International Journal of Current Research and Review
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IJCRR - 13(5), March, 2021

Pages: 157-162

Date of Publication: 03-Mar-2021


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Radiation-Induced Dysphagia and Life-Threatening Stridor in Head and Neck Cancer: A Review

Author: Santosh Kumar Swain, Satyabrata Acharya, Smarita Lenka

Category: Healthcare

Abstract:Radiotherapy plays an important role in the treatment of head and neck cancer. Radiation therapy to the head and neck cancer can cause an uncommon long term swallowing and breathing difficulties by causing stenosis at the pharynx, larynx and oesophagus. The dysphagia or breathing difficulties by radiation therapy may occur be mechanical, structural and neurological deficits. It hurts the quality of life among cancer survivors. This acquired pharyngeal stenosis after radiotherapy may threaten to live by compromising the airway. Radiation-induced pharyngeal stenosis may occur in cases with head and neck cancer which cause significant morbidity and mortality. This article reviews details of radiation-induced pharyngeal or upper aerodigestive stenosis with manifestations of dysphagia and compromised airway including its epidemiology, pathophysiology, clinical presentations, investigations and possible treatment options. The pathogenesis for dysphagia and stridor due to pharyngeal and oesophagal stenosis following radiotherapy is unclear. Severe mucositis in the pharynx might be the predisposing factor for causing fibrosis and leads to stenosis. The upper aerodigestive tract stenosis following radiotherapy is an unusual complication which can be treated with dilation or excision with scar tissue. Although there is no specific or gold standard treatment option found for this stenosis, many supportive, restorative and palliative treatments are available under various clinical conditions.

Keywords: Pharyngeal stenosis, Radiotherapy, Dysphagia, Stridor

Full Text:

INTRODUCTION

Radiotherapy is an important treatment option in head and neck squamous cell carcinoma. Along with surgery or chemotherapy, radiotherapy plays an important role in the treatment of the malignancy in the head and neck region.1 Many surgeons prefer preoperative radiotherapy while some choose planned postoperative radiation. In some patients, full therapeutic doses of radiotherapy are used, although in a reduced dose. The pharyngeal or oesophagal stenosis may be found as a complication of radiation exposure of the head and neck cancer. These manifestations can cause morbidity and life-threatening situation among the cancer-free survivors. Nasopharyngeal carcinoma is an important head and neck cancer where the treatment of choice is radiotherapy.2 There are several associated complications following radiotherapy to the head and neck region such as endocrine dysfunction and temporal lobe injury other than synechia the pharynx and oesophagus.3 The uncommon and dreaded complications of radiotherapy such as dysphagia and stridor are due to fibrosis and narrowing at the pharynx and oesophagus following radiotherapy. These clinical entities are less reported in the medical literature. The delayed effects of the radiation on the pharynx, oesophagus and larynx have not been studied adequately but these parts are often exposed to the radiation during the time of treatment of the head and neck cancer like nasopharyngeal carcinoma. The stenosis at the hypopharynx or upper oesophagus affects the swallowing at the initial period. However, in severe stenosis, it can lead to stridor along with dysphagia to the solid foods. This review article summarizes the epidemiology, pathophysiology, clinical manifestations, investigations and current treatment of the radiation-induced dysphagia and stridor.

MATERIALS AND METHODS

For searching the published research articles, we conducted an electronic survey of the SCOPUS, Medline, Google Scholar and Pubmed database (Figure 1). A search strategy using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines was developed (Fig. 1). Randomized controlled studies, observational studies, comparative studies, case series and case reports were evaluated for the eligibility. This review paper focuses only on the radiation-induced dysphagia and stridor. The search articles with no primary data related to the radiation-induced upper aerodigestive stenosis causing dysphagia and stridor were excluded. Non-English articles were also excluded. The search terms in the database included dysphagia, stridor, pharyngeal stenosis and oesophagal stenosis and radiation complication on the head and neck. The abstracts of the published articles were identified by this search method and other articles were identified manually from citations. This manuscript reviews the epidemiology, pathophysiology, clinical outcome, investigations and treatment of the radiation-induced dysphagia and stridor. This review article will surely act as a baseline for further prospective studies of radiation-induced dysphagia and stridor by pharyngeal or upper aerodigestive stenosis could be designed and helps as a spur for further research in this dreaded clinical entity.

EPIDEMIOLOGY

Head and neck cancer survivors are living longer because of the epidemiological changes in cancer and advancement in the treatment. However, clinicians encounter a growing number of patients with late effects of radiotherapy. Radiation associated dysphagia which progresses throughout the years after head and neck cancer treatment is often challenging in the era of organ preservation.4 The epidemiological studies of radiation-induced dysphagia and stridor are less documented in the medical literature. Dysphagia and stridor are extremely rare and morbid complaint by the patients following radiation therapy in nasopharyngeal carcinoma or any head and neck squamous cell carcinoma.5 Despite the hazardous effect of dysphagia and stridor on quality of life, the prevalence of this pharyngeal or oesophagal stenosis in patients who had radiated as part of their treatment for head and neck malignancy remains unclear. Nasopharyngeal carcinoma is commonly found in southern China and Hong Kong. 6 The incidence of the nasopharyngeal carcinoma is 20/100,000 population in a year at a high-risk region.7 Although uncommon, the late side effects like dysphagia and stridor are morbid complaint by radiotherapy in nasopharyngeal carcinoma or any head and neck squamous cell carcinoma. Radiotherapy is the treatment of choice in patients with nasopharyngeal carcinoma without distant metastasis. There were different late complications of radiation therapy documented in that region such as endocrine dysfunction and injury to the temporal lobe.8 The nasopharyngeal carcinoma is mainly treated by radiotherapy and it needs to follow up based on clinical, endoscopic radiological monitoring. The curative doses of radiotherapy in nasopharyngeal carcinoma can lead to complications like choanal stenosis and pharyngeal stenosis. The pharyngeal stenosis can cause dysphagia and severe variety of manifests stridor. Only a few such cases are reported in the medical literature and this may be a lack of follow up of these patients.

PATHOPHYSIOLOGY

The exact pathophysiology for radiation-induced pharyngeal stenosis is not well understood. The pathophysiology for dysphagia and stridor following radiotherapy to the head and neck area is complex. Radiotherapy induced xerostomia may induce the damage of the salivary glands, esophagitis and tracheobronchial aspiration which lead to stenosis of the pharynx and oesophagus.9 It is believed that radiation exposure to the neck causes fibrosis, gradual reduction of the vascularity and denervation atrophy of the pharyngeal muscles and mucosa leads to the pharyngeal stenosis and the severity is associated with the dose of radiation and field of radiation. In the affected area of the radiation-induced fibrosis, there is an increased proliferation of the fibroblasts, infiltration of the inflammatory cells and increased amount of the extracellular matrix.10 Radiotherapy alone or combined with chemotherapy in head and neck cancer may induce pharyngeal or oesophagal stenosis despite the preservation of the organ.11 The muscles of the pharynx, oesophagus and larynx are found deep to the submucosal and overlaid by stratified squamous epithelium and the lamina propria of the mucosal layer. The seromucous glands and lymphoid aggregates are seen throughout the mucosal layer and so radiation injury to these areas lead to noticeable soft tissue deformities like stenosis or stricture by altering the contour of the pharynx, larynx and oesophagus. Despite advancement in radiotherapy technique, there are still associated complications of radiation and these include mucositis, dermatological changes, swallowing defects due to changes in pharynx and oesophagus. These manifestations are found at the time of acute clinical period, the first 6 months after radiotherapy.12

Head and neck squamous cell carcinomas are common types of malignancies found in the population. The treatment options for squamous cell carcinoma of the head and neck region are usually surgery and chemoradiation. The radiotherapy and concomitant chemotherapy are widely accepted treatment options for organ preservation.13 There are considerable shuffling of the treatment options by the clinicians for treating the head and neck cancer. Some surgeon chooses preoperative radiotherapy, while some prefer postoperative radiation therapy. In a few cases, full therapeutic doses of radiation are given, although in the reduced dose. However, clinicians should know about the benefits of combinations of these two treatment modalities. The upper aerodigestive tract of the head and neck region is highly susceptible to radiation-induced damage and cause stenosis of the pharynx with impairment of the swallowing.14 The chemotherapy for malignancy of the head and neck region may increase the chance of stenosis of the upper aerodigestive part in cancer patients as adjuvant chemotherapy has been found to increase the chance of stricture formation in patients of oesophagal cancer.15 The benign hypopharyngeal or oesophagal fibrosis is usually secondary to the fibrosis at the lamina propria and sub-mucosa although inflammation, oedema and spasm of the muscles play important role in the etiopathogenesis of stricture formation. One study reported that absorbed dose of the radiation to the cricopharyngeal muscle and cervical part of the oesophagus plays a vital role in causing dysphagia.16  The resultant structure cause temporary or permanent dysmotility. Ulceration at the hypopharynx or oesophagus may also increase the chance of stricture formation. It has been documented that oesophagal stricture can occur up to 5 years after completion of the radiotherapy.17

The introduction of intensity-modulated radiation therapy (IMRT) in the treatment of the head and neck cancer greatly minimized the damage to the adjacent part and adjust maximum to the target tissue. However, the loco-regional control of the malignancy of the head and neck region needs aggressive radiation treatment for reducing the tumour cells.18 These increased radiation schedules and high doses of the radiation (60 to 70 Gray), leading to rapid dose accumulation which is less tolerable. 19

CLINICAL PRESENTATIONS

Stenosis at the hypopharynx or upper aerodigestive tract is an uncommon late complication of the radiotherapy for head and neck cancer. Severe radiation exposure to the patients is often prone to such complication, which may be found months to years after radiotherapy. Although the technique of radiotherapy in head and neck cancer is offering a promising treatment outcome, the complications during or after irradiation are inevitable and the quality of life after radiotherapy is usually compromised. The strictures of the hypopharynx, larynx and cervical part of the oesophagus are often complications of the radiotherapy. The cervical part of the oesophagus is usually included in the lower margin of the radiotherapy portal for head and neck cancer. The severity of the clinical presentations is closely related to the degree of the stenosis. The symptoms occurred due to the obstruction of the pharynx. The obstruction of the pharynx leads to dysphagia and breathing difficulty. Severe stenosis of the pharynx may lead to compromised airway and lead to stridor.20 Patients may also present with symptoms due to radiation effects on the other area of the head and neck such as dry mouth and impairment of hearing because of the eustachian dysfunction.21 The diagnosis of the pharyngeal stenosis is often late as patients are usually asymptomatic in the initial period after radiotherapy. So, follow up endoscopic examinations should be done at regular interval. Patients with post-radiotherapy hypopharyngeal and oesophagal stenosis or strictures initially show dysphagia to the solid foods and then progresses to the liquid foods over time. The degree or severity of the dysphagia is associated with the size of the lumen of the pharynx and oesophagus. In the case of oesophagal stricture, the diameter less than 12mm causes dysphagia to the normal diet. Patients may also present with chest or abdominal pain, regurgitation of food, aspiration of food and weight loss if the stenosis is found at the upper oesophagus.

INVESTIGATIONS

The diagnosis of the pharyngeal stenosis should be properly evaluated with help of the fiberoptic nasopharyngolaryngoscopy and computed tomography (CT) scan of the neck. Fiberoptic nasopharyngolaryngoscopy or rigid nasal endoscopy is helpful to assess the site and severity of the stenosis (Figure 2).

Endoscopic examination reveals the anatomical location of the obstruction and confirms whether the lumen is obstructed completely or not. CT scan allows the confirmation and quantifying the degree of the stenosis (Figure 3).

Direct laryngoscopy and biopsy should be mandatory from the stenosis site for excluding any residual or recurrent neoplasm and to assess the characteristics of the stricture. If the stenotic site is narrow and irregular the pediatric endoscope can be used for proper evaluation and biopsy.22 Stenosis at the hypopharynx is frequently found following total laryngectomy. Radiological examination often shows the narrowing at the superior surgical closure sites. Anastomotic strictures are seen after hypopharyngeal reconstruction in resection of the hypopharyngeal malignancy.23

TREATMENT

The treatment of the pharyngeal or oesophagal stenosis following radiotherapy to malignancy of the head and neck area is often challenging because of the high incidence of recurrence. Stenosis at the upper aerodigestive tract may require dilatation or nasogastric tube feeding depending based on the severity of the obstruction. Surgical intervention is the treatment of choice for pharyngeal or oesophagal stenosis. There are many techniques available for correction of the pharyngeal stenosis. The techniques include simple dilatation, excision of the scar tissue, resection of the scar tissue with the use of rotational mucosal flaps, use of stent and coblation excision of the scar tissue and topical injection of the mitomycin-C injection. Patients often referred to the gastroenterologist for therapeutic oesophagal of pharyngeal dilatations if the stenosis is confirmed. If patients again complain of dysphagia after dilatation, repeat dilatation is advised. The endoscopic dilatation is the first line of treatment for the pharyngeal and oesophagal strictures. The dilatation should not be forceful as there is the risk of perforation. The first dilatation of the stenosis was reported in the seventh century with help of carved whalebone. 24 and the several dilators have been developed. Mercury-filled Maloney dilators are flexible bougies without guide wires are useful to dilate the benign strictures. 24 Balloon dilators are a useful technique for a successful outcome but more costly and may not be used more than once. The microdebrider is also a good option for excision of the scar tissue from the pharyngeal stenosis. The major challenge of this procedure is re-stenosis. The timing of the repair is important in case of pharyngeal stenosis. Early intervention can cause re-stenosis as scar bands which continue to contract and obstruct the pharynx. The surgeons those do not keep postoperative stenting often perform serial dilatations or revision endoscopic excision or removal of the crusting.25

After dilation of the stenotic segment, the pharyngeal wall at the site of the widening can be applied with mitomycin-C. Mitomycin-C is an antineoplastic antibiotic which acts as an alkylating agent and inhibits protein, DNA synthesis and fibroblast proliferation. Mitomycin-C is an antibiotic produced from Sterptomyces caespitosus.26,27 Mitomycin-C gives its effect by cross-linking to the DNA at the cellular level. It does not act randomly, rather it acts preferentially bind to the genes that are being induced. The Mitomycin-C is safe and used topically at various surgical locations for preventing re-stenosis without any major side effects.28 It also prevents the chance of synechia formation at the upper aerodigestive tract after dilatation or surgery with coblation. Although Mitomycin-C is a toxic drug, there has been no report regarding systemic toxicity.29 The safety dose of Mitomycin is topically 0.4 mg/ml in the treatment of the pharyngeal stenosis.29

Currently use of the radiofrequency or coblation for excision of the scar tissue with application of mitomycin is providing effective result with less chance of re-stenosis. 30 Coblation technology uses bipolar radiofrequency energy which generates a field of ionized sodium molecules that ablates and coagulates soft tissues without any thermal injury. Conductive saline solution is kept in the gap between the soft tissue and device tip and converts the saline into the ionized plasma layer. One this plasma layer touches the tissue, there is enough break the molecular bonds, causing molecular dissociation. This effect of the tissue dissociation occurs at the temperature of about 400C to 700C, so reduce the thermal damage to the tissue.31,32  

The complications of the above procedures are minimal. After procedures of dilatations, slight bleeding and erosions of the mucosal linings are commonly found and these manifestations spontaneously resolve without any specific treatment. However, there are two important life-threatening complications may be found such as perforation of the pharynx or oesophagus and hematemesis. Post-dilatation check-up should be done by endoscope to rule out such complications. In the case of severing hypopharyngeal stenosis, the airway is also compromised which leads to stridor and this life-threatening situation need emergency tracheostomy for securing the airway. After successful dilation of hypopharyngeal stenosis, the tracheostomy tube can be decannulated.

CONCLUSION

Radiotherapy is the treatment of choice in nasopharyngeal carcinoma without distant metastasis and also play an important role in the treatment of other head and neck squamous cell carcinoma. Radiation-induced biological alteration after radiation therapy to the head and neck area can be undetected for years but eventually lead to functional deficits by causing pharyngeal or oesophagal stenosis. In the early stage of the complications, patients may be asymptomatic but once the stenosis develops in the upper aerodigestive tract, leads to dysphagia and stridor. It minimizes the quality of life and increases the incidence of mortality even in the cancer-free survivor. Although there is no effective treatment available, dilatation of the pharynx or oesophagus with help of the different technique like bougies, microdebrider and coblation are treatment options. Clinicians should be aware of the radiation-induced complications leading to pharyngeal stenosis and its severity along with its treatment options.

Conflict of interest: Nil

Funding: No Funding sources were granted or used specifically for this work.

Author Contribution:

SKS: Concept, data collection and data analysis;

SA: Data collection, data analysis, and drafting the manuscript;

SL: Data collection and drafting.

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A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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