International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 13(1), January, 2021

Pages: 70-74

Date of Publication: 05-Jan-2021


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Features of Renal Function in Women with Complicated Preeclampsia

Author: Akhmedov F.K., Negmatullaeva M.N., Tuksanova D.I.

Category: Healthcare

Abstract:Introduction: Study of features of renal function, some indicators homeostasis in women with mild preeclampsia. We have studied 50 women with physiological pregnancy, 100 pregnant women with mild PE (II group) in gestational age 30-34 weeks. The results of the data, it should be emphasized that among the numerous violations of various functions of the body of pregnant women with mild preeclampsia. The most prominent is hypovolemia due to preferential reduction of plasma volume, hypoproteinemia due to proteinuria and reduced renal perfusion parameters with the deterioration of their functional capacity.
Objective: The study of the features of the functional state of the kidneys, some indicators of homeostasis in women during pregnancy complicated by preeclampsia.
Method: We studied 50 women with physiological pregnancy, 100 pregnant women with mild PE (group I), 50 pregnant women with severe PE (group II) at a gestational age of 30-34 weeks. Clinical and laboratory studies were used, including general analysis of blood and urine, fibrinogen, time blood according to Sukharev, a study of the amount of protein in the blood, counting the amount of protein in daily urine and functional methods for assessing the condition of pregnant women.
Result: Assessing the results obtained, it can be indicated that pregnant women with severe preeclampsia have a greater tendency to hypernatremia than pregnant women with mild preeclampsia, which significantly exceeds the concentration of sodium in the plasma of healthy pregnant women. Changes from other electrolytes are not significant.
Conclusion: All this indicates that such a contingent of pregnant women poses a great danger in terms of the occurrence of various complications during pregnancy, childbirth and the postpartum period.

Keywords: Kidney, Renal hemodynamic, Homeostasis, Renal plasma

Full Text:

Introduction

Preeclampsia is one of the most common and serious complications in the world of obstetrics, and in recent years a large number of scientific studies have focused on the possibility of preventing this pathology and identifying high-risk groups complicated by preeclampsia. According to the World Health Organization (WHO), preeclampsia is observed in developed countries in 5-15%, and in developing countries - 30-35%. Hypertension in pregnant women in different regions of our country is 15-25%. Preeclampsia is one of the main causes of maternal and perinatal death and remains one of the most acute problems of modern medicine.1-3

Preeclampsia is one of the main problems in the world leading to pathologies leading to complications during pregnancy. PE is an important interdisciplinary problem and occupies a leading position among pathologies that complicate the course of pregnancy.4,5 The relevance of studying PE is explained by the high prevalence of this complication, an adverse effect on the course of pregnancy, as well as a risk factor for the mother to develop arterial hypertension, chronic kidney diseases, endocrine disorders, and fatal cardiovascular complications.4-6

Nevertheless, based on an analysis of recent scientific studies in several countries (Norway, Ireland, Scotland, Israel), a total of 800,000 pregnancies showed a twofold increase in the risk of death in patients who underwent preeclampsia, especially in preterm birth.2,7 Studying the features of renal and systemic hemodynamic during “critical periods of pregnancy” during physiological pregnancy and with the development of PE will reveal early diagnostic signs of hypertension that has joined pregnancy.7,8

The debatability of several aspects of aetiology and pathogenesis, the heterogeneity and inconsistency of the listed risk factors for PE development, as well as the use of an exclusively anamnestic approach in identifying risk groups for the development of this complication in early pregnancy, emphasizes the need for an in-depth analysis of this problem.1,2,9,10

Materials and methods

Laboratory diagnostics included biochemical studies of renal function and determination of coagulation factors. Evaluation of the excretory function of the kidneys is important both from a clinical and a research point of view. It is known that an increase in serum creatinine, a decrease in creatinine clearance or the estimated glomerular filtration rate (GFR), microalbuminuria are independent prognostic factors of cardiovascular diseases and, in particular, hypertensive syndrome. Accurate direct measurement of GFR is methodologically difficult, therefore, until recently, elevated plasma creatinine levels and special formulas have been widely used in clinical practice. Moreover, their use is not only possible but also does not imply a significant increase in the cost of evaluating kidney function with a definite increase in the accuracy of the study.2-4

Cockcroft-Goult Formula (Cockcroft-Goult, FCG),

GFR={140- age× body mass/ serum creatinine (mg /dl)×72}×0.85

The study of the renal plasma flow was carried out after a water load (1liter of water drunk for one hour before the study). After the eve of the test, iodine was slowly (3–5 minutes) injected with 3 ml of 70% triombrost solution. It was established that such a dose of triombrast creates its concentration in the blood within 1-4 mg% for 40-60 minutes or more. Women urinated 10 minutes after the end of the introduction of triombrast, and from that time they collected urine for three 15-20 minute intervals by natural urination. In the middle of these gaps, blood was drawn from a vein to determine the concentration of triombrast in it. The study of blood and urinary triombrost was performed by the iodometric method of White, Rolf, using the formula:

DM= Ic/ Pk× V

Where DM is the coefficient of blood purification from triombrost; Ic - the concentration of triombrast in the urine; Pk is the concentration of triombrast in plasma; V - minute diuresis. The calculation of diabetes was carried out for each 15-20-minute period separately. The final result was the numbers of 2-3 periods of the study.

To calculate a renal blood flow was calculated for whole blood based on hematocrit indices using the formula:

Effective renal blood flow (RBF) = renal plasma flow (RPF)/ 1-? (Hematocrit)

The determination of KF and PP allowed us to calculate the filtration fraction (FF) - the volume of liquid that the plasma gives out during the filtration:

FF(Filtration fraction)= Glomerular filtration rate (GFR) / renal plasma flow (RPF)

Statistical processing of the results was carried out using Student's test using the Statgraf software package and Microsoft Excel version for Windows.

Results and discussion

A comprehensive study of the functional state of the kidneys and indicators of homeostasis in women during pregnancy with complicated preeclampsia in the period 30 to 34 weeks was carried out.

Many women in this group have a burdened obstetric history (bleeding, placenta previa and placental abruption, intrauterine hypoxia of the fetus, cesarean section).

Pay attention: pallor of the skin, swelling of the lower extremities, abdominal wall and lumbar region. Table No. 1 reflects the indicators of a clinical study of blood and urine in pregnant women of this group, where, for greater clarity, identical indicators of the control group are given (Table 1).

The table shows that for pregnant women with hypoproteinemia, proteinuria, a decrease in daily diuresis by almost 44.3% relative to healthy women at the same stages of pregnancy.

The table shows that women with mild PE are characterized by hypoproteinemia and severe proteinuria. Their total protein content in the blood is 14.4% lower than in the control group. A decrease in the volume of daily diuresis by 25.5% was also characteristic, relative to that in women with a normal pregnancy with an increase in the night fraction and a slight decrease in the fluctuation in the relative density of urine. Proteinuria increased by almost 18%.

A study of the functional state of the kidneys showed that during pregnancy with severe preeclampsia, GF decreases to 1.047 ± 0.048 ml/s, which is 0.704 ml/s (34.2%), (P<0.001) lower than the GF of pregnant control groups and lower than in pregnant women with severe preeclampsia (P <0.001), respectively, 0.020 ml/s (1.9%).

Tubular reabsorption, amounting to 98.4 ± 0.5%, as in the severe preeclampsia group, was reduced relative to the same indicator of the control group by only 0.3% (P> 0.05).

A decrease in GF was combined with a violation of the concentration function of the kidneys in women of this group. The concentration of urea and creatinine in the blood, averaging 5.8 ± 0.6 mmol / l and 123.7 ± 1.4 mmol / l, was higher than the control values by 30.9%, respectively (P <0.05) and 77.2% (P <0.05) and higher than in the group with mild preeclampsia by 28.4% (P> 0.005).

In this study group, the increase in creatinine significantly exceeded the growth of urea in the blood and was already above the upper limit of physiological values. The lag of urea growth in pregnant women with severe PE is possibly associated with a decrease in urea with the synthesis ability of the liver.

The above table reflects the nature of changes related to blood electrolytes in pregnant women with severe preeclampsia (for comparison, we give the data of the control group).

Assessing the results obtained, it can be indicated that pregnant women with severe preeclampsia have a greater tendency to hypernatremia than pregnant women with mild preeclampsia, which significantly exceeds the concentration of sodium in the plasma of healthy pregnant women. Changes from other electrolytes are not significant.

The study of clearance and excretion of electrolytes by the kidneys with severe preeclampsia showed that these indicators are very similar to the data of clearance and excretion of electrolytes with mild preeclampsia. For clarity, we have reduced them to a table.

The table shows that with severe preeclampsia of all the studied electrolytes, the most significant was a decrease in sodium excretion, which amounted to 34.6% relative to healthy pregnant women, causing hyperhydration.

            In contrast to sodium, both clearance and potassium excretion, despite the stated hypokalemia in these women, remain relatively high, which can adversely affect neuromuscular conduction in general, including in myometrium during childbirth.

In this group, the lowest renal plasma, effective renal blood flow and filtration fraction were noted, which corresponds to the degree of impaired renal functional ability.

Discussion

In women with severe preeclampsia, the lowest (relative to the previous groups) effective renal blood flow was registered, which turned out to be lower than the control values by 37.0%, while the renal plasma flow was underestimated by 26.0%. A decrease in kidney perfusion in pregnant women with a similar form of severe preeclampsia is understandable from the standpoint of the hypovolemia that occurs in them.

Hypovolemia, worsening renal blood and plasma, could not but affect the functional state of the kidneys in pregnant women of this group. Statistically significantly decreased GF by 59.7% relative to the same indicator in the pregnant control group. All this affected the amount of daily urine output, which turned out to be the lowest relative to all previous groups and was 44.4% lower than that of healthy women in the same period of pregnancy.

In pregnant women of this group, a marked violation of the concentration function of the kidneys is noted. Urea and creatinine were the highest among the examined groups. An interesting difference was the growth in urea and creatinine. So, if blood urea in this group of pregnant women was higher than the control values by 32.9%, then their creatinine increased by 75.7%, which may indirectly indicate a violation of the liver functions. Reduced clearance and especially sodium excretion creates the prerequisites for its delay in the body of such a contingent of pregnant women.

Conclusion

Summarizing the changes taking place on the part of the studied parameters in women with severe preeclampsia, it can be noted that they are characterized by hypoproteinemia, proteinuria, and a decrease in daily diuresis, the severity of which exceeds all other studied groups of pregnant women. Marked hypovolemia, extracellular hyperhydration, a tendency to myocardial hypodynamia, deterioration of renal hemodynamic with a decrease in FF and renal functional ability in women of this group are most pronounced. All this indicates that such a contingent of pregnant women poses a great danger in terms of the occurrence of various complications during pregnancy, childbirth and the postpartum period. Such pregnant women approach childbirth, having almost exhausted all their reserve capabilities. One of the weakest links in the general chain of occurring disorders in women with severe preeclampsia is the kidneys.

Conflict of Interest: None

Source of Funding: None

References:

1. Vasiliev V, Tyagunova  AV, Drozheva VV. Renal function and indicators of endogenous intoxication with gestosis.  Obstet Gynaec 2013; 4:16-20.

2. Ivanova OI; Ponomareva MG; Gazazyan ZL. Features of central hemodynamics during pregnancy complicated by gestosis. J Obstet Female Dis 2008;7(3)4-9.

              3. Alper AB, Yi Y, Weber LS.Estimation of glomerular filtration rate in preeclamptic patients. Am J Perinatol 2007;24:569.

4. Alieva TM, Abdukarimov TA. Preeclampsia factors, prerequisites, climatogeographic features.  News  Dermatol Reprod Health 2016; 4;50-54.

               5. Akhmedov F.K. Features of renal function and some indicators of homeostasis in women with mild preeclampsia. Eur Sci Rev 2015;4(5):58-60.

6. Akhmedov FK, Avakov VE, Negmatullaeva MN. Status of cardio-hemodynamics and cardiac geomerms in women with complications with severe preeclampsia.  News  Dermatol Reprod Health Tashkent 2017;3(I):27-29.

           7. Buchbinder A, Sibai ?, Caritis S. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynec 2002; 186(1):66-71.

8. Nishanova FP, Mustafayeva ME. Maternal mortality from preeclampsia in the Republic of Uzbekistan. Physician Bull 2009; 2:78-81.

9. Guryeva MV, Yu B,  Kotov VA.  Daily monitoring of blood pressure and heart rate in the diagnosis. Russ Bull Obstet Gynec 2013;3: 4-9.

10. Makarova OV, Nikolaev NN, Volkova EV. Features of central hemodynamics in pregnant women with arterial hypertension.  Obstet Gynec 2003; 4:18-22 .

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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