International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 08 Issue 02, January, 2016

Pages: 84-90

Date of Publication: 22-Jan-2016


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A COMPARITIVE STUDY BETWEEN VAGINAL HYSTERECTOMY AND LAPAROSCOPICALLY ASSISTED VAGINAL HYSTERECTOMY

Author: Kavitha G., Renukadevi B., Rathna Ramamurthi, Rajarajeshwari S.

Category: Healthcare

Abstract:Introduction: Hysterectomy is the second most common surgical procedure performed by an Obstetrician and gynecologist next to Cesarean section. It can be performed by various methods, depending upon the pathology in the uterus, size of the uterus and the skill of the surgeon. Though there are a lot of advances in laparoscopic surgeries, most of the senior gynecologists feel that the laparoscopic hysterectomy have to replace abdominal hysterectomies but not vaginal hysterectomy and when ever feasible vaginal hysterectomy should be the method of choice for most cases of benign gynecological disease requiring hysterectomy. Objectives: The objective of the study is to compare the surgical and immediate post operative outcome for vaginal hysterectomy (VH) with those of laparoscopic assisted vaginal hysterectomy (LAVH). Methodology: This was a retrospective comparative study conducted among 200 patients who underwent vaginal hysterectomy/ (VH) laparoscopic assisted vaginal hysterectomy (LAVH) for various indication in the department of obstetrics and gynecology of Velammal medical college hospital and research centre from august 2012 to august 2015 (over period of 3yrs). The data were collected from medical records of the patient. The patients were divided into two groups of 100 each. Patients who underwent vaginal hysterectomy were grouped as VH and patients who underwent laparoscopic assisted vaginal hysterectomy were grouped as LAVH. The data was collected in terms of age, parity, history of previous surgeries, indications for surgery, operative time, and blood loss during surgery, intra-operative complication, post-operative complication and duration of hospital stay. The results were statistically analyzed with SPSS 16.0 version. Results: The baseline characteristics of both groups were similar. The mean operative time for the VH group was 90 minutes and 148 minutes for LAVH group (p=0.00). The mean blood loss for VH group was 152ml and 66ml for LAVH group (p=0.00). The incidence of vault hematoma was significantly more in the VH group and paralytic ileus was significantly higher in LAVH group. There was no significant difference between both groups in the incidence of hemorrhage, visceral injury and post operative pyrexia. Conclusion: Vaginal hysterectomy should be the preferred route of hysterectomy for benign conditions of the uterus whenever feasible, as it is associated with shorter operative time and early disappearance of post-operative pain.

Keywords: Vaginal hysterectomy, Laparoscopic assisted vaginal hysterectomy, Operative time, Post-operative pyrexia, Vault- hematoma, Paralytic ileus

Full Text:

INTRODUCTION
In a country like India, were resources are limited, women generally refuse medical management and conservative surgical management for most of the benign uterine pathology, so hysterectomy has become one of the most commonly performed gynecological operation. Up to 20% of women undergo hysterectomy by the age of 601. Most common reasons for performing hysterectomies are fibroid uterus, menstrual irregularities, endometrial hyperplasia, cervical dysplasia, genital malignancies, endometriosis, adenomyosis and genital prolapse.

Traditionally uterus has been removed by either the abdominal or vaginal route. Nowadays, we distinguish three different surgical approaches to hysterectomy: vaginal, abdominal, and laparoscopic. There is no universal agreement among gynecologist about the optimal route of hysterectomy for various uterine pathologies. Origin of Vaginal hysterectomy dates back to the ancient times. There is reference that vaginal hysterectomy was performed by Themison of Athens in 50 BC2 . The first authenticated vaginal hysterectomy was performed by the Italian anatomist Berengario da Carpi of bologna in 15073 .

The first planned vaginal hysterectomy for non prolapse uterus with entry into the peritoneal cavity was done for cervical cancer in 1822 by Santer of Baden3 . The most common cited contraindication to vaginal hysterectomy is uterine size, nulliparity and uterine descent, need for oophorectomy and previous abdominopelvic surgery and extrauterine disease. The first vaginal hysterectomy with laparoscopic assistance was described in 1984. The true role of laparoscopy in facilitating vaginal hysterectomy was to convert cases that could be done only by abdominal route to a laparoscopically assisted vaginal hysterectomy. Laparoscopic assistance during vaginal hysterectomy not only provides visualization of the real anatomic picture in the abdominal cavity, but allows the surgeon to perform correction of the associated pathology and some steps of the hysterectomy itself, thus reducing the operative risk of this, to a certain degree, ‘blind intervention. Kovac4 has described a scoring system which involves grading of uterus, length of infundibulopelvic ligament, presence of adnexal adhesion, status of cul-de-sac, and degree of endometriosis.

Patients with scores of 10 or less were considered as candidates for vaginal hysterectomy; those with 11- 19 were candidates for laparoscopic surgery to reduce their scores to less than 10. ACOG established some guidelines for the route of hysterectomy by staging that the choice depends on the patient’s anatomy, surgeons’ experience, and that vaginal hysterectomy is usually performed in women with mobile uterus not larger than 12 weeks gestation, especially if there is uterine descent. The purpose of this study was to compare laparoscopic assisted vaginal hysterectomy versus vaginal hysterectomy in terms of surgery time, total blood loss, post operative stay in hospital, intra operative and post operative complication.

MATERIAL AND METHODS This was a retrospective comparative study done among 200 women who underwent laparoscopic assisted vaginal hyster ectomy or vaginal hysterectomy for various indications in the department of obstetrics and gynecology of Velammal medical college hospital and research institute. The study was conducted over a period of 3yrs from August 2012 to August 2015.

Method of Collection of data The data of the patients were obtained from hospital medical records. The first 100 cases of laparoscopic assisted vaginal hysterectomy were compared with the cases of first 100 cases of vaginal hysterectomy among women who met the eligibility criteria, done during the study period. The patients were matched for pathological diagnosis, age, parity, size of uterus between laparoscopic assisted vaginal hysterectomy and vaginal hysterectomy group. Group VH was designated for patients who underwent vaginal hysterectomy and LAVH was designated for patients who underwent laparoscopic assisted vaginal hysterectomy. Medical records of the patients were reviewed; factors examined included demographic details, indication for surgery, and history of previous surgeries, intra operative details, post operative recovery and complication.

Inclusion Criteria Women who underwent vaginal hysterectomy or laparoscopic assisted vaginal hysterectomy for Fibroid uterus, Adenomyosis, AUB, Cervical dysplasia and Postmenopausal bleeding and with size of uterus measuring less than or equal to16 weeks size were included in the study.

Exclusion criteria Women who underwent vaginal hysterectomy or laparoscopic assisted vaginal hysterectomy for Malignancies of cervix, endometrium, ovary and size of uterus measuring more than from the study 16 weeks were excluded from the study.

Operative procedure A standardized procedure for vaginal hysterectomy was followed. The procedure started with a circumferential incision all along the uterine cervix, followed by anterior and posterior colpotomies. The cardinal and uterosacral ligaments were clamped, cut and ligated on both the sides. Then the bilateral uterine vessels were clamped, cut and ligated, followed by the clamping, cutting and ligation of cornual structures. Finally the vaginal cuff closure was done. Laparoscopic assisted vaginal hysterectomy were started by introducing a 10mm trocar and canula supraumbilically to hold the camera. Two 5mm trocar and canula were inserted into the lower abdomen. Bilateral round ligaments, the fallopian tubes and ovarian ligaments were electrocoagulated and cut. The vesicouterine fold of peritoneum was opened using monopolar hook and rest of the procedure were accom- plished by vaginal route.

At the end of procedure the peritoneal cavity was inspected laparoscopically for hemostasis. The size of the uterus was measured in weeks of pregnancy. The operative time was calculated from the first incision to end of wound closure. The blood loss was estimated by calculating the blood volume in the suction apparatus and by weighing the swabs. Major and minor intra operative complication and post operative complications like hemorrhage requiring transfusion or re-operation, visceral injury to bladder, bowel or ureter, conversion to laparotomy, fever ( >380 c in two consecutive occasions more than or equal to four hours apart after 24 hrs of surgery), paralytic ileus and vault hematoma. Day of disappearance of pain was the post operative day when the patient needed no analgesics.

The patients were discharged from the hospital when they were pain free, able to tolerate normal diet, apyrexic and ambulant. The collected data was analysed with SPSS 16.0 version. The descriptive statistics, frequency analysis, percentage analysis were used for categorical variables and the mean and standard deviation was used for continuous variables. To find the significant difference between the bivariate samples in Independent groups (VH and LAVH) unpaired sample t-test was used. To find the significance in categorical data ChiSquare test was used. In both the above statistical tools the probability value P<0.05 is taken as significant (S).

RESULTS There was no significant difference between both groups in age distribution (p=0.44), parity (p=0.68), number of cases with previous cesarean section (p=0.50) and indication for hysterectomy (p=0.28).

Baseline characteristics

The mean age of patients in VH was 42.79yrs and 43.6yrs in LAVH group. There was no significant difference in two groups in age distribution (P >0.05).

There was no significant difference in two groups in the distribution of previous LSCS cases (P >0.05).

Vault hematoma: 7 cases of vault hematoma were seen in VH group against 0 cases in LAVH group (P < 0.05)

Paralytic ileus: 8 cases of paralytic ileus in LAVH group against 0 cases in VH group (p< 0.05).

Wound infection: There were 2 cases of vault infection in VH group and 9 cases of port site infection in LAVH group (p<0.05).

DISCUSSION
Laparoscopic hysterectomy has never been indicated for hysterectomy if the surgery is feasible by vaginal route. Laparoscopic assisted vaginal hysterectomy is a useful adjunct to vaginal hysterectomy for lysis of extensive adhesion and sometimes for concomitant surgery for adnexal pathology. A recent Cochrane review of surgical approach to hysterectomy for benign gynecological disease, involving 3643 women in 27 trials, concluded that the vaginal approach is preferred to the abdominal approach. When vaginal hysterectomy is not possible, laparoscopic hysterectomy may avoid the need for an approach by laparotomy. The purpose of our study was to compare the surgical and immediate post-operative outcome for vaginal hysterectomy with those for laparoscopically assisted vaginal hysterectomy. In our study there was homogeneity among demographic characteristics with regards to their age, parity, indications for surgery and uterine size. The most common indication for surgery in our study was fibroid uterus (44.5%), AUB (26%), Adenomyosis (19%), similar findings were found in a study by Shretha et al4 in which fibroids contributed to 53%, Adenomyosis (20%) and DUB (13.3%) of cases of hysterectomy. In literature, several studies report that operation time is longer with LAVH than VH6-12, 17. Even in our study the mean operating time was significantly shorter with VH than with LAVH (P=0.00).

This might be because the surgeries were performed by assistant professors who were well experienced in performing VH, but were comparatively less experienced in performing LAVH, and as we know the learning curve of VH is very short compared to laparoscopic surgery. In our study LAVH group had less blood loss compared with VH (P=0.00), similar to that observed by Summit et al13 (100-1000ml in VH versus 25-100ml in LAVH) and Aniuliene R et al14, but unlike to that observed by Ottosen C et al, Doucette et al, Riberio SC et al7, 5, 9 that blood loss was less in VH. Intra-operative complication (visceral injury and hemorrhage) rates did not significantly differ between both groups in a study by Abdelmonem A et al15. The incidence of vault hematoma was significantly more in VH group than LAVH group in our study; this may be because during laparoscopic approach hemostasis is checked at the end of the procedure16. In our study the incidence of paralytic ileus was significantly high in the LAVH group, probably due to the prolonged procedure time and bowel handling.

CONCLUSION
Vaginal hysterectomy can be considered as a preferable route of hysterectomy for uterine sizes less than 16weeks because it involves shorter operative time, earlier disappearance of post-operative pain and lesser incidence of paralytic ileus and wound infection. LAVH can be considered as a better approach to larger uterus in view of easier approach to upper pedicle, better visualization of adnexal pathology, lesser blood loss and lower incidence of vault hematoma.

ACKNOWLEDGEMENT
Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Ethics committee approval: Obtained Informed consent: Obtained from each patient Source of funding: None Conflicts of interest: None

 

References:

1. Royal college of Obstetricians and Gynaecologists. National Evidence - based Clinical Guidelines. The management of menorrhagia in secondary care. London, Engl: RCOG Press, January 1999.

2. Sutton C. Past, Present and Future of hysterectomy. J Minim Invasive Gynecol. 2010 Jul- Aug; 17(4):421-35.

3. Baskett TF. Hysterectomy: evolution and trends. Best Pract Res Clin Obstet Gynaecol. 2005;19:295-305.

4. Kovac SR. Guidelines to determine the route of hysterectomy. Obstet Gynecol 1995 Jan;85(1):18–23.

5. Shrestha R, Yu LH. Comparison between laparoscopic hysterectomy and abdominal hysterectomy. NJOG. 2014JanJun;17(1):26-8.

6. Ottosen C, Lingman A, Ottosen L. Three mehods for hysterectomy: a randomized, prospective study of short term outcome. BJOG. 2000;107(11):1380-5.

7. Doucette RC, Sharp HT, Alder SC. Challenging generally accepted contraindication to vaginal hysterectomy. Am J Obstet Gynecol. 2001Jun;184(7):1386-9.

8. Ribeiro SC, Ribeiro RM, Santos NC, Pinotti JA. A randomized study of total abdominal, vaginal and laparoscopic hysterectomy. Int J Gynaecol Obstet. 2003 Oct;83(1):37-43.

9. Garry R, Fountain J, Mason S, Hawe J, Napp V, Abbot J, et al. The evaluate study; two parallel randomized trial, one comparing laparoscopic with abdominal hysterectomy, the other comparing laparoscopic with vaginal hysterectomy. BMJ. 2004 Jan 17;328(7432):129.

10. Cook JR, O’Shea RT, Seman EI. Laparovaginal hysterectomy: a decade of evolution. Aust N Z J Obstet Gynaecol. 2004 Apr;44(2):111-6.

11. Johnson N, Barlow D, Lethaby A, Tavender E, Curr E, Garry R. Surgical approach to hysterectomy for benign gynaecological disease. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD003677.

12. Richardson RE, Bournas N, Magos AL. Is laparoscopic hysterectomy a waste of time Lancet. 1995 Jan7;345(8941):36-41

13. Summit RL Jr, Stovall TG, Steege JF, Lipscomb GH. A multicenter randomized comparison of laparoscopically assisted vaginal hysterectomy and abdominal hysterectomy in abdominal hysterectomy candidates. Obstet Gynecol. 1998 Sep;92(3):321- 6.

14. Aniuliene R, Varzgaliene L, Varzgalis M. A comparative analysis of hysterectomies. (Article in Lithuanian). Medicina (Kaunas). 2007;43(2):118-24.

15. Abdelmonem A, Wilson H, Pasic R. Observational comparison of abdominal, vaginal and laparoscopic hysterectomy as performed at a university teaching hospital. J Reprod Med. 2006 Dec;51(12):945-54

16. Karl Olah. Vaginal hysterectomy in the absence of prolapse. The obstetrician and Gynaecologist. 2005 Oct; 7:233-40.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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