International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 13(1), January, 2021

Pages: 16-18

Date of Publication: 05-Jan-2021


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Diagnosis and Management of Gestational Diabetes with Oral Glucose Tolerance Test and HBA1C

Author: Anjana Chaudhary, Baljeet Kaur Bhatia

Category: Healthcare

Abstract:Introduction: Gestational diabetes mellitus (GDM) is a potentially serious and prevalent condition such as fetal growth abnormalities, shoulder dystocia, birth injury, prematurity and increased Caesarean section rate, which may lead to serious effects in mothers and neonates. Recently HbA1c used diagnostic criterion for diabetes (DM).
Objective: Diagnosis and Management of Gestational Diabetes with Oral Glucose Tolerance Test and Hba1c.
Methods: A total of 241 pregnant women recruited in the study. Pregnant women in prenatal care, without previous DM, were included to perform OGTT tests in the third trimester of pregnancy. written informed consent was obtained from all the patients.
Results: All the patients were between 23 and 35 years of age in the third trimester of pregnancy (gestational age = 27\?5 weeks). In patients without GDM mean SBP was 110\?11.8and with GDM 119\?12.6 (p < 0.001). In cases without GDM mean DBP ( Diastolic blood pressure) was 70\?8.4 mmHg and with GDM 82\?15.1 mmHg (p < 0.001). In patients without GDM mean FBS (Fasting blood sugar) was 77.4\?9.4 and with GDM 95.4\?12.6 mg/dl. Mean 1hrs. Glucose was 120.6\?12.4 in patients without GDM and with GDM it was 176.8\?16.4. In patients without GDM mean 2HRS.Glucose was 115.2\?11.4 and with GDM 147\?15.4. In patients without GDM mean HbA1c was 5.2\?0.3and with GDM 5.9\?0.6 (p < 0.001). In patients without GDM mean Hb was 11.6\?0.7and with GDM 11.8\?0.5 (p 0.022). In patients without GDM mean Cholesterol was 210\?22.4 and with GDM 225\?35.7 (p < 0.001).
Conclusion: Different HbA1c cut-off points may be useful in a diagnostic tool for GDM in combination with OGTT. This will result in a considerable decrease in the research workload on both patients and the testing centre, employees and equipment.

Keywords: Gestational diabetes mellitus, GDM, HbA1c, Hb, Cholesterol, Blood glucose

Full Text:

INTRODUCTION

Gestational diabetes mellitus (GDM) is a potentially serious and prevalent condition such as fetal growth abnormalities, shoulder dystocia, birth injury, prematurity and increased Caesarean section rate, which may lead to serious effects in mothers and neonates.[i],[ii] The risk of adverse perinatal and maternal outcomes are directly proportional to the level of hyperglycaemia, and there is a linear relationship between maternal glucose and various neonatal outcomes.3 Detection of GDM and treatment reduces the risks for the mothers as well as for the neonates.[iii]

Customarily, the OGTT has been the test of choice for this condition. It can be preceded by a screening methodology, for example, fasting glycemia (FG) or a glucose load test. But still are controversies regarding OGTT cut-offs which should be used for the diagnosis of GDM and also a recent review concluded that the evidence is insufficient to permit assessment of which strategy is best to diagnose GDM.[iv] HbA1c test as a diagnostic criterion for diabetes (DM) in the general population and was included in 2010 by the American Diabetes Association (ADA). The cut-off of HbA1c ≥48 mmol/mol (6.5%) was set up for the conclusion, and was endorsed by the World Health Organization (WHO) in 2011.[v],[vi] However weak agreement was seen in between HbA1c and glucose tests and these two tests may identify different populations of patients.[vii]

OGTT is a cumbersome test which is time-consuming, labour intensive and generally poorly tolerated by pregnant women. It is important to fasten the patient, sit for more than 2 h and have at least three venipunctures. Pregnant women are susceptible to nausea and vomiting from delayed emptying of the stomach. This may contribute to an invalid test result, combined with gestational oedema compromising venous access. Also, the recommendation for universal screening has greatly increased the research burden. HbA1c is the result of glucose's irreversible non-enzymatic binding to plasma proteins, in particular haemoglobin. (Hb).HbA1c is a single, non-fasting blood test and reflects glucose levels over the previous 4 to 8?weeks. HbA1c has been shown to have greater reliability compared to glucose monitoring. [viii],[ix]

Based on this study was carried out to analyse HbA1c test for detection of GDM based on OGTT as a reference test.

MATERIAL AND METHODS:

The present study was carried out in the department of OBGY. A total of 241 pregnant women recruited in the study. Pregnant women in prenatal care, without previous DM, were included to perform OGTT tests in the third trimester of pregnancy. written informed consent was obtained from all the patients. There have been records of the era, gestational age, obstetric background, smoking, family history of cardiovascular disease (CVD), DM, arterial hypertension (HT), alcohol intake, and drug usage. The weight and height of patients have also been reported and used to measure BMI (kg/m2) values.

Patients were excluded from the study if observed with the following conditions which are known to interfere with or lead to the misinterpretation of HbA1c results, anaemia, chronic renal disease and/or presence of haemoglobin variants. After an overnight fast, blood samples were taken to determine HbA1c levels, blood cell counts, lipid profile, creatinine and glucose concentrations. The OGTT was performed according to recommendations.

All data were entered in the Excel sheet,  Data were expressed as mean and SD for normally distributed variables, and as median (range) for non-Gaussian variables. Student’s T-tests and kappa coefficients were used as appropriate.

RESULTS

A total of 241 pregnant women recruited in the study. Pregnant women in prenatal care, without previous DM, were included to perform OGTT tests in the third trimester of pregnancy and were assessed as to the presence or absence of GDM. All the patients were between 23 and 35 years of age in the third trimester of pregnancy (gestational age = 27±5 weeks) ( Table 1).

In patients without GDM mean age was 27±5.2and with GDM 33±5.4 (p <0.001). In patients without GDM mean Gestational age was 27±5.2and with GDM it was observed as 26±4.5 weeks. Mean BMI was observed to be 28.5±5.2 kg/ m2 in cases without GDM and 31±6.8 in GDM (p <0.001)

In patients without GDM mean SBP was 110±11.8and with GDM 119±12.6 (p <0.001). In cases without GDM mean DBP (Diastolic blood pressure) was 70±8.4 mmHg and with GDM 82±15.1 mmHg (p <0.001). In patients without GDM mean FBS (Fasting blood sugar) was 77.4±9.4 and with GDM 95.4±12.6 mg/dl. Mean 1hrs. Glucose was 120.6±12.4 in patients without GDM and with GDM it was 176.8±16.4. In patients without GDM mean 2HRS.Glucose was 115.2±11.4 and with GDM 147±15.4. In patients without GDM mean HbA1c was 5.2±0.3 and with GDM 5.9±0.6 (p <0.001). In patients without GDM mean Hb was 11.6±0.7and with GDM 11.8±0.5 (p 0.022). In patients without GDM mean Cholesterol was 210±22.4 and with GDM 225±35.7 (p <0.001).

There has been a statistically important disparity between women with and without GDM in age, BMI, blood pressure and GDM history. 82 pregnant women were classified with GDM based on these results and taking into account HbA1c  (5.8%) as a guideline in the cut-off point for GDM. The agreement between the diagnoses provided in this study according to the HbA1c cut-off and the results of the OGTT was fair.

DISCUSSION

Laboratory testing of HbA1c has been highly systematic and has evolved to be an easier, more reliable and automatic test to examine the importance of HbA1c for GDM diagnosis.[i] As predicted, our data revealed that in pregnant women without GDM, HbA1c values were significantly lower than those seen in pregnant women with GDM. There was some overlap between the HbA1c values showed by participants in the two groups, however. These findings were in agreement with another study by Balaji et al.[ii] and Rajput et al.[iii]

Differences in HbA1c values are more likely to be caused by other physiological causes during pregnancy.[iv] Anaemia could not describe these variations in our research, as women with and without GDM presented with similar levels of total haemoglobin. When we used the HbA1c cut-off point of (5.8 per cent) to detect participants with and without GDM, it was found that those identified as having the disorder were more likely to be older and had prior GDM and DM family history, as well as higher BMI, blood pressure (systolic and diastolic), glycemia (fasting, 1h and 2hG) and cholesterol levels. Due to these parameters, there is an increase chance of adverse outcome for both mother and child[v]. A different GDM group from that diagnosed by glucose-based tests appears to be identified by the HbA1c test. The weak diagnostic agreement between tests corroborates this fact.

In our findings, it was found that 34.02% of GDM patients were diagnosed with the HbA1c cut-off point of around (5.8%) and that 6% of pregnant women were classified by the OGTTT as GDM negative. A study in Australia[vi] found that a subgroup of pregnant women had a normal OGTT but elevated HbA1c, indicating that a clinically significant result is HbA1c > 40 mmol/mol (5.8 per cent) during pregnancy which is similar to our findings.

CONCLUSION

To conclude different HbA1c cut-off points may be useful in a diagnostic tool for GDM in combination with OGTT. This will result in a considerable decrease in the research workload on both patients and the testing centre, employees and equipment. Further investigations are needed to incorporate HbA1c with optimization of the cut-off value as a single non-fasting screening method for GDM.

Conflict of Interest: Nil

Source of Funding: Nil

References:

  1. Casey BM, Lucas MJ, McIntire DD. Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population. Obstet Gynecol 1997;90:869–73.

  2. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. WHO/NCD/NCS/99 2 ed, Geneva 1999. 

  3. Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Donovan L. Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research. Ann Intern Med 2013; 159(2):123-9.

  4. Buckley BS, Harreiter J, Damm P, Corcoy R, Chico A, Simmons D, Vellinga A, Dunne F, DALI Core Investigator Group. Gestational diabetes mellitus in Europe: prevalence, current screening practice and barriers to screening. A review. Diabet Med 2012 Jul; 29(7):844-54.

  5. Farrar D, Duley L, Medley N, Lawlor DA. Different strategies for diagnosing gestational diabetes to improve maternal and infant health. Cochrane Database Syst Rev 2015; 1:CD007122.

  6. American Diabetes Association. Classification and diagnosis of diabetes. Diabetes Care. 2015;38:S8-S16.

  7. Cavagnolli G, Comerlato J, Comerlato C, Renz PB, Gross JL, Camargo JL. HbA(1c) measurement for the diagnosis of diabetes: is it enough? Diabet Med 2011; 28(1):31-5.

  8. Sacks DB. A1C versus glucose testing: a comparison. Diabetes Care 2011; 34(2):518-23.

  9. d'Emden M. Glycated haemoglobin for the diagnosis of diabetes. Aust Prescriber 2014;37:98–100.

  10. Gillery P. A history of HbA1c through Clinical Chemistry and Laboratory Medicine. Clin Chem Lab Med 2013;51:65–74.

  11. Balaji V, Madhuri BS, Ashalatha S, Sheela S, Suresh S, Seshiah V. A1C in gestational diabetes mellitus in Asian Indian women. Diabetes Care 2007; 30(7):1865-7.

  12. Rajput R, Yogesh Yadav, Rajput M, Nanda S. Utility of HbA1c for diagnosis of gestational diabetes mellitus. Diabetes Res Clin Pract 2012; 98(1):104-7.

  13. Hiramatsu Y, Shimizu I, Omori Y, Nakabayashi M, JGA (Japan Glycated Albumin) Study Group.Determination of reference intervals of glycated albumin and hemoglobin A1c in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy. Endocr J 2012; 59(2):145-51.

  14. HAPO Study Cooperative Research Group., Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, Hadden DR, McCance DR, Hod M, McIntyre HD, Oats JJ, Persson B, Rogers MS, Sacks DA. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008; 358(19):1991-2002.

  15. Rowan JA, Budden A, Sadler LC. Women with a nondiagnostic 75 g glucose tolerance test but elevated HbA1c in pregnancy: an additional group of women with gestational diabetes. Aust N Z J Obstet Gynaecol 2014; 54(2):177-80.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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