International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 12 Issue 10, May, 2020

Pages: 14-17

Date of Publication: 19-May-2020


Print Article   Download XML  Download PDF

Synchronous Early Breast Cancer and Locally Advanced Primary Bladder Adenocarcinoma

Author: Sepideh Meshgi, Sahel Valadan Tahbaz, Hossein Yahyazadeh, Mahsa Mohammadzade, Abdollah Nasehi, Saadat Molanaei

Category: Healthcare

Abstract:Aim: Synchronous occurrence multifocal tumors across multiple tissues are common and mostly metastatic and sometimes include a small number of concurrent multiple primary tumors that are not metastatic poses so it is a difficult challenge to treatment, so we present a case of synchronous primary well differentiated adenocarcinoma of bladder and invasive ductal carcinoma of breast.
Case report: A 59-year-old female patient presented to urology department with the complaint of pain and hematuria. There was no relevant family history for all type of cancers. Clinical examination was normal. The patient had no history of tobacco using and any other cancer in the past. Through core needle biopsy,the patient was diagnosed with invasive ductal carcinoma of left breast.Allsentinel lymph node of breast was sent to pathology and it revealed that the node is involved.Simultaneously, partial mastectomywas donefor patient, and then axillary lymph node dissection has been done; six lymph nodes were removed and sent to the lab.
Discussion: A comorbid manifestation of breast and bladder carcinomas is rare, little similar case has been published so far. Synchronous primary cancers have rarely been reported, but it is believed that the incidence is rising. Prevention, making an early diagnosis and the treatment of multiple cancers will become even more important in the future.
Conclusion: It is important to present this case because of many literature have been reported cases of bladder metastasis of the breast, but we presents a concurrent primary breast and bladder cancer report.

Keywords: Synchronous Cancer, Bladder Tumor, Breast Tumor, Adenocarcinoma, Malignancies

Full Text:

  1. Introduction

The incidence of breast cancer in the early stages concurrent with the primary bladder tumor has rarely occurred in the literature and research papers. Bladder cancer has the highest prevalence rate among the urologic cancers1,2. Breast cancer is the most common malignant disease affecting women, after non-melanoma skin cancers, and the second reason for cause of death for cancer in women, mainly due to metastatic spread3,4. Common areas for breast cancer metastatic are lung, bone, liver, lymph nodes, and skin but rarely spreads to other sites, such as urinary bladder and retroperitoneum4. For the first time, Avicenna, Iranian (Persian-Muslim) philosopher and physician, reported primary multiple tumors (PMTs) as a case with bilateral mammary glands malignancies5 . Billroth et al. described the phenomenon of multiple primary malignancies (MPC) in a single individual, in the late 19th century6. Warren and Gates's criteria define the necessary condition which tumors must fulfill to be included in the MPCs. The criteria consist of: each tumor should belong to a specific malignancy and they should not be the result of metastasis from another tumor7. MPCs are categorized to either metachronous and synchronous, which the second one is rather rare8. Concurrent association of two primary malignancies or appearance of the second one within 6 months would be called synchronous cancer9. Among many cancers, bladder cancer has the highest incidence rate among the urologic cancers8.  We describe here an extremely rare case of synchronous double primary cancer involving the bladder and breast. Therefore, we report a remarkable case of completely synchronous primary bladder and breast cancer.

  1. Case Reports:

A 59-year-old female patient presented to our urology department in Milad General Hospital, a part of Iran Social Security Organization, with the complaint of pain and hematuria. In urine analysis, RBC was found to be 25-30 units with trace protein, hyaline casts, and pus. There was no relevant family history for all type of cancers. Clinical examination was normal. The patient had no history of tobacco using and any other cancer in the past.

In the CT scan, tumor mass was confined to the bladder, and there was no lymphadenopathy in the pelvic (Figure. 1). The patient underwent transurethral resection (TUR). TUR results showed well differentiated adenocarcinoma (Figure 2.A) and no thickness of invasionwas reported in pathology comments.Inimmunohistochemistry staining, which its findingswere consistent that CK7, GATA3, ER, PR, HER-2, CD15, CA125, B-Catenin, and Vimentin were negative; CDX2 (Figure 2.B), CK20,and EMA were positive (Figure 2.C).

Figure 2: (A), The pathologic features of the bladder tumor (H&E stain, ×100); (B), CDX2 biomarker in bladder tumor is positive (H&E stain, ×100); (C), CK7biomarker in bladder tumor is positive; (D),CK20 biomarker in bladder tumor is positive. The microphotograph showed well differentiated adenocarcinoma with bladder origin.

In checking of primary origin and for excluding metastatic bladder adenocarcinoma of gastrointestinal origin, after colonoscopy and endoscopy was conducted, so results confirmed that the malignancy didn't in gastrointestinal (GI) origin.(Figures3A and 3B).

 

Figure 4: Mammography image, (A), Cranio-caudal view; (B), Mediolateral view. Mammogram showing nodular irregular homogenous density present in left breast.

Through core needle biopsy, the patient was diagnosed with invasive ductal carcinoma of left breast. All sentinel lymph node of breast was sent to pathology and it revealed that the node is involved. Simultaneously, partial mastectomy was done for patient, and then axillary lymph node dissection has been done, six lymph nodes were removed and sent to the lab. According to laboratory reports, one of the nodes was involved and the tumor size was 2.5 ×2×2 cm (T2).The TNM stage of breast tumor determined as pT2N1M0 (stage IIIA). That axillary lymph node was sent to the lab for immunohistochemistry examination. As a results of IHC tests; ER (Figure 5.B), PR were positives, and HER-2 was(+2) but the result of FISH test was negative. Ki67 was positive in 5% of cells

Figure 5: (A),The pathologic features of the breast tumor that ERpositive in breast tumor;(B),PRpositive in breast tumor; (C), Haematoxylin and eosin staining, x100 magnification of breast tumor. Histopathology slide with immunohistochemistry stain showing ductal carcinoma of breast cancer.

Finally, the patient was returned to urology department and partial cystectomy was done for her. Microscopic findings supported that she had well-differentiated adenocarcinoma and tumor was invaded to serosal layer and peripheral fat but all margins were free and no lymphadenopathy was performed.TNM stage of the bladder tumor was pT3NxM.

Tumor marker tests indicated serum levels of CA15-3, CA125-ECL, CEA-ECL AFP- Tumor marker ,and Beta HCG which they were respectively 39.4 U/ml (High Level), 5.6 U/ml, 1.8 ng/ml, 4.5 IU/ml ,and <0.5 mlu/ml. As a double check, cystectomy samples were sent for IHC andthe result was as before; CK7, CK20, CA125 and Vimentin were negative and EMA and CDX2 were positive. These findings confirmed the final diagnosis is primary bladder well differentiated adenocarcinoma so there is a synchronous primary bladder and breast cancer.

Discussion:

Characteristics of her disease met the Warren and Gates conditions; we reported her case as an MPC. By searching the databases a few similar cases, with synchronous bladder and breast cancer, were found. One of them was a 57-year-old male patient with triple simultaneous neoplasms including transitional cell carcinoma (TCC) of the urinary bladder, infiltrating ductal breast carcinoma, and squamous cell carcinoma (SCC) of the forehead skin, which was reported by Pastore et al. in 2013.The reports represent He was a farmer and chronic smoker, and his family history contains two relatives with malignancies; his father with rectal cancer and his sister who had kidney neoplasm. He was sent to the institute for hematuria. Ultrasound findings illustrated several bladder papillary lesions rooted from the left wall of the bladder, and cystoscopy results validate the primary findings of multiple bladder papillary lesions. Additional examinations including TURB and Later second histopathological tests revealed grade III papillary transitional cell carcinoma. IHC staining showed positive results for cytokeratin 7 and negative for cytokeratin 20 and GCDFP-15. After his doctor noticed a hard mass and retraction on his left nipple, he underwent radical mastectomy and dissection of the axillary lymph node. According to histopathological investigations, a grade III infiltrating ductal breast carcinoma (90% ER and 20% PR positive) and metastasis to axillary lymph nodes was diagnosed. Proliferative index, by ki-67 marker, was assessed 10%. Suggested treatments for his condition were cystoprostatectomy, pelvic lymphadenectomy, continent ileal urinary diversion and adjuvant therapy 10. The next case was documented in an article in 2011 by William Makis. They described another unique patient with triple primary tumors. The case was a 66-year-old woman with a history of MS, diarrhea, and losing weight symptoms. No familial history was mentioned. Through F-18 FDG PET/CT scanning method, physicians discovered suspicious masses in her rectum, breast, and bladder, which after biopsyinvestigations; it became clear that they were three synchronous cancers. The patient underwent radiotherapy and anastrozole therapy. After three months, PET/CT was conducted. The result shows a reduction in rectum tumors’ size, and breast masses were resolved (gone-demolished)10,11.

 Conclusion:

In our case, dual primary malignancies were detected, breast and bladder. A comorbid manifestation of breast and bladder carcinomas is rare, and to the best of our knowledge, little similar case has been published so far. Synchronous primary cancers have rarely been reported, but it is believed that the incidence is rising. Prevention, making an early diagnosis and the treatment of multiple cancers will become even more important in the future. The study case report of synchronous malignancies may provide important evidence not only for clinical evaluation for future treatment of tumors, but also provide clues for the pathogenesis and the management of cancer usually for improvement of effective screening with the approach of treatment of patients effectively.

Acknowledgements

The work was supported by Milad General Hospital, Tehran, Iran.

Abbreviations:

Primary multiple tumors (PMTs); Multiple primary malignancies (MPC); Transurethral resection (TUR); Gastrointestinal (GI);Transitional cell carcinoma (TCC); Squamous cell carcinoma (SCC).

Conflict of Interest Statement:

Authors disclosed no conflicts of interests.

Declaration of Patient Consent:

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient has given her consent for her images and other clinical information to be reported in the journal that the patient understands that her name and initial will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Funding

This project has been funded by Milad General Hospital.

References:

1.            Mydlo JH, Gerstein M. Patients with urologic cancer and other nonurologic malignancies: analysis of a sample and review of the literature. Urology. Dec 2001;58(6):864-869.

2.            Jiang W, Ding Y, Shen Y, et al. Identifying the clonal origin of synchronous multifocal tumors in the hepatobiliary and pancreatic system using multi-omic platforms. Oncotarget. Jan 17 2017;8(3):5016-5025.

3.            Arjunan R, Kumar D, Kumar KV, Premlatha CS. Breast Cancer with Synchronous Renal Cell Carcinoma: A Rare Presentation. J Clin Diagn Res. Oct 2016;10(10):XD03-XD05.

4.            Cormio L, Sanguedolce F, Di Fino G, et al. Asymptomatic bladder metastasis from breast cancer. Case Rep Urol. 2014;2014:672591.

5.            Zhai C, Cai Y, Lou F, et al. Multiple Primary Malignant Tumors - A Clinical Analysis of 15,321 Patients with Malignancies at a Single Center in China. J Cancer. 2018;9(16):2795-2801.

6.            Billroth T. [General surgical pathology and therapy. Guidance for students and physicians. Lecture]. Khirurgiia (Mosk). Oct 1991(10):136-143.

7.            Testori A, Cioffi U, De Simone M, et al. Multiple primary synchronous malignant tumors. BMC Res Notes. Nov 27 2015;8:730.

8.            Komiyama S, Nishio E, Ichikawa R, et al. Asymptomatic synchronous quintuple primary cancers. Gynecol Obstet Invest. 2012;74(4):324-328.

9.            Jiao F, Yao LJ, Zhou J, Hu H, Wang LW. Clinical features of multiple primary malignancies: a retrospective analysis of 72 Chinese patients. Asian Pac J Cancer Prev. 2014;15(1):331-334.

10.          Pastore AL, Palleschi G, Autieri D, et al. Synchronous primary neoplasms of the bladder, skin and breast in a male patient: a case report. World J Surg Oncol. Oct 20 2013;11:282.

11.          Makis W, Ciarallo A, Lisbona R. Three synchronous primary malignancies detected by F-18 FDG PET/CT: breast, rectal, and urothelial bladder carcinomas. Clin Nucl Med. Sep 2011;36(9):791-794.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2022 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions


Fatal error: Uncaught Error: Function name must be a string in /home/u845032518/domains/ijcrr.com/public_html/footer-bottom.php:487 Stack trace: #0 /home/u845032518/domains/ijcrr.com/public_html/article_html.php(51): include() #1 {main} thrown in /home/u845032518/domains/ijcrr.com/public_html/footer-bottom.php on line 487