International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 13(10), May, 2021

Pages: 170-172

Date of Publication: 19-May-2021


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A Systematic Review of Relation between COVID-19 and Diabetes

Author: Vikrant Mankar, Archana Dhengare, Ranjana Sharma, Swarupa Chakole

Category: Healthcare

Abstract:To study compactly the general quality of the novel coronavirus (SARS-CoV-2) and provide a well understanding and treatment of the coronavirus disease (COVID-19) in persons with diabetes. Diabetes-related to incidence & death in COVID-19 patients. Inflammation, hypercoagulation, impaired immunity can lead to increased morbidity and death. Evidence does not support the discontinuation of ACEIs, ARBs or thiazolidinediones. Chloroquine use can cause hypoglycemic events in people with diabetes and COVID-19. Inflammation, hypercoagulation, impaired immunity can lead to increased morbidity and death. Evidence does not support the discontinuation of ACEIs, ARBs Or thiazolidinediones. Chloroquine use can cause hypoglycemic events in people with diabetes and COVID-19.

Keywords: COVID-19, Inflammation, Diabetes, SARS-CoV-2

Full Text:

Introduction

Although most human coronavirus infections are mild, major two beta-coronavirus outbreaks, severe SARS-CoV in the 2002–2003 period, and Middle East Coronavirus Respiratory Syndrome (MERS-CoV) in 2012 have caused fatal pneumonia, with increasing mortality. Multilateral pneumonia Coronaviruses have enveloped positive RNA viruses that are widely spread to humans and animals all over the world.1 To include a brief overview of the general characteristics of COVID-19, as well as a more detailed explanation and critical assessment of the relationship between this emerging infectious disease and diabetes, we performed a scope analysis. We hope this analysis will provide useful knowledge for future studies and eventually lead to improved clinical management of COVID-19 and diabetes patients.1

The COVID-19 pandemic poses a health threat to humanity like never before. And people with diabetes, as in many other cases, are paying a very high price. Unfortunately, statistics indicate that people with diabetes are at greater risk for COVID-19 and the prognosis is very low. Due to the constraints imposed by many governments, they also have to face tough challenges in the daily management of their disease in having required treatments as well as the requisite help from specialists and other healthcare professionals, all completely engaged in the COVID-19. Around the same time, they are not getting the most effective care while treated in such a challenging health crisis.

Rates of Diabetes and Obesity in Subjects with Coronavirus Infections

Diabetes is associated with an elevated risk of serious bacterial and viral infections in the respiratory tract including influenza H1N1. A study of more than 500 individuals hospitalized with SARS-CoV in China showed that increased death levels were associated with elevations in fasting glucose; however, hyperglycemia was mostly transient and generally resolved after discharge from hospital in the majority of subjects.3

Diabetes, Infection, and Immune Responses

Acute respiratory virus infection has been linked to the rapid development of transient insulin resistance, whether in otherwise stable individuals with normal euglycemic weight or overweight. In addition, cancer, serious disease, and drugs such as glucocorticoids impair insulin sensitivity and therefore need hospital modification of glucose-lowering medications and insulin dosage. Infectious diseases worldwide contribute to excess mortality in diabetes sufferers.3

Use of Glucose-Lowering Therapies in Subjects with Coronavirus Infections

In preclinical studies, metformin exerts anti-inflammatory action and decreases circulating inflammatory biomarkers in people with T2D.4 Metformin has also been widely used in non-hospitalized subjects with stable hepatitis or HIV infections; however, information on metformin's immunomodulatory activities in the sense of coronavirus infection is scarce. Several studies investigating antibody titers in a limited number of individuals have indicated that immune responses to influenza vaccination in metformin-treated subjects are modestly impaired; however, the clinical relevance of these findings, if any, is unclear. Metformin should be used with caution in depressed hospitalized patients and stopped in persons with chronic sepsis.5

Type 1 Diabetes and SARS-CoV-2

The knowledge available does not suggest that children or adults with T1D are more vulnerable to coronavirus infections. People with T1D can find that interrupting regular daily activities, changing exercise form and duration, and changing dietary habits can alter glucose regulation, requiring re-examination of the insulin requirements.6 The available evidence does not suggest that children or adults with T1D are more vulnerable to coronavirus infections. People with T1D may find that interrupting regular daily activities, changing exercise form and duration, and altering dietary habits will alter glucose regulation requiring re-examination of the insulin requirements.7

Implications on diabetes management

We have assembled a simple flowchart for the metabolic testing and care of COVID-19 patients or those with a risk of metabolic disease. The clinical significance of the above mechanisms is currently not clear, but the effects on patients living with diabetes should be known to health care providers. These include guidelines both for the prevention of primary diabetes and the prevention of serious diabetes-related sequelae (figure). Further, the panel provides detailed guidance on anti-diabetes drugs commonly used in COVID-19 patients with type 2 diabetes.8

To stop the coronavirus that triggers COVID-19 everybody must be alert. I have diabetes type 1 or type 2 then can be even more vigilant. Your chance of contracting the virus is no greater than that of anyone else. But if do get sick, might have worse complications. That's especially true if diabetes isn't regulated properly.

To lower the risk of being infected:

• Hold distance from others

• Provide good hygiene

• Keep blood sugar in order9

Diabetes and Coronavirus

Approximately 25% of people with grave COVID-19 infections have been hospitalized with diabetes in recent studies. Patients with diabetes were more likely to suffer serious complications and die from the infection. One explanation is that high blood sugar weakens the immune system and reduces its ability to prevent infections. If another disease, such as heart and lung diseases, is present, the risk of serious coronavirus infection is much higher. The risk of diabetes complications like diabetic ketoacidosis ( DKA) from infection may be increased if get the COVID-19. DKA occurs when blood builds up at elevated levels of acids known as ketones. This can be very dangerous.9

Tips to Avoid Infection

Staying home as soon as can, is the safest way to stop getting sick. According to the American Disability Act, persons with diabetes have the right to "reasonable workplace accommodation," which includes the right to work at home or to leave when required. When out and when get home or using a hand sanitiser, wash your hands regularly. Position self at least 6 feet from other people when have to leave and wear a face mask of textile. Wash hands until a finger stick or insulin shot is given. First, clean any place with water and soap or rub alcohol.9

COVID-19 Diabetes Plan

Social distancing and shelter-in-place regulations can make it more difficult to get the supplies to need. Stock up enough supplies to last for a few weeks, in the case are quarantined.

Make sure you have:

  • Simple carbs like honey, sugar-sweetened soda, fruit juice, or hard candies in case your blood sugar dips. 

  • A maximum number of refills from insulin and other medicines you can get. 

  •  Extra glucagon and strips of the ketone. 

  • Your phone and health insurance company telephone numbers.9

Medicare and other private insurance providers also cover expenses relating to telehealth visit

• How often to check for sugar and ketones in your blood.

• How to change the medications for your diabetes if you are sick.

• Every cold and flu treatments you can take are free.

To Do is Get Sick

I begin to feel sick, then stay home. Check the sugar in the blood more often than usual. COVID-19 may lower appetite and may cause to eat less, which may affect levels. If are sick will need more fluids than normal. Hold water close by, and sometimes drink it.9 Diabetes is a chronic disease that occurs when the insulin is no longer produced by the pancreas, or when the body can not make good use of the insulin it produces. Insulin is a pancreatic hormone that acts as a gateway to enable glucose from the food we consume to pass from the bloodstream into the body's cells to generate energy. All foods made with carbohydrates are broken down into blood glucose.  The epidemiology of diabetes is evident from many GBD studies.10 Effects of diabetes on various body systems and proneness to infections have been reported in several studies.11 Subhadarsanee et al compared Coronavirus Disease and Diabetes as the interplay of two pandemics.12

CONCLUSION

The rapid flow of clinical news from the SARS-CoV-2 epidemic requires ongoing monitoring to understand the conservative uses, risks and benefits of individual glucose-related agents and medicines commonly used in high-risk individuals, or those hospitalized with coronavirus-relevant diabetes. The pandemic emphasises that wearables and portable monitors and the regular communication among diabetes and their health care practitioners must continue and expand innovative diabetes treatments.

Source of funding: Nil

Conflict of interest: Nil

References:

  1. Mohanty SK, Satapathy A, Naidu MM, Mukhopadhyay S, Sharma S, Barton LM, et al. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) – anatomic pathology perspective on current knowledge. Diagn Pathol 2020; 15:103.

  2. Antonio C. COVID-19 and Diabetes: A Call To Action: International Diabetes Federation. 2020;161: 218.

  3. Drucker DJ. Coronavirus Infections and Type 2 Diabetes—Shared Pathways with Therapeutic Implications. Endocr Rev 2020;41(3):011.

  4. Cameron A. Anti-inflammatory effects of metformin irrespective of diabetes status. Circulation Res 2016;119(5):652-665.

  5. Frydrych LM, Fattahi F, He K, Ward PA, Delano MJ. Diabetes and Sepsis: Risk, Recurrence, and Ruination. Front Endocrinol (Lausanne) 2017;8:271.

  6. Basu A. Direct evidence of acetaminophen interference with subcutaneous glucose sensing in humans: a pilot study. Diabetes Tech Therapy 2016;18(S2):S2-43.

  7. Yamamoto JM, Donovan LE, Feig DS, Berger H. Urgent update – temporary alternative screening strategy for gestational diabetes screening during the COVID-19 pandemic. Diabetes Tech Therap 2020;2(5):122-126.

  8. Bornstein S. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol 2020; 8:546–50

  9. Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol 2020:1–20.

  10. James S, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, et al. Global Injury Morbidity and Mortality from 1990 to 2017: Results from the Global Burden of Disease Study 2017. Injury Prevention 2020;26(1): i96–114.

  11. Gupte Y. Assessment of Endothelial Function by Fmd (Flow Mediated Dilatation) in Prediabetes. Int. J Pharm Res 2019;11(2):1808–1812.

  12. Subhadarsanee C. Coronavirus Disease and Diabetes – Interplay of Two Pandemics. Int. J Pharm Res. 2019; 11(1): 1243–46.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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