International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 8(4), February, 2016

Pages: 61-67

Date of Publication: 21-Feb-2016

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Author: Rajesh R., S. Arunchandra Singh, K. Anandraj Vaithy, K. Manimekalai, Dhananjay Kotasthane, S. S. Rajasekar

Category: Healthcare

Abstract:Aims and Objectives: The study was to evaluate the remedial effect of alcohol extract of Mucuna pruriens seeds on pancreas and liver of Streptozotocin induced diabetic rats. Materials and Method: Five day old neonate wistar rats (n -24) were used for the study. Out of this, 6 rats were kept as Normal control i.e. Group A. Remaining 18 rats were made diabetic by intraperitoneal injection of streptozotocin (65mg/kg body weight). After 12 weeks, they were divided equally into 3 groups i.e. Group B - Diabetic control, Group C- Mucuna Pruriens group (200mg/kg), Group D - Glibenclamide group (1 mg/kg body weight). Drugs were administered orally for 28 days in group C and D. Blood Glucose Level was monitored once in a week during this period. On completion of drug treatment period, animals were sacrificed for the collection of blood and visceral organs to carry out histological and biochemical investigations. Results: The Mucuna Pruriens seed extract (200mg/kg) were effectively controlled blood glucose levels in diabetic rats. Serum insulin and cholesterol levels were significantly improved when compared to diabetic group (p >0.05). In pancreas, the islets showed increase in beta cell mass and reduced necrotic changes. Liver functions were partially restored and hepatocytes showed minimal necrotic changes. Conclusion: Mucuna pruriens seeds are capable of exerting positive structural changes in pancreas & liver through its antioxidant and antidiabetic properties.

Keywords: Glibenclamide, Islets of langerhans, Intraperitoneal, H&E staining

Full Text:

Diabetes mellitus is considered as one of the most serious threat to human in the twenty first century(1). it is a systemic disease characterized by consistent hyperglycemia by damage to the liver and pancreas .The word diabetes is derived from the Greek word ‘diabetes’ meaning 'siphon' - 'to pass through' and the Latin word ‘mellitus' meaning honeyed or sweet(2). This is because the presence of excess sugar in blood and urine. Sushrutha (6th century BC) identified diabetes and named it as ‘Madhumeha' meaning honey in the urine(3). Of the two types of diabetes mellitus, Type II is more prevalent than the Type I variant. The underlying pathology is defect in the mechanism of insulin secretion and insulin resistance(4) by the damage in the beta cells of pancreatic islets and disturbances in the liver, which hampers carbohydrate, protein and lipid metabolism(5). The free radical formation is also playing a pivotal role in the progress of diabetes (4). The common drugs used in the management of Type 2 Diabetes in the modern medicine are Metformins, Biguinides, Sulphonylurea etc. However, the efficacy of these drugs is limited in long term due to its side effects. In Ayurvedic med icine, Momordica Charantia, (Bitter gourd)(6)(7)(8) Helicterus Isora(9), Curcurmin(10), Trigonella foenum graecum (Fenugreek)(11)are used for the treatment for diabetes. Researches on these herbal drugs documented minimal adverse effects and prevention of the secondary complications (6). Mucuna Pruriens (Linn), a leguminous plant which belongs to fabaeceae family, is found in the tropical regions of India, Africa and West Indies(12). The seeds and leaves of this plant are well known and widely used for the treatment of Erectile dysfunctions(13)(14)(15), Epilepsy and Parkinsonism in Ayurveda. The seeds are rich in fiber content and antioxidants (27). Previous researchers like Anusha et al, Enechi et al and Majekudunni et al studied the biochemical aspects of Mucuna seeds in Type I diabetes. None of these works examined the histological perspective to reveal the structural modifications in pancreas and liver, Moreover no studies have been reported on Type II diabetes in this drug. The present study was undertaken with a novel aim to explore the histological and biochemical aspects of medicinal properties of Mucuna Pruriens seeds in Type II diabetic rats.

Source of plant extract The ethanolic extract of Mucuna pruriens was procured from Herbal Research Department, VPSV Ayurveda College. Kottakkal, Kerala. Experimental Study Design The experimental protocol was approved by Institutional Animal Ethics Committee (IAEC) of Mahatma Gandhi Medical College and Research Institute, SBV University, Puducherry (686/02/a/CPCSEA). Five-day-old neonate wistar rats (n-24) were received from the Central Animal House of Mahatma Gandhi Medical College and Research Institute. The neonate rats were made diabetic by a single dose i.p. injection of streptozotocin (Sigma Aldrich, U.S.A) (65 mg/kg body weight) dissolved in freshly prepared citrate buffer (0.1M, pH-4.5) (18) (19). After 6 weeks, blood sugar levels [BGL] were measured by using a one-touch glucometer (AccuChek, Roche Diagnostics, USA) and animals showing value > 150mg/dl of BGL were selected for the study. After 12 weeks, rats were classified into four groups of six animals each. Food and water were provided ad libitum to the rats. The groups are as follows Group A – Normal control (Non diabetic rats); Group B – Diabetic control; Group C – Experimental drug (Mucuna); Group D-Standard drug (Glibenclamide).

Mode of feeding of drugs The Mucuna Pruriens (200mg/kg body weight) and glibenclamide (1 mg/kg body weight) administered orally for 28 days in Group C and D respectively. Group A and B were given equal volume of purified water.

Assessments of Biochemical Parameters: The Total Body Weight and Fasting Blood Glucose Levels [FBGL] were measured once in a week during the drug treatment period by using standard glucometer strips with working principle of lactate dehydrogenase method. After the completion of experiment period, all the rats were deprived of food overnight and then sacrificed by painless cervical dislocation under mild chloroform anesthesia. The blood samples were collected in a heparinized tube for biochemical assessments. The parameters evaluated were (A) Serum insulin level-using a standard commercial diagnostic kit with reference values. (B) High Density Lipoprotein , Low Density Lipoprotein and Total Protein were assessed by Spectrophotometric method as per standard laboratory guidelines(20).

Histological studies
Pancreas and Liver were carefully dissected out and fixed in 10% neutral buffered formalin for 48 hours. After processing, the tissues were embedded in paraffin wax. Histological sections were cut at 5micron thickness by using a semiautomatic rotary microtome and stained with H and E. Photographic and Light microscopic studies are carried out by using Olympus research microscope (CX41RF), Germany.

Statistical analysis One-way analysis of variance (ANOVA) (SPSS 15.0) and the related post- hoc test were applied for data investigation. All the observed data are entered, tabulated and shown as Mean ± SD range and P value < 0.05 were identified as significantly different.

A. Blood Glucose Level and Bodyweight.
During the experimental period, the animals among the experimental groups and diabetic control groups were ill looking and showed marked weight loss. In diabetic group, there was a significant increase in the blood glucose level on comparison with the normal rats (P-value <0.05). Mucuna pruriens seed extract treatment resulted in statistically significant reduction of blood glucose levels when compared to diabetic control. Simultaneously treatment with glibenclamide showed more significant hypoglycemic activity at the initial phase of two weeks and in the latter two weeks, Mucuna pruriens extract showed amplified hypoglycemic activity.

The total body weight was gradually increased among the Mucuna pruriens and glibenclamide groups. Mucuna pruriens were found to be more effective in gaining body weight in diabetic rats (Table.1).

B. Biochemical parameters I. Serum insulin Serum insulin level was significantly enhanced in both the experimental groups (P value < 0.05). The potency of glibenclamide to improve the insulin level was observed to be more significant in comparison to Mucuna Pruriens (Table -II). II. Lipid profile The lipid profile analysis of diabetic group showed decrease in High-Density Lipoprotein (HDL) and Total Protein levels (TP) whereas a clear increase in Low-Density Lipoprotein (LDL). These changes are moderately reversed in Mucuna pruriens and glibenclamide groups (Table-III).

C. Histopathological changes I. Pancreas Group A: Histology of islet cell clusters of normal control group, sacrificed on 28th day, showed normal histology of exocrine and endocrine pancreas. The islet of Langerhans appeared as pale-stained rounded clusters with normal cytoarchitecture. On high power view, the islets appeared in loose clusters comprising of polygonal cells arranged in cords and interspersed with numerous blood capillaries. Group B: In diabetic group, a complete distortion of architecture and reticular changes were observed. Other findings observed were: 1) Infiltration of inflammatory cells (mostly lymphocytes) in the islets and surrounding connective tissues. 2)

Severe necrotic changes in the central part of the islets involving apparent destruction of the beta cells, dilated nucleus with mild fragmentation and congestion of the blood vessels. Exocrine part appeared highly eosinophilic. Group C: Histological analysis of endocrine part showed improvement in size and shape of islets with restoration of beta cells, better vasculature, decreased inflammatory cell infiltrations and the exocrine part showed enhanced cellular architecture. Group D: Islets showed evidence of reduced number of inflammatory cellular infiltrations, symmetrical vacoulations, moderate level of cellular necrosis and a few active beta cells in the central area of islets clusters with better cellular architecture.

Group B: The hepatic sinusoids were non-radiating and tend to be wider and interrupted in the untreated STZ diabetic rats. Hepatocytes were degenerated with loss of architecture with decreased number of central nuclei and mild steatosis with geographical necrosis and inflammatory cell infiltrates. Group C: Treatment with extracts of Mucuna pruriens caused partial reversal in the damage observed with diabetic group. The nuclei of the hepatocytes were rather faint with reduced inflammatory cell infiltrates with minimal fatty changes. Group D: Treatment with glibenclamide showed almost similar observations in Group C. The hepatocytes were distinctly outlined together with their nuclei, reduced necrotic changes and vacoulations, implying an increase in activity of the cells.

Diabetes mellitus is a chronic metabolic disorder which affects almost all systems of the body and the management includes various treatment modalities (5). Apart from the currently available drug regimens for management of diabetes, a wide range of drugs extracted from plant species were examined for their possession of anti diabetic properties(5), (6) .These drugs found to be relatively less toxic with minimal adverse effects in comparison with common allopathic drugs. On these backgrounds, the present study was designed to evaluate the hypoglycemic effects of Mucuna pruriens seed extract on the structural changes in liver and pancreas of neonatal Streptozotocin induced diabetic rats.

Streptozotocin (STZ) carrying a chemical formula 2-Deoxy -(3- methyl -3-nitrosurea)-1-D-glucopyranose, is a naturally occurring compound synthesized by the soil bacterium Streptomyces Achromogenes, which selectively destroys beta cells by means of a glucose transporter (GLUT2) and generates alkylation of DNA resulting in rapid necrosis. Hyperglycemia and hyperlipidemia are considered as most critical problems in Diabetes mellitus. The observations of the present study showed the effectiveness of STZ in producing persistent hyperglycemia in experimental animals and are in concordance with studies performed by Abdollahi et al., in 2008 Lee et al., in 2009.

Earlier pharmacological studies shows that the ethanolic extract of the Mucuna seeds are rich source of dietary fibres and antioxidants and it contains anti diabetic components like saponins, squalenes, D-chiro-inositol and oligocyclitols(23). The outcome of the present study showed that Mucuna pruriens seed extract and Glibenclamide treatment significantly decreases the hyperglycemia caused by STZ.

Anusha et. al, reported that alcohol extract of Mucuna pruriens seeds ef- fectively reducing blood glucose level in Type I diabetic animal models and concluded that the hyperglycemic activities may be attributed to its rich dietary fibre content, which reduces glucose absorption , suggesting an extra pancreatic mechanism. Another interesting point we observed in this study was the efficacy of glibenclamide found to more than Mucuna Pruriens in the initial two weeks and towards the end of the treatment period Mucuna showed improved hypoglycemic effect.

This evidence suggests the efficacy of MP seeds in long term treatment I diabetes. Majekudonmi et al also put forwarded the same hypotheses in 12 weeks long animal study on type I diabetic rats. In the present study, analysis of lipid profile revealed decrease in the high density lipoproteins (HDL) and also Total Protein levels (TP) with subsequent increase in Low Density Lipoproteins (LDL), these evidences supports the observations made by Enechi et al. and Murugan et al., The proposed mechanism may be due to the presence of squalenes, which increases biliary cholesterol excretion, leads to decreased level of serum cholesterol (30). The animals treated with STZ are appeared ill-looking with reduction in body weight due to the injurious effects of STZ which caused alkylation of DNA and produced hyperglycemia and necrotic lesions. Present observations are in agreement with the findings of Mohammad Zafar et al (2010); Piyachaturawat et al .Weight gaining in the Mucuna Pruriens group was statistically significant when compared to STZ and Glibenclamide.

This may be attributed to the antioxidant property of the drug(24)(26). Studies conducted by Stephen. O. Majekodunmi et al (2011) also supporting the findings of our study. The structural changes seen in diabetic rats are due to DNA methylation activity and free radical production by STZ. It has been reported in various studies that increased oxidative stress may play a role in the pathogenesis and progression of diabetic tissue damage(8)(11)(12). Here, the partial destruction of the islet beta cells produced moderate hypoglycemia without ketosis in STZ injected animals (26)(28).

Moderate restoration in islet beta cell mass seen in Mucuna Pruriens group may be due to its rich antioxidant properties(27) . The structural changes observed in liver histology were the distorted hepatic lobule, necrosis, vacoulations in hepatocytes, fatty changes and lymphatic infiltrations in the parenchyma(29) (11). These changes indicate the metabolic disturbances generated by STZ through oxidative stress. Mucuna seed extract partially reversed liver pathology by controlling hepatocellular necrosis, preventing cellular infiltrations and vacoulations. Thus, the present study indicates Mucuna seeds possess hypoglycemic and hypolipidemic properties and reduces the lesions in Liver and Pancreas by diabetes.

Administration of Mucuna Pruriens extract alleviated the streptozotocin lesions in experimental rat group and ameliorated to certain extent in histopatholgical lesions and morphological alterations produced by Streptozotocin. Mucuna Pruriens may block many other complications of diabetes by reducing oxidative stress and hence protects from oxidative damage and dyslipidemia. It is recommended to conduct a long term study for a close evaluation of the anti diabetic properties of Mucuna pruriens seeds.

The author is thankful to Mr. Lokesh Maran A, Assistant professor in Statistics, Department of Community medicine, for his valuable suggestions and Mr. Chandrasekar, Histology lab technician, Department of Anatomy, for his assistance in histological preparations. We are thankful to the scholars whose articles are cited and included in references of this manuscript and we are grateful to authors, editors and publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. Conflict of interest The authors don’t have any conflict of interest.


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A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


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