International Journal of Current Research and Review
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IJCRR - Vol 13 Issue 07, April, 2021

Pages: 64-69

Date of Publication: 12-Apr-2021


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Review of Viparit lajjalu (Biophytum sensitivum Linn.) and its Effect on Sperms

Author: Dhiraj Zade, Swanand Pathak, Pramod Khobragade, Sonali Wairagade, Prafulla Fadanvis

Category: Healthcare

Abstract:Medicinal plants are commonly used by traditional medical practitioners to treat different illnesses in their everyday practices. In various diseases such as stomach ache and burning sensation, inflammation, arthritis, wounds, gonorrhoea, amenorrhea and dysmenorrhea, asthma, cough, degenerative joint disease, urinary calculus, diabetes, snake bite, Viparit Lajjalu (Biophytum sensitivum Linn) of the family Oxalidaceae is one of those used as traditional folk medicine. It is a small, flowering, annual herb with sensitive leaves in the opposite direction. It grows in the warmer parts of India and Nepal and in tropical Africa & Asia. Several ethano-botanical reviews illustrate the same plant's aphrodisiac activity and sterility activity. An aphrodisiac is a drug or food that activates sexual instinct, induces desire, or enhances sexual enjoyment or efficiency.

Keywords: Viparit Lajjalu, Sperm, Vajikaran

Full Text:

Introduction

Folklore herbal medicines are getting more attention now a day. Folklore medicines are a more important source of knowledge for research and development.1 The traditional therapist more often carries the traditional philosophies, civilisations, and stories of a community, which they receive from the previous generations.2 There is scope to encourage the new idea, manner and treatment modalities from older healing procedure.3 The traditional medical practitioner provides health maintenance by using herbal plants, inorganic and organic materials and certain other approaches based on the societal, ethnic and spiritual backgrounds as well as the fundamental knowledge.4,5 Traditional practitioner used different medicinal formulas from various natural substances (herbal plants, inorganic and organic materials). They have wide knowledge based on herbal plants for treatment and dietary purposes. Currently, traditional therapists have their area of expertise. There are different types of medicinal plants that are known to traditional therapists, Biophytum sensitive Linn is one of the tremendous effect, variety of uses even though not into the lumen of research.

There are so many therapeutic myths on different types of traditional medicine but lacking scientific study on them.6 Most of the folklore medicines are given without doing any ethical, well-mannered research even in this era of science. Single herbs have so many qualities, activity on different diseases in so many types of permutation and combinations.

Infertility is emerging as one of the embarrassing problems in the present world. But now the male infertility of a day is unexpectedly raising & putting up a major concern for both patients and doctors. Infertility affects around 1 in 7 reproductive-age couples, frequently causing significant psychological distress. In men, infertility may results from impaired sperm quality, quantity and abnormality. Azoospermia or Oligospermia is usually idiopathic but may be a consequence of hypogonadism.1 Male infertility is commonly due to deficiency in the semen and semen quality is used as a surrogate measure of male fecundity.2 It may cause due to y-chromosomal microdeletions, varicocele, hypogonadism, previous vasectomy, previous sexually transmitted infection and others.3 To verify the number, shape and movement of sperm in the ejaculate, the diagnosis should require a medical history of the individual and a physical examination along with a semen analysis. To verify the levels of hormones that regulate the development of sperm, blood tests may also be performed. Genetic investigations and testicular biopsies are sometimes done. For this there are some treatments, today doctors will advise that the couple take Reproductive Assisted Technologies (ART), such as IVFF (in vitro fertilisation). The cause of infertility is not healed or treated by ART but may help couples achieve pregnancy even if the man's sperm count is very low.4,6,7

All these treatments may be expensive, prolonged which cannot possible for every couple and there is no reassurance about fertility after these treatments. It ultimately results that some men have to deal with the reality that nothing can be done about their infertility. In Bhavaprakash about Laxmana as Putrajanani means ability to produce healthy progeny. Viparit Lajjalu (Biophytum sensitive) is one drug under the category of Laxmana in Bhavprakash5. Laxmanamula Strivandhtyatvanashana and Vandhyatva in Shushrutasamhita, which improves the consistency, quantity and abnormality of the female reproductive system, have also been described by Acharya Shushruta.6

B. sensitive Linn. has been liberally used all over India. Even in Folklore in West Africa and Mali region it is used for Aphrodisiac activity, wound healing and malaria.7 B. sensitive Linn the whole plant is also eaten to induce sterility in man.8 Due to different opinion on the activity of sperm of B. sensitive Linn.,  the proper scientific study should be done for an accurate conclusion of the effect on sperms.

Ayurvedic review

Shukra is considered as the last of the seven Dhatus which are responsible for maintaining and providing strength to the human body. Ingested food material after digestion “Rasa Dhatu” is produced which after the action of Agnis of different Dhatus produces Rakta, Mamsa, Meda, Asthi, Majja while these Dhatus are formed different types of waste products are produced and are thrown out of the Dhatu resulting into the Mala Rahit (devoid of waste products) Last Dhatu i.e. Shukra.9

As the function described to Shukra Dhatu is to produce “Garbha” (Fetus) it must be the cleanest Dhatu. Being cleanest of the Dhatus it is also one of the “Ten Pranayatanani” i.e. one of the ten body parts where the “Jiva” i.e. life resides10. Any harm to these ten parts costs the life of the person who is hurt at those places. Shukra Dhatu is formed or produced in the body from the Rasa Dhatu i.e. an absorbed form of the digested food material from the Gut. Rasa Dhatu then produced Rakta and then Mansa& so on till the Shukra the last of the Seven Dhatus is produced.  Acharyas consider that it requires 3 day nights to produce the next Dhatu thus it takes 21 days for producing Shukra. Some Acharyas believe that after one month Shukra Dhatu is produced. There are interesting theories to explain the formation of these Dhatus one of which is denoted by giving an example of a canal that irrigates the farm turn by turn, this theory is known as “Kedar kullya nyay”.

The second theory indicates that as the milk is turned into curd and so on likewise Rasa turns to Rakta and Rakta to Mansa and so on, this theory is known as “ksheer dadhi nyay”.11,12

The third theory explains that as the pigeon collects grain from the field where grains are extracted, pigeons whose nest is nearby will reach earlier whereas whose nest is faraway will take more time to reach likewise Rakta being the next Dhatu will be formed earlier; Mansa being third in line will take more time. Shukra being the farthest will be the last to be formed. This theory is known as “khale kapot nyay.11 When these theories are seen collectively it becomes clear that rasa contents raw material to produce different Dhatus. It flows in the body continuously providing raw material to different manufacturing systems of the Dhatus, which after receiving the suitable raw material produces particular Dhatu with help of Dhatawagnis which converts them properly and the waste material ready to be thrown out of the body.

There are many opinions regarding the production of Dhatus particularly that of Shukra. Some Acharyas consider that it takes one day and one night (i.e. 24 Hrs) to produce the next Dhatu likewise at the end of the seventh day after ingestion of food Shukra is produced.

The digested and absorbed Rasa contents the raw material required for the formation of different Dhatus which are processed by different Agnis and next Dhatu have formed including Shukra and oja there after. When these processes go wrong due to various reasons including heredity, to dietary deficiencies, the previous history of the diseases, deficient Dhatawagnis, abnormalities of the system concerned whether congenital or acquired, the Dhatu produced is not normal or optimum. Such abnormal or deficient Dhatu is also deficient in its performance. The same is the case of ShukraDhatu; if the production of the ShukraDhatu is deficient due to any reasons mentioned above or any other reason it cannot produce “Garbha”. The production of “Garbha” is the prime function of ShukraDhatu.13,14,15

According to Kashyap Samhita, though Shukra is present in the body it remains dormant and becomes vyakta at the age of 16 years. As it becomes Sampurna i.e. Complete hence becomes visible. Of these, the SarvdehikShukra produces secondary sex characters and the SthanikShukra is ready for ejaculation and producing Garbha. The “Garbhotpatti” is possible only if a good “Shonit” i.e. Stribija and good healthy Shukra unite to form a Garbha” i.e. Zygote. This Zygote when reaches the healthy uterus it’s implanted and grows normally in a well-nourished mother. But, if any of these four factors are deficient the formation of “Garbha” i.e. Zygote or its implantation is hampered causing ApatyaKamana or “Vandhyatwa” i.e Infertility. Ayurvedic literature describes the lakshan of “ShuddhaSukra” and “AshuddhaSukra”. Facilities of microscopic examinations were lacking for ancient physicians who were aware of the fact that the “Vikrities” abnormalities of the semen cause infertility.16-18

Modern view

With the advancement of Teratozoospermia, the physics and tools offered by it for medical usage the microscopic examination of the semen reveal abnormalities of the semen particularly of the sperms and their viability. The sperm with abnormalities in its anatomy and physiology is unable to fertilize the ovum. In cases where the number of such abnormal sperms is high ovum cannot be fertilized causing infertility. Many such abnormalities of the sperm ranging from semen without sperm (Azoospermia), Dead sperms (Necrospermia), Fewer sperms (Oligozoospermia), sperms with pus cells (Pyospermia) & abnormalities of its head, body, tail are now encountered. Amongst these abnormalities, Teratozoospermia is one such abnormality where the head, body or tail of the sperm is abnormal separately or collectively.19,20

Modern drug review

There is a generic medicine that affected sperm quality and quantity. Clomiphene is the licensed medicine for female infertility, but clomiphene can also be administered to males by physicians.12 It will decrease hyperandrogenic (low testosterone) symptoms, increase sperm count, and potentially help boost non-obstructive azoospermia, a blockage that prevents semen from entering the sperm.13

Originally designed for breast cancer, Anastrozole or Arimidex has become a viable off-label treatment for particular groups of infertile men. Anastrazole inhibits the enzyme, aromatase, which prevents testosterone from transforming into estradiol, unlike most fertility medications.14 This process helps increase the level of testosterone and reduces the level of estrogen. Anastrozole was found to decrease symptoms of male hypoandrogenism, such as low energy, decreased muscle mass, low libido, and erectile dysfunction. It has also been shown in males who are azoospermic or have a low sperm count to increase sperm production and sperm recovery rates.15

By directly stimulating the testes, human chorionic gonadotropin acts to produce its testosterone and increase sperm production. In hypogonadism men, research has found HCG to improve energy, libido, strength, and mood. This was observed in men who are hypogonadism due to unknown reasons, as well as in men with lower production of testosterone due to long-term replacement therapy with testosterone. The improvement in testosterone output from HCG can also increase the chance of successful sperm retrieval in men with non-obstructive azoospermia, according to another study.16 One of the declines in sperm motility and seminal vesicle secretions, irregular sperm morphology, is also methadone hydrochloride.17,18 Spermatogenic arrest/decreased sperm count by nitrofurantoin (in high doses).19,20

Ayurvedic drug review

Taxonomical Description

Botanical name –  Biophytum sensitive Linn.

Synonyms

Sanskrit:   Jhullipuspa, Lajjaluka, Panktipatra, Pitapushpa, Vipareetalajjaalu20

Common name:  Life plant, little tree plant, sensitive plant21

Hindi: Lajalu, Lajjaalu, Lakshmana, Zarer22

Marathi: Jharera, Lajwanti, Lahanmulaka23

Family: Oxalidaceae

Genus: Biophytum

Species: sensitivum24

It has been used in traditional medicine, especially in Indian medicine, for different ailments. 25,26 In the tradition and culture of the state of Kerala in India, the flower of this plant is regarded as one of the ten sacred plants called Dasapushpam27

Botanical description

It is an annual herb that looks like a miniature palm, with 2.5 to 25 cm of unbranched, erect, glabrous or hairy stems. Leaves, with 6-12 pairs of leaflets, are sensitive, pinnately compound, crowded into rosette at the top of the stem, and 5-12 cm long. The leaflets are opposite, the petiole is short, and the size increases upwards steadily, being 1.5 cm long, oblong and apiculate at the apex. Flowers are dimorphic, numerous, and up to 10 cm long, 8 mm across the yellow peduncle. With parallel nerves, sepals are 5, lanceolate, imbricate, and acute. Petals are 5, red-marked gold, connate into a salver-shaped corolla and rounded lobes far exceeding the sepals. The fruit is a capsule that is apiculate, ellipsoid, slightly exceeding the sepals. Seeds are ovoid and striate transversely. There are 10 stamens, free of separate filaments, five inner ones are longer, and five styles.28

Movement of plant leaves

B.sensitivum displays nastic movement in the leaves in response to touch, contact with the foreign body, rainfall, wind, vibration, heat, and closing of its leaflets, and the movement is independent of the direction of the stimulus. Depending on the stimulus intensity applied, the degree of motion varies. When the sensitive plant's leaf apex is gently touched, only a few pairs of leaflets close up, and when roughly touched, all the leaflets respond in the same way from the apex downward. A motor structure formed by a rod of collenchyma surrounded by sclerenchyma is the pulvinus. In their extended location, the cells of the entire collenchyma are distended with water, and the cells in the lower half of the pulvinus react by expelling potassium and chlorine ions and taking up calcium ions upon receipt by contact of the action potential signal. This results in an osmotic gradient that pulls water out of the affected cells. The lower pulvinus cells temporarily shrink due to water depletion. In the manner of a fan, this causes the entire structure to bend down. The pulvinus no longer acts as a support in this contracted role and the petiole droops.29 Furthermore, botanists have found a signalling molecule called turgorin, which is known to be a new phytohormone class that regulates all leaf motions by regulating the turgor of plant cells. A highly acidic, free sulphuric acid group is included in the turgorin molecule and it was found that diluted sulphuric acid-induced leaf closing as strongly as turgorin. Therefore it was concluded that turgorin's leaf-closing activity is due to its sulphuric acid group's high acidity.30

Properties of Vipareeta lajjaalu(Biophytum sensitivum Linn) -

Guna: Laghu

Rasa - Tikta, Madhur, Kashaya,

Veerya – Sheeta

Vipak - Katu

Gana:-Guduchyaadivraga B.H.P.

Chemical composition: There are different chemical components in the whole plant, such as phenolic and polyphenolic compounds, saponin, essential oil, polysaccharides and pectin. The key constituent was found to be amentoflavone in methanolic extract of roots, stems and leaves.31

Other therapeutic utilities of the plants:-

1.  In Urine calculus Quath of the root of B. sensitivum administered.

2. In piles Roots powder paste applied.

3. The root of B. sensitivum is tied on Hydrocele patient on locally.32,33

Safety profile

Acute toxicity for B. Sensitivum extracts has been tested in rodents. Aqueous plant leaf extract was tested and found to be non-toxic at 100, 200 and 300 mg/kg dose levels by oral route in mice 33 Methanol extract B. Sensitivum whole plant is well tolerated up to an oral dose of 4000 mg/kg as no mortality was observed within 24 h34 The median dose (LD50) of plant in hexane, chloroform, ester, N-butanol and ethanol extracts found to be greater than 1 g/kg when intraperitoneally administered to rats.35

Clinical Studies

B. sensitivum is used for the treatment of diabetes traditionally said to have an insulin-like compound. The mechanism of action is not well understood, but tropical insulin properties appear to be present. Clinical studies on the B. Sensitivum containing formulation have been published36 Since 2002, DB14201 has been sold under an Ayurvedic license granted under the trade name Diabedrink by the Drug Controller of the State of Kerala.

In Ayurveda, it is a mixture of 16 herbs used including B. sensitivum. Blinded, placebo-controlled, randomized clinical trials have been reported in 30 patients with type 2 diabetes aged 29-71 with single oral diabetes in both sexes. It is confirmed that when administered along with glibenclamide, the herbal formulation DB14201 is safe in T2DM patients and enhances the efficacy of glibenclamide in providing improved glycemic control. Compared to the addition of placebo, it also offers a substantial increase in fasting and post-prandial blood sugar levels and also significantly decreases HbA1c levels.36

Herbal emulsifying creams and gels are prepared by adding the dry methanolic extract of the whole plant B. Sensitivum has been assessed for in-vitro antibacterial efficacy against four distinct bacterial strains (Salmonella typhi, Staphylococcus aureus, Escherichia coli and Bacillus subtillis). The findings revealed that when formulated as cream and gel for topical use B. sensitivum has a high potential as an antibacterial agent.37

B. sensitivum was prepared with an optimized tablet formulation by using the methanolic extract from the dried whole plant. Their antioxidant properties were evaluated in vitro based on their total flavonoid content (TFC) against the regular flavonoid, Quercetin, and also in vivo for the antidiabetic activity of Streptozotocin (STZ)-induced diabetic rats against the anti-diabetic drug Glibenclimide.38-39 The drug with the formulations showed antioxidant and anti-diabetic properties37,40 anti-inflammatory anti-cancerous,41-43  Immunomodulatory effect and Radioprotective.

Conclusion

It has historically been recognized that parts of the plant have a broad range of medicinal properties, including antiseptic properties, including beneficial effects on a variety of skin infections and diabetes care. Scientific study has shown that anti-bacterial, anti-fungal and anti-diabetic practices have been carried out. The plant has been extensively assessed and confirmed to have anti-inflammatory, antipyretic, antimicrobial, anti-obesity, antioxidant, anti-diabetic, anti-fungal, anti-cancer, larvicidal, anti-obesity, anti-hypertensive, anti-epileptic, wound healing and anti-fertility activity for various pharmacological activities. In the treatment of different diseases, the entire plant is often traditionally used. B. sensitivum has been traditionally recommended for Diabetes treatment in the Ayurvedic Philosophy of Medicine. After critical review, no clinical work has been done previously and the conclusions of existing studies are contradictory to each other in therapeutic uses. One article is suggesting Aphrodisiac activity and the other one sterility activity of B. sensitivum. Whereasthe drug is used for infertility by tribal people. Previous evidence search on B. sensitivum no fact has been generated to prove the exact mechanisms on sperm by B. sensitivum.To generate the evidence regarding specific action B. sensitivum, it is necessary to overcome the confusion about the activity of B. sensitivum on sperm in a scientific manner.

Conflict of interest: Nil

Source of funding: Nil

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17. Albert PS, Mininberg DT, Davis JE. The nitrofurans as sperm immobilising agents: their tissue toxicity and their clinical application. Br J Urol 1975;47:459–462.

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Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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