International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 08 Issue 02, January, 2016

Pages: 19-22

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CLINICAL PRESENTATION, MANAGEMENT AND OUTCOME OF 100 CONSECUTIVE CASES OF CONGENITAL NASOLACRIMAL DUCT OBSTRUCTION SEEN IN A REGIONAL INSTITUTE OF OPHTHALMOLOGY

Author: Garima Agrawal, Swati Ravani

Category: Healthcare

Abstract:Introduction:
2-6 % of full term newborn children manifest symptoms of congenital nasolacrimal duct obstruction. The most frequent presentation is tearing associated with mattering of the eyelashes and recurrent infection. We designed a study to document the clinical presentation, management and outcome of 100 consecutive cases of congenital nasolacrimal duct obstruction seen in a regional institute of ophthalmology. Aim: Clinical presentation, management and outcome of 100 consecutive cases of congenital nasolacrimal duct obstruction seen in a regional Institute of Ophthalmology. Material and Methods: 100 consecutive cases of congenital nasolacrimal duct obstruction, seen in our regional institute of ophthalmology were enrolled from June 2011 to June 2015. Patients of age less than 6 months were treated with massage four times a day and topical moxifloxacin 0.5% as and when discharge was seen. Probing was reserved for patients with acute infection or acute dacryocystitis in children aged 6 months to one year. Probing was the treatment of choice for children between one year and four years. Silicone intubation was done in patients who failed probing. Dacryocystorhinostomy was the procedure of choice for patients who failed probing or silicone intubation and as the primary procedure in children greater than four years. Observations and Results: Massage with topical antibiotics were given to all patients. Probing was done in 37 children. Repeat probing was required in nine children. Two out of these nine children required probing with silicone intubation with inferior turbinate in fracture. Four children were managed with dacryocystorhinostomy. The success rate of various procedures were 60% for conservative management, 70.3% for probing, 77.8% for repeat probing, 50% for probing with silicone intubation with inferior turbinate in fracture and 75% for dacryocystorhinostomy. Conclusion: Children with congenital nasolacrimal duct obstruction can be successfully managed with good outcomes.

Keywords: Congenital nasolacrimal duct obstruction, Clinical presentation, Management and outcome

Full Text:

INTRODUCTION
30% infants have an obstructed nasolacrimal duct at birth. 1 Only 2-6% of full term newborn children manifest symptoms of congenital nasolacrimal duct obstruction. The most frequent presentation is tearing associated with mattering of the eyelashes and recurrent infection. The most common cause of obstruction is incomplete canalization of the nasolacrimal duct with a vestigial membrane at its distal end.1 Conservative management of the child with massage and topical antibiotics is recommended. More definitive treatment in the form of probing may be required for cases that fail to canalize or early in cases with recurrent infection, acute dacryocystitis or the presence of congenital dacrocystocele.1 We designed a study to document the clinical presentation, management and outcome of 100 consecutive cases of congenital nasolacrimal duct obstruction presenting to a regional Institute of ophthalmology.

AIM: Clinical presentation, management and outcome of 100 consecutive cases of congenital nasolacrimal duct obstruction seen in a regional Institute of Ophthalmology.

lMATERIAL AND METHODS: The study was carried out at our regional Institute of ophthalmology.100 consecutive cases of congenital nasolacrimal duct obstruction presenting to our Institute were enrolled. The study period was June 2011 to June 2015. The study was a prospective interventional study. Ethical approval was taken from the institutional review board. The diagnosis was made on the basis of clinical presentation of constant watering , mattering of eyelashes ,regurgitation of fluid , mucus or exudate on pressure over the lacrimal sac. Other causes of epiphora pertaining to the eyelids, ocular surface and congenital glaucoma were ruled out. Cases of punctal, canalicular or common canalicular block on probing were excluded from our study. The patients of age less than 6 months were treated with massage four times a day and topical moxifloxacin 0.5% as and when discharge was seen. Probing was reserved for patients with recurrent infection or acute dacryocystitis in children between 6 months to 1 year of age .

Probing was the treatment of choice for children between one year and four years. Informed consent was taken from the parents of the patient. Probing was performed under general anesthesia. Patients were followed at 1 week, 3 weeks, 3 months and 6 months after the procedure. Outcome was defined as resolution of symptoms and signs of nasolacrimal duct obstruction within 3 weeks of the procedure and continued remission for 6 months post procedure. Probing was done twice before the procedure was declared a failure. 2 Silicone intubation without intranasal fixation was done in patients who failed probing. The silicone tubes were kept in place for 6 weeks. Inferior turbinate in fracture was done in all cases of silicone intubation. In children greater than 4 years dacryocystorhinostomy was the treatment of choice. Dacryocystorhinostomy was also the procedure of choice in cases who failed probing/silicone intubation.

RESULTS AND OBSERVATIONS Table I shows the patient demographics. Majority of the patients were less than6 months of age (51 out of 100). 33 patients were between 6 months to 1 year. 13 cases were between one to four years of age. Only three patients presented after four years of age. Many patients were treated elsewhere initially and then referred to our regional institute of ophthalmology for management. Table II shows the clinical presentation of congenital nasolacrimal duct obstruction. Watering, regurgitation on pressure over the lacrimal sac, mattering of the eyelashes and increased tear lake were seen in all patients. Discharge at some point in the history of nasolacrimal duct obstruction was seen in 46 patients. 15 patients had acute dacryocystitis and 22 had persistent dacryocystitis. Recurrent conjunctivitis was seen in 35 patients. We did not come across a case of congenital dacryocystocele. Table III shows the management of congenital nasolacrimal duct obstruction.

The observed results were similar in both eyes in cases of bilateral affection and thus have not been presented separately. Massage with topical antibiotics were given to all patients. Probing was done in 37 children. This included those who presented after one year plus those who presented within one year but failed conservative management. Repeat probing was required in 9 children out of 37. Two out of these nine children required probing with silicone intubation with inferior turbinate in fracture. Three children who presented after four years of age were managed with dacryocystorhinostomy. One more child who failed probing with stenting was also managed with daryocystorhinostomy. Table IV shows the outcome of all procedures. Massage with topical antibiotics was successful in 60 out of 100 patients (60%). Probing was successful in 26 out of 37 children(70.3%). 9 children required repeat probing. Repeat probing was successful in 7 out of 9 children (77.8%). 2 children were subjected to probing with silicone intubation and inferior turbinate in fracture. It was successful in one child. Four children underwent dacryocystorhinostomy. It was successful in three children with only one child requiring a repeat procedure.

DISCUSSION In our institute probing was successful in 26 out of 37 children (70.3%) between one to four years of age. Repeat procedure was required in nine children. This resulted in resolution in 7 out of 9 children (77.8%). The overall success rate of probing in children between 1 to 4 years of age was 89.2%.These results are comparable with those in other studies. Hanover SG et al reported the outcome of probing for congenital nasolacrimal duct obstruction for children 2 years and older. 73.3% patients (44 of 60) had resolution after one attempt of probing. 16 patients needed a repeat procedure. Overall success rate was 80% (48 of 60). Factors predictive of poor prognosis were identified.2 MacEwena CJ et al reported that the use of nasal endoscope facilitated the success of probing in children with congenital epiphora.3

Maheshwari R reported the results of probing in children aged 13 months and above. The success rate in group 1 (13- 24 months ) was 88.1% and in group 2 (> 24 months) was 80.9%. 4 Deok Sun Cha et al reported that the success rate of initial probing in patients aged 6 – 71 months was 80%. The success rate of second probing was 61% for all patients. 5 The Paediatric Eye Disease Investigator Group concluded that probing is a successful primary treatment of nasolacrimal duct obstruction in about three/fourth cases in children aged 6 to < 36 months old.6 Kushner BJ reported the results of simple probing in children aged 18 months to 4 years. 70% children had a good outcome. 100% children with simple membrane at valve of Hasner had a good outcome. Only 36% of those with complicated obstruction had a good outcome. 7 Katowitz JA et al reported 97% success rate of initial probing in children under 13 months of age. Only 54.7 % success rate is reported in children over 13 months of age.

They concluded that initial probing should be done prior to 13 months of age depending on severity of symptoms and parent compliance with medical management. 8 Hirohiko K et al reported that congenital nasolacrimal duct obstruction in Japanese infants had a 82.9 % resolution rate with conservative management before the first year of age. 9 In our institute dacryocystorhinostomy was safe and successful in three out of four children with only one child requiring a repeat procedure. This result is comparable to that of other studies. Hakin K et al concluded that dacryocystorhinostomy in children in experienced hands is a safe procedure achieving relief of symptoms in most cases particularly in absence of canalicular disease. 10

CONCLUSION Children with congenital nasolacrimal duct obstruction can be successfully managed with good outcomes. Probing is the treatment of choice for children less than four years of age with great success rates. Children with persistent symptoms after four years of age plus those presenting after four years of age are best treated with dacryocystorhinostomy.

ACKNOWLEDGEMENT Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/ editors/publishers of all those articles journals and books from where the literature for this article has been reviewed and discussed.

Ethical Clearance: Taken

Informed Consent: Taken

Source of funding: none

Conflict of Interest: none

References:

1. Yeatts RP. Lacrimal Drainage System Surgery.in Principles and Practice of Ophthalmology Albert DM,JakobiecFA ,Azar DT,Gragoudas ES. 2000 WB Saunders company USA Vol 4,chpt 268, pp3556-3558.

2. Hanover SG. Outcome of probing for congenital nasolacrimal duct obstruction in older children. Am J Ophthalmol ;130(1),2000 :42-48.

3. MacEwena CJ, Younga JDH, Barrasa CW, Ramb B, Whiteb PS. Value of nasal endoscopy and probing in the diagnosis and management of children with congenital epiphora. Br J Ophthalmol 2001; 85: 314-318.

4. Maheshwari R. Results of Probing for Congenital Nasolacrimal Duct Obstruction in Children Older than 13 Months of Age. Indian J Ophthalmol 2005;53:49-51.

5. Deok Sun Cha, Hwa Lee, Min Soo Park, Jong Mi Lee, Se Hyun Baek. Clinical outcomes of initial and repeated nasolacrimal duct office based probing for congenital nasolacrimal duct obstruction. Korean J Ophthalmol 2010; 24(5) :261-266.

6. Paediatric Eye Disease Investigator Group. Primary treatment of nasolacrimal duct obstruction with probing in children younger than 4 years. Ophthalmology 2008 ; 115(3) : 577-584.

7. Kushner BJ. The management of nasolacrimal duct obstruction in children between 18 months and 4 years old. J AAPOS 1998 ; 2(1) : 57-60.

8. Katowitz JA , Welsh MG. Timing of initial probing and irrigation in congenital nasolacrimal duct obstruction .Ophthalmology 1987; 94(6) : 698-705.

9. Hirohiko K, Yasuhiro T, Shinsuki f, Kunihiko S, Masayoshi I. The rate of symptomatic improvement of congenital nasolacrimal duct obstruction in Japanese infants treated with conservative management during the first year of age. Clin Ophthalmol 2008;2 (2) : 291-294.

10. Hakin K, Sullivan T, Sharma A, Welham R. Paediatric dacryocystorhinostomy. Australian and New Zealand Journal of Ophthalmology 1994 ; 22 :231-235.

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Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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