International Journal of Current Research and Review
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IJCRR - 12(6), March, 2020

Pages: 01-08

Date of Publication: 25-Mar-2020

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Healthy Gait: Review of Anatomy and Physiology of Knee Joint

Author: Prathap Kumar J., Arun Kumar M., Venkatesh D.

Category: Healthcare

Abstract:The knee joint is a largest, complex synovial joint of a modified hinge variety. There are three articulations. in the knee joint i.e. two between the tibial and femoral condyles and the third with the patella and femur. The main movements occurring on it are flexion and extension on a horizontal axis; but in addition it displays some degree of rotatory movement called locking and unlocking on a vertical axis. It is mainly weight bearing but also helps in locomotion. Man has evolved and has got erect posture and hence advantage of standing on two legs which means weight of the upper part of the body needs to be balanced and carried by the lower limbs. Knee joint along with other structures carries and bears the body weight. This can produce adverse effects on the joint which is subjected to constant stress and thus undergoes wear and tear. This disturbs the homeostasis of the knee joint. Understanding the normal structural organization and functional homeostatic limits is necessary to predict the disease of knee joint.

Keywords: Anatomy and Physiology, Knee joint, Femorotibial articulation, Patella and femur

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The knee joint is a largest, complex synovial joint of a modified hinge variety. There are three articulations in the knee joint i.e. two between the tibial and femoral condyles and the third with the patella and femur. There is no articulating surface on the fibula to contribute in the formation of the knee joint. Knee is one of the most unprotected joint and it is subjected to all types of acute and chronic injuries leading to pain and disability.

Traumatic injuries of the knee joint can occur anytime during walking, or during sports or road traffic accidents. In a 10 years study 17,397 patients were found to have 19,530 sport injuries it was found that 68.1% of those patients were men and 31.6% were women; and the age of 50% of the patients ranged between 20-29 years (43.1%) at the time of injury [1].  Global adolescent knee injury prevalence ranges between 10% to 25% and in more recent studies it is reported with even higher percentages [2,3].

The principle intra-articular structures in knee are two cruciate ligaments, two menisci and synovium lining the fat pad. They perform functions to maintain the coherence of the knee and any injury therefore; need to be assessed for the proper functioning of these structures. The injury to these intraarticular structures is generally termed as ‘internal derangement of knee [4].  Such knee injuries are assessed by the clinical examination, stability tests and radiographic methods with about 70% accuracy [5].  However thorough physical examination of a recently injured knee with hemarthrosis it is often difficult because of pain, swelling and guarding. The various imaging techniques currently used to evaluate pathological status of the knee include radiography, ultrasonography, nuclear medicine, computed tomography (CT Scans) and magnetic resonance imaging (MRI). Radiography is the initial screening modality, it has limited role in the diagnosis of internal derangement of knee, subtle fractures and bone contusions.  Computed axial tomography is used for evaluation of complex fractures, however it has limited role in the evaluation of internal derangement. Recently, CT arthrography is being evaluated for its role in intra-articular pathologies [6].

The interaction of physical and biochemical structures of cartilage is necessary to allow the normal function of providing nearly frictionless motion, wear resistance, joint congruence, and transmission of load to subchondral bone. Chondrocytes are responsible for synthesizing and maintaining the material required for this purpose. Osteoarthritis occurs when there is disruption of normal cartilage structure and homeostasis [7]. Osteoarthritis results from a complex interaction of biochemical and biomechanical factors that occur concurrently to perpetuate degenerative changes. The progressive pathologic change that occurs in osteoarthritis has been characterized, not only for articular cartilage but also for periarticular tissues.

Anatomic organization and stabilizing factors of the knee Joint

The articulating surfaces of the knee joint are contributed by the lower end of femur, superior surfaces of the tibia and patellar posterior surface [8] (Figure 1).

The intercondylar notch of femur and intercondylar eminence of tibia provides bony stability to the joint much similar to horse rider straddling on back of the horse [9].

The extensor compartment muscle, the quadriceps femoris provides a greater mechanical advantage for the extension. The medial stabilizer is semimembranosus muscle with its five extensions at insertion. During flexion, the semimembranosus and its attachment to medial meniscus pulls the meniscus posteriorly so as to prevent the crushing of meniscus between medial condyles of tibia and femur [10].

Posterior cruciate ligament (PCL) is part of medial tibiofemoral joint and acts like a major stabilizer of knee joint. It is made up of two parts: antero-lateral and postero-medial. The tension within each cruciate varies with the movements of the knee joint [11]. Iliotibial tract and biceps femoris is the main knee joint stabilizer from lateral side. The insertion of biceps femoris reinforces the posterior 1/3rd of the lateral part of capsule. The posterior third of lateral tibiofemoral joint is supported by “Arcuate complex”. This complex is composed of 4 components: fibular collateral ligament, posterior 1/3rd of lateral capsular ligament, popliteal tendon and arcuate ligament [12]. The anterior cruciate ligament (ACL) is taut during extension and lax during flexion of the knee, this ligament is also a chief stabilizer of the knee joint [13].

The menisci increase stability for femorotibial articulation, distribute axial load, absorb shock and provide lubrication and nutrition to the knee joint [14-16]. The Injuries to the menisci are recognized as a cause of significant musculoskeletal morbidity. The unique and complex structure of menisci makes treatment and repair challenges or the patient, surgeon and physical therapist. Long-term damage may lead to degenerative joint changes such as osteophyte formation, articular cartilage degeneration, joint space narrowing, and symptomatic osteoarthritis (OA) [17-19]. Preservation of the menisci depends on maintaining their distinctive composition and organization.

Early in embryonic life, the normal menisci develop within the limb bud from mesoderm. They are well defined at 8th week of gestation and by 14th week they gain appropriate anatomical shape [20] and lack a discoid shape [21] the peripheral blood supply recedes during this maturity. By the 9th month of development, the inner third becomes avascular, finally at 10 years of age only the peripheral third has its blood supply [22] and the inner two-thirds receive nourishment via diffusion from the synovial fluid.

In adults’ medial meniscus covers 50% of the medial tibial plateau whereas the lateral meniscus covers 70% of the lateral tibial plateau The average width of medial meniscus is 11mm and 6mm high whereas lateral meniscus is 12mm and 4 mm [23] Thus, the average excursion of the meniscus during flexion and extension is greater laterally (10 mm vs. 2.5 mm), a feature that protects against the incidence of lateral menisci tear [24].This helps the convex femoral surface and the flat tibial surface like cushions for the tibial plateau and femoral condyles, respectively (Figure 2).

The menisci serve as shock absorbers and load distributors and play a role in joint stability as well as in synovial fluid distribution and cartilage nutrition. Partial meniscectomy of normal shaped menisci was shown to increase the contact stresses in proportion to the amount of removed meniscus. Following total meniscectomy, the contact area was decreased by 75% while contact stresses increased by 23% [25]. Comparison of thickness and width of various studies is shown in the Table 1.

Structural Assessment of Knee joint

There are several methods of structural assessment of knee joint in health and disease.  Among that the direct examination is the most ideal method but it is practically possible only on cadavers or during the knee surgeries. Apart from that the Joint X-rays, the MRIs are the most common methods [35].

Radiographs of the knee joint can be done in three views like merchant’s view, antero-posterior and lateral view. The anteroposterior view is generally easiest to understand as it looks like the skeleton we are familiar with. The kneecap is difficult to see in this view as it overlaps the thigh bone and produces a faint outline. The x-ray of the knee joint with anteroposterior view is used for investigation of arthritis and the region affected like intra-articular or extra-articular.  The lateral view is used for diagnosis of arthritis between the femur and patella.  The skyline view looks between the kneecap and the thigh bone. It is taken with the knee bent (about 30 degrees) and is used to diagnose arthritis. It is much less common. Only about 30% of orthopaedic surgeons use this view during a routine examination. Radiograph of knee that had no OA features in the patellofemoral compartment were classed as OA absent. All the X-rays that had any of the features representing Kellgren and Lawrence grade 1 or above in the patellofemoral compartments were classed as “OA present” [36]. Once all the grading had been obtained, the data needs to be analysed by comparing the readings of the skyline and lateral views as well as the presence of patello-femoral crepitus individually against the operative findings. Kellgren and Lawrence Grading system- grade 0: no radiographic features of OA are present, grade 1: doubtful joint space narrowing (JSN) and possible osteophytic lipping, grade 2: definite osteophytes and possible JSN on anteroposterior weight-bearing radiograph, grade 3: multiple osteophytes, definite JSN, sclerosis, possible bony deformity, grade 4: large osteophytes, marked JSN, severe sclerosis and definite bony deformity). In patients who reported with chronic knee pain a tunnel view is used. It is necessary to find out the presence of knee osteoarthritis [37-38].

The role of MRI in imaging of knee has steadily increased over years. The development of newer sequences, improved signal to noise ratio, higher resolution, shorter imaging times, reduced artefacts and improved accuracy has changed the traditional algorithm for work up of internal derangement of knee joint. Fast spin echo and fat suppression MRI is best for the review of the structure of the ligaments, fibro-cartilage and articular cartilage.  MRI is also used to detect bone contusions, marrow changes and tibial plateau fractures. Hence it has become the best modality for pre operative planning of knee joint injuries. MRI has made it possible to look into the injured knee joint non-invasively [39].

Another advanced modality in the management of internal derangement of knee is arthroscopy; it is a minimally invasive surgical procedure in which a fiberoptic endoscope is inserted into the joint through a small incision. The surgeon makes a second incision through which to insert surgical instruments that can be used to debride or resect areas within the knee under visualization through the arthroscope. A variety of treatments can be delivered by arthroscopy, and different elements of treatment might well determine the efficacy of the arthroscopy in osteoarthritis. Arthroscopy can be used as a dual mode either as a diagnostic or therapeutic tool [40].

Knee Physiology

Knee has the largest and most complex joint structure. It carries load when the person is standing stationary as well as during movement. Understanding the factors which stabilize the joint during standing and movements in health and disease is a huge challenge. Few main concepts and their role in the health like maintaining stability and mobility is described along with its disturbance in most common disease like osteoarthritis. How important is gait of a person! In maintenance of health and development of disease is what is reviewed further.

There are several factors which affect the stability and mobility of the knee Joint. They can be broadly divided into external and internal factors.

The external joint factors which govern the mobility and stability are line and centre of gravity, size and number of base of support and body weight [41]

Line and centre of gravity:Standing on two legs with narrow base is the unique feature of the few mammals. This erect posture enables the human beings to use their forelimbs for exploring the world and thus suitable for working, learning and procreation. Movement through two limbs was possible due to complex arrangements of different types of joints at trunk, hip, knee and ankle. The architecture is such that during standing the body parts should align themselves to fall in the line of gravity.  Same principle is also applicable while moving, where there is a dynamic arrangement of the structures of the knee and other parts. For example, fall in the forward direction is prevented by posterior spine muscle contraction, hip extension and knee flexion [42-45].

This is achieved by change in the tone of muscle at appropriate time. In humans on standing posture, the centre of gravity is marked on the anterior part of sacrum. The centre of gravity changes according to the posture of the individual:  When the person sits, the distance between the ground and centre of gravity reduces and this increases stability. Stability is achieved when the imaginary line from the centre of the gravity falls at the centre of distance between the two limbs at the ground [46].

Size and number of base of support: In order to increase the stability, the base needs to be increased. This can be made by placing the feet in a certain position. More stability can be achieved by using other body parts, as when an athlete assumes a four-point stance. In people with injured limbs as well as older individuals, support can be achieved by using the cane or crutch. Another way of maintaining the balance is by using the length of foot, stability is achieved by leaning forward and backward. This is achieved by change in tone of muscles according to body requirement [47]. In another study it is reported that, the stability maintained through preferred limb is different from non-preferred limb [48].

Body weight:The body weight contributes to stability.  The objects with more weight are harder to move and thus more stable and vice versa [49]. During pregnancy, the female body experiences structural changes, such as weight gain. As pregnancy advances, most of the additional mass is concentrated interiorly on the lower trunk [50]. In such conditions increase in the load with the increase in joint movements increases stress on the musculoskeletal system and contribute to pain [51].

Stability and mobility is mainly due to the frictional resistance at the foot and ground.  A young basketball player trying out the new shoes on a freshly polished gymnasium floor would encounter relatively high friction that would improve the stability.

In a study reported by Roszlin et al, the required coefficient of friction (RCOF) was analyzed. The differences in the friction among the flooring types was assessed and found that there were gender differences during the heel contact phase in barefoot gait [52]. The elderly patients tend to fall due to frequent slips because of lower friction, low heel velocity, shorter slip distances.  But there is higher hamstring activation rate in young people and the heel contact velocity is less during the gait cycle, particularly during the heel contact phase which makes them more stable [53-55].

More stability is possible with increased body weight but with lesser mobility.  Other factors for higher stability are lower centre of gravity, increased friction at the ground contact.  


The shape of the condyles and menisci in combination with passive supporting structures gives stability of the knee joint. The passive supporting structures are mainly four ligaments. They are Medial/Tibial Collateral Ligament (MCL), Lateral/Fibular Collateral Ligament (LCL), Anterior Cruciate Ligament (ACL) and Posterior Cruciate Ligament (PCL).Medial/Tibial Collateral Ligament connects the femur and tibia, provides stability to the medial aspect of the knee (Figure 3).                                         

Medial and lateral collateral ligaments relax at 20 to 30 degrees of flexion.  The MCL and posterior oblique ligament resists abnormal internal rotation of tibia. MCL injury occurs when direct blow occurs on lateral side of semi flexed knee.  Further severe blow can cause cruciate ligaments injury [56].

Lateral/Fibular Collateral Ligament provides stability to the lateral side of knee (Figure 4).The static stabilizer to the lateral part of knee joint is LCL, augmented by cruciate ligaments and popliteofibular ligament. The popliteofibular ligament is the primary restraint to posterolateral rotation, augmented by the LCL and the popliteus tendon [57-60]. The posterolateral corner contributes to the stability of the knee. It has a complex structure and makes assessment and surgery difficult. There is considerable variation in the anatomy from person to person [60].

Biomechanical tests for assessing these   structures were done, by simulating a pure varus stress on knee. It revealed that the LCL failed first, followed by popliteofibular ligament, and then the popliteal muscle belly. The mean maximal force to failure of the popliteofibular ligament approached 425 N (204 to 778), compared with 750 N (317 to 1203) for the LC [61]. A study done by Yoon et al 2013 on the computational studies:  revealed that translational and external rotational stabilities were contributed by the posterolateral corner structures [62].

Anterior Cruciate Ligament (ACL) is in the centre of the knee, limits rotation and forward movement of the tibia.  The major role of the ACL is to give stability against anterior tibial translation (ATT). Cutting-edge studies have demonstrated an important role of ACL for ATT and also pivot shift at different flexion angles. In studies done on cadavers, a posterolateral fibres of ACL has a stabilizing role in controlling the ATT at near-to-extension angles and an anteromedial fibre of ACL has a role in controlling higher flexion angles of knee [63-65]. The Anteromedial fibres of ACL is taught during flexion and postero-lateral fibres of the ACL is tighter during extension. This allows different portions of ACL to be taut throughout the range of motion, allowing the ligament to function throughout flexion and extension. The ACL also contains proprioceptive nerve endings [66, 67] (Figure 5).

Posterior Cruciate Ligament (PCL), is also located in the centre of the knee, and like the ACL secondarily limits rotation, while primarily limits backward movement of the Tibia (Figure 6).

In a study, computer simulation knee model was used and a simulation of squatting activity was done in weight-bearing deep knee flexion.  PCL length was changed to represent different PCL tension models as it significantly influences knee kinetics and kinematics [68] (Figure 7).

The knee joint is one of the vulnerable joints which are easily injured. Unlike the hip joint which has a very stable ball-and-socket configuration, the architecture of the knee imparts little support to the joint's stability. This makes the knee ligaments prone to injury with any stretch to the knee, like the force of a hard muscle contraction (e.g. performing a quick change of direction when sprinting) [69-71].


The knee is a complex joint with different articulating compartments inside. The ligaments and the tendons attached to it work in coherence in a pattern to support the actions of knee joint. In addition, the support of structures in maintaining the posture is also reviewed. Such review will help us in understanding the specific pathophysiological process for the onset of diseases related to knee joint like osteoarthritis. The literature concerning kinematic and kinetic studies on the knee joint is comprehensively reviewed in this article. The architecture of menisci and investigations to diagnose osteoarthritis and role of healthy gate in prevention of degenerative joint diseases is also elaborated.

Acknowledgement: Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Source of funding: Nil

Conflict of interest: Nil

Abbreviations used:

MRI - Magnetic Resonance Imaging

CT- Computed Tomography

FBOS - Functional base of support

RCOF- Required Coefficient Of Friction

MCL- Medial Collateral Ligament

LCL- Lateral Collateral Ligament

ACL- Anterior Cruciate Ligament

PCL- Posterior Cruciate Ligament

ATT- Anterior Tibial Translation

OA- Osteoarthritis


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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to for more details.

Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


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