International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 8(1), January, 2016

Pages: 20-24

Print Article   Download XML  Download PDF

IMPACT OF IMMUNOSUPPRESSIVE DRUGS ON SUDANESE RENAL TRANSPLANT RECIPIENTS INFECTED WITH INTESTINAL PARASITES

Author: Lienda Bashier Eltayeb, Hisham Ali Waggiallah

Category: Healthcare

Abstract:Objectives:Enteric parasites are important agents of disease throughout the world. And they increasingly have significant role in transplant candidates. Intestinal parasites that are asymptomatic before transplantation may become clinically significant under immunosuppressive treatment. In the other hand some immunosuppressive regimens has anti-parasitic effects that may result, in lower rates of parasitic infections. Methods: Stool samples were collected from renal transplant recipients attending Sudanese Kidney Association hospital and from a control group from January 2012 to April 2012. For the detection of parasites, fresh stool samples were separated into two samples; one was preserved in SAF fixative. From this sample smears were made for permanent stains. The second sample was examined by wet preparation. Modified trichrome staining method was used for permanent smears for microsporidia. Result: All (200) renal transplant recipients were on immunosuppressant drugs; (76.5%) of the study patients were on tacrolimus (prograf) therapy and only (23.5 %) were on cyclosporine A (CsA) therapy. Of the total patients on tacrolimus there (22.5%) were diagnosed with intestinal parasites and only (1.5%) of them were on Cyclosporine therapy. There was statistically significance between immunosuppressant agents and infection with intestinal parasites positivity in group I (P value= 0.019). All details are summarized in (Table 2). Multiple parasitic infections were observed in a total of 5/200 (2.5%) renal transplant recipients and 1/100(1%) controls (p < 0.05). G lamblia,and B. hominiswas frequently seen species as multiple infections in renal transplant recipients. Conclusion: Intestinal parasitic infections should not ignore in renal transplant recipients, So Cyclosporine therapy should be recommended as first line immunosuppressant drugs as well as prophylactic against wide range of parasitic diseases.

Keywords: Immunosuppressive drugs, Transplants, Intestinal parasites

Full Text:

INTRODUCTION
Organ transplant recipients can experience serious diseases from infections due to emerging and reemerging parasitic infections. So they are at risk for infections-particularly opportunistic parasites, and occult intestinal infection can remain quiescent for many years, becoming apparent after initiation of immunosuppression because of the continuous administration of immuno-suppressive drugs 1, 2. The impact of intestinal parasitic infection in renal transplant recipients requires careful consideration in the developing world. However, there have been very few studies addressing this issue in Sudan. On the other hand parasitic infections are easily forgotten by clinicians, and they are often regarded as mild, unimportant. However, parasites continue to be a significant health problem and the commonest causes of morbidity and mortality in many parts of the world especially in the developing countries. With increasing ease of international travel and increasing number of immunocompromised hosts, one might expect to see exotic or unusual parasitic infections anywhere in the world.

For instance, several contributing factors affect the prevalence of intestinal parasites in a geographic location, like socioeconomic status, climatic changes, and poor standards of public and personal hygiene 3 . Immunocompromised hosts, including patients withAIDS, solid organ transplantation, and patients on immunosuppressivetherapy, are at higher risk for opportunistic parasiticin fections.Renal transplant recipients (RTRs) are proneto parasitic infections due to immunosuppressive therapy.Giardiasis comprises <1% of parasitic infections among RTRs.It is well known that Giardiasis can be treated with simple antibiotics like metronidazole and albendazole with adequate responses. But in clinical situations like common variable immunodeficiency (CVID), lymphoproliferative diseases, HIV/AIDS, Giardiasis is refractory to usual therapies4 . Very few reports of Giardiasis among RTRs have been reported from Sudan.

Parasitic diseases may affect transplant recipients as a resultof Recrudescence of latent infections in the previously infected recipient, ‘De novo’ infection by means of(i) Natural infection.(ii) Transmission by transplanted organ (or blood product,either before or after transplantation) into a naive recipient. For the most part, only those organisms that can completetheir life cycle within the human host result in more severe infections in an immunocompromised host. Coinfection isa common feature of parasitic infection in transplantation, and invasive disease may be associated with viral infection(particularly cytomegalovirus) or with disseminated bacterialinfection5 .

The incidence of parasitic infection is expected to grow insolid organ transplant recipients due to multiple factors: Many geographic areas where parasitic infections arehighly prevalent have now active organ transplant programs, donors and recipients from endemic areas, with latentor asymptomatic infections, are sometimes referred totransplant centers in Western countries, some patients from developed countries undergotransplantation in highly endemic areas (transplanttourism) and return home with either donor derivedor naturally acquired infection(s).4 Immigrants to Western countries, unaware of their infectiousstatus, are accepted for organ donation withoutfurther evaluation for diseases that are prevalent intheir countries of origin; finally the decrease in cyclosporine-based immunosuppressiveregimens and the increased use of newer drugsthat lack the anti-parasitic effects of cyclosporinemetabolites may result in higher rates of parasitic infections5, 6. Eosinophilia, gastroenteritis and other clinicalmanifestations of parasite infections prior to transplantshould trigger an appropriate workup.

Cryptosporidium, I. belli,Cyclospora, Microsporidia, Blastocystishominis and Giardiacan all cause significant gastroenteritis in transplant recipients.While the use of mycophenolatemofetil is most common cause of chronic diarrhea in transplant recipients,these fastidious organisms can mimic such colitis. Cryptosporidiumand Giardia are among the most common parasiticpathogens seen in transplant recipients, especiallyin endemic regions; severe cryptosporidiosis has been reportedin numerous transplant recipients. Transmission ismore common in the developing world, where rates of infectionas high as 20% have been noted7 , and can occur from contaminated food and water, person-to-personspread, and zoonotic exposures; intestinal protozoa havealso been reported as donor-derived infections with intestinal transplantation7, 8. This study aimed to determine the impact of immunosuppressive drugs on renal transplant recipients infected with intestinal parasites.

MATERIAL AND METHODS:

Study Design: This is analytical cross sectional study approach on patients who underwent renal transplantation. It was conducted at the parasitology lab, faculty of Medical Laboratory Sciences, University of Khartoum from March 2014 to December 2015. Stool specimens were collected from 200 renal transplant recipients attending Sudanese Kidney Association hospital in Khartoum state, Sudan, and 200 control group that were collected from different wards.9 Patients were enrolled based on the following inclusion criteria: Both sexes, different ages, recipients whom passed between 6 months to 10 years of their renal transplantation, use of immunosuppressant drugs, they suffering from diarrhea either chronic (two or more watery or loose stools per day for a period of greater than 28 days) or acute diarrhea (two or more watery or loose stools per day for less than 4 weeks) or without diarrhea.

Methods: Three groups of study subjects were enrolled in this study as follow; group (I) includes patients underwent renal transplantation and complained of diarrhea, group (II) were patients who underwent renal transplantation but without symptoms and group (III) was control group (apparently healthy individuals). The sample was taken from each participant into a dry air tight leak proof plastic stool container and transferred to the laboratory at the end of each working day. For the detection of parasites, fresh stool samples were separated into two samples; one was examined by wet preparation. The second sample was preserved in SAF fixative. From this sample smears were made for permanent stains. 10 Direct Wet Smear Examination (Cheesbrough M)11andModifiedTrichrome Stain (Weber- Green) were done each sample12.

Sampling and sample size: The type of the sample needed for the study is multistage simple random sampling with population proportional to size (PPS)

Tools for Data Collection: A well-constructed questionnaire was used for collection of demographic and clinical data and observation check list for stool specimens. Statistical analysis: Data was analyzed using SPSS (version 12) software. Significance of difference was analyzed by Chi-squared test. P< 0.05 was considered significant.

Result: A total of 400 fecal samples were collected from study participants for parasitological study. Two hundred were renal transplant recipients receiving immunosuppressant drugs with a mean age of 24.5 years. Of those, 112(56%) were males and 88(44%) were females. There were no statistically significant differences between age and sex in the two groups (p > 0.05), figure 1.

Majority of patients infective with intestinal parasites were in were in age group (21- 40) figure 2. All (200) renal transplant recipients were on immunosuppressant drugs; (76.5%) of the study patients were on tacrolimus (prograf) therapy and only (23.5 %) were on cyclosporine A (CsA) therapy. Of the total patients on tacrolimus there (22.5%) were diagnosed with intestinal parasites and only (1.5%) of them were on Cyclosporine therapy. There was statistically significance between immunosuppressant agents and infection with intestinal parasites positivity in group I (P value= 0.019).9 All details are summarized in (Table 1).

Table 2 shows the magnitude of single and multiple parasitic (poly parasitism) infections in renal transplant recipients and in controls. Multiple parasitic infections were observed in a total of 5/200 (2.5%) renal transplant recipients and 1/100(1%) controls (p < 0.05). The species of parasites was frequently seen as multiple infections in renal transplant recipients were G. lamblia, H. nana and B. hominis. Table 3 summarizes the frequency of enteric parasites among different types of patients receiving Tacrolimus and Cyclosporine A, were the majority of parasites (16%) in patients receiving tacrolimus.

DISCUSSION This study has evaluated the frequency of opportunistic and common intestinal parasitic infections among renal transplant recipients receiving immunosuppressant drugs (Tacrolimus and CsA). There was an association between frequency of parasitic infections and age group, enteric parasites were common in themiddle age group (21- 40) years old, and this may be this age group were more exposed to factors which enhance parasitic infections so continuous health supervision, annual medical examination and prompt treatment of infected renal transplant recipients minimize the infection rates.

In our study, G. lamblia was the first most prevalent parasite detected in cases and control group (8.5% vs. 10%), without significant difference and followed byB. hominis(4% vs. 1%) and H. nana (2% vs.1%). This is concurrent with that reported by M Nateghiet.al (10) who found that G. lamblia is the second most prevalent parasite (10/706).In other study carried out on renal transplant recipients in Brazil, G. lamblia was the third most prevalent parasite (3/16) and S. stercoralis was the common parasite (11/16). The reason is that CsA acts as an immunomodulator enhancing trypanosomes and Giardia multiplication, and exacerbating the infection. This is more or less could explain the higher incidence of giardiasis infection among the population. There are few reports in the literature regarding giardiasis in immunocompromised hosts 13.

With regard to helminthes, Strongyloidesstercoralis, there are considerable reports of cases of S. stercoralis hyperinfection as a consequence of immunosuppressive treatment following kidney transplantation. However, culture of 200 stool specimens from renal patients yielded lack of infection with S. stercoralislarva. The same result obtained by M Nateghi Rostami et.al14.This might be under the influence of parasiticidal action of CsA. Reportedly CsA has reduced the incidence of strongyloidiasis in renal transplant recipients. Although in the analysis of Valvar et al. the most prevalent infection was reported to be S. stercoralis, but none of infected patients received CsA in their immunosuppressive drug protocol 8 .

The low use of cyclosporine A (23.5%) by study participants is likely to affect the overall frequency of intestinal parasites. It is a fact that, the use of Cyclosporine A (CsA) has become a cornerstone in prophylactic immunosuppression among renal transplant recipients. Cyclosporine A with powerful properties of immunosuppression, acts on parasitic infections in various ways 8 . In laboratory models, CsA reduces survival and growth in a wide range of protozoa and helminthes. CsA is apparently antiparasitic against malaria, Schistosoma, adult tapeworms and filarial nematodes. By contrast, it acts as an immunomodulator against trypanosomes and Giardia, by exacerbating the infection. This more or less could explain the higher incidence of Giardiasis among the population reconvening cyclosporine A. There are few reports in the literature regarding giardiasis in immune-compromised hosts 15. In the other hand patients use tacrolimus were more infected with enteric parasites comparing with transplant patients using CsA (16% versus 8%) respectively.

It was evident that multiple parasitic infections were more common in renal transplant recipients (2.5%) than in controls (1%), this is in agreement with Mehdi Azamiet.al16that found (8% vs. 2.2%) in renal transplant recipients and control respectively. In our study, C. parvumoccurred in co-infection with other intestinal protozoan parasites, such as B. hominis, G. lamblia and H. nana. Hence this strongly indicates the facility of worsen immune system in establishment of multiple parasites in immunocompromised patients. Also detection of such common intestinal parasites in both patients and controls could be a reflection of the poor environmental sanitation and personal hygienic practices, which emphasize the need for intervention measures at the community level to reduce the risk factors of acquiring intestinal parasites. So it is very important to target these common infections while treating renal transplant recipients for opportunistic infections in developing countries like Sudan 17.

CONCLUSION Intestinal parasitic infections should not ignore in renal transplant recipients, and giardiasis should be suspected in RTRs with malabsorption syndrome in a developing country like Sudan. So Cyclosporine therapy should berecommended as first line immunosuppressant drugs as well as prophylactic against wide range of parasitic diseases.

ACKNOWLEDGEMENT Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Conflict of interests: Authors have no conflict of interest in this research paper .

 

 

References:

1. Fantry L. Gastrointestinal infections in the immunocompromised host. Current Opinion in Gastroenterology 2002; 18(1):34-9.

2. Barsoum RS. Parasitic infections in organ transplantation. Exp Clin Transplant 2004; 2 (2):258-67.

3. Syafinaz AN, Hamat RA, Malina O, Siti NM, Niazlin MT, Jamal F Hymenolepis nana in a renal transplant recipient: to treat or not to treat? Med J Malaysia 2011 Aug; 66(3):259-60.

4. Kiran Kumar Mukku, Sreebhushan Raju And Ramesh Yelanati, Refractory Giardiasis In Renal Transplantation: A Case Report Nephrology 20 (2015) 44–48.

5. C. N. Kottona R. Lattesb and the AST Infectious Diseases Community of PracticeParasitic Infections in Solid Organ Transplant Recipients. American Journal of Transplantation 2009; 9 (Suppl 4): S234–S251Wiley Periodicals Inc.

6. Barsoum RS. Parasitic infections in organ transplantation. Exp Clin Transplant 2004; 2: 258–267.

7. Udgiri N, Minz M, Kashyap R et al. Intestinal cryptosporidiosis in living related renal transplant recipients. Transplant Proc 2004; 36: 2128–2129

8. Jay A. Fishman, Infection in Solid-Organ Transplant Recipients. N Engl J Med 2007; 357:2601-14

9. Eltayeb LB, BirarSl, Waggiallah HA. Prevalence of Intestinal Parasites among Renal Transplant Recipients in Khartoum State. IJHSR. 2015; 5(11): 90-95.

10. Linda BashierEltayeb, Sara LaviniaBrair, Awad Ahmed Nasr. Frequency of intestinal parasites with emphasis on opportunistic parasites among renal transplant recipients with and without diarrhea in Sudan 2012. Sudanese Journal of Public Health. 2013; 8 (4): 135-140.

11. Cheesbrough M. District Medical laboratory manual of tropical countries part 1publishied by tropical health technology and butterworth- heinemannlt second edition 1987; 200-214.

12. Patil K, De A, Mathur M. Comparison of Weber Green and Ryan Blue modified trichrome staining for the diagnosis of microsporidial spores from stool samples of HIV-positive patients with diarrhoea. Indian J Med Microbiol. 2008; 26(4):407

13. Chappell LH, Wastling JM. Cyclosporin A: antiparasite drug, modulator of the hostparasite relationship and immunosuppressant. Parasitology 1992; 105 Suppl: S25-40.

14. M Nateghi Rostami, H Keshavarz, E Eskandari, EB Kia, M Rezaeian Intestinal. Parasitic Infections in Renal Transplant Recipients. Iranian J Parasitol 2007; 2(3)16-23209.

15. Valar C, Keitel E, Dal Pra RL, Gnatta D, Santos AF. Parasitic infection in renal transplant recipients. Transplant Proc 2007; 39 (2): 460-2.

16. Mehdi A, MehranSh, Sayed H, Mehdi T. Intestinal parasitic infections in renal transplant recipients. Braz J Infect Dis 2010; 14(1):15-18.

17. Fantry L. Gastrointestinal infections in the immunocompromised host. Current Opinion in Gastroenterology 2002; 18(1):34-9.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions