International Journal of Current Research and Review
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IJCRR - 8(4), February, 2016

Pages: 29-33

Date of Publication: 21-Feb-2016


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HISTOPATHOLOGICAL PATTERN AND RELATIVE FREQUENCY OF OVARIAN MASSES IN TERTIARY CARE HOSPITAL

Author: Shreedhan G. Prajapati, Smita A. Shah, Nirali S. Amin, Hansa M. Goswami

Category: Healthcare

Abstract:Introduction: Ovarian tumours are one of the major causes of gynaecological problems in females and present marked variation in their histological types. Relative frequency of these lesions is different for Western and Asian countries. This study was designed to find out frequency of various histological patterns of ovarian tumours in patients attending Pathology Department of Tertiary care Hospital.
Material and Methods: A retrospective case \? series study was conducted on 186 cases of ovarian masses, reported from august 2013 to July 2014.
Results: Mean age of the subjects was 35.6 years, ranging from 4 to 80 years. In a total of 186 cases of ovarian masses, 104(55.91%) were non-neoplastic and 82 (44.09%) were neoplastic. Among neoplastic lesions, 80.48% (66/82) were benign and 19.52% (16/82) were malignant. The commonest non-neoplastic lesion was Luteal cyst (43/104) followed by simple serous cyst (25/104). The commonest benign tumor was serous cystadenoma(40/66) followed by dermoid cyst(12/66). The commonest malignant tumour was serous cystadenocarcinoma (5/16) followed by mucinous cystadenocarcinomama (3/16).
Conclusion: Non-Neoplastic lesions were more common than neoplastic lesions, while benign tumours outnumbered the malignant ones. The commonest benign tumour was serous cystadenoma and malignant was serous cystadenocarcinoma. The commonest non-neoplastic lesion was Luteal cyst. Among histological types of ovarian tumours, surface epithelial tumours dominated the other types.

Keywords: Ovarian tumours, Luteal cyst, Serous cyst, Dermoid cyst, Cystadenocarcinoma

Full Text:

INTRODUCTION The incidence of cancer is increasing in developing countries.1,2 There are marked differences in distribution of different cancers in different regions of the world.2,3 Ovarian cancer is the most frequent cause of death from gynaecological cancers and the fourth most frequent cause of death from cancer in women in Europe, United States4 and Eastern India.5 Exact incidence in India is not known, but ovarian cancer is the 4th most common cancer among females of India and continues to present at an advanced age.6 The lifetime risk of ovarian cancer in women with no family history is 1.6%; with one affected first degree relative is 5%,7 and 7% with two or more affected first degree relatives.8 Ovarian tumours are insidious in onset and usually diagnosed at a late stage. They are rare in young age group.9 They commonly present with abdominal pain, a lump or menstrual irregularities.10 In addition to biopsy, various diagnostic modalities include transvaginal ultrasonography, MRI, positron emission tomography,11 and markers like serum CA 125.8 Diverse histopathologies are common in ovarian lesions. Relative frequency of different ovarian tumours is different for western world and Asian countries.

For example surface epithelial tumors account for 50.0 – 55.0% of all ovarian tumors and their malignant counterpart for approximately 90.0% of all ovarian cancers in Western world whereas this figure is 46.0 – 50.0% and 70.0 – 75.0% respectively in Japan. Similarly mucinous tumors account for 12.0 – 15.0% of all ovarian tumors in Western world. This figure is 20.0 – 23.0% for Japan. Germ cell tumors account for 30.0% of primary ovarian tumors and malignant germ cell tumors account for 3.0% of all ovarian cancers in Western world.12 Determination of  these patterns is important for diagnosis, management and prognosis. This study was conducted to find out the histopathological patterns of ovarian lesions in patients attending a civil hospital, Ahmedabad.

MATERIALS AND METHODS A retrospective case – series study was carried out on 186 patients who had undergone surgical oophorectomy. Samples were analysed in the Pathology department of B.J.M.C., Civil Hospital, Ahmedabad. All Histopathological diagnosed cases of ovarian lesions referred to this department during August 2013 to July 2014 were included in this study. These were mostly referred from gynaecology and obstetrics department of our civil Hospital, Ahmedabad, but a few were referred from other hospitals in the vicinity. The data was retrieved from the record files of pathology department. Patients with abdominal– pelvic masses other than of ovarian tumours diagnosed on histopathology were excluded from the study. The histological characterisation of ovarian tumour was done according to the International Classification of Diseases, 9th ed. (ICD9) (WHO Classification, 1995).13 The acquired data was analysed using the descriptive statistics.

RESULTS During the study period from august 2013 to July 2014, one hundred and eighty six consecutive cases of ovarian lesions were selected. Ages of the patients and their histopathology diagnoses were recorded. Patients were divided into eight age groups, with a difference of 10 years in each group. The commonest age group affected was from 21 to 30 years followed by age group from 31 to 40 years. The youngest patient was 4 years old and the oldest was 80 years old. Mean age was 35.6 years (Table 1). In a total of 186 ovarian lesions, 104 (55.91%) were non-neoplastic and 82 (44.09%) were neoplastic. The neoplastic lesions comprised 66/82 (80.48%) benign and 16/82 (19.52%) malignant tumours (Fig. 1).

In non-neoplastic lesions, Luteal cyst was the predominant category (43/104) followed by simple serous cyst (25/104) (Table 2). The neoplastic tumours were divided in four groups, namely, epithelial tumours, germ cell tumours, sex cord stromal tumours and metastatic tumours. Epithelial tumours were maximum in number(62/ 82; 75.60%), followed by Germ cell tumours (14/82; 17.07%) (Table 3). Frequency pattern of different classes and subtypes of benign and malignant ovarian neoplasms (n = 82) is show in table 4. The commonest histological class is surface epithelial tumours (62/82; 75.60%) followed by germ cell tumours (14/82; 17.07%). Among all the benign lesions (n = 82), serous cyst adenoma is the commonest (40/82), while dermoid cyst is at the second number (14/82).

Frequency pattern of different classes and subtypes of benign and malignant ovarian neoplasms (n = 82) is show in table 4. The commonest histological class is surface epithelial tumours (62/82; 75.60%) followed by germ cell tumours (14/82; 17.07%). Among all the benign lesions (n = 82), serous cyst adenoma is the commonest (40/82), while dermoid cyst is at the second number (14/82). On the other hand, among all the malignant lesions (n = 16), serous cyst adenocarcinoma is at the top (05/45), followed with a little difference by mucinous cyst adenocarcinoma (03/45) and endometrioid carcinoma (01/45) respectively.

DISCUSSION Age range of our subjects was from 4 to 80 years and mean age was 35.6 years. Mean age observed in our study is lower than that observed in few other studies carried out in india. Our study shows the maximum incidence of ovarian masses between 21 and 40 years of age. This differs from the western data where it is between 50 and 70 years16 but correlates with other studies conducted in India. In our study non-neoplastic lesions were 55.91% (104/186) and neoplastic lesions were 44.09% (82/186). Neoplastic lesions contained (66/82) benign and (16/82) malignant. Tanwani19 documented 31.4% non-neoplastic lesions, 46.4% benign tumours and 22.2% malignant tumours. Among non-neoplastic lesion, Luteal cyst was most common (43/104) followed by simple serous cysts (25/104) in our study.

The pattern of distribution of non-neoplastic lesions is quite variable in other studies. Among the 82 neoplastic lesions in our study, 80.48%were benign and 19.82% were malignant. The higher incidence of benign tumours is also documented in various other studies,19,21,22 where it is 85%, 78%, 89.7% and 72.73% respectively and ratio of benign to malignant tumours is lower in these studies as compared to our study. No borderline tumor was found in our study. Among the major histological classes, the commonest type of ovarian neoplasm seen in our study was surface epithelial tumours, whether benign or malignant (62/82; 75.60%). Our finding is closer to the observations made in several other studies i.e. 64%, 66% and 70%7,24,25 respectively. However, Guppey et al26 documented a higher incidence of epithelial tumours than in our study i.e. 90%.

Germ cell tumours (GCT) in our study were 17.07%. This value is quite high as compared to Western data (370)4 and data collected from other parts of india (1470)16 and (27.13%).7 This difference may be due to variations in sample size but genetic, socioeconomical and environmental factors may also be involved. The frequency of sex – cord – stromal tumours (SCST) in our study was 4.87%. This value is comparable with that of studies carried out in the west (5%)27 and other parts of india (370).16 Our study showed that serous tumours (whether benign or malignant) were more common than mucinous tumours (40/67 vs 16/67 cases). This finding correlates with other studies.28,29 The studies carried out by Khanum and Rehman22 and Aziz et al17 also observed serous cyst-adenomas to be the commonest tumours.

The frequency of malignant tumours in our study was highest for serous cyst adenocarcinoma (5/16) followed by mucinous cyst adenocarcinoma (03/ 16). Similar pattern of distribution of malignant tumors are shown by many other studies.7,20 However, Study conducted by Yasmeen et al shows endometrioid carcinoma to be more prevalent.21 Germ cell tumours (GCTs) comprise the second largest group in our study in which benign tumours dominated the malignant ones (12/14 vs. 02/14 ). Among the benign GCTs our study showed the highest incidence of mature teratomas followed by dermoid cysts (08/14and 04/14 respectively). A study of Thanikasalanm et al 30 conducted in India shows teratomas to be the predominant GCT, whereas study conducted by Ahmad et al 7 in Pakistan documents dermoid cysts to be the commonest GCT.

Sex cord stromal tumours (SCSTs) were the least common in our study, next to metastatic tumours (4/82; 4.87%). The incidence of these tumours is variable in other studies. Zohra18 found only 1% SCSTs while Tanwani19 documents 10.1% cases of SCST. Granulosa cell tumours were the commonest SCSTs in our study (2/4) while studies carried out by Yasmeen et al21 and Ahmad et al31 mentioned a variable incidence of 28.5% and 5.62% respectively. In conclusion according to this study ovarian tumours are common in age group of 21 to 40 years. Neoplastic lesions are more common than non-neoplastic lesions. Luteal cyst is the commonest nonneoplastic lesion.

Among the histological classes of neoplastic lesions, surface epithelial tumours are predominant type, followed by germ cell tumors. The commonest benign tumour is serous cystadenoma and commonest malignant tumour is serous cystadenocarcinoma. This study is institutional – based, therefore the results obtained may or may not reflect the actual histological pattern of ovarian tumours in indian women. Therefore, multicentric study with larger sample size should be carried out.

CONCLUSION Non-Neoplastic lesions were more common than neoplastic lesions, while benign tumours outnumbered the malignant ones. The commonest benign tumour was serous cystadenoma and malignant was serous cystadenocarcinoma. The commonest non-neoplastic lesion was Luteal cyst. Among histological types of ovarian tumours, surface epithelial tumours dominated the other types.

ACKNOWLEDGEMENTS Acknowledgements are due for my colleagues and the paramedical staff of the department of pathology, B.J.M.C., Civil Hospital, Ahmedabad for their cooperation and continuous moral support. Thanks are also due for the staff of Gynec and Obstetric department of our hospital and all others who sent the biopsy specimens of ovarian masses to our department.

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16. Mariam Malik, Farooq Aziz. Malignant ovarian tumors: a study of 75 patients. Pak J Obstetric Gynaecology May 1999; 12 (1,2): 83-6.

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18. Zahra F. The pattern of ovarian masses. Ann King Edward med Coll Oct – Dec 2006; 12 (4): 480-2.

19. Tanwani A.K. Prevalence and pattern of ovarian lesions. Ann Pak Inst Med Sci Oct – Dec 2005; 1 (4): 211-4.

21. Yasmin S, Aiman yasmin, Mohammad Asif. Frequency of benign and malignant ovarian tumors in a tertiary care hospital. J postgrad Med Inst Oct – Dec 2006;20 (4): 393-7.

22. Khanum Z, Amanur Rehman. The prevalence and age distribution of ovarian cysts. Ann King Edward Med Coll Oct – Dec 2005; 11 (4): 392-3.

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Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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Awards, Research and Publication incentive Schemes by IJCRR

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

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A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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