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IJCRR - 12(18), September, 2020

Pages: 118-123

Date of Publication: 22-Sep-2020


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Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology

Author: Sonali Banerjee, Mary Mathews N.

Category: Healthcare

Abstract:Background: Diagnosis and related advanced fertility treatments are multifaceted and protracted with unstipulated outcomes. There remains a risk of bodily burden, psychological distress, furthermore may impact the quality of life among infertile couples. Objectives: Study was aimed to 1. assess the quality of life among infertile couples undergoing fertility treatment and compare it between respective partners. 2. explore in-depth their perceived experiences. Methods: Explanatory mixed method design with sequential data collection, nested sampling technique was adopted. Participants included 300 women & 300 men attending a fertility clinic at a tertiary hospital. 300 couples were administered FertiQoL questionnaire for quantitative data collection while qualitative data were collected by in-depth interview of eleven couples, and thematic analysis was done. Ethical compliance was maintained throughout the study. Analysis: Socio-demographic data revealed that the mean age of the wives and husbands were 31.17\? 5.4 and 35.4\? 5.6 years respectively. BMI was higher in 39.7 % of wives and 58.7 % of husbands. The mean of total FertiQoL score of 300 couples in Western India was 29.3 \? 9.2. Wives had significantly lesser scores than their husbands in emotional (p=0.007*), social (p= 0.001*) and environmental (p=0.013*) subscales. The total FertiQoL mean scores were significantly lower among wives (p=0.001*). Themes emerged from qualitative data as a societal burden, physical pain and distress, monetary crisis and interpersonal problems. Conclusion: Infertile couples in western India reported poor QoL. Wives have poorer FertiQoL scores as compared to their partners. Couples undergoing fertility treatment face various challenges jeopardising their quality of life.

Keywords: Infertility, Quality of life, FertiQoL, Experiences of infertile couples.

Full Text:

Introduction

Reproduction and enduring the lineage are amid the most innate and important instincts of all living beings. Indian Statistics (2017) showed a decline in total fertility rate (TFR), 2.4 in rural areas and 1.7 in urban. Western state Maharashtra reported TFR 1.7.1 Furthermore, global statistics conjecture that approximately 15% of the reproductive age population is affected by infertility. Indian scenario, as per WHO records shows a wide-ranging figure i.e. 3.9 to 16.8% as per different states.2 Both the datasets implied a decline in TFR on other hand an incline in infertility prevalence.

 In the past few decades, fertility treatment has been advanced immensely, concurrently awareness and treatment-seeking behaviour also displays a steady upsurge among the infertile couples. The labelling of the infertility diagnosis itself triggers consequences like changes in emotions, thoughts, and beliefs of the couples. They not only face a medical condition but also pertinent challenges. As per the description given by the World Health Organization (WHO), Quality of life is individuals’ perceptions of their position in life in the context of culture and the value systems where they live .3 Thus, it may be considered that fertility QoL encompasses a replication of Indian infertile couples’ life status during their infertile period. Inability to conceive eventually trails to stigma, eviction and social anguish in milieu to Indian societal framework as parentage is considered with utmost repute, significance and urgency. Both partners endure tremendous family and social pressure for commencing a family. Infertility is an intricate and situational predicament predisposing to psychologically threatening, emotionally traumatic, monetary challenging, and physically painful due to the diagnostic-curative procedures.

            Furthermore, enormous marital life unhappiness and repetitive pregnancy trials play a vital role in worsening the experiences and the couple, especially women are predisposed to marital distress.4 As spouses become more discreet toward one another, their marriage life may also be adversely altered affecting their Quality of life.

With extensive literature review, it was observed that QoL was explored typically among infertile women, very few studies were conducted considering both the partners. However, an in-depth study about the impact on the quality of life of such couples is less into documentation with Indian population context.  The present study was conceptualized to explore exhaustively the quality of life among couples undergoing fertility treatment, and compare it between respective partners and also to explore in-depth the related experiences of infertile couples.

Materials and methods 

Explanatory mixed method design with sequential data collection (QUAL -› Quan) 5 was aptly adopted. The qualitative data was collected to support the quantitative findings. The study was merged at the time of interpretation of findings. The current study was conducted as a part of the larger project, from October 2018 to June 2020 in various phases. Settings of the study were at a tertiary hospital and research centre, at Navi Mumbai, with a super specialised fertility clinic.

Couples who were willing to participate, women aged above 18 years and below 50 years, men aged above 21 years and below 55 years and who can read, write, speak and understand English/Hindi/ Marathi were included in the study. As per exclusion criteria couples with secondary infertility, previous history of In Vitro fertilization treatment, were not enrolled in the study. For creating better participation and interaction, the couple- based dyadic approach was incorporated. All participants were interviewed in one or two sessions lasting approximately 30 to 60 minutes.  This study was part of research approved by the Ethics Committee for Research on Human Subjects (ECRHS) at MGM Institute of Health Sciences, Kamothe, Navi Mumbai, approval letter: MGMIHS/RES/02/2017-18 dated 20.03.2018. Before the commencement of the project, all written permissions were procured from authorities.  Before the interviews, participant couples were acquainted with the research aims and informed consent was obtained from both the partners. Confidentiality was the utmost priority of the study and they could withdraw from the project as desired.

Data collection was done with the sequential approach, 346 couples were screened for the study, 300 couples (300 women, 300 men) were finally selected through purposive sampling technique with maximum variations for quantitative strand.  Qualitative data was collected by in-depth interview of eleven couples, using nested sampling until data saturation. All couple of interviews were recorded and transcribed. Conventional thematic analysis was done. The trustworthiness of the data was ensured by maximal variation, peer debriefing and 3rd party review of transcripts.

The tools for data collection: a. Socio-demographic sheet, b. Standardised FertiQoL questionnaire to elicit QOL among the infertile couples. FertiQoL is a worldwide validated tool to quantify the quality of life of couples undergoing fertility issues and was used with author permission.6 FertiQoL consists of 36 questions, two general questions, Core FertiQoL with 24 questions,  four domains ( emotional, mind-body, relational and social ), and optional Treatment module with 10 questions and two subscales ( environment and tolerability)  It is available in English and Hindi, translated to Marathi (Cronbach’s alpha internal consistency r = 0.89). Scaled scores range from 0 to 100, lower QoL was inferred with lower scores.

Statistical analysis was performed using SPSS 21.0 software. Categorical variables were expressed as frequency and percentage, continuous variables as mean and standard deviations. Comparisons were done using the Mann-Whitney z test and two-sample z test. Statistical significance was inferred with a p-value less than 0.05.

Results

Quantitative Data Analysis

Data were analysed for 300 couples with 100% participation. The mean age of the wives and husbands 31.17± 5.4 and 35.4± 5.6 years respectively. Both the groups were homogenous in terms of religion and education as shown in Table 1 below.

 

Significant Difference in terms of age & occupation.

 Around 27.4 % of the wives quit their jobs to conform with the frequent schedules for hospital appointments and treatment. Revised Kuppuswami scale 7was incorporated to determine the socio-economic status of the couples, it was seen that the majority (67 %) couples belonged to Upper middle class. The majority (58%) of the couples stayed as a nuclear family, around 19.9% has separated from joint families due to family pressure. Body mass index revealed that 119 (39.7%) wives and 176(58.7%) were overweight. As per personal habits, women were non-smokers and non-alcoholics. Among men 27.8 % were smokers and 48.3 % reported occasional alcohol indulgence.

            Reproductive health per se, the average age at marriage of women was 24.9 ± 4.7 years, men were 29.2 ± 5.0 years. Majority 36% were married for 3 to 6 years and 56.3% reported duration of infertility less than 3 years. Around 74% of couples reported the frequency of physical relation was less than 2 times/week, and around 56.7% had ovulation unmatched relationship. Majority i.e. 70 % of the couples were staying together, 14 % of them stayed separately due to different location of the job of spouse and remaining 16 % stayed separately due to personal issues with the duration of 1 to 3 years. 

As per psychological aspects, majority i.e. 88.0 % wives were stressed while in a physical relationship with the partner, whereas 70.7 % of husbands reported as stressed.  Towards the treatment expenses, the majority (54.7%) of the couples expressed that they would meet the financial expenses by taking loans.

Infertility causes identified female index case: 39.3 %, male index case: 22%, mixed: 21, idiopathic:  17.7 %.  Majority of the women i.e. 27.3 % had the polycystic ovarian syndrome, whereas, among men, 27.3 % were diagnosed with oligospermia.

Quality of life was measured among the infertile couples using the FertiQoL tool. The mean FertiQoL score of infertile couples was 29.3 ± 9.2. depicted in Fig1 as below.

 

The comparison was done between the partner scores. Wives had significantly lower scores than respective partners about emotional and social, treatment environment domains (p<0.05), whereas mind-body and relational, tolerability domains it was similarly lower scores for both (p>0.05). Total FertiQoL scores were significantly lower among wives (p<0.05) indicating wives had poorer QoL as shown in Table2 below.

Couples were also evaluated for the association between selected demographics and FertiQoL scores. Fisher’s exact test was used to find the association of Quality of Life with educational status (p= 1.000), duration of infertility(p=0.085) and comorbidity(p=0.847). Chi-square test was used for age(p=0.766), diagnosis (p=0.230) Since the p-values corresponding to all the variables were greater than 0.05, none of these variables had a significant association with quality of life among infertile couples.

Qualitative Data Analysis: In-depth interviews of pertinent experiences from eleven couples were taped and transcribed. Content analysis revealed three major themes, few verbatims were put together as before (W denotes wife, H denotes Husband)

  • Societal burden and seclusion

Mostly all participants reported societal pressure in response to their infertility and were quite uneasy when asked questions about having children.

W2: “Social gatherings are nightmares as everyone is more interested to know about us rather than the celebration. Probing questions and sympathy aches my heart, feel like I am a sinner.”

H5: Gossips increase about our visit to a fertility centre, “her man must be having some defect, she looks healthy”. It is indeed struggling to lead a normal life. We have consciously stopped attending such ceremonies and meeting people.          

  • Physical Pain, shame and distress

W7: Fertility treatment requires many injections to increase my egg quality, they are not only painful, but I am so much worried about the side effects to baby and me. I feel shy while getting the vaginal ultrasound done.

H9: Semen collection at the hospital makes me anxious and stressed.

  • Monetary crisis

    1. The treatment is expensive which includes blood tests, ultrasound, medicines, injection, and procedure. I have put my marriage jewellery for taking the loan. So much anxiety and pain despite all efforts. 

H11: Every month when her periods come, my worry sores with the thought of next month expenses on medicines and scans. We are trying with IUI now, if not for IVF we will require borrowing money.

  • Interpersonal problems with their respective partners

    1. “Our marriage is at stake now, as I am unable to conceive, it may end with a Talakh (divorce). It is dying daily bit by bit; we are drifting apart; our arguments and difference of opinions had increased. Whenever we try to talk about our infertility problem it eventually led to an argument. We have almost stopped sharing thoughts and expressing, rather hiding feelings has become a habit.

    2. “I have no problem with her, but I am under tremendous pressure to give a child to the family. She can cry and pour out her emotion, men have to just bear it. I am exhausted balancing between the family and her.”

Meta Inferences: The mean FertiQoL score for infertile couples was 29.3 ± 9.2. The mean FertiQoL score of wives was 28.2 ±8.5, and husbands had a mean value of 30.5 ±9.8. FertiQoL scores were significantly lower among wives (p<0.05) in comparison to respective partners.  The findings were further supported by the thematic analysis of qualitative data, wherein the couples shared various experiences concerning Indian cultural context, which declined the quality of life pertinent to fertility treatment and diagnosis.

            DISCUSSION

There remain a constant peril and burden to conceive, the programmed method to conception, negatively impacting the quality of life of the couples undergoing treatment. With societal pressure, repetitive and prolonged cycles of treatment, furthermore situations worsen incurring mental agony, physical pain and monetary burden. The current study was conceptualised to explore the QoL of such couples. 5,6

Couple Demographics

            In the current study, the mean age of the wives and husbands was 31.17± 5.4 and 35.4± 5.6 years respectively. Mean age of Portuguese participants in a study was 32.51± 3.92 for women and 34.77± 4.20 for men. The findings were similar. It was also reported from the same study that most couples had medium socio-economic status (72.9%), whereas subjects in the current study majority (67 %) couples belonged to upper-middle class. 8

In the current study as per the educational status majority of the wives (40%), husbands (36%) were graduates and education had no association with QoL. Previously study done in Turkey9 concluded with similar findings, despite higher education, the total FertiQoL scores were low. It can be inferred that advanced education cannot recompense the emotions and QoL. Whereas an Iranian study concluded that lower academic education is associated with lower QoL.10

Type of family was classified as a nuclear and joint family, the majority (58%) of the couples stayed as the nuclear family, whereas one-fourth of couples were living with extended families as reported in a Turkish study.9

BMI was higher in 39.7 % of wives and 58.7 % of husbands which is similar to findings of an Indian study with significantly higher BMI, which may be associated with poor treatment outcomes. 11

Majority 36% were married for 3 to 6 years and 56.3% reported duration of infertility less than 3 years,  the figures were comparable to 60.6 % with less than 5 years.10 Duration of infertility had no association with QoL, whereas the extended duration of infertility was associated with lower scores of mind/bodies, social, tolerability domains and total QoL score (p<0.05) which probably could be related to secondary infertility.9

Majority of the women i.e. 27.3 % had Polycystic Ovarian Syndrome, similar findings were reported from another study done in India wherein PCOS led to the major cause of infertility among women.12 Distribution of infertility causes documented in the current study was female index case: 45 %, male index case: 23%, mixed: 15, idiopathic:  17 %. These findings were analogous to a study finding where in causes documented female: 41.4%; male: 30.0%; mixed: 12.9%; and idiopathic:15.7%. 9

 Quality of life among infertile couples

In the current study, the mean FertiQoL score among infertile couples was 29.3 ± 9.2. and the mean FertiQoL score of wives and husbands was 28.2 ±8.5 and 30.5 ±9.8 respectively, inferring significantly lower scores among wives (p<0.05). A study conducted in Iran, the sample consisted of 514 women and 514 men, SF -36 tool was used to assess infertility related QOL. Results revealed that women had poorer quality of life (p<0.05) about a health-related domain, social functioning role-emotional domain as well as mental health domain Quality of life.13. Table 3 below shows the mean FertiQoL scores of women across the globe.9, 14–17

It was evident that Indian women had poorer QoL as compared to western women, the variances in scores may be linked with the family system and societal framework.

In an Indian study, the raw/unscaled mean scores of women were 17.34, 16.12, 15.94 and 16.57 on the domains of emotional, mind-body, relational and social dimensions respectively.11 This may be comparable with the findings of the current study( scaled means: 27.9, 31.3, 27.4, 17.6 ) inferring a diminishing of QoL among the infertile women concerning same country cultural context.

The core FertiQoL scores documented for infertile men with irregular cohabitation was 43.32 ± 7.72, and 64.55 ± 11.17 with regular cohabitation 18 whereas in the present study it was much lesser i.e. 30.5 ±9.8.

The study conducted in Taiwan compared the QoL among partners, females had significantly lower (p<0.05) Core and Treatment FertiQoL (54.39 ± 13.52 vs 60.63 ± 14.07 and 56.03 ± 10.71vs 59.13 ± 12.44). 19 Women scored significantly lower on the FertiQoL total scores [B = -6.31; 95% confidence interval (CI) = -7.63 to 4.98] and three of the FertiQoL subscales (Emotional, Mind-Body and Social) than their partners, indicating lower QoL.20 Even though the scores were higher but the comparison was congruent with present study findings inferring women have lower QoL than men irrespective of geographical locations.

STRENGTH AND LIMITATION

The explanatory mixed methodology emerged as the strength of the research, reasons for poor QoL among infertile couples in western India was explored in-depth, giving comprehensiveness and clarity. Relevant perspectives in-relation to Indian context have been brought to light to further justify the poorer QoL perceived by infertile couples.          Limitations of the study were in terms of likely bias as the setting of the study was a single fertility centre and data was the totally subjective response of the couples.

CONCLUSIONS

Inferences drawn from the findings suggest couples undergoing fertility treatment in western India reported poor QoL. Wives have poorer FertiQoL scores as compared to their partners. The study was instrumental in highlighting the colossal challenges and related poor quality of life which may be a contributory factor to non- conception and can gravely compromise the treatment outcomes.

CONFLICTS OF INTEREST: None

FUNDING: None

ACKNOWLEDGEMENTS

            This study is part of the first author’s Ph D dissertation, from MGM Institute of Health Sciences, Navi Mumbai. A researcher is thankful to the parent institute for constant support. All the Reproductive medicine specialists, administrative authorities, participants, fertility centre staffs are immensely acknowledged for contributing to efficacious completion of the research study.           

AUTHOR CONTRIBUTIONS

Data Collection, Writing -original drafting: SB, Writing- review & editing: MMN

References:

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2.  Prevalence of Infertility in India. National Health Portal https://www.nhp.gov.in/disease/reproductive-system/infertility. 2016.

3.    WHO. Health statistics and information systems. Metrics: Disability-Adjusted Life Year (DALY) [Internet]. 2012;0:2–3. Available from: http://www.who.int/healthinfo/global_burden_disease/metrics_daly/en/

4.      Barani Ganth D, Thiyagarajan S, Ganth BD, Thiyagarajan S, Nigesh K. Role of infertility, emotional intelligence and resilience on marital satisfaction among Indian couples. International Journal of Applied Psychology. 2013;3(3):31–7.

5.     Creswell JW. The Selection of a Research Approach. Research Design [Internet]. 2014;3–23. Available from: http://www.sagepub.com/upm-data/55588_Chapter_1_Sample_Creswell_Research_Design_4e.pdf

6.   Boivin J, Takefman J, Braverman A. The fertility quality of life (FertiQoL) tool: Development and general psychometric properties. Human Reproduction. 2011;26(8):2084–91.

7.  Sharma R. Revised Kuppuswamy’s socioeconomic status scale: Explained and updated. Indian Pediatrics. 2017;54(10):867–70.

8.   Moura-Ramos M, Gameiro S, Canavarro MC, Soares I, Almeida-Santos T. Does infertility history affect the emotional adjustment of couples undergoing assisted reproduction? the mediating role of the importance of parenthood. British Journal of Health Psychology. 2016;21(2):302–17.

9.  Karabulut A, Özkan S, O?uz N. Predictors of fertility quality of life (FertiQoL) in infertile women: Analysis of confounding factors. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2013;170(1):193–7.

10.  Jahromi BN, Mansouri M, Forouhari S, Poordast T, Salehi A. Quality of life and its influencing factors of couples referred to an infertility centre in Shiraz, Iran. International Journal of Fertility and Sterility. 2018;11(4):293–7.

11.   Valsangkar S, Bodhare T, Bele S SS. An evaluation of the effect of infertility on marital, sexual satisfaction indices and health-related quality of life in women. J Hum Reprod Sci. 4(2)(2):80-5.

12.   Desai HJ, Gundabattula SR. Quality of life in Indian women with fertility problems as assessed by the FertiQoL questionnaire: a single-centre cross-sectional study. Journal of Psychosomatic Obstetrics and Gynecology. 2019 Jan 2;40(1):82–7.

13.  Rashidi B, Ramezanzadeh F, Montazeri A, Shariat M, Abedinia N, Ashrafi M. Health-related quality of life in infertile couples receiving IVF or ICSI treatment. BMC Health Services Research. 2008;8:1–6.

14.  Gao M, Ji X, Zhou L ZZ. The fertility quality of life (FertiQol) in Chinese infertile women. Transl Androl Urol. 2016;Apr;5(Supp(DOI: 10.21037/tau.2016.s084. PMCID):56–7.

15.   Aarts JWM, Huppelschoten AG, van Empel IWH, Boivin J, Verhaak CM, Kremer JAM, et al. How patient-centred care relates to patients quality of life and distress: A study in 427 women experiencing infertility. Human Reproduction. 2012;27(2):488–95.

16.    Santoro N, Eisenberg E, Trussell JC, Craig LB, Gracia C, Huang H, et al. Fertility-related quality of life from two RCT cohorts with infertility: Unexplained infertility and polycystic ovary syndrome. Human Reproduction. 2016;31(10):2268–79.

17.    Neumann K, Kayser J, Depenbusch M, Schultze-Mosgau A, Griesinger G. Can a quality-of-life assessment assist in identifying women at risk of prematurely discontinuing IVF treatment? A prospective cohort study utilizing the FertiQoL questionnaire. Archives of Gynecology and Obstetrics [Internet]. 2018;298(1):223–9. Available from: https://doi.org/10.1007/s00404-018-4797-2

18.    Taha EA, Sabry M, Abdelrahman IFS, Elktatny H, Hosny A. Impact of irregular marital cohabitation on quality of life and sexual dysfunction in infertile men from upper Egypt. Clinical and Experimental Reproductive Medicine. 2020;47(1):77–82.

19.    Hsu PY, Lin MW, Hwang JL, Lee MS, Wu MH. The fertility quality of life (FertiQoL) questionnaire in Taiwanese infertile couples. Taiwanese Journal of Obstetrics and Gynecology. 2013;52(2):204–9.

20.     Huppelschoten AG, van Dongen AJCM, Verhaak CM, Smeenk JMJ, Kremer JAM, Nelen WLDM. Differences in quality of life and emotional status between infertile women and their partners. Human Reproduction. 2013;28(8):2168–76.

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A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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