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IJCRR - 2nd Wave of COVID-19: Role of Social Awareness, Health and Technology Sector, June, 2021

Pages: 63-66

Date of Publication: 11-Jun-2021


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Red Cell Distribution Width in Hospitalized Covid Patients - A Study in a Tertiary Care Covid Centre in Eastern India

Author: Dasgupta Senjuti, Osta Manish, Talukdar Manas

Category: Healthcare

Abstract:Introduction: The global pandemic caused by coronavirus disease 2019 (COVID-19) is associated with a high rate of hospitalisation and mortality in severe cases. This emphasizes the requirement of parameters that can predict the progression of the severity of the disease among COVID-19 infected patients. Red cells distribution width (RDW) is a cheap and easily available parameter included in Complete Haemogram and is associated with an increased risk of mortality with various diseases. Objective: The present study aimed to find out if there is any correlation between RDW and the severity of COVID-19 infection. Methods: The study was conducted on 111 admitted patients of COVID 19 diagnosed by RT-PCR, among those who were 18 years or older and not requiring treatment for anaemia. Eighty-seven of the patients were having moderate and 24 severe diseases. Analysis of the EDTA blood samples was done by Sysmex XT-4000i automated haematology analyser. RDW-CV and RDW-SD along with haemoglobin and haematocrit values were recorded. Statistical analyses were performed using GraphPad QuickCalcs. Results: Mean value for haemoglobin, haematocrit, RDW-SD and RDW-CV were 11.48 \? 2.22 g/dl, 35.18 \? 6.07 %, 47.26 \? 6.50 fl and 15.69 \? 2.12% respectively. Values for haemoglobin, RDW-CV and RDW-SD were statistically significant when compared between moderate and severe COVID-19 infected patients. Conclusion: Patients with raised RDW values are at a significantly higher risk of developing severe COVID-19 disease which can be fatal.

Keywords: RDW-CV, RDW-SD, Covid-19, Correlation, Prognostic significance, Pandemic

Full Text:

Introduction

The global pandemic of the acute respiratory disease called coronavirus disease 2019 (COVID-19) has been wreaking havoc since December 2019. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease has been associated with a high rate of hospitalisation, the requirement of critical care and mortality.1 It has been reported that 26.1 to 32% of confirmed cases become critical and of these severe cases, the fatality rate is as high as 61.5%.2 These figures emphasize the requirement of parameters that predict the progression of the severity of the disease among COVID-19 patients. In third world countries like India, which has a huge population at risk and limited resources in hospitals, it is especially necessary to define simple and feasible predictors of severity. 

The complete hemogram is a baseline investigation undertaken in hospitalized patients and one of the common parameters included in the report is red cell distribution width (RDW).  An increase in RDW has been reported to be associated with increased risk of mortality in various diseases ranging from heart diseases, pulmonary diseases, sepsis and carcinomas. This observation led to the assumption that RDW may be a potential marker of risk stratification in COVID-19 as well.3

There is a dearth of studies from India regarding the role of RDW in predicting the prognosis of COVID-19. The present study aimed to find out if there is any correlation between RDW and the severity of COVID-19 infection. Even with the advent of vaccines, it is invariably a matter of substantial time before the entire population is protected from the deadly disease. So, the importance of exploration of the role of cost-effective parameters like RDW which has the potential to guide proper triaging of patients cannot be overemphasized.

Materials and methods

            A hospital-based study was conducted in a dedicated tertiary care COVID centre of Eastern India for one month. The study had been approved by the Institutional Ethics Committee (Ref no. MC/KOL/IEC/NON-SPON/855/12/2020, dated 22nd December 2020). The study subjects were those adult patients who had been admitted in the COVID ward and COVID ICU (intensive care unit) during this period and had tested positive for COVID-19 by RT-PCR (reverse transcriptase-polymerase chain reaction) test. Those patients who were below 18 years of age were excluded. Patients who were already receiving treatment for anaemia were also excluded.    

            The patients included in the study were then categorized into “moderate disease” and severe disease” based on criteria defined by the Ministry of Health and Family Welfare and Director General of Health Services, Govt. of India.4 A patient was classified as “severe” when there was the presence of clinical signs of pneumonia along with any one of the following: respiratory rate >30 breaths/min, severe respiratory distress, SpO2 <90% on room air. When the patients suffered from dyspnoea and/or hypoxia, cough, fever, SpO2 <94% (range 90-94%) on room air, respiratory rate ≥ to 24 per minute (range 24-30 breaths/min), they were categorized as “moderate”. Relevant clinical data for each patient was recorded.

            At admission, blood samples were collected from each patient in an EDTA vial. Analysis of the blood samples was done by Sysmex XT-4000i automated haematology analyser. RDW-CV (coefficient of variation) and RDW-SD (standard deviation) were both noted for each patient included in the study. The haemoglobin and haematocrit values were also recorded. All collected data were meticulously tabulated.

Statistical analysis

Statistical analysis was done online with the help of Graphpad Quickcalcs software.  Unpaired t-test was done to compare the haemoglobin, haematocrit and RDW values between moderate and severe groups of Covid patients (p-value <0.05 was considered as statistically significant).

Results

            A total of 120 patients were initially included in the study. It was found that anaemia was present in 6 patients and another 3 patients refused to give consent for the study. So, finally, the study population consisted of 111 patients.

            The mean age of the study participants was 59 ± 16.8 years. Among the patients, 74 were males (67%) and the rest (37, 33%) females. The mean value of haemoglobin of these patients was 11.48 ± 2.22 g/dl with values ranging from 5.4g/dl to16.9 g/dl. The mean value of haematocrit was 35.18 ± 6.07 % and the values ranged between 17.8% and 47.2%. The range of RDW-SD varied between 32.7fl and 65.3fl, the mean being 47.26 ± 6.50 fl. The mean RDW-CV was noted to be 15.69 ± 2.12 % with a range between 12.2% and 22.4%.

            The number of patients suffering from moderate Covid infection was found to be 87 (78%) and the rest (24, 22%) were diagnosed to have severe disease.  The age and sex distribution in the two groups have been shown in table 1. The mean values of haemoglobin, haematocrit, RDW-SD and RDW-CV in both groups have been shown in table 2. The difference in haemoglobin, RDW-SD and RDW-CV between the two groups was found to be statistically significant.

Discussion

            SARS-CoV-2 is more contagious than the SARS-CoV that caused the outbreak of severe acute respiratory syndrome (SARS) in 2003. It is also more infectious than MERS-CoV (Middle East Respiratory Syndrome Corona Virus) which was responsible for MERS (Middle East Respiratory Syndrome) outbreak in 2012.5 This is perhaps a “once in a century pandemic” mainly due to two reasons – first, even though the case fatality rate is 1%, COVID-19 has proved to be fatal both to healthy adults and the elderly with pre-existing morbidities, and second, the efficient way in which the virus transmits itself both from sick patients and healthy carriers.6

            The majority of the patients of COVID-19 have mild disease but some of the affected people undergo rapid deterioration of condition within a span of 7 to 14 days.7 The need for cost-effective parameters to identify patients with a risk of progression to severe disease is apparent from the fact that the mortality rate of severely affected individuals is 20 times more than that in non-severe patients.8

            Gong J et al. found RDW to be an important parameter for the determination of prognosis of COVID-19 patients.9 Previous studies have reported a statistically significant increase in RDW in patients with critical illnesses.10,11 It is interesting to note that RDW has been considered to be a prognostic predictor of patients with sepsis.12 Foy BH et al. stated in their study that a raised RDW during admission and increasing value of RDW during hospital stay were both adverse risk factors for COVID-19 patients. They concluded that RDW is a helpful parameter for the risk stratification of these patients.3

            The basis of increase in RDW in severe COVID-19 infection has been sought for. RBCs are reservoirs of cytokines.13 In severe illnesses, the deformability of red blood cells (RBCs) is compromised leading to their breakdown and thereby release of the inflammatory cytokines. These mediators may further shorten the life span of RBCs and cause enhanced morphological variations in RBCs, which are reflected in the increased value of RDW.14 Other authors have suggested that inflammatory conditions are associated with the suppression of erythropoiesis. The structural and functional changes of RBCs in such inflammatory states lead to their early demise. IL-1 (Interleukin-1) and TNF-α (Tumor necrosis factor-α) are released and they reduce the synthesis of erythropoietin. These cytokines also play a role in attenuating the response of erythroid precursors to erythropoietin. INF-γ (Interferon-γ) is instrumental in causing apoptosis of erythroid progenitor cells and reduction of expression of erythropoietin receptors.15 So, a combination of early destruction and reduced production of RBCs has been implicated for increased variation of RDW in critical illnesses.

            Gong et al. suggested that the symptom of fatigue which is experienced by severe COVID-19 patients may be explained by the raised value of RDW.9 Wang C et al. found both RDW-SD and RDW-CV to be significantly higher in patients with severe COVID-19 infection than those with moderate disease.16 Similar results were found in the present study. Other studies have reported the rise of RDW to be a predictor of the occurrence of complications in COVID-19 infection.17,18

Conclusion

            Both RDW-SD and RDW-CV are simple and easily available parameters, which may be used to triage patients with COVID-19 infection. Those with raised RDW values are at a significantly higher risk to develop a severe illness which can lead to serious complications and even prove to be fatal. In developing countries with limited resources, a simple parameter like RDW has the potential to provide life-saving information.

Acknowledgments: The authors thank all patients who participated in the study.

Conflict of interest: Nil.

Funding: Nil.

Author’s contributions

  1. Dasgupta Senjuti had contributed by developing the concept and the design of the study. She defined the intellectual content of the paper and undertook a literature search. She also contributed to data acquisition, data analysis, statistical analysis, manuscript preparation, manuscript editing and manuscript review.

  2. Osta Manish had contributed to formulating the design of the study. He undertook literature search and helped in data acquisition, data analysis, statistical analysis, manuscript preparation, manuscript editing and manuscript review.

  3. Talukdar Manas had defined the intellectual content of the paper. He undertook literature search and contributed to data acquisition, data analysis, statistical analysis, manuscript preparation, manuscript editing and manuscript review.

References:

1. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel corona virus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. 

2. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centre, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-81.

3. Foy BH, Carlson JCT, Reinertsen E, Valls RPI, Lopez RP, Palanques-Tost E, et al. Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection. JAMA Netw Open 2020;3(9):e2022058.

4. Clinical Management Protocol for COVID19. https://www.mohfw.gov.in/pdf/ClinicalManagementProtocolforCOVID19.pdf.

5. Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses 2020;12(2):135.

6. Gates B. Responding to Covid-19-A Once-in-a-Century Pandemic? N Engl J Med 2020;382(18):1677-9.

7. Feng Z, Yu Q, Yao S, Luo L, Duan J, Yan Z, et al. Early Prediction of Disease Progression in 2019 Novel Coronavirus Pneumonia Patients Outside Wuhan with CT and Clinical Characteristics. medRxiv 2020: 2020.02.19.20025296.

8. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395(20): 507-13.

9. Gong J, Ou  J, Qiu  X,  Jie Y, Chen Y, Yuan L, et al.  A tool to early prediction of severe coronavirus disease 2019 (COVID-19): a multicenter study using the risk nomogram in Wuhan and Guangdong, China. Clin Infect Dis. 2020;71(15):833-40. 

10. Wang B, Gong Y, Ying B, Cheng B. Relation between Red Cell Distribution Width and Mortality in Critically Ill Patients with Acute Respiratory Distress Syndrome. BioMed Res Int. 2019;2019:1942078.

11. Havens JM, Seshadri AJ, Salim A, Christopher KB. Red cell distribution width predicts out of hospital outcomes in critically ill emergency general surgery patients. Trauma Surg Acute Care Open. 2018;3:e000147.

12. Mahmood NA, Mathew J, Kang B, DeBari VA, Khan MA. Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis. Int J Crit Illn Inj Sci. 2014;4(4):278-82.

13. Karsten E, Breen E, Herbert BR. Red blood cells are dynamic reservoirs of cytokines. Sci Rep. 2018; 8:3101.

14. Janz DR, Ware LB. The role of red blood cells and cell-free haemoglobin in the pathogenesis of ARDS. J Intens Care 2015;3:20. 

15. Sarkar M, Rajta PN, Khatana J. Anemia in Chronic obstructive pulmonary disease: Prevalence pathogenesis, and potential impact. Lung India 2015;32(2):142-51.

16. Wang C, Deng R, Gou L, Fu Z, Zhang X, Shao F, et al. Preliminary study to identify severe from moderate cases of COVID-19 using combined haematology parameters. Ann Transl Med. 2020;8(9):593.

17. Lu G, Wang J. Dynamic changes in routine blood parameters of a severe COVID-19 case. Clin Chim Acta. 2020; 508:98-102. 

18. Vaid A, Somani S, Russak AJ, Freitas JDK, Chaudhry FF, Paranjpe I, et al. Machine learning to predict mortality and critical events in COVID-19 positive New York City: Model Development and Validation. J Med Internet Res. 2020;6;22(11):e24018.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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