International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 8(9), May, 2016

Pages: 64-67

Date of Publication: 12-May-2016


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SQUAMOUS CELL CARCINOMA OF TONGUE - A CASE REPORT AND REVIEW OF LITERATURE

Author: L. Kayal, S. Jayachandran, Y. Hemavathy Bhaskar

Category: Healthcare

Abstract:Oral Squamous cell carcinoma is the most common cancer of the Oral Cavity and it is usually seen in patients above the age of 50 years. It rarely occurs in patients who are less than 30 years old (0.4-5.5%). Diagnosis in advanced stage, misdiagnosis usually lead to inappropriate treatment and delayed definitive treatment. Studies show that nearly 30-40 % of all cancer-related mortality are due to human behaviors such as smoking, consumption of alcohol, poor diet quality and physical inactivity. The morbidity of this malignant neoplasm is low in young patientsonly about 2 % of patients was diagnosed with tongue cancer in patients under the age of 35 years. This case report describes a squamous cell carcinoma, involving anterolateral border of tongue in young adult.

Keywords: Malignant, Neoplasm, Morbidity, Squamous cell carcinoma

Full Text:

INTRODUCTION
Squamous cell carcinoma (SCC) constitute more than 90% of all head and neck cancers. It typically occurs in the elderly men during the fifth-eighth decade of life and rarely occurs in the young patients under the age of 401 . The recent literature has given increasing attention to SCC of tongue in young adults2 . Only approximately 2% of patients are diagnosed before the age of 35 and another 7% before the age of 45, despite the fact that there is an increasing prevalence of tongue SCC3 . Literary reports regarding the etiology, history, and management is limited due to the rarity of this tumor in young patients. Even though tobacco and alcohol abuse is said to be the main etiological factor, it was reported only for a small percentage of patients in some series.

The lack of significant habits in young patients have prompted many to postulate other factors like immune deficiency, genetic factors, and dietary factors in the etiology of cancer. Viruses like herpes simplex virus and human papilloma virus have also been reported as contributing factors.4 Patients in the younger age group were claimed to have a more aggressive disease with a higher incidence of local recurrence or regional lymph node involvement after treatment and a higher mortality rate compared with older patients5 In this paper a young adult male with a chronic non-healing ulcer which turned out to be a SCC is discussed. He had the habit of pan chewing and smoking and sharp teeth in relation to the affected site of the tongue. Case scenario A 29 year male patient reported to the department of oral medicine and radiology with the chief complaint of an ulcer in his tongue for past 6 months.

History revealed he was chronic smoker and pan chewer for past 10 years. Patient was well nourished with BMI 29.5 Kg/m2 .So patient was referred to tobacco cessation center for counselling regarding his habits . During our routine investigation he had a high blood pressure (160/100 mm Hg) and blood sugar level – FBS 111mg/dl, PBS- 181mg/dl. Patient then started taking medication tab, metformin 500mg 1-0-1 for diabetes and tab. Envas 2.5mg 1-0-1 for hypertension.

On extra-oral examination, no facial asymmetry was observed and level 2 lymph nodes palpable on left side. On intra-oral examination, an ulcero-proliferative growth was seen in left side of anterior two-third involving lateral border of tongue extending into ventral surface , which measures about 4.5 × 2cm, mixed white and red in colour, surface was granular, and margins were everted. On palpation, the growth bleeds on touch and soft in consistency, base is not indurated.

The presence of sharp cuspal edges in lingual cusp of 35,36 and buccal cusp of 24,25 was also noted in the region of the ulcer causing obvious trauma in the area. Provisional diagnosis of malignant ulcer with clinical staging of the tumour T3N1M0 was given and chair side investigation was carried away by applying toluidine blue stain which stained malignant cells and also helped in selecting biopsy site , laterincisional biopsy was performed under Local anaesthesia.

Histopathology revealed islands of malignant squamous epithelial cells with keratin differentiation in connective tissue stroma and result was well differentiated squamous cell carcinoma. CT scan revealed evidence of subtle soft tissue thickening of size 20.6 cm and minimal contrast enhancement on left lateral border of tongue and evidence of no lymph node enlargement Patient was then referred to department of surgical oncology, Royapettah govt. hospital for treatment, which consisted of modified unilateral radical neck dissection and wide local excision. After surgery, radiotherapy of 2Gy for 5 days/week for 5 weeks period. After RT patient has lost weight and his BMI is 20 kg/m2 . Despite radical neck dissection followed by radiotherapy , patient was comfortable for one month and again there was relapse, for which chemotherapy was advised. Patient had tab. Cisplastin 100mg once in 3week for 3 cycles of chemotherapy. Patient became thin and very ill, unable to walk. From the reports of the relatives of the patient we came to know that the patient died after 5months.

DISCUSSION SCC in young adults arerare. Tongue cancer has a male predominance and occurs in 6-8th decade of life after long term exposure to cigarette smoke and alcohol abuse. Tobacco use and alcohol consumption are not only risk factors for oral cancinoma but there also strong effects on patient morbidity, recurrence and second primary tumour and mortality6 . Chronic mechanical trauma due to sharp teeth, under fillings, badly fitting dentures in the etiology of oral squamous cell carcinoma has been reported in literature In the present case, patient was chronic smoker and pan chewer which has a significant adverse effect on survival7 Though environmental exposure to tobacco and other carcinogens are important factors for cancer, it is now well documented that other factors such as diet have play an important role in the carcinogenesis process. Several dietary factors act as risk modifiers. In general, dietary deficiencies have not been shown to initiate events, but epidemiological and experimental studies provided strong evidence for dietary substance, in promotion, progression and inhibition of cancer8 .In the present report also due to dietary deficiencies patient become immaciated which might be a factors for his death.

Dental health care workers are a largely untapped resource for providing advice, educate and brief counseling to tobacco-using patients, and there are good reasons to believe that they can be effective in this role. Here in this case report , our patient underwent tobacco cessation counselling9 . Friedlander et al , in a study of younger and older (6oyrs) patients with tongue cancer matched for alcohol and tobacco usage and other factors, found no difference in survival, although younger group of patients had a higher incidence of local regional recurrence1 . Kuriakose et al found that in young patients the cancer was more aggressive with an invasive pattern and prognosis was poor in early stage of disease compared to older patients10. In diabetic patients, alterations occur in the oxidative equilibrium of free radicals.

Increased consumption of saturated fats increases the risk of diabetes mellitus, but recently it has been suggested that it also increases the risk of oral cancer11 Treatment of squamous cell carcinoma of tongue remains mainly surgery, with adjuvant radiotherapy added for advanced stage disease or in patients at risk of local regional failure. The achievement of clear resection margin is important because survival is closely related to resection regardless of any subsequent therapy the patients may receive12. In the present case, tumour removed with 1cm clearance followed by adjuvant radiotherapy.

Metastatic spread of squamous cell carcinoma of tongue is facilitated by the tongue’s rich lymphatic network, which tends to increase with the size of the primary tumour. Approximately 50% of tongue cancers present with lymph node involvement. Lymph node metastasis is a well known negative prognostic factor for squamous cell carcinoma of tongue, and it decreases the survival rate by 50%12. Studies have shown that survival rates in men are lower than women with tongue cancer13.It is well documented that the incidence of local recurrence is higher with positive histological resection margin compared with negative histological resection margin in head and neck cancer14.The reported incidence of local recurrence rates in the margin ranged from 29% - 70% and were 4%-38% for negative resection margins15.

CONCLUSION Oral cancer occurring in young adult is uncommon but nevertheless should always considered such patients present with sharp tooth will produce ulceration particularly in the high-risk sites of the tongue. Several studies suggested that oral cancer in younger patients is inherently more aggressive with a worse prognosis than the disease in older individual. By prompt diagnosis and treatment stratergies the life span of these patients may be prolonged further.

References:

1. Friedlander PL, Schantz SP, Shaha AR, Yu G, Shah JP : Squamous cell carcinoma of the tongue in young patients: A matchedpair analysis. Head Neck 1998;20:363-368.

2. Myers JN, Elkins T, Roberts D, Byers RM. Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes :Head Neck Surg 2000; 122: 44-51.

3. Aleksandra Crede, Michael Locher and Marius Bredell : Tongue cancer in young patients: case report of a 26-year-old patient. Head and Neck Oncology 2012, 4:20.

4. Elizabeth Mathew Iype, Manoj Pandey, AleyammaMathewy, Gigi Thomasz, Paul Sebastian and Madhavan Krishnan Nair : Squamous Cell Carcinoma of the Tongue Among Young Indian Adults: Neoplasia . Vol. 3, No. 4, 2001, pp. 273–277

5. Sarkaria J N, Harari P M. Oral tongue cancer in young adults less than 40 years of age: rationale for aggressive therapy. Head And Neck 1994; 16: 107-111.

6. G. Bachar, R. Hod, D.P. Goldstein, J.C. Irish, P.J. Gullane, D. Brown, R.W.Gilbert, T.Hadar, R. Feinmesser, T. Shpitzer: outcome of oral tongue squamous cell carcinoma in patients with and without known risk factors. Oral oncology 47(2011) 45-50.

7. Orbak R, Bayraktar C, Kavrut F, Gundogdu C. Poor oral hygiene and dental trauma as the precipitating factors of squamous cell carcinoma. Oral Oncol 2005;41:109–13.

8. MPR. Prasad, TP Krishna, S Pasricha, MA Quereshi, K Krishnaswamy:Diet and oral cancer - a case control study:Asia pacific j clinnutr(1995) 4: 259-264.

9. PavanUdayPatil , S Vivek , Thatimatla Chandrasekhar, NaliniParimi , B H Praveen , Sunil Lingaraj: Patient Receptivity to Tobacco Cessation Counseling and Services in a Dental Teaching Institute: A Patient Review: Journal of International Oral Health 2015; 7(1):1-4).

10. Kuriakose M, Sankara Narayanan M, Nair MK et al.: comparison of oral squamous cell carcinoma in younger and older patients in India. Eur J cancer B Oral Oncol 1992: 288: 113-20.:

11. AjitAuluck : Diabetes Mellitus: An Emerging Risk Factor for Oral Cancer?: JCDA: July/August 2007, Vol. 73, No. 6.

12. Mildasuslu MD, Ali sefikHosal MD, TugbaAslan MD, BulentSozeri MD, and Anil Dolgunphd : carcinoma of the oral tongue : a case series analysis of prognostic factors and surgical outcomes: J Oral maxillofacsurg 71: 1283-1290, 2013.

13. BerrinoF ,Gatta G: variation in survival of patients with head and neck cancer in Europe by the site of origin of tumours. Eurocare Working Group. Eur J cancer 34:2154, 1998.

14. Po Wing Yuen, FRCS, FACS, King Yin Lam, FRCPA, Alexander Chak Lam Chan, FRCPA, William Ignace Wei, FRCS, FACS, Lai Kun Lam, FRCS, Hong Kong: Clinicopathological Analysis of Local Spread of Carcinoma of the Tongue: Am J Surg. 1998;175:242–244. © 1998.

15. Zieske LA, Johnson JT, Myers EN, Theale PB. Squamous cell carcinoma with positive margins. Arch Otolaryngol Head Neck Surg. 1986;112:863–866.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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