International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 08 Issue 04, February, 2016

Pages: 06-12

Date of Publication: 21-Feb-2016


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A STUDY OF HEMATOLOGICAL PARAMETERS AND ANTHROPOMETRIC INDICATORS IN HYPERTENSIVE AND NORMOTENSIVE MALES

Author: Divya R., Ashok V.

Category: Healthcare

Abstract:Introduction: Hypertension is one of the factors associated with stroke, congestive heart failure, heart or kidney failure. Overweight and obesity are the two most key determinants of health that leads to adverse metabolic changes including increase in blood pressure. The cellular components of blood contribute to the viscosity and volume of blood, thus playing a vital role in regulating blood pressure. Objectives: To compare the hematological parameters and anthropometric indicators in hypertensive and normotensive males. Materials and Methods: This was a hospital based case control study which included 60 normal healthy male subjects and 60 hypertensive male subjects. Blood pressure was measured in supine position by mercury sphygmomanometer. Hematological indices were estimated using an autoanlayser. The data collected were entered and analyzed using software Statistical Package for the Social Science 16.0 (SPSS 16.0). Results and Discussion: The mean levels of hemoglobin and hematocrit were significantly lower in the hypertensive group compared to the normotensives in our study. The anthropometric measurement waist hip ratio, showed a statistically significant positive correlation with systolic blood pressure. Multiple regression analysis showed waist hip ratio, hemoglobin and hematocrit were significant predictors of systolic blood pressure. Conclusion: The present study concludes that Waist hip ratio, a simple and inexpensive anthropometric measurement can be used as a significant predictor of systolic blood pressure. Also monitoring of hematological indices like hemoglobin and hematocrit is essential in the prevention of development of cardiovascular complications in hypertension.

Keywords: Hypertension, Anthropometric indicators, Hematological indices, BMI, WHR

Full Text:

INTRODUCTION Hypertension is defined as blood pressure more than 140/90 mm Hg as per US Seventh Joint National Committee on Detection, Evaluation and Treatment of Hypertension (JNC VII).1 The prevalence of hypertension in India is 23.10 % among men and 26.60% among women.2 Prevalence of hypertension in South India was found to be 20% according to the CURES 2007 study.3 Overweight and obesity are the two most important key determinants of health that leads to adverse metabolic changes including increase in blood pressure.

Obesity and weight gain are independent risk factors for hypertension. Also 60- 70% of hypertension in adults may be directly attributable to adiposity.4 Body mass index or BMI is propagated by the WHO as the most beneficial epidemiological measure of obesity. Waist hip ratio (WHR) and waist circumference (WC) are frequently used to forecast the danger of obesity linked morbidity and mortality as they account for regional abdominal adiposity.

Visceral fat is a more significant determinant of blood pressure elevation than is peripheral body fat.5 In longitudinal studies, a direct association exists between change in weight and change in blood pressure over time.4 Though hypertension and obesity are closely linked but there is no universal anthropometric marker due to distinct population features. Studies in urban population showed a strong relationship between different anthropometric indicators and blood pressure levels but very little is known about these relationships in rural Indian population.6, 7, 8

The cellular components of blood contribute to the viscosity and volume of blood, thus playing a vital role in regulating blood pressure. It has been newly realized that many hematological parameters varies with hypertension in comparison with normotensives. This gives a vision into the connection between blood cell defects and blood pressure. There are number of disputes in different studies with respect to variability of hematological parameters in hypertensive and normotensive subjects.9, 10, 11 The pathophysiology of hypertension is multifactorial which is affected by sympathetic over activity contributing to alterations in hematological parameters like hematocrit, viscosity and hypercoagulability of blood.

These factors change the kinetics of blood flow acting as contributory risk factor for coronary artery diseases, stroke and thromboembolism.12Thus the hematological parameters gives an insight to prognosis of disease also. So the present study was therefore undertaken to compare the hematological parameters and anthropometric indicators in hypertensive and normotensive males. The present study was carried out with the following objective: To compare the hematological parameters and anthropometric indices in normotensive and hypertensive males.

Materials andmethods This study was conducted in Sri ManakulaVinayagar medical college hospital(SMVMCH) Madagadipet, Puducherry. Study design: Hospital based case control study. Sample size: 120 subjects. We included 60 normal healthy male subjects of 35-55years of age. 60 hypertensive male subjects of 35-55 years of age. Data collection: A representative sample of local population comprising of 120 subjects aged 35-55 years were selected from 1. Hypertensive patients attending medicine OPD in SMVMCH. 2. Normotensives were attendants of patients, workers in SMVMCH. Inclusion criteria 1. Hypertensive subjects having blood pressure >140/90 mmHg. 2. Normotensive subjects having blood pressure ≤120/80mmHg.

Exclusion criteria Subjects with any systemic illness, subjects on drug medications (steroids, α methyl dopa) for past three months Subjects who fulfilled the inclusion and exclusion criteria were included in the study. After explaining the nature of the study, informed consent was obtained from the study subjects.

Methodology 1. Measuring Blood pressure: Blood pressure was measured by a mercury sphygmomanometerin supine position. Blood pressure was measured two times. The average of two readings was taken as correct systolic and diastolic blood pressure.13, 1 The classification of blood pressure is as follows4 Normal BP: 160/100 mmHg. 2. Hematological parameters: From the subjects 2 ml of blood were withdrawn to which anticoagulant solution was added and fed into the ABX Pentra DF120 Hematology analyser from Horiba Medicals Pvt Ltd. The RBC’s, WBC’s and PLT’s are measured by an electronic impedance variation principle. The hemoglobin(Hb) freed by the lysis of the red blood cells combines with potassium cyanide to form a cyanmethemoglobin compound.

Absorbance is then measured by spectrophotometry, at a wave length of 550 nm.MCV (Mean Corpuscular Volume) is calculated directly from the RBC histogram.MCH (Mean Corpuscular Hemoglobin) is calculated from the Hb value and the RBC count. MCHC (Mean Corpuscular Hemoglobin Concentration) is calculated according to the Hb and HCTvalues.The hematocrit is measured as a functionof the numeric integration of the MCV.14 3. Body weight: Body weight was measured while the subject minimally clothed and without shoes, standing steady on a weighing scale and it was recorded to the nearest 0.1kg.15 4. Height: Height was measured to the nearest 0.1 cm while the subject was standing barefoot in erect position with a wallmounted stadiometer.15 5. Body mass index:

BMI was measured by weight in kilograms divided by square of height in meters (kg/m2). (BMI in the range of 18.50 to 24.99 kg/m2 is considered to be normal.15 6. Waist circumference: Waist circumference was measured in centimeters over light clothing at a point mid-way between the lower rib and iliac crest.15 7. Hip circumference: Hip Circumference was measured in centimeters over light clothing at the widest girth of the hip. For waist and hip circumference two consecutive readings were made at each site on a horizontal plane without compression of the skin. The mean was taken as the final reading. 15 8. Waist Hip Ratio: It was calculated by dividing waist circumference by hip circumference.15

Statistical analysis The data collected were entered and analyzed using software Statistical Package for the Social Science 16.0 (SPSS 16.0). All parameters were presented as mean ± standard deviation (mean ± SD). Comparison of parameters between hypertensive subjects and normal healthy controls was done with student ‘t’ test. Correlation analysis was done with Pearson’s correlation method. A linear regression analysis was performed to evaluate the independent predictors of hypertension. A p value of less than 0.05 was considered statistically significant.

RESULTS Table 1 presents the demographic characteristics and the anthropometric indices of the study participants. A significant difference however existed between the cases and controls with respect to systolic blood pressure and diastolic blood pressure (p<0.001).The mean values of blood indices are presented in Table 2. Within the hypertensive and normotensive groups, the mean levels of hemoglobin and hematocrit were significantly higher in controls compared to hypertensive patients. Correlation analysis showed a statistically significant positive correlation between WHR and systolic blood pressure (Table 3).

Hemoglobin and hematocrit showed a negative correlation with systolic blood pressure among the cases. Systolic blood pressure was also found to be positively correlated with the duration of hypertension among the cases (Table 3). Pearson’s correlation analysis showed a statistically significant positive correlation between age and duration of hypertension. Hemoglobin and hematocrit showed a negative correlation with duration of hypertension among the cases (Table 4). Correlation analysis of Waist hip ratio with other anthropometric indicators like body mass index and waist circumference are shown in Table 5. Waist hip ratio showed a statistically significant positive correlation with the body mass index and waist circumference among the hypertensive subjects.

The association was found to be stronger with waist circumference (r = 0.778) than the body mass index(r = 0.699). Figure 1 shows the regression curve of Waist hip ratio (WHR) with Body mass index (BMI) in the hypertensive subjects. A linear regression analysis was performed to evaluate the independent predictors of systolic blood pressure. Regression analysis with systolic blood pressure as a dependent variable showed a linear relationship with WHR, hemoglobin and hematocrit levels among the cases (Table 6). Further regression analysis with duration of hypertension as a dependent variable showed a linear relationship with hemoglobin and hematocrit levels among the cases (Table 7).

DISCUSSION Our study showed significant differences in the mean levels of hematocrit and hemoglobin concentration between hypertensive and the normotensive subjects. The mean levels of hemoglobin and HCT were significantly lower in the hypertensive group compared to the normotensives in our study. Although a number of studies have shown significant differences in the levels of hemoglobin, RBC, MCV, HCT and MCH between hypertensive and normotensive individuals, there are also a few studies that has not shown any significant difference between the two groups.9, 11, 16 According to Richard D.

Gordon, sympathetic activity is responsible for an increase in renal afferent arteriolar constriction which in turn causes an increase in renin secretion and eventually, a rise in aldosterone secretion. Renin, via the effect of angiotensin on aldosterone, is a key factor for sodium and water retention in the body. The subsequent increase in blood volume thereby causes haemodilution and may be responsible for decreased hemoglobin and hematocrit level in hypertensives.17, 18, 19

The other probable mechanism responsible for decrease in hemoglobin levels in hypertension may be reduced production of erythropoietin and resistance of the bone marrow to erythropoietin stimulation.20 Hypertension if not treated promptly leads to cardiac and renal failure.21Congestive cardiac failure may also cause a low hemoglobin level due to hemodilution in later stages. Ultimately, the fall in hemo- globin concentration due to hypertension leads to an increase in cardiac output and heart failure.22 According to Julius S sympathetic stimulation in hypertensives is associated with elevation of plasma renin levels. Increased renin circulation leads to sodium and water retention in the body, which leads to hemodilution and may be the cause for low hemoglobin concentration in hypertensives.23

The anthropometric measurement waist hip ratio, showed a statistically significant positive correlation with systolic blood pressure in hypertensive individuals. (Table 3) This finding is in accordance with the study by Hartz et al, 24 in which it was revealed that Waist hip ratio is a strong independent indicator of hypertension, particularly in men aged 40-59 years. However, in our study BMI and waist circumference did not independently correlate with blood pressure. Multiple regression analysis showed that variables like WHR, Hb, Hct were significant predictors of systolic blood pressure.

Visceral fat, measured as WHR, showed a positive correlation with Waist circumference, body mass index (Table 5).Various mechanisms may explain the association between visceral obesity and arterial blood pressure. 25, 26The greater quantity of visceral fat may favor an increase in sympathetic activity mediated by the associated insulin resistance, besides potentializing the activity of the renin-angiotensin-aldosterone system due to the increased angiotensinogen secretion by visceral adipocytes, when compared to the subcutaneous fat.27, 28The visceral fat accumulation could also exert a mechanical effect, inducing renal compression and promoting arterial blood pressure exacerbation.29, 30 In our study the best association was found between Waist hip ratio and Waist circumference.

This correlation’s magnitude is similar to the one that was found by Beauloye et al.88 But in a study by Freedman et al indicate that arterial blood pressure changes in a certain population do not necessarily correlate to obesity changes. 31These evidences suggest that anthropometric’s influence on hypertension is quite complex and needs to be better investigated. Also the results suggest that visceral fat as measured by waist hip ratio exerts greater influence in systolic blood pressure levels.

CONCLUSION The present study concludes that Waist hip ratio, a simple and inexpensive anthropometric measurement can be used as a significant predictor of systolic blood pressure. It may be useful as an assessment tool in screening programs to assess the risk of hypertension. In addition, we also conclude that monitoring of hematological indices like hemoglobin and hematocrit is essential in the prevention of development of cardiovascular complications in hypertension.

ACKNOWLEDGMENT We are grateful to the Sri Manakula Vinayakar Medical College and Hospital for providing the facilities to perform this study. We acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. We are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

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2. Jyotsna Singh. World Health Organisation. Global Health Statistics. India has low rates of hypertension reveals WHO study. New Delhi, DHNS: 2012.

3. Mohan V, Deepa M, Farooq S, Datta M, Deepa R. Prevalence, awareness and control of hypertension in Chennai-the Chennai Urban Rural Epidemiology Study(CURES-52). J Assoc Physicians India 2007; 55:326-32.

4. Fauci A, Branwald E, Kasper L, Larry L. Hypertensive vascular disease. In: Naomi DL, Gordon HW eds. Harrison’s principles of internal medicine. 17th ed. Newyork: McGraw Hill Publishers: 1463-1480.

5. Deshmukh PR, Gupta S, Dongre A, Bharambe M, Maliye C. Relationship of anthropometric indicators with blood pressure levels in rural Wardha. Ind J Med Res 2006; 123:657-64.

6. Bose K, Ghosh A, Roy S, Gangopadhyay S. Blood pressure and waist circumference: an empirical study of the effcts of waist circumference on blood pressure among Bengaleemale jute workers of Belur, West Bengal, India. J Physiol Anthropol Appl Human Sci 2003; 22:169-73.

7. Shanthirani CS, Pradeepa R, Deepa R, Premalatha G, Saroja R, Mohan V. Prevalence and risk factors of hypertension in selected South Indian population – the Chennai Urban Population Study. J Assoc Physicians India 2003; 51:20-27.

8. Gupta R, Mehrishi S. Waist-hip ratio and blood pressure correlation in an urban Indian population. J Indian Med Assoc 1997; 95(7):412-415.

9. Cirillo, M Laurenzi, M Trevisan and J Stamler. Hematocrit, blood pressure, and hypertension. The Gubbio Population Study.Hypertension 1992; 20:319-326.

10. Chien S. Blood rheology in hypertension and cardiovascular disease. Cardiovasc Med 1977; 2:356-360. 

11. Dan SJ, David C, Irwin J, Herbert J, Timothy C, Cecil M et al. Mean red cell volume as a correlate of blood pressure. Circulation 1996; 93: 1677.

12. Al-Muhana F, Larbi E, Ali A, Sultan A, Ateeq S Soweilem L et al. Haematological, lipid profile and other biochemical parameters in normal and hypertensive subjects among the population of the eastern province of Saudi Arabia. East Afr Med J 2006; 83(1):44-48.

13. Badaruddoza, Navneet K, Basanti B. Inter-relationship of waist-to-hip ratio (WHR), bodymass index (BMI) and subcutaneous fat with blood pressure among university-going Punjabi Sikh and Hindu females.International Journal of Medicine and Medical Sciences 2010; 2(1):5-11.

14. Corberand JX, Segonds C, Fontanilles AM, Cambus J, Fillola G, Laharrague P. Evaluation of the PENTRA 120 Hematology Analyzer in a university hospital setting. Clin Lab Haem 1999; 21:3-10.

15. Tambe B, Phadke V, Kharche S, Joshi R. Correlation of blood pressure with body mass index and waist to hip ratio in middle aged men. Internet Journal of Medical Update 2010; 5(2):26-30.

16. Bruschi G, Minari M, Bruschi E, Tacinelli L, Cavatorta A. Similarities of essential and spontaneous hypertension. Volume and number of blood cells. Hypertension 1986; 8:983-89.

17. Gordon RD, Küchel O, Liddle GW, Island DP. Role of the Sympathetic Nervous System in Regulating Renin and Aldosterone Production in Man. J Clin Invest 1967; 46(4):599–605.

18. Williams GH. The renin-angiotensin system and hypertension. Clin Exp Pharmacol Physiol Suppl 1982; 7:31-40.

19. Esler M, Julius S, Zwelfer A, Randall O, Harburg E, Gardiner H. Mild high–renin in essential hypertension: Neurogenic human hypertension. N Engl J Med 1977;296:405– 411.

20. Kes P, Jukic B, Kes V. The cardiorenal syndrome and erythropoietin. Acta Med Croatica. 2008; 62(1):21-31.

21. Silverberg DS, Wexler D, Iaina A, Schwartz D. The interaction between heart failure and other heart diseases, renal failure, and anemia. Semin Nephrol. 2006; 26(4):296-306.

22. Androne AS, Katz SD, Lund L. Hemodilution is common in patients with advanced heart failure. Circulation. 2003; 107:226–229.

23. Julius S. Corcoran Lecture. Sympathetic hyperactivity and coronary risk in hypertension. Hypertension. 1993; 21:886-893.

24. Hartz, A, Rupley D, Rimm A. The association of girth measurements with disease in 32,856 women. Am J Epidemiol 1984; 119:71-80.

25. Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Vancilters GW, Dea MK et al. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab 2005; 288(2):454-61.

26. Després J. Obesity and lipid metabolism: relevance of body fat distribution. Curr Opin Lipidol 1991;2(1):5- 15.

27. Karlsson C, Lindell K, Ottosson M, Sjostrom L, Carlsson B, Carlsson L. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J Clin Endocrinol Metab 1998;83(11):3925-9.

28. Lee S, Bacha F, Gungor N, Arslanian SA. Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr 2006;148(2):188-94.

29. Hall JE, Jones DW, Kuo JJ, da Silva A, Tallam LS, Liu J. Impact of the obesity epidemic on hypertension and renal disease. Curr Hypertens Rep 2003;5(5):386-92.

30. Silverberg DS, Wexler D, Iaina A, Steinbruch S, Wollman Y, Schwartz D. Anemia, chronicrenal disease and congestive heart failure-the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists. Int Urol Nephrol 2006; 38(2):295- 310.

31. Beauloye V, Zech F, Tran HT, Clapuyt P, Maes M, Brichard SM. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab 2007; 92(8):3025-32.

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


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A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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