International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 13(3), February, 2021

Pages: 02-05

Date of Publication: 03-Feb-2021


Print Article   Download XML  Download PDF

Interaction of Correction of Lipid Peroxidation Disorders with Oxibral

Author: Sharipov R. Kh., Akhmedova M.M., Rasulova N.A., . Erbutayeva L.T.

Category: Healthcare

Abstract:Introduction: Cerebral pathology is leading reason of not only morbidity and death rate but also heavy disability in subsequent ontogenesis At the of aggressive free radicals, hydroperoxides that render the destructive operating on the membranes of neurons. Objective: To ground the efficiency of therapy of \"oxibral\" of pectoral children with the perinatal damages of CNS by the account of changes LPO in red corpuscles. Methods: An analysis was conducted for 70 pectoral children of age with the perinatal damages of CNS and with pathogeny of consequences of perinatal damages of the nervous system. Oxibral rendered the positive operating on the maintenance of MDA after incubation. At comparing of the indicated index it is not reduced to the norm of statistical difference. Results: The correction of \"oxibral\" of neurological violations opens the prospect of rehabilitation and assists a considerable reduction of per cent of children with the remaining phenomena of perinatal damages of CNS. Peroxide oxidation of lipids indicators in healthy infants have their characteristics, and the studies carried out can be used as controls for various pathological conditions, including perinatal CNS injuries. Conclusions: Thus, it was found that LPO indicators in healthy infants have their characteristics, and the results of the studies carried out can be used as controls for various pathological conditions, including perinatal CNS injuries.

Keywords: Peroxide oxidation of lipids, Malonic dialdehyde, Degree of hemolysis of red corpuscles, The symptom of Grefe, Oxibral, Damages of CNS

Full Text:

INTRODUCTION

The perinatal damages of the brain make more than 60 per cent pathology of the nervous system of child's age, directly participate in the development of such diseases, as child's cerebral paralysis, epilepsy, minimum cerebral disfunction, that, in turn, assist the increase of recurrent respiratory diseases Presently the basic hypothesis of a pathogeny of consequences of perinatal damages of the nervous system (CPDNS) is cerebrovascular violations. In the conditions of hypoxia peroxide oxidization of lipids is violated with the accumulation of aggressive free radicals, hydroperoxides that render the destructive operating on the membranes of neurons.1

In case of impaired cerebral circulation in newborns, several researchers conclude about the intensity of lipid peroxidation in this pathology based on an increase in the content of LPO products. Only with an integrated approach, i.e. using several research methods in combination, one can count on the possibility of a more complete assessment of pathological changes in plasma membranes.2

As you know, LPO indicators characterize not only the severity of the pathological process but to a certain extent the effectiveness of the correction of disturbed metabolism. Consequently, according to these indicators, it is possible not only to assess the degree of pathological changes but also, most importantly, the effectiveness of the therapy.3

Recently, several experimental and clinical studies have appeared, indicating the beneficial effect of the new herbal preparation oxybral on circulatory and metabolic cerebral disorders. The active ingredient of oxybral is a vinca alkaloid vincamine. Numerous studies have confirmed the presence of an active metabolic effect of oxybral on ischemic tissue. The drug helps to increase the consumption and use of oxygen and glucose by brain tissues improves and normalizes glycolysis, is well tolerated by patients. It has been proven that the drug is rapidly absorbed for any method of application, uniformly distributed in the brain tissues, metabolized and eliminated through the kidneys. A great deal of clinical experience has been accumulated confirming the selective vaso regulatory effect of vincamine on cerebral vessels.3,4

However, there are no studies in which the effect of this drug in perinatal damage to the nervous system in children of the first year of life would be studied, the questions of the optimal dosage and duration of the course of using this drug are not substantiated.5,6

The work aimed to substantiate the therapy with oxybral in infants with perinatal CNS injuries by taking into account changes in the processes of lipid peroxidation (LPO) in erythrocytes. We were the first to study the effect of oxybral on the state of the nervous system in CPDNS based on studying LPO processes

Materials and Methods

The paper analyzes the results of clinical and biochemical studies in 70 children of the first year of life. The main group consisted of 44 infants with perinatal CNS injuries. The control group included 26 children with CPDNS who have not prescribed the drug we tested. Since the processes of lipid peroxidation have age-related dynamics, we also studied the state of LPO processes in 20 healthy children.

The state of lipid peroxidation in erythrocytes was assessed according to the following indicators: the degree of erythrocyte hemolysis before incubation (mechanical stability of erythrocytes) and after incubation under physiological conditions (peroxide hemolysis without incubation), the MDA content in erythrocytes, the MDA coefficient/hemolysis after incubation of MDA in the intensity of erythrocyte degradation. To determine lipid peroxidation parameters, only 170 μl of erythrocytes (approximately 0.7-0.8 ml of blood) were required. Determination of the activity of LPO processes in erythrocytes was studied twice: before and after treatment.7,8

Results

Most children with perinatal CNS damage were born to mothers suffering from chronic diseases of the cardiovascular system, endocrine system, nasopharynx, kidneys, digestive organs, and genitals. Complicated pregnancy was observed in all mothers of children with CPDNS. All children were born to mothers with a complicated course of labour.

            In the neurological status, the hypertensive-hydrocephalic syndrome was 42.8% and was characterized by the opening of the sagittal suture more than 0.5 cm, the large fontanelle over 3x3 cm, non-closure of the small fontanelle in most children, pronounced development of collateral veins of the head, and baldness of the head. Various ocular symptoms were found in the form of Graefe's symptom, “setting sun”, and unstable horizontal nystagmus. The diagnosis was confirmed by ECHOEG, and upon examination of the fundus, by the detection of retinal vasospasm.

            The main changes in the syndrome of vegetative-visceral dysfunctions (38.5%) were persistent regurgitation, persistent hypotrophy, respiratory rhythm disturbances, skin colouration, acrocyanosis, paroxysms of tachy, bradypnea, thermoregulation disorders, gastrointestinal dysfunction, temporal lobe hair loss.

            With the syndrome of increased neuro-reflex excitability (11.4%), against the background of normal mental and physiological development, the child reveals emotional lability, motor anxiety arising from minor changes in the environment, when exposed to visual, auditory, tactile analyzers. Such children have a periodic small-amplitude tremor, startle, difficulty falling asleep, anxious superficial, not long enough sleep.

            Psychomotor development retardation syndrome (7.1%) is characterized by impaired reduction of unconditioned congenital reflexes. Children are not actively interested in toys and surrounding objects, do not react enough to the presence of their mother, humming is inactive and short-lived, manipulations with objects are delayed, there is no active attention.

            In the department, children of the control group received complex therapy: drugs that improve cerebral circulation (vinpocetine), piracetam was used, and syndrome therapy was performed. Depending on which clinical manifestations prevailed, they used anticonvulsants, diuretics and vitamin preparations. Parallel correction of disorders caused by underlying diseases was also carried out.

Discussion

The results of the research showed that children with perinatal CNS injuries were found to have significant disorders in LPO processes, which can be characterized as a decrease, and in some cases, their imbalance. This was evidenced by a significant increase in the MDA content before and after incubation, the MDA / hemolysis ratio after incubation, an increase in erythrocyte hemolysis after incubation, and a decrease in the percentage of increase in hemolysis compared to the data.5,9,10

            In children of the control group, the hemolysis of erythrocytes before incubation, although significantly reduced compared to the data before treatment, still does not normalize. Hemolysis of erythrocytes after incubation practically did not differ from those of healthy children. Therefore, despite the increased value of erythrocyte hemolysis before incubation, the hemolysis of erythrocytes after incubation in children of this group does not differ from those of healthy children.6,11,12 In this regard, the percentage of increase in erythrocyte hemolysis in children of this group was significantly reduced in comparison with healthy children. Before incubation, the MDA content remained at high values, although there was a tendency to decrease it. In children of this group, MDA after incubation was significantly higher than the norm, however, the treatment carried out contributed to a significant decrease in this indicator compared with the data before treatment.13-14

            The MDA / hemolysis ratio after incubation was higher than in healthy children, but there was a significant decrease in comparison with the initial data. The intensity of MDA degradation significantly increased in comparison with the initial data and did not differ from the indicators of children in the healthy group. The same changes were observed in the degradation / MDA ratio.7,8

            Thus, in children with AED who received conventional therapy, there is a significant positive dynamics in the indicators of LPO processes, but most of them do not reach the norm. Positive dynamics was also noted in terms of clinical symptoms: children became calmer, their sleep returned to normal, the size of the brain ventricles gradually normalized, and the functions of internal organs stabilized. Appetite improved and, therefore, the children began to gain weight. An active interest in the environment appeared. In general, clinically significant improvement was observed between 10-15 days of therapy.15

            The presence of changes in LPO processes in children with perinatal CNS injuries, which persist despite the course of therapy, dictates the need to include new drugs in the treatment complex, the action of which is more effective. We have used a new herbal preparation oxybral, the effect of which in infants has been insufficiently studied. High efficiency, absence of side effects, as well as good tolerance, served as the basis for the appointment of Oxybral for the correction of cerebral and metabolic disorders and, indirectly, for the correction of LPO in children with perinatal CNS injuries.3,4

            Given the fact that infants were prescribed oxybral for the first time, it became necessary to scientifically substantiate the appointment of this drug, to select the dose and duration of the course of treatment based on studying the effect on LPO in erythrocytes. To determine the dose and duration of the course of treatment, initially, oxybral was prescribed at 7.5 mg/day. Complete normalization of indicators in most children was observed between 7 and 10 days.

            Treatment with oxybral turned out to be most effective when applied for 10 days. For an objective assessment of the therapeutic effect of oxybral, the results of treatment of these patients were compared with the corresponding data in children of the control group. Erythrocyte hemolysis before incubation in children of the study group did not differ from the data obtained in healthy children and was significantly lower than in the control (1.4 ± 0.05% and 1.17 ± 0.12%, respectively). When comparing the hemolysis of erythrocytes after incubation in children with AED who received oxybral with the data obtained in healthy children and children of the control group, no statistically significant difference was found (2.37 ± 0.16%, 2.21 ± 0.44% and 2, 3 ± 0.03%, respectively). Due to the normalization of mechanical and peroxide hemolysis, the percentage of increase in hemolysis did not differ from the data of healthy children and was significantly higher than in the control group (99.7% and 64%, respectively).

            The MDA content before incubation in children of the main group did not differ from the data obtained in the control study. That is, despite the course of therapy with oxybral, the MDA content before incubation in children with PEP remained significantly higher than in healthy children (2.7 ± 0.24 nmol/106 erythrocytes versus 0.86 ± 0.12 nmol/106 erythrocytes). However, one cannot fail to note a significant decrease in this indicator compared with the initial data (2.7 ± 0.24 nmol/106 erythrocytes versus 3.3 ± 0.33 nmol/106 erythrocytes).

            Oxybral had a positive effect on the MDA content after incubation. When comparing this indicator with the norm, no statistical difference was found (1.6 ± 0.18 nmol/106 erythrocytes and 1.4 ± 0.16 nmol/106 erythrocytes). At the same time, in the children of the main group, the MDA content after incubation was significantly lower than in the control (1.6 ± 0.18 nmol/106 erythrocytes and 2.0 ± 0.17 nmol/106 erythrocytes, respectively ).5,9,10

            The MDA / hemolysis ratio after incubation when receiving oxybral did not

differ from the data in the control group and was significantly higher than normal values (0.9 ± 0.2, 1.0 ± 0.07 and 0.5 ± 0.1, respectively). Clinical symptoms also had a pronounced positive trend: children became calm and active. Sleep has returned to normal. Normalization of ECHOEG parameters against the background of the use of oxybral was noted much faster (7-10 days, versus 10-15 in the control, depending on the degree of the initial change). Pulse and breathing became rhythmic, the activity of the gastrointestinal tract stabilized, the children began to gain weight. The temperature decreased or returned to normal, regardless of the use of antipyretic drugs in children with a history of unmotivated febrile conditions. Children began to take an active interest in their surroundings, and a tendency to develop motor skills began to appear. In general, a pronounced clinical effect was observed on days 6-10 of therapy (Table 1).

Conclusion

Thus, it was found that LPO indicators in healthy infants have their own characteristics, and the results of the studies carried out can be used as controls for various pathological conditions, including perinatal CNS injuries. A scientifically substantiated approach to the appointment of oxybral for the correction of perinatal CNS injuries under the control of changes in LPO processes was carried out. Studies have shown that the appointment of children with perinatal damage to the central nervous system oxybral. Along with the normalization of most indicators, LPO contributes to more rapid normalization of neurological symptoms. The possibility of correcting neurological disorders with oxybral opens up the prospect of rehabilitation and contributes to a significant reduction in the percentage of children with residual symptoms of perinatal CNS damage.

Conflict of Interest: None

Source of Funding: None

References:

1. Barashnev YI. Hypoxic encephalopathy: hypotheses of the pathogenesis of cerebral disorders and the search for methods of drug therapy. Russian Bull Perinatol Pediatr 2002;5(6):45-49.

2. Volodin NN, Medvedev MI, Rogatkin SO. Perinatal encephalopathy and its consequences - controversial issues of semiotics and therapy. Russian Pediatr J 2001;12(4):56-61.

3. Akhmedov FK. Features of renal function and some indicators of homeostasis in women with mild preeclampsia. Eur Sci Rev (Austria) 2015;4(5):58-60.

4. Akhmedov FK, Avakov VE, Negmatullaeva MN. Status of cardio-hemodynamics and cardiac geomerms in women with complications with severe preeclampsia.  News  Dermatol Reprod Health 2017;3(I):27-29.

5. Guryeva MV, Yu. B,  Kotov VA.  Daily monitoring of blood pressure and heart rate in the diagnosis. Russian Bull Obstet Gynecol 2013;3:4-9.

6. Garg SA, Chakravarti R, Singh NR, Masthi RC, Goyal GR, Jammy E, Dengue serotype-specific Seroprevalence among 5- to 10-Year-Old Children in India: A Community-Based Cross-Sectional Study. Int J Infect Dis 2017;54:25–30.

7. Taksande A, Meshram R, Lohakare A. A Rare Presentation of Isolated Oculomotor Nerve Palsy Due to Multiple Sclerosis in a Child. Int J Pediatr 2017;5(8):5525–5529.

8. Prusakov VF, Morozov EA, Marulina VI, Belousova MV, Utkuzova MA, Gamirova RG, Knyazeva OV. The role of perinatal damage to the nervous system in the formation of neurological pathology in childhood.Vestnik modern Clin.Med. 2016; 9(2): 65-70.

9. Vasiliev V, Tyagunova  AV, Drozheva VV. Renal function and indicators of

10. Wu YW, Colford Jr JM. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. Jama. 2000 Sep 20;284(11):1417-24.

11. Mallick S. Study On The Clinical Profile Of Patients With Cerebral Palsy (Doctoral dissertation) 2011.

12. Puri S, Fernandez SA. Puranik D. Anand, A. Gaidhane Z. Quazi S, Patel S. Policy Content and Stakeholder Network Analysis for Infant and Young Child Feeding in India. BMC Public Health. 2017;17:217-221.

13. Savchenkov Y, Soldatova O, Shilov S. Age physiology (physiological characteristics of children and adolescents).Textbook for universities 2019:182.

14. Dautov AA.  HPLC determination of malonic dialdehyde in plasma and saliva. Sorption Chromatogr Proc 2018;18(1):73-82.

15. Williams CE, Mallard EC, Tan WKM, Gluckman PD. Pathophysiology of perinatal asphyxia. Clin Perinatol 1993;3(4):91-94 

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions