International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 13(1), January, 2021

Pages: 134-140

Date of Publication: 05-Jan-2021

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Ayurvedic Immuno Booster: Is it Myth or Reality in COVID-19 Pandemic

Author: Ashok Kumar Panda, Sarbeswar Kar

Category: Healthcare

Abstract:Ayurveda Immune boosters (AIB) are Rasayana drugs which increase the number of white blood cells and train them to fight against microbes causing diseases. Some of them kill microorganisms, increase immunoglobulin, repair of DNA of an inflamed cell, increase Agni, and conditioning the gut to increase the beneficial gut microbiota. This review aimed to generate scientific evidence for Ayurveda Immune boosters (AIB) are effective to prevent and cure COVID-19 infection or it is a myth through Ayurveda and modern literature review. The properties of Rasayan are reviewed from Ayurveda Literature. The immunopharmacology, mechanism of immuno-booster and Rasayana herbs are reviewed from current medical literature for its subclinical and clinical evidence. Ayush kwatha and single herb like Guduchi (500-1000mg) extract, Aswagandha powder (3-5gm), and Haridra milk/gargling recommended as AIB by the Ministry AYUSH are safe and effective for prevention and cure of COVID-19 with sufficient preclinical and some Randomised clinical trials (RCT) evidence. So, the myth of Traditional Ayurveda herbs won't boost our immunity to the virus is not true rather Ayurveda Medication (AIB) can boost our immunity to fight against COVID-19. More RCT evidence is required for clinical practice.

Keywords: Ayurveda Immuno booster (AIB), Rasayana, Ayush kwatha, Guduchi, Aswagandha, Haridra

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In the COVID-19 pandemic situation, Immuno -boosting is a matter of dialogue among common citizens and mostly appearing in social, press, and electronic media.  Common people want to use it with a high expectation for prevention and cure corona virus1.  Therefore, there is an increasing demand for Ayurvedic Immuno-booster (AIB) to strengthening Immuno system to prevent coronavirus infection rather than treating existing diseases. Looking at the demand in India, several initiatives have been taken to utilise the vast potential of Ayurveda in this pandemic.1,2 The Ministry of AYUSH has released a set of guidelines for boosting immunity and measures for self-care by using Ayurvedic principles. Further, the Indian Prime Minister in his address to the nation also advised using Ayurveda medicines for improving immunity against COVID-19.  The demand for the AYUSH system across the country has increased and has also been put on alert for being called anytime to serve the nation.2  Unfortunately, the idea that Ayurveda pills, preparations, functional foods, or wellness yogic habits can provide a shortcut to a healthy immune system is a myth. Many authors enumerated that the concept of "boosting" your immune system doesn't hold any scientific meaning.3 But a study on 9,000 US children has shown that the administration of some complementary therapies, including chiro-practice and other shorts of alternative medicine (excluding multivitamins/multi-minerals) is related to a lower uptake of influenza vaccine.4

Immunity is a natural protective mechanism to protect from exposed harmful pathogens and environmental pollutants that affect the health status and homeostasis of an organism. This is maintained through a chain of networks of cells, tissues, organs, and biochemical mediators generated to defend the organism against any foreign invaders that threaten the integrity of the organism. One of the key features of immunity is to recognise its cell or tissues (self) and rejection of foreign protein molecule or microbes of the environment5. In the past two decades, epidemiological data have provided evidence of an increase in immunological diseases, therefore a new branch of pharmacology i.e Immuno-pharmacology developed, and a new group of molecules in immunotherapy is called Immunomodulators.5,6 Immuno-modulators are a specific group of molecules that suppress the immune response or stimulate the immune cells in immune-mediated disorders and infection. The immunosuppressive drugs are hugely used to inhibit the immune response in many immune-mediated diseases (Organ transplant and Autoimmune diseases) whereas immunostimulatory drugs are used to prevent or cure the infection. The synonyms used for immune stimulants are Immuno booster/buster. Immuno boosters are vitamins, minerals, probiotics, functional food as well as traditional medicines and approaches to stimulate the immune system to prevent and cure diseases.6,7 However, the concept of Vaccine is a well-recognized and effective way of Immuno booster to prevent infection. On the contrary, Ayurveda is a live traditional system of medicine with an unbreakable practice for 3000 years. Its principles and its approaches including oral administration of preventive drugs, herbs, formulae, decoction, indoor herbal medicine fumigation, etc. were recommended for effective prevention and treatment whenever the emergent of new disease7.  Rasayana is one of the main branches of eight specialities (Astanga Ayurveda) which can enhance longevity, memory intelligence, freedom from disorder, youthfulness, the excellence of lustre, complexion, and voice, optimum of physique and sense organs, mastery over phonetics, and brilliance. These are health-promoting and rejuvenating procedures to prevent and cure diseases by enhancing physical strength (Bala), energy (Urja), Immunity (Vyadhi khamatwa), and mental power.8 Immuno boosting study was concluded to be commercially biased without scientific evidence.9  In this context, new and innovative approaches to Ayurveda Immuno boosters are to be studied for more effective prevention and treatment of infectious diseases special reference to COVID-19   as Ayurveda has vast literature that would represent some inspiration.8,9

The properties of Rasayan are reviewed from Ayurveda Literature. The immunopharmacology and Rasayana herbs are reviewed from current medical literature for its subclinical and clinical evidence.

Immuno system and its responses

The immune system is the network of cells, tissues, organs, and biochemical mediators that work together to protect the body. The immune cells are phagocytic cells and lymphocytes. Phagocytic cells are large white cells (monocytes, macrophages, mast cells, and neutrophils) are the most prevalent cells that can engulf and digest foreign organisms. The second most abundant cells are lymphocytes which are distinguished as B and T cells. Again, helper T cells are regulating the function of T cells whereas cytotoxic T cells destroy the infected cells or cancer cells. Natural killer cells destroy abnormal cells/cancer cells. The primary lymphoid organs are bone marrow and thymus and secondary lymphoid organs lymph nodes, spleen, tonsil, and payer's patches in the small intestine. Complement is also a series of proteins worked together with antibodies. The chemical messenger of the immune system is a cytokine. The cytokines that release T and B cells are Lymphokines whereas monokines are secreted from monocyte and macrophages. Cytokines encourage cell growth, promote cell activation, destroy target cells. The cytokines are Interferon, Interleukin, chemokines.10  

         Immuno response is traditionally classified as innate and adaptive immunity. Innate immunity is a short-term response that includes phagocytic cells, complement system, and receptors (TLRs, PPPs), whereas adaptive immunity is long term response that includes antigen-specific system mediated through memory cells and their specialised receptors. It is also known to be acquired as a specific antigen strategically used to create an immune response. Innate immunity recognises the infection and alerts the adoptive system through antigen, MHC, and cytokine. The total immune response worked through well recognised humoral and cell-mediated immune components. The moral response or antibody-mediated response starts from phagocytosis to the huge production of an antibody by plasma cells to memorize the specific antigen for quick mobilization of the system in later life. The cell-mediated immune response started with the recognition of antigen, secretion of lymphokine to stimulate T & B cell growth, enhance the macrophages to engulf and destroy the microbes.11,12

Immuno system does remarkable work to defend against diseases causing microbes, but sometimes it fails due to age, poor nutrition, environmental pollutants, organ damage/ dysfunction, and unhealthy lifestyle.13   

Immuno response against COVID-19

          The invasion of coronavirus and immunopathology of COVID-19 are associated with host immunity. The spike of glycol protein (S Protein) on the virus envelops binds to its receptor, angiotensin-converting enzyme 2 (ACE2), on the surface of human cells. Innate immunity is the first line of defence against virus invasion. The identification of pathogen-associated molecular patterns, such as RNA & uncapped m RNA results in subsequent cytolytic immune responses, mainly through the type I interferons (IFN) and natural killer cells.  Adaptive immunity also plays a crucial role in viral clearance via activated cytotoxic T cells that destroy virus-infected cells and antibody-producing B cells that focus on virus-specific antigens. Patients with COVID-19, especially those with severe pneumonia are reported to possess significantly lower lymphocyte counts and higher levels of plasma concentrations of a variety of inflammatory cytokines like IL-6 and tumour necrosis factor (TNF). Another study reported that CD4+ T cells, CD8+ T cells, and natural killer cells were reduced in severely ill patients compared with those with mild disease symptoms. Moreover, a significant reduction of CD4+ T cell and CD8+ T cell counts in the peripheral blood was also observed in a patient who died in Covid 19 infection. The pro-inflammatory subsets of T cells, including IL-17-producing CCR4+ CCR6+ CD4+ (T-helper 17 or Th17) cells and perforin and granulysin-expressing cytotoxic T cells were remarkably increased, which could be quite responsible for the severe immune injuries in the lungs of this patient.13,16 Antiviral immune response is vital for the elimination of virus by overproduction of inflammatory cytokines which damaged the host tissues and aberrant immune-activation is called a cytokine storm. Cytokine storm is found in COVID-19 which is a serious explanation of disease progression and eventual death. They also found that increased plasma concentrations of both Th1 (e.g., IL-1β and IFNγ) and Th2 (eg. IL-10) cytokines. Patients admitted to the intensive medical unit (ICU) had higher plasma concentrations of IL-2, IL-7, IL-10, granulocyte-colony stimulating factor, IFNγ-induced protein-10 (IP-10), macrophage chemoattractant protein-1, macrophage inflammatory protein 1α, and TNF compared to those not admitted to ICU. Secondary haemophagocytic lymphohistiocytosis (sHLH) might be related to severe COVID-19 cases.17 HLH is a disease condition manifested by an uncontrolled cytokine storm and expansion of tissue macrophages or histiocytes that exhibit haemophagocytic activity. HLH can result from genetic defects in cytolytic pathways (familial or primary HLH) or other diseases like infection, malignancy, and rheumatic disease (sHLH). The proposed laboratory tests include serum ferritin, total lymphocyte or leukocyte counts, platelet counts, erythrocyte counts, and sedimentation rates that could be used to screen patients to exclude the high risk of hyper inflammation in small setup.14

Mechanism of Immuno booster

            The impact of Rasayana drugs as Immuno boosters in the COVID-19 situation can be studied from the vast pharmacopoeia of Ayurveda which is also a matter of research. The mechanism of immune-boosting properties of Rasayana drugs is not established. Rasayana drugs have a profound effect on the body system so Immuno booster properties can be discussed as,

Rasayana drugs increase digestive power (Agni)

Rasayana drugs increased the enzymatic reaction to increasing digestion and assimilation, and clear the microchannels to provide adequate and appropriate nutrition for cellular function including immune cells. Further, the immune system is activated during infection which requires more nutrients for a good immunological outcome. Diminished digestive power (Agni) leads to the production of ama (undigested food) which can create a subclinical situation for the onset of infection or sopha (Chronic infection).15

Rasayana drugs conditioning the gut 

                     Maximum immune cells in the human body are found within gut-associated lymphoid tissue (GALT), reflecting the crucial role of these immune tissues in maintaining host health.  Several microbes with massive antigenic stimulation are present in ingested food, that provide us with strong protective immunity against invasive pathogen and tolerating various food proteins.  GALT can produce a variety of sensing and effector immune functions to combat those foreign insults. Dendritic cells and M cells within the gut content, while plasma B cells within the lamina propria produce IgA, protecting pathogenic organisms. Peyer's patches are rich in immune cells, allow for communication networks between immune cells residing within the GALT, propagation of signals to the wider systemic immune response, and the recruitment or efflux of immune cells16. The gut microbiota will give a signal to produce antigen to interact with the systemic immune system. The human gut microbiome will provide antigens and signals with the potential to interact with resident and systemic immune cells within the gut lumen itself. Several Rasayana drug interventions have demonstrated the capacity to improve gut health or to reduce gut inflammation. Polyphenols in Rasayana drugs modulate the human gut microbiome and thereby promote the growth of beneficial Bifidobacteria and Lactobacillus while inhibiting the growth of undesirable gut microbes. The bioactive compounds of Triphala are elicited by gut microbiota to generate a variety of anti-inflammatory compounds.17,18 Again, there are more ammonia generated bacteria and lactobacillus bacterial are less in constipated patients.18 Most of the Rasayana drugs have bowel clear property.19,20

Rasayana drugs reduce chronic systemic inflammation

Chronic systemic inflammation is the key underlying feature of a wide range of chronic non-communicable disease conditions such as cardiovascular disease, stroke, and autoimmune disorders. This chronic inflammation is positively correlated with ageing. immunotolerance and reduced immune response, and other co-morbidities (e.g., obesity, cardiovascular disease, insulin resistance) which is related to bad outcomes of any infection and sepsis. A study in healthy adult found that risk factor of chronic systemic inflammation is increased with increased age irrespective other risk factors such as obesity, hypertension and blood lipids21. Histamine, bradykinin, neuropeptides, prostaglandins, thromboxane, leukotrienes, and platelet-activating factor stand out among the non-cytokine/chemokine mediators that are involved in the inflammatory response. Chronic inflammation involves the progressive changes in inflammatory cells as well as in tissue destruction and repair due to the on-going inflammatory process and loss of immune response due to the failure of h toll-like receptors (TLRs) of innate immunity.22 The active components from some of Rasayana plants that can modify inflammatory pathways are linked to chronic inflammatory diseases.23  

Rasayana drugs can produce immune cells and Cytokine

Rasayana drugs are inherently non-specific as they enhance the body's resistance to infection. It acts through innate as well as adaptive immune response.24 Some of the Rasayana drugs improve phagocytic function by increasing PMN count, T helper cells, and NK cells.25,26 It also increased immunoglobulin proteins in the intestinal tract to combat foreign invaders. Rasayana also modulation of mono-amine function and reduction of stress, anxiety, and depression which increase the cytokines through psycho-neuro-Immuno mechanism.27

Rasayana drugs can target COVID-19 directly

Rasayana drugs can damage the coronavirus structure by binding the spike protein, E protein, and N protein. It can act by inhibiting virulence by binding Nsp1, Nsp 3c, and ORF7 protein. Most of the Rasayana drugs act through inhibiting RNA synthesis and replication by binding the active site of COVID-19 proteases.28,29

Potential Immuno booster from Rasayana drugs

Scientists realised the need for Ayurveda which mentioned epidemic management and defines immunity as the ability to preventing and arresting the progression of the disease to maintain homeostasis. The Ayurveda has emphasized building strength in the mind and body to cope with various environmental and biological stressors, including infection. Similar to innate and acquired immunity, the Ayurveda concept of immunity (Bala or strength) is classified as natural (Sahaja), chronobiologic (Kalaja), and acquired (Yuktikrut).  Several treatment options are available in Ayurveda for enhancing immunity against respiratory illnesses, these include certain immuno-stimulant(Rasayana), local and systemic interventions.29 The Ministry of AYUSH, Government of India with an interest in health promotion in the COVID-19 outbreak situation recommended Ayush kwatha which consists of holy basil leaf, cinnamon bark, ginger rhizome, black pepper mostly used in Indian kitchen.30-32  Guduchi (500-1000mg) extract, Aswagandha powder (3-5gm), and Haridra milk/gargling are also recommended as single drug immuno-booter by Ministry AYUSH.33,34 Makardwaja is gold-containing mercurial preparation used for vigour and vitality.35 The mechanism of action of different potent Ayurveda drugs is described in Table 1.


Ayurveda describes many drugs as Rasayana and Ojovardhak, which ae claimed to possess’ immuno-stimulatory effect. Some of the Rasayans which have been subjected to scientific studies are found to possess immunomodulatory and anti-inflammatory effects. If our immune system is working properly then it protected from all dangers caused by microbes. If not, we suffer sickness and disease.36,37 It is possible to intervene in this natural protective process to make our immune system stronger using immune boosters.  Immune boosters work in many dimensions such as Ayurveda Immuno Booster can increase the number of white blood cells in the immune system, train them to fight against microbes causing diseases.38,39 Some of them are killed microorganism, increase immunoglobulin, repair of DNA of inflamed cell.40,41 The RCT’s investigation showed the potential clinical improvement of herbal medication for COVID-19 in terms of Symptom score, WBC count, Lymphocyte count and CRP.47 Ayush Kwatha and the other single herbs as advised by Ministry of AYUSH have excellent preclinical pieces of evidence (Table no-1). More research studies of Ayurveda formulations are registered for clinical trials.48 The presenting herbs and their phytochemicals, flavonoids act directly in the priming of SARS-CoV-2 attachment proteins by the host and viral enzymes, and the release of HMGB1 by host immune cells.46 The small observational study of Guduchi and Aswagandha have a good preventive effect on COVID-19. One of the therapeutic targets of anti-COVID-19 drugs is angiotensin-converting enzyme 2 (ACE2). ACE2 is the main functional receptor for CoV associated with COVID-19. Ashwagandha binds ACE2 effectively and the spike protein of CoV, thus enabling the virus to infect the epithelial cells of the host. The natural flavonoids have potential efficacy against COVID-19 through ACE2 receptor inhibition.42-45 Herbal medicines as immuno-booster can be used in the battle of COVID-19 pandemic before the inoculation of vaccine.  So the myth of Traditional Ayurveda herbs won't boost your immunity to the virus is not true rather Ayurveda Medication can boost your immunity to fight against COVID-19. Ayush kwatha which is consisting of holy basil leaf, cinnamon bark, ginger rhizome, black pepper and single herb like Guduchi (500-1000mg) extract, Aswagandha powder (3-5gm) and Haridra milk /gargling recommended as immuno-booter by the Ministry AYUSH are safe and effective for prevention and cure of COVID-19.


Ayush kwatha and single herb like   Guduchi (500-1000mg) extract, Aswagandha powder (3-5gm) and Haridra milk /gargling are recommended as immuno-booter by the Ministry AYUSH are safe and effective for prevention and cure of COVID-19. More RCT pieces of evidence are required for common clinical practices.

Conflict of Interest: None

Source of Funding: None


  1. Wagner DN, Marcon AR, Caulfield T. Immune Boosting” in the time of COVID: selling immunity on Instagram. Allergy Asthma Clin Immunol 2010;16:76.

  2. Ministry of AYUSH, Government of India, Ayurveda’s immunity-boosting measures for self-care during COVID 19 crisis.

  3. Zoria Gorvett. COVID-19: can boost your immuno system protect you, BBC Future, 10th April 2020.

  4. Bleser WK, Elewonibi BR, Miranda PY, Belue R. Complementary and alternative medicine and influenza vaccine uptake in US children. Pediatrics 2016; 138:e20154664.

  5. Yatim KM, Lakkis FG. A brief journey through immuno system. Clin J Am Soc Nephol 2015;10:1274-1281.

  6. Trevor AJ, Katzung BG. Kruidering-Hall, Marieke.Masters, Susan B.  Immunopharmacology, in Katzung & Trevor's pharmacology  New York, McGraw-Hill Med;12th edition 2013:890-92.

  7. Panda AK, Dixit A, Rout S, Mishra B, Purad UV, Kar S. Ayurveda Practitioners Consensus to Develop Strategies for Prevention and Treatment of Corona Virus Disease (COVID-19). J Ayurveda Integr Med Sci 2020;5(1):98-106.

  8. Soni MK, Sharma OP, Importance of Rasayana in Immunity. World J Phar Med Res 2018;4(3):196-98.

  9. Cassa Macedo, Oliveira A, Vilela de FA, Ghezzi, P. Boosting the immune system, from science to myth: analysis the infosphere with Google. Front Med 2019;6:165.

  10. Yatim KM, Lakkis FG. A brief journey through the immune system. Clin J Am Soc Nephrol 2015;10:1274–1281.

  11. Shishido SN, Varahan S, Yuan K, Li X, Fleming SD. Humoral innate immune response and disease. Clin Immunol 2012;144(2):142-158.

  12. Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: Mechanisms of differentiation and function. Annu Rev Immunol 2012;30:531–564.

  13. Lerner A, Jeremias P, Matthias T. The world incidence and prevalence of autoimmune diseases is increasing. Int J Celiac Dis 2016; 3:151–155.

  14.  Zhong J, Tang J, Ye C, Dong L. The immunology of COVID-19: is immune modulation an option for treatment? Lancet Rheumatol. 2020;2(7):e428-e436.

  15. Kuchewar VV, Borkar MA, Nisargandha MA. Evaluation of the antioxidant potential of Rasayana drugs in healthy human volunteers. Ayurveda 2014;35(1):46-49.

  16. Macdonald TT, Monteleone G. Immunity, inflammation, and allergy in the gut. Science 2005; 307:1920–25.

  17. Peterson CT, Denniston K, Chopra D. Therapeutic Uses of Triphala in Ayurvedic Medicine. J Altern Complement Med 2017;23(8):607-614.

  18. Ohkusa T, Koido S, Nishikawa Y, Sato N. Gut Microbiota and Chronic Constipation: A Review and Update. Front Med (Lausanne). 2019;6:19.

  19. Singh SK, Rajoria K. Ayurvedic management of chronic constipation in Hirschsprung disease-A case study. J Ayurveda Integr Med. 2018;9(2):131-135.

  20. Metri K, Bhargav H, Chowdhury P, Koka PS. Ayurveda for chemo-radiotherapy induced side effects in cancer patients. J Stem Cells 2013;8(2):115-29.

  21. Hotamisligil, G.S. Inflammation, metaflammation and immuno-metabolic disorders. Nature 2017, 542, 177–185.

  22. Rogero, M.M.; Calder, P.C. Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids Nutr 2018;10:432.

  23. Aggarwal BB, Prasad S, Reuter S, et al. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach. Curr Drug Targets 2011;12(11):1595-1653.

  24. Doshi GM, Une HD, Shanbhag PP. Rasayans and non-rasayans herbs: Future immunodrug - Targets. Pharmacogn Rev 2013;7(14):92-96.

  25.  Elsayed Y, Khan N.A, Immunity-boosting spices and the novel coronavirus. ACS Chem Neurosci 2020;11(12):1696-1698,

  26.  Kumar D,  Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system.

      J Microbiol Immunol Inf 2012; 45: 165-184.

  1. Rajkumar RP. Ayurveda and COVID-19: Where psychoneuroimmunology and the meaning response meet. Brain Behav Immun 2020;1591(20):30637-1.

  2. Hastantram M, Ramaiah S. Molecular docking analysis of selected natural products from plants for inhibition of SARS-CoV-2 main protease. Curr Sci 2020; 118(7):1087-1092.

  3. Golechha, M. Time to realise the true potential of Ayurveda against COVID-19. Brain Behav Immun 2020;87:130–131.

  4. Gautam S, Gautam A, Chhetri S, Bhattarai U. Immunity Against COVID-19: Potential Role of Ayush Kwath. J Ayurveda Integr Med. 2020;10:1016.

  5. Rajlaxmi SP,  Sneha V. Efficacy of Rasayana Dravya on Covid–19 –A Brief Review. Int J Res Pharm Sci 2020;11: 323-327.

  6. Rastogi S, Pandey DN, Singh RH. COVID-19 pandemic: A pragmatic plan for Ayurveda intervention. J Ayurveda Integr Med 2020; S1(20):30019.

  7. Shree P, Mishra P, Selvaraj C. Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania Somnifera (Ashwagandha), Tinospora Cordifolia (Giloy) and Ocimum sanctum (Tulsi) – a molecular docking study. J Biomol Struct Dyn 2020;15:1-14.

  8. Sanjoy BK,  Prajapati PK, Galib R, Batgiri P. A scientific review of gold-containing herbo-mineral preparation: Makaradwaja. Int J Green Pharm 2015; 9(4): 7-8.

  9.  Damanhouri ZA. A review on therapeutic potential of Piper nigrum L. (Black Pepper): the king of spices. Med Aromat Plants 2014; 3:231-5. 

  10. Aha S, Ghosh S. Tinospora Cordifolia: One plant, many roles. Anc Sci Life 2012;31(4):151-159.

  11. Leyon PV, Kuttan G. Effect of Tinospora Cordifolia on the cytokine profile of angiogenesis-induced animals. Int Immunopharmacol 2004;4:1569–75.

  12. More P, Pai K. In vitro NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of macrophages after Tinospora Cordifolia (Guduchi) treatment. Immunopharmacol Immunotoxicol 2012;34:368–72.

  13. Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med 2011;8(5 Suppl):208-213.

  14. Davis L, Kuttan G. Effect of Withania Somnifera on cytokine production in normal and cyclophosphamide treated mice. Immunopharmacol Immunotoxicol 1999 Nov;21(4):695-703.

  15. Malik F, Singh J, Khajuria A, Suri KA, Satti NK, Singh S, Kaul MK, Kumar A, Bhatia A, Qazi GN. A standardized root extract of Withania Somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up-regulation of Th1-dominant polarization in BALB/c mice. Life Sci 2007 Mar 27;80(16):1525-38.

  16. Liu Z, Ying Y. The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia. Front Cell Dev Biol. 2020;8:479.

  17. Dhundi S, Ashok B, Ravishankar B, Patgiri B, Prajapati PK. Immunomodulataory activity of Triguna Makaradhwaja an ayurvedic compound formulation. Indian J Nat Prod Resour 2012;3: 320-7.

  18. Greetha RV, Laxmi T, Roy A. A review on Nature’s immune-booster. Int J of Pha Sci Rev Res 2012;13(1):43-49.

  19. Panyod S, Ho CT, Sheen LY. Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective. J Tradit Complement Med. 2020;10(4):420-427.

  20. Ang L, Song E, Lee HW, Lee MS. Herbal Medicine for the Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2020;9(5):1583.

  21. Boukhatem, M.N.; Setzer, W.N. Aromatic Herbs, Medicinal Plant-Derived Essential Oils, and Phytochemical Extracts as Potential Therapies for Coronaviruses: Future Perspectives. Plants 2020; 9: 800.

  22. Wyganowska-Swiatkowska, M.; Nohawica, M.; Grocholewicz, K.; Nowak, G. Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review. Int J Mol Sci 2020; 21: 4639.


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A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
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A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


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