisciplinary interventions. To add insult to the injury are the travel restriction which has made it difficult for some cancer patients to reach the hospital.13

Citgez et al. in their review in a Turkish hospital explained some changes in the approach to breast cancer and emphasized the tailored thera­py must be our first goal individually. Breast cancer treatment requires a multidisciplinary approach. Dynamic changing of local conditions may affect the priori­ty levels and treatment options. Patient treatment decisions should be made by think­ing about both during and after the pandemic management of healthcare systems. Social distancing and precautionary measures are still in effect. More recently, regions with low rates of infection are planning to gradually reopen their economies and begin lifting some of these measures. Un­fortunately, remaining at home may be difficult for patients among us with severe medical conditions that require ur­gent attention, but COVID-19 impacts everything, includ­ing how we manage breast cancer.14

As the experts in Italy rightly said that in the coming future we will see and assist in a shift toward a clinical presentation of more advanced breast cancer which could impair the oncological outcome, worsen the quality of life due to more invasive surgery, chemotherapy radiotherapy, and also increase the relative cost for the Public Health System. To organize our departments and hospitals as efficient as possible and to be ready to restart, epidemiological studies could be useful tools to evaluate the impact of screening programs to prevent a setback to where we were 20 years ago when a 2 cm lesion was considered an early diagnosis of breast cancer.15

One modelling study of 6281 new stage 1 to 3 cancer cases in the United Kingdom who were delayed multidisciplinary workup during the  covid-19 pandemic suggested that an additional 181 lives and 3316 life years would be lost with a conservative estimate of only 25% of cases backlogged for 2 months.16 Just in the early phases of the pandemic, the number of new cancers diagnosed decreased.17,18 This drop was likely secondary to patients not presenting for care and not a true drop-in incidence. Thus, these cancers will come to the radar eventually at greater size or stage than they would have with earlier detection, which may affect prognosis. A model that assumed only a 6-month disruption of care during the pandemic estimated the potential excess deaths from breast and colorectal cancer secondary to the Covid-19  pandemic disruptions in care simply demonstrates an excess of more than 10,000 deaths in the next decade, peaking in the first few years.19

Analysis from a study in the UK suggests that the number of breast cancers diagnosed during the first half of 2020 is not as low as initially feared, and a substantial proportion of the shortfall can be explained by the suspension of routine screening in March 2020, thus underscoring the importance of the very first step of routine screening in this organ.20

CONCLUSION

We all need to gear up for the extra burden of this disease which is unaccounted for but highly anticipated for in this very common but curable disease. We all should have consensus guidelines to guide fair decision-making and developing empathic communication about these issues. Also, the effects of limiting care during this pandemic, and potentially in future crises, on both cancer specialists and patients should be carefully managed.

ACKNOWLEDGEMENTS: All the authors of this study have contributed to the scientific content and/or providing technical support. Further authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Source of Funding: Nil

Conflict of Interest: Nil

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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