International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 08 Issue 06, March, 2016

Pages: 18-21

Date of Publication: 22-Mar-2016


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EVALUATION OF THE EFFECTS OF PH AND TEMPERATURE ON THE ADSORPTION ISOTHERM OF ACTIVATED MEDICOAL FROM NIGERIA PLANTS. MAGNIFERAINDICA, PERSEAGRATISSIMA AND PSIDIUMGUAJAVA

Author: Edwin N. Oguegbulu, Emmanuel A. Nwokeboth

Category: Healthcare

Abstract:Activated charcoal, also referred to as medicoal is known to be a versatile tool in the field of Pharmaceutical Medicine. This was successfully prepared from the stem parts of Mangiferaindica (Mango), Psidiumguajava (Guava) and Perseagratissima (Avagado pear) by process of carbonization and thermal activation. Liquid phase study was conducted using Freundlich isotherm model to evaluate the equilibrium adsorption data generated for methylene blue (MB) sulphanephthalein dye stuff on activated medicoal test samples. Ultra violet spectroscopic method was used to assess the effect of variation of pH and temperatures on the adsorption profile of all the medical samples, including the commercially available standard. The results were found to be statistically significant using the one-tail analysis of variance (ANOVA) at confidence interval of p ≤ 0.05. The research showed that the availability of negatively charged groups at the adsorbent surface is necessary for the adsorption of alkaline dye - stuff, thus the pH increase resulted to an increase in adsorption. The investigation also indicated that adsorption of locally sourced medicoal increases with temperature. The adsorption pattern of Perseagratissima compared favorably with that of the commercially available standard whereas Psidiumguajava ranked lowest.

Keywords: Locally sourced activated medicoal, Adsorption capacity, Function of, Temperature and pH

Full Text:

INTRODUCTION Adsorption is the adherence of atoms, ions or molecules from a gas, liquid or dispersed solid to surface Abrowski, A. D. (2005). By this, a film of the adsorbate is created in the surface of the adsorbent. Adsorption being distinct from absorption is a surface phenomenon whereas the later involves the whole volume of the material. There are two types of adsorption with their characteristic features and several applications in Pharmaceutical Medicine. These uses extend to control of odour, remedy for toxins and flatulence as well as in chromatographic techniques. Oguegbulu and Nwoke (2015).

Some physico- chemical factors are known to influence the adsorption performance of materials; Solids, particularly in finely divided state have large surface area and therefore, charcoal, silica gel, alumina gel, clay, colloids, metals of finely divided particles, all act as good adsorbents Transtutor.(2013). Usually, smaller particles equilibrate more easily and nearly full adsorption capacity canbe attained. Piero (2013). The high contact time between the adsorbent and the adsorbate creates more complete adsorption process. Zhu et.al (2012),so also, do the effects of the following impact on adsorption; pH, degree of ionization of molecules, temperature and the affinity of the solute for the adsorbent. Christmann.(2010/2011). Generally, pH has been found to affect the; activity, solubility, stability and absorption of medicinal products Niebergall(1980).

An increase in temperature implies that the molecules attract a quantum of heat energy equivalent to a product of the heat capacity and such infinitesimal increase in temperature. The associated increase in temperature alters the kinetic energy (Entropy) at the surface region thereby resulting in enhanced enthalpy which favours the surface phenomenon of adsorption.

At constant volume, this temperature effect can be expressed by the following transformation derivable from ClausiusClapeyron equation as: ? s = 2.303Cv log T2 /T1 Where; ? s is the change in entropy, Cv is the heat capacity at constant volume, where T1 and T2 are the limits of changes in thermodynamic temperatures. Florence and Attwood (1981). Three isotherm models are indentified, namely: Langmuir, Freundlich and Brunauer, Emmett-Teller (BET). Of these models, the Freundlich Isotherm model is the most appropriate for this study. Oguegbulu and Okumiahor (2013)

MATERIALS AND METHODS: The stem parts of Psidiumguajava (Guava), Perseagratissima (Avocado pear) and Margiferaindica (Mango) were harvested from Obelle village in Emoha Local Government Area of Rivers State in Nigeria. Each was chopped into chips, air dried for 28 days under the ambient laboratory temperatures. They were thereafter carbonized respectively using the Muffler furnace (Nabertherm, Germany)at 650o Cfor 30 minutes Fiyyaz et.al. (2000).

Each of the medicoal samples was collected, pulverized with mortar and pestle as well as sieved using mesh size number 250. The fine powdered samples so obtained were stored in air tight containers separately and labeled accordingly Ademiluyo et.al.(2009). The sieving process was also carried out for the commercial (standard) medical sample. The test samples were reactivated at a temperature of 100o C for 2 hrs prior to the experiments. This reactivation process helps to expel moisture and volatile oil impurities.Wikipedia. (2014). For the assessment of temperature effect, a 150 ml MB dyestuff solution was prepared with a concentration of 50mg/L and adsorbent dose of 2.0g/150ml.

This was prepared by dissolving 7.5mg of MB in 150ml of distilled water in a conical flask and adding the 2.0g of activated medical to each. The mixtures were stirred to propel percolation and then subjected to different experimental temperatures as; 25, 30, 37 and 45o C in a water bath. Samples were collected from the mixtures, filtered and absorbance determined at different time intervals (5, 10, 20, 30, 60 and 120 minutes), for the different temperatures. Graphs of the amount adsorbed per unit mass of adsorbent (mg/g) against time (minutes) were plotted for each of the temperatures for various activated medicoal samples.

Effect of pH on the adsorption of MB on the test samples was conducted by preparation of five solutions as above. 150ml with concentrations of 50mg/L by dissolving 7.5 mg MB in 150ml of distilled water and their initial pH determined using pH meter(Mettler Toledo, Germany). The pH thereafter was adjusted by using 0.05N HCL for acidity and 0.05N KOH for alkalinity to obtain pH of 2, 5, 7, 9 and 12. To each of the various mixtures was added 2.0g of the various test medicoal samples. These were properly shaken and maintained at room temperature for 2 hrs. Following this, the samples were collected, filtered, the absorbance measured and concentrations extrapolated. A graph of amount adsorbed per unit mass of adsorbent (mg/g) versus corresponding pH of solutions was plotted. Hema, Martin, (2009).

DISCUSSION Results of comparative temperature and pH effects on the adsorption isotherm of developed medicoal samples as shown in figures 1 to 5 above, were used in the evaluation ofthe adsorption profiles of all the test medicoal samples. The study was conducted under the same experimental conditions such as, the particle size of adsorbent; uniform contact time; temperatures and pH. The effect of initial pH and temperatures on the adsorption of methyleneblue, dye stuffon medical was assessed by this research. At pH 2, adsorption was minimal, but was enhanced with an increase in the initial pH of the M.B dye solution. The adsorption of this cationic dye on the adsorbent surface was proportionately influenced by the surface charges on the adsorbent-medicoal samples, and is a function of the pH of the solution.

The results showed further that the availability of the negatively charged ions at the adsorbent surface is necessary for the adsorption of the MB dye and such was observable at pH above2. Adsorption was almost unlikely at that pH of 2 since there is a net positive charge in the adsorption system due to the presence of H3 O+ . Thus as the pH increases, more negatively charged surfaces are available, thereby facilitating a greater methylene blue adsorption. It was observed that adsorption increases with increasing pH in the case of all charcoal samples. This may be due to the fact that they all basically hadthe same composition and were activated using same activation method.The acidic stomach environment,will impact positively charged groups in the adsorbent surfaces and is a major condition for adsorption of an acidic adsorbates such as toxins that should exist in their unionized form there in. The reverse occurs in the basic pH region of the small intestine where basic adsorbates would be adsorbed more. The result of investigation of temperature effect on adsorption of medicoal samples showed that the adsorption of MB by the samples increased with increase in temperature.

This increase in adsorption may be as a result of increase in mobility of the large dye ions with temperature. An increasing number of adsorbate may also acquire sufficient energy to undergo an interaction with the active sides at the surface. Additionally, an increase in temperature may produce a swelling effect within the structure of the activated medicoal, thereby enabling large dye molecules to penetrate with ease and faster.. This temperature effect can as well be extrapolated to the human body environment of about 37o C as a useful phenomenon for maximal activity of medical in treatment. Thus in the case of pyrexia due to poisoning, the adsorption action of activated charcoal may be slightly enhanced which is a desirable effect for the poison victim.

CONCLUSION The adsorption Isotherm has highlighted the individual sample of Perseagratissima as ranking equally with the commercially available standard sample. It can then be established that the adsorption of MB on the various medicoal samples increased with an increase in both pH and temperature.

ACKNOWLEDGEMENT The authors are thankful to the entire staff members of Laboratories of Pharmaceutical and Medicinal Chemistry as well as Pharmacognosy and Physiotherapy Departments of University of Port Harcourt, Rivers State, Nigeria, for their co-operation during this research work. Much gratitude also should go to the Laboratory staff of National Agency for Food and Drug Administration and Control (NAFDAC), Port Harcourt Nigeria for their highly valued technical support in the realization of this research.

References:

1. Abrowski, A. D. (2005). Adsorption- from theory to practice, Advanced colloid interface science;pg 135 – 224.

2. Ademiluyo, F., Amadi, T., Nimisingha, J. (2009). Adsorption and Treatment of Organic Contaminants Using Activated Carbon from Waste Nigeria Bamboo, Rivers State University of Science and Technology, Port Harcourt, Nigeria, J. Appl. Sci. Environ. Manag.; 13(3): pp39 – 47.

3. Christmann, K. Adsorption. Lecture Series2010 /2011.”Modern Methods in Heterogenous Catalysis Research”. Institut Fur Chemie und Biochemie, Freie Universitat. Berlin.Pp. 1 -39.

4. Fiyyaz, A., Zill-i-hima, N., Waseem, S. (2000).Conversion of some Agro-Industrial Wastes into Useful Industrial Products. Pak. J. Agri. Sci.; 37: pp3 - 4.

5. Florence AT and Attwood D.(1981). Physicochemical Principles ln Pharmacy. Macmillan Ltd. N.y. Pp 66 -102.

6. Hema, M., Martin, D. (2009). Adsorption of malachite green onto carbon prepared from Borassus bark, The Arabian Journal for Science and Engineering;Vol. 34, Number 2A, July 2009.

7. NiebergallPJ(1980).Ionic solutions and Electrolytic Equilibria. InOsol Arthur (ed.).Remington’sPharmaceuticalSciencesMackP ublishing.Co.,Pennsylvania.Pp225-243.

8. Oguegbulu EN and Okumiahor J. Evaluation of the adsorption isotherm of activatedcharcoal used in pharmaceutical medicine from someNigerian plant parts, corn cobs, the wooden parts ofMangiferaindicaand Azandirachtaindica. Advancement in Medicinal Plant Research.Vol. 1(4), pp. 72-76, October 2013

9. Oguegbulu EN and Nwoke EA.(2015).Physicochemical and Spectroscopic Evaluation of Adsorption Potentials of Activated charcoal from stem parts of Mangiferaindica, Perseagratissima and Psidiumguajava for Pharmaceutical medicine. Novo Journal of Medical and Biological Sciences.Vol.4(2).2015.1-9.

10. Piero, M. A. Adsorption (last modified June 2005). Cited 8th November 2013 at 10:20am http://cpe.njit.edu/dlnotes/ CHE689/ Cls11-1.pdf

11. Transtutor. Surface area and adsorption (Last modified January, 2013). Cited 15th December 2013 at 1:15amhttp://www. transtutors.com/chemistry-homework-help/surfacechemistry/ adsorption.aspx

12. W.ikipedia (The Free Encyclopedia). Reactivation of Charcoal (Last Modified 17th November, 2012). Cited 9th January 2014 at 10am.http://en.m.wikipedia.org/wiki/Activated _carbon#section_7.

13. Zhu, J., Gao, J., Li, Y., Sun, T., Wu, S., (2012). In Preparation of Activated Carbons for SO2 Adsorption by CO2 and steam activation. J Twain Inst Chem Eng; 43(1): 112-119.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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