International Journal of Current Research and Review
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IJCRR - 13(1), January, 2021

Pages: 174-180

Date of Publication: 05-Jan-2021


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A Prospective Study of Post-Operative Surgical Site Infection

Author: Ketul Shah, Rohit Singh, Pratik Shapariya, Honeypalsinh H Maharaul

Category: Healthcare

Abstract:Introduction: Procedures causing a break in the skin continuity, the natural barrier against infection, predisposes to infection. SSIs are defined as a discharge that may be serous or purulent discharge and presents within 30 days of a surgical procedure (within 1 year in case of a prosthetic implant). There is an emerging problem of SSIs due to resistant organisms.
Objective: To identify the possible risk factors related to the development of SSIs and the common pathogens encountered in the development of SSIs.
Methods: This is prospective, observational study. Patients of either gender that aged more than or equal to 18 years, who reported to the surgery department and underwent either elective or emergency surgeries and developed post-operative surgical site infections were included after taking consent. A swab was collected and sent to the microbiology department for culture and sensitivity reports.
Results: A total of 103 patients with surgical site infection were enrolled. SSIs were predominant in males (62.14%) as compared to females (37.86%). The mean age of the patients was 52.58 \? 19.77years. Maximum patients were in the age group of 58 to 77 years. SSIs were common in surgeries performed in an emergency setting rather than those performed electively. SSIs were common in a contaminated wound (45.63%) followed by dirty wounds (28.16%). History of hospitalization is positively correlated with the development of SSIs.
Conclusion: Both, patients, as well as a surgical factor, acts as the risk for its development. Each hospital must have its list of antimicrobials to be used for empirical therapy. An antimicrobial stewardship program needs to be implemented to bring this incidence of resistant SSIs down.

Keywords: Surgical Site Infection, Wound, Antibiotics, Skin, Pathogens

Full Text:

INTRODUCTION

Procedures causing a break in the skin continuity, the natural barrier against infection, predisposes to infection.1 It also means that surgery, a planned breach in the skin continuity, also exposes patients to a risk of postoperative infection. These have created problems since the inception of surgery and are considered a surgeon's nightmare. The infection impairs wound healing and cause significant morbidity and sometimes mortality.2 These infections are categorized under the broad term of nosocomial infections. They are the 2nd most common cause of nosocomial infections just after urinary tract infection. It leads to prolongation in the hospital stay, which not only imposes a cost burden but also causes significant morbidity and mortality.

Grossly any purulent discharge that comes out of a closed surgical incision and is associated with signs of inflammation in the surrounding tissue should be regarded as wound infection, whether the micro-organisms can be cultured from it or not. The definition of surgical site infection was first of all provided by Horan and colleagues. This greatly helped in differentiating it from the term which was used earlier as wound infection These infections at different surgical sites were then classified into majorly 3 groups. The basis of this classification was the site and extent of infection. , These 3 groups were namely, 1. Superficial incisional SSIs, 2. Deep incisional SSIs and 3. Organ-space SSIs.3 These CDC has accepted this definition. It is also used widely across the United States of America and European nations.3

Discharge that may be serous or purulent discharge and presents within 30 days of a surgical procedure (within 1 year in case of a prosthetic implant). Superficial incisional SSI’s are limited to the skin and subcutaneous tissue at the site of incision It has at least one of the below-mentioned feature:

  • There is purulent drainage from the incision The purulent drainage may or may not have been confirmed in labs.

  • The culture of fluid/tissue which is obtained from the site of incision shows other growth of the organisms.

  • There is the presence of at least one of the signs or symptoms of infection. These infections may be associated with certain symptoms like pain or tenderness, local swelling, There may also be redness or heat. These superficial incisions are also intentionally left open by the surgeon.

  • A Surgeon or attending physician making a diagnosis of superficial incisional.

Deep incisional SSIs are kinds of infections, there is the involvement of deep tissues like fascial and muscle layers.

  1. Organ space SSI’s- Herein the infection involves distant sites such as the organs or spaces which are not opened or manipulated during operation.

These infections are highly prevalent in low to middle-income countries, but this does not mean that developed nations are free from SSIs. Globally around 2 million cases of SSIs occur annually.4 WHO describes these as one of the major infectious diseases having a significant economic impact.5 The prevalence of SSIs varies widely from region to region to region and hospital to hospital to hospital, grossly it ranges between 5-16%. In India, per se literature reveals that the prevalence of SSI varies between 5% and 24%.

Various factors affect the susceptibility of any wound to the infection, these may be related to a patient, type of surgery, type of wound, surgical technique, surgeons experience, etc. The factors related to patients that influence the development of SSIs are as following: extremes of age, patient's immunity, comorbidities such as diabetes mellitus, malnourishment both obesity as well as undernourished and presence of anaemia, patient's lifestyle including alcohol and drug abuse, smoking and lack of exercise or sleep.6

These factors start right from the duration of the preoperative stay of the patient in the hospital. Common factors that act as risks for SSIs are shaving technique of the operative site, surgical procedure type, surgeon skills, duration of surgery, prophylactic use of antibiotics, and pre-operative use of drugs such as steroid therapy that have the potential to cause immune-suppression. With the increased use of diagnostic and treatment modalities, there is increased bacterial exposure of the patient.6

These factors are the bacterial inoculum that gets introduced into the wound either during the procedure or immediately after the procedure, the degree of virulent nature of the micro-organisms. Toxins produced by microorganisms increase their ability to invade host tissue and produce damage to the host tissue. Gram-negative bacteria are known to produce endotoxin that stimulates cytokine production. These cytokines, in turn, can trigger the systemic inflammatory response syndrome which causes significant morbidities and may even cause multiple system organ failures.7-9

The presence of necrosis, hematoma, or dead space provides a milieu for the growth of bacteria. The presence of foreign bodies inhibits local tissue resistance and allowing uninhibited bacterial growth.8 The wound microenvironment influences bacterial growth. With this, it can be seen that the incidence of infection is affected by factors that are intrinsic to the patient and factors related to the type and circumstances of surgery. Thus, as a result of exogenous or endogenous bacterial contamination of the operative procedure SSIs develop. Host – bacteria equilibrium gets disturbed and the equilibrium is one that is in the favour of bacteria. The common causative agents are gram-positive cocci and gram-negative bacilli. However, a variety of aerobic and anaerobic species of bacteria may co-exist. 

The presence of these bacteria induces an inflammatory reaction that causes tissue destruction and ultimately pus formation. Bacteria involved in pus formation are labelled as "pyogenic" (pus producing). CDC Study on the Efficacy of Nosocomial Infection Control (SENIC) suggested the following four risk factors for the development of SSIs:7

1. Operation involving abdomen;

2. Operation lasting beyond 2 hours;

3. Operations that are classified as contaminated, dirty, or infected; and

4. Patient having multiple diagnoses at discharge.

With the advancement in the field of medicine, there is a possibility of prevention and control of these infections. With the discovery of anti-microbial agents even dirty surgeries can be performed without the risk of mortality. In 1964, the US National Research Council group had classified the operative wounds. This classification was done based on the degree of microbial contamination, It then proposed 4 wound classes. Each class had an increased risk of SSIs. These 4 classes were namely:

1. Clean

2. Clean and contaminated

3. Contaminated

4. Dirty10

With the progress of time and wide use and misuse of antimicrobial agents, anti-microbial, once referred to as "MAGIC BULLETS" to eradicate the infection, have seemed to fail in their purpose. The use of antimicrobial agents for the prevention of surgical site infection has become controversial and a disappointment in surgical practice, as the widespread use of antimicrobials has resulted in the problem of the emergence of resistance among micro-organisms. This had made it difficult to control, eliminate, or completely eradicate the surgical site infection.11

The advances that have been made to reduce the incidence of SSI are improvement in the operating theatre ventilation, proper sterilization methods, use of barriers, improved surgical technique, etc, but the rate of SSIs has not zeroed. On the other hand, there is an emerging problem of SSIs due to resistant organisms.4 It is a must to combine advances in the field of microbiology with the advances in the field of surgery. It is a must to understand the bacteriology and emergence of resistance patterns of bacteria properly and use the antibiotics judiciously and meticulously to deal with this menace of SSIs due to resistant organisms. Thus it is pertinent that every hospital has an overall understanding of all the aspects of surgical site infections. The present study was undertaken to identify the possible risk factors related to the development of SSIs and the common pathogens encountered in the development of SSIs. Identifying the pathogens and their antimicrobial sensitivity will ultimately help in the empirical management of SSIs.

MATERIALS AND METHODS

We conducted this prospective, observational study in the Surgical Department of Dhiraj General Hospital, Piparia. This study was conducted throughout one and a half years that is from January of 2018 to June of 2019. The patients that met all the criteria for inclusion and none of the criteria for exclusion were enrolled in the study. The study was conducted as per Institutional ethical approval no: SVIEC/ON/MEDI/BNPG17/D18034 guidelines as well as the bioethical guidelines provided by ICMR 2016 and in accordance to ICH (International Conference on Harmonization) E6 (R2) ‘Guideline for Good Clinical Practice’.

Inclusion criteria

  1. Patients of either gender aged more than or equal to 18 years.

  2. All patients who reported to the surgery department and underwent either elective or emergency surgeries.

  3. Patients who developed postoperative surgical site infections.

  4. The patient gave written informed consent.

Exclusion criteria

  1. Patients having a history of previous surgical site infection.

  2. Patients who received antibiotics more than a week before surgery.

  3. Patients that underwent re-operation, except for the management of surgical site infection.

  4. Patients who took DAMA, or did not follow up within 30 days of operation.

  5. The patient did not want to participate in the study.

A swab was collected and sent to the microbiology department for culture and sensitivity reports. The patient was also investigated for: complete blood count, urine routine and microscopy, random blood sugar, liver function test, renal function test, ECG, chest x-ray PA view, and other special investigations like CT scan, if required.

The findings were computed and analyzed.

RESULTS AND DISCUSSION

Gender comparison

In the present study, we observed that SSI was predominant in males as compared to females, of the 103 patients were enrolled with surgical site infection 62.14% were males while 37.86% were females (Table 1). Similar findings were also observed by Chada et al., 2017 in their study the authors observed that males with SSI were 61% while 39% of females had SSIs.6 Saxena et al., 2013 also observed that the SSIs were common in males as compared to females.2 In contrast to our study, Khairy et al., 2011 observed that SSIs were common in females rather than males.12 Bandaru et al., 2012 and Kikkeri et al., 2014 also observed that SSI was common in males.10,13 One of the reasons for these gender differences could be the biological differences between the skin of men and women. Studies have shown that there is greater colonization with bacteria of the skin surrounding the insertion site of a central venous catheter in men than in women, even when controlling for baseline colonization.14 Additionally adherence to wound dressing is impacted by hair growth and shaving, and this may be responsible for the higher risk of infection among men that have thicker, coarser hair.

Age distribution

In the present study, the mean age of the patients was 52.58 ± 19.77years and maximum patients were in the age group of 58 to 77 years (Table 2). In the study by Mahesh CB et al.,2010, the incidence of SSIs increased with advanced age, the authors observed that 33.33% of patients in the age group of 61-70 yrs and 46.66% of patients in the age group of >70 yrs were infected.15 In contrast to this Khairy et al., 2011 observed that SSIs were common in the age group >12-19years.16 In the study by Kikkeri et al.,2014, the majority of the patients with SSIs were in the age group of 18-30 years, 64.44%.13 Saxena et al., 2013 observed that age > 50 years is a risk factor for the post-operative wound infections.2 This may be because of the co-morbidities, impaired immunity with advancing age, low healing rate, malnutrition, mal-absorption, and increased catabolic processes.

Comparison of SSI in Emergency vs elective surgery

In the present study, we observed that SSIs were common in surgeries performed in an emergency setting rather than those performed electively. Of the patients with SSIs, 56.31% had undergone surgeries under emergency settings while another 43.69% had undergone surgeries in an elective setting (Table 3). In the study by Chada et al.,2017, of the patients with SSIs, 56% had undergone surgeries under emergency settings while another 44% had undergone surgeries in an elective setting.6 Saxena et al., 2013 the infection rate was 16.48% in patients operated in an emergency setting while in patients operated electively the rate was 13.39%.2 Similar findings were also observed by Khairy et al. 2011 14.28% of the patients operated in emergency setting developed SSIs while only 3.37% operated in the elective setting developed SSIs (Table 3).16 Since the surgeries performed under emergency lack routine pre-op preparations such as management of co-morbidity, control of diabetes, etc. Also, the fact that emergency operations involve contaminated areas like bowel and the perianal region.

Comparison of SSI in different wounds

We observed that the rate of SSIs was common in a contaminated wound (45.63%) followed by dirty wounds (28.16%) (Table 4). We observed a lower incidence in operations labeled as dirty as compared to contaminated wounds is because we choose patients who had already developed SSIs and the overall incidence of operations labeled as dirty in that group was lower as compared to operations labeled as contaminated.  This classification of operations is based on the probability of developing the SSIs following operations. The probability of contamination and thereby the chances of developing SSIs increases as the type of operation proceeds from clean to dirty. However, with proper aseptic precautions and proper use of antibiotics, the risk of SSIs can be reduced.

Correlation of SSI with hospitalization

When the history of hospitalization in the past 6 months was evaluated, it was observed that 73.79% of patients had undergone hospitalization in the past 6 months due to some or other reasons. History of hospitalization is positively correlated with the development of SSIs. Similar to our study Chada et al.,2017 observed that prior hospitalization had taken place in 74% of the study population (Table 5).6 Saxena et al., 2013 evaluated the impact of pre-operative stay on SSIs in elective surgeries and observed that there was a positive correlation between pre-operative stay and SSIs in case of elective surgeries. Various literature also suggests that there is a positive correlation between the pre-operative waiting period and the development of SSIs, Kikkeri et al., 2014  observed that SSIs developed in 9% of patients operated in less than 48 hours and in 43% of patients who waited for more than a week to undergo surgery.13 Mahesh CB et al.,2010 also observed a direct correlation between pre-operative hospitalization and the development of SSIs. 15 The reason for the higher incidence of infections with prolonged hospitalization could be the colonization of patients with nosocomial strains in the hospital. Also, longer pre-operative stay in the hospital reflects the severity of existing illness and the presence of co-morbid conditions that may have required workup and management before the operation.

Correlation of SSI with diabetes mellitus

Diabetics are at higher risk of infections; uncontrolled diabetics are at even higher risks. This is because of impaired micro-circulation and sugar-rich blood providing ideal media for bacterial growth. In the present study, we observed that SSIs occurred in 37.86% of patients with uncontrolled diabetics, 28.16% with controlled diabetics, and 33.98% without diabetics (Table 6). Thus, in the present study of the developing SSIS, 66.02% had diabetes, either controlled or uncontrolled. In the study by Chada et al., 2017, 39% of patients had uncontrolled diabetes while 27% of patients had controlled diabetes.6 Saxena et al., 2013 observed that the incidence of SSIs was 24.13% in diabetics while the same was 13.28% in non-diabetics.2 Kikkeri et al.,2014 observed that 83.33% of diabetes developed SSIs while it was observed in only 12.18% of patients without diabetes.13 Khairy et al., 2011 observed that the incidence of SSIs was 20% and 3.77% in diabetics and non-diabetics respectively.16 Cheng et al., 2015 observed that the incidence of SSIs in diabetics and nondiabetics was 14.3% and 2.5% respectively.17 Apart from diabetes various other co-morbidities impact the outcome in patients, these factors are BMI (both the extremes that are malnourishment as well as obesity), anaemia, etc.

Comparission of operative procedure and SSI

In the present study of the patients that developed SSIs, laparotomy, cholecystectomy, appendicectomy and amputations were performed in 35.92%, 23.30%, 21.36%, and 19.42% of the patients respectively (Table 7). Most of these operations are classified as clean-contaminated or dirty. In the study by Chada et al., 2017, of the patients with SSIs, 4.9% had undergone amputation, 7.1% had undergone appendicectomy and 17.6% patients had undergone laparotomy.6 In the study by Olowo-okere et al., 2018 >30% of patients that underwent exploratory laparotomy and appendicectomy developed SSIs.18 Laparotomy is a contaminated type of operation and hence at a high risk of developing SSIs, which was also observed in the present study.

Comparison of bacterial growth

In the present study of the 100 swabs collected, gram stain showed pus cells in 96.12% while bacteria were seen in 94.17% (Table 8). Bacterial growth in culture was obtained in 94 swabs (91.26%). In the study by Chada CKR et al., 2017, pus cells were seen in 92% of cases undergoing gram staining, and bacteria were seen in 94% of cases. Bacterial growth was obtained in 91% of culture cases. Bandaru et al., 2012 reported growth was seen in culture in 83% (35 out of 42) of cases. Arora et al., 1990, and colleagues (87% cases) and Masood Ahmed et al., 2007 also reported positive cultures for their SSI cases.19,20

In the present study, staphylococcus aureus (23.30%) was the commonest bacterial isolate (Table 9). Similar findings were also observed by Kownhar et al., 2008  the authors reported that of all the isolates, 37% were staphylococcus aureus of which MRSA was 27%.21 Chada et al., 2017 reported Staphylococcus aureus in 25.34% of the cases.6 The common isolates various from study to study and depend on the hospital, its location, common nosocomial organism prevalent, other physical and operational factors, etc. A literature review has shown that some authors have reported major isolates of Pseudomonas aeruginosa and Escherichia coli also in their studies. Bandaru et al., 2012 reported staphylococcus aureus (38% cases) followed by Escherichia coli as the common pathogens causing post-operative wound infections.10

Staphylococcus aureus was a major isolate across all the different type of surgeries. Chada CKR et al., 2017observed that staphylococcus aureus was a major isolate from orthopedic SSI, followed by L.S.C.S. surgeries and was common in an emergency procedure. In the study by Chada et al., 2017, MRSA was seen in 37% of S aureus isolates.6 Contradictory to our study, Chada et al., 2017, Bericon et al., 2007 and Anvikar et al.,1999 reported higher isolation of E.coli and Klebsiella pneumoniae from surgical wards.6,22,28 In the present study, of the various gram-negative organisms isolated, Escherichia coli and Pseudomonas aeruginosa were predominant. Suljagic et al., 2010 reported that E.coli was the major isolate from intestinal and abdominal surgeries.24 Staphylococcus aureus are common contaminants in various parts of the hospitals. Bedsheets, instruments, and dressing material are known to act as reservoirs for infections. Mehta et al., 2014 collected 196 swabs/pus specimens from different parts of a surgical unit, they found that Staphylococcus aureus was predominant as contaminant, which explains the predominance of Staphylococcus aureus as a causative organism for SSIs.29

We observed that isolated Staphylococcus aureus was resistant to various antibiotics such as amoxicillin, ampicillin, etc. which was also the observation in other studies.25,26 We also observed that a higher proportion of Staphylococcus aureus strains was also resistant to Amoxycillin + clavulanic acid and this has resulted in a decline in the use of this antibiotic for the treatment of SSIs with S aureus. We also observed that MRSA infection is widespread, which is also confirmed by other studies. Some strains of Staphylococcus aureus were also resistant to clindamycin. Despite resistance to various antibiotics, no resistance was not observed to vancomycin and linezolid in the present study.

CONS that were isolated in the present study showed a high degree of resistance to various antibiotics. However, none were resistant to vancomycin and linezolid. Chada et al., 2017and Cantlon et al., 2006 also reported CONS isolates that were resistant to various organisms.6,27 Rudresh et al., 201230 concluded adequate antibiotic prophylaxis is just not sufficient for the prevention of salmonella infection of the port in chronically infected gall bladder extraction. Every gallbladder should be extracted with an endo bag especially in developed countries, where the chances of chronic Salmonella infections are common.

In the present study, gram-negative isolates showed a high degree of resistance to commonly used low generation antibiotics. These were the observation in the various other studies also. One of the reasons for the emergence of resistance is the widespread empirical use of antibiotics for various infections. Most gram-negative isolates demonstrated multidrug-resistant. However, these organisms showed sensitivity to carbapenems like meropenem, imipenem, and doripenem and Piperacillin/tazobactam. Sensitivity to a higher generation of cephalosporins was also preserved by most Pseudomonas aeruginosa and 100% Proteus sp isolated. With this, it can be recommended that higher generation cephalosporins and carbapenems can be used for empirical management of SSI. Each hospital should develop its list of essential and empirical antibiotic lists and these lists should be updated periodically based on the common nosocomial infections and their resistance pattern.

CONCLUSION

It can be concluded that SSIs are quite prevalent and there is an emerging menace of multi-drug resistant organisms. Both, patients, as well as a surgical factor, acts as the risk for its development. Each hospital must have its list of antimicrobials to be used for empirical therapy, conduct regular surveillance. Empirical Use of higher antibiotics should be limited to high-risk patients.

Conflict of interest: Nil

Source of funding: Nil

Acknowledgement: Immeasurable appreciation and deepest gratitude for the help and support are extended to my mentor Dr. Rajesh P Bharaney who in a way or other has contributed to making this study possible.

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Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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