International Journal of Current Research and Review
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IJCRR - Vol 11 Issue 10, May, 2019

Pages: 07-11

Date of Publication: 30-May-2019


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A Tertiary Care Hospital Based Study on Antimicrobial Sensitivity Pattern Among Septic Patients

Author: Spenta Rachel Thomas, Sajeena Jose C., Deepthi Damodaran, Eldhose Benny, Ateendra Jha, Viresh K. Chandur, Ramakrishna Shabaraya A.

Category: Healthcare

Abstract:Introduction: Sepsis is a common and highly fatal clinical syndrome that is characterized by systemic inflammatory response syndrome due to infection. It is a final common pathway of many infectious processes, e.g. bacterial, viral, fungal and parasitic infection in critically ill patients. There is a need of study regarding the sensitivity and resistivity pattern of antimicrobials for the proposal or implementation of rational therapy guidelines. This study will also provide the best microbiological information to clinicians to pick the most effective treatment options, positively influencing patient outcomes.
Methodology: A retrospective observational study was conducted among 202 patients at tertiary care teaching hospital during the period from March to November 2018. Patients with sepsis of either gender who are 18 years old or above are included in the study. Non-sepsis adult patient and special populations (pregnant women, psychiatry, HIV) or patients younger than 18 years of age are excluded from the study. Data were collected using validated data collection form. Data were analysed using SPSS 20.0 and Microsoft Excel 2013.
Results: From a total of 202 patients involved in the study, the highest incidence rate was found in the age group >68 years. Gram negative organisms isolated were 81.86%, of these Klebsiella species being the most frequent. This isolates showed high rates of sensitivity towards Colistin (96%) Tigecycline (93. 3%).
Conclusion: The sensitivity of antibiotics towards species are going down and it is an unpleasant warning of emergence of resistance. From our study it can be anticipated that routine culturing and sensitivity testing should be performed to detect the appearance of resistance

Keywords: Antibiotic, Organisms, Sepsis, Sensitivity

Full Text:

INTRODUCTION

 Sepsis is a common and highly fatal clinical syndrome that is characterized by systemic inflammatory response syndrome due to infection [1]. Sepsis is commonly defined as the presence of infection in association with the systemic inflammatory response to microbial infection which can cause organ damage, shock, and eventual death [2]. There are typically four progressive stages of sepsis specifically Systemic inflammatory response syndrome, sepsis, septic shock and multi organ dysfunction. Systemic inflammatory response syndrome is stated as the presence of 2 or more of the following: (1) temperature greater than 38°C (100.4°F) or less than 36°C (96.8°F); (2) pulse rate greater than 90 beats/min; (3) respiratory rate greater than 20 breaths/min (or partial pressure of carbon dioxide less than 32); and (4) WBC count greater than 12,000/mm3 or less than 4,000/mm3, or greater than 10% immature band forms [3]

 Age, male gender, black race, and increased burden of chronic health conditions are important risk factors for severe sepsis.  It is also more likely to occur in individuals with chronic obstructive pulmonary disease, cancer, chronic renal and liver disease, and diabetes. [4,5] Other risk factors include residence in long-term care facilities, malnutrition, and use of immunosuppressive medications and prosthetic devices. Severe sepsis is more common in colder months, both in the UK (35% higher in winter than in summer) 44 and US (17.7% higher in fall than in summer). [4] The elderly patient also presents with many symptoms, thus affecting the diagnosis and making it more difficult to make an early diagnosis and to provide therapeutic management [6].

Although SIRS (Systemic inflammatory response syndrome) often occurs in the setting of infection, non-infectious conditions, such as burns, acute pancreatitis, and trauma, can lead to SIRS. Sepsis was defined as the presence of the SIRS criteria and presumed or proven infection. Severe sepsis was defined as sepsis accompanied by acute organ dysfunction.[4] The high incidence of sepsis in elderly patients is affected by aging factors that cause the decline in body systems such as metabolism, cardiovascular, visual, genitourinary, immune, nervous system, and drug response.

Worldwide, 31.5 million cases of sepsis occur annually and 5.3 million people have died annually. [1,7]  In 1996, there were 4774 patients admitted to a teaching hospital in Surabaya, Indonesia and 504 patients were diagnosed with sepsis, with a mortality rate of 70.2%. In another study at a teaching hospital in Yogyakarta, Indonesia, there were 631 cases of sepsis in 2007, with a 48.96% mortality rate [6]. Gram-positive organisms as a cause of sepsis have increased in frequency over time and are now almost as common as gram-negative infections, likely due to greater use of invasive procedures and the increasing proportion of hospital-acquired infection. More frequent use of broad-spectrum antibiotics in increasingly sick patients who remain in the ICU for longer periods of time has likely resulted in an increased bacterial resistance over time. Antibiotic resistance is problematic, prolonging length of stay and duration of mechanical ventilation, although the effect on mortality is uncertain. International variations in the implementation of the two main strategies to control resistance (the more rational use of antibiotics and the prevention of cross-infection between patients) may explain different rates in different countries.[4]

The discrimination of infection from non-infectious causes of inflammation could also be tough. Biomarkers are prompt to help physicians during this call. There is presently no biochemical technique obtainable that alone permits a speedy and reliable discrimination between infection and non-infectious inflammation. Procalcitonin (PCT) is presently the foremost investigated biomarker for this purpose. C-reactive protein and interleukin 6 perform inferior to PCT in most studies and their value in identification infection is not outlined. All biomarkers together with PCT also are released after various non-infectious inflammatory impacts.

Sepsis is often diagnosed based on simple measurements such as temperature, heart rate and breathing rate. Other tests can help to determine the type of infection and where it is located in body and which body functions have been affected. These include urine or stool samples, wound culture, vaginal secretion, pus or fluid is taken from the affected area for testing, respiratory secretion testing taking a sample of saliva, phlegm or mucous secretion, blood pressure tests, imaging studies such as an X-ray, ultrasound scan or computerised tomography (CT) scan.

A wide spectrum of organisms has been represented that cause blood stream infections and this spectrum is subject to geographical alteration. Increasing antimicrobial resistance is a worldwide concern. The prevalence of resistance of blood borne isolates is increasing and it also varies in accordance with geographical and regional location.

The infection caused by MDR organisms is more likely to prolong the hospital stay, increase the risk of death, and require treatment with more expensive antibiotics. In the majority cases, antimicrobial medical care is initiated through empirical observation before the results of blood culture are available. Keeping in mind the high mortality and morbidity associated with septicaemia, right choice of empiric therapy is of importance.

Therapeutic management of sepsis, severe sepsis, and septic shock requires a systematical approach which combines an accurate diagnosis, rationality of antibiotic use, as well as a rapid and right treatment. Appropriateness in antibiotic use is very important to decrease the mortality and morbidity rate in patients with sepsis. The selection of antibiotics requires information about the location of source infection, the common pathogen that develops into an infection, and the local sensitivity pattern of antibiotics Aggressive, early antimicrobial therapy is critical in the management of sepsis patients. The regimen selected should be based on the suspected site of infection, likely pathogens, and the local antibiotic susceptibility patterns, whether the organism was acquired from the community or a hospital, and the patient’s immune status. Although antibiotic therapy is the cornerstone in the treatment of infections, several studies have questioned that inadequate initial antibiotic treatment of sepsis and bacteraemia is associated with increased mortality. [8]

One out of four patients in Indian intensive care unit suffer sepsis, a life threatening condition due to bacteria and germs and nearly half of those patients die as a result. An average age of incidence of sepsis in western countries is 57 years and in India 55 years. Economic burden on the patient due to sepsis is very high so the selection of antibiotics should be rational and more appropriate to avoid the burden.

METHODOLOGY

A retrospective observational study was carried out at a multispecialty tertiary care teaching hospital in Mangaluru from November 2017 to March 2018. The study protocol was approved by Institutional Ethics Committee (IEC). Medical records of (male & female) admitted in hospital between November 2016 and November 2018 were obtained from the Medical Records Department of the hospital. A total of 202 cases were collected. Patients with sepsis of either sex who are 18 years old or above were included in the study. Non-septic adult patient and special populations (pregnant women, psychiatry, HIV) and Patients younger than 18 years of age were excluded in the study. The collected data were analysed by using Microsoft Excel 2013 and SPSS 20. The resistivity and sensitivity pattern of antimicrobial agents and prescription pattern were noted and the same were observed and concluded on the basis of prescription to the hospitalized patients in tertiary care hospital

RESULT

Data from 202 patients were collected from the medical record department of tertiary care hospital, out of which 124 (61.4%) were males and 78 (38.6%) were females(Table 1). Out of total population 95 patients had been hospitalized for a duration < 1 week, 68 patients for 1-2 weeks, 28 patients for 2-3 weeks, 8 subjects for 3-4 weeks, 3 patients for > 4 weeks. Most of the patients stayed in hospital for less than one week. Mortality rate  of males were  57.25% (N=124)  and  females, 51.28% (N=78). 77 people were cured during the course of treatment. On analysis we founf that out of 78 femles and 124 males the percetage of cured population were 41.02% and 36.29% respectively. While 6.93% (14) patients discontinued therapy under LAMA (Leaving Against Medical Advice ).

            In the present study diabetes mellitus 74(36.6%) is the most common risk factor among patients followed by acute kidney injury 68 (33.6%), bronchopneumonia 47 (23.2%) , chronic kidney disease 36 (17.8%) , urinary tract infection 18 (8.9%)  chronic obstructive pulmonary disorder  15(7.4%) , urosepsis  14(6.9%) , chronic liver disease 11(5.4%) and acute pulmonary edema 4 (1.9%). We found that 182 culture sensitivity test were conducted out of 202 patients. Out of 182 culture sensitivity tests, gram negative organisms were 149(81.86%) and gram positive organisms were 33(18.14%) (Table 2).

During the study period, 182 culture sensitivity tests were done for 21 organisms out of which klebsiella spp. (39, 21.40%) (Figure 1), Acinetobacter spp.(33, 18.10%) (Figure 2), Escherichia coli (30, 16.40%) (Figure 3) and Pseudomonas aeruginosa (18, 09.80%) (Figure 4) were analysed to prescribe antimicrobials.

DISCUSSION

Globally burden of sepsis in healthcare is of considerable importance. Patients with sepsis and no ongoing sign of organ failure at the time of diagnosis have increased chance of death. Patients with severe sepsis or septic shock have the highest mortality rate.

A total of 202 patients, 124 males (61.4%) and 78 females (38.6%) were diagnosed with sepsis. The present study shows that incidence rate of sepsis remains high in males which was also supported by study done by Angus-DC and Schroder et al[9,10]

Our study found that mortality rate was higher in men than women which was 63.96% and 36.03% respectively, same result was found in study by Schroder, et al[9] Also according to the study conducted by Adrie et al, in a group of severe sepsis patients of 50 years of age, women have a lower mortality risk than men. [11] The differences of incidence and mortality rate between male and female is due to hormonal and non-hormonal factors that influence the immune system. Women have more estrogens production than men, which influences greater activity of the immune system. [12]

In the present study the highest percentage 32.18% incidence of sepsis is seen in age group above 68 followed by 25.74% fall into age group 59-68 and 31% in age group of 49-58. The highest mortality rate was found in the age group ≥68 years. The similar result was found in a study conducted by Ivan pradiptha et al. At Bandung private hospital in Indonesia, which showed that highest mortality rate was found in the age group ≥ 65 years.

In critically ill sepsis patients, lacking the quality of antimicrobial therapy at admission to the ICU is associated with a significant attributable mortality. Major among those survivors who did not receive adequate antimicrobial therapy, there is a remarkable increase in ICU and hospital length of stay with the consequences that this implies.

Our study showed that highest risk factor was diabetes mellitus 36.6% which was similar to the result found in the study done by G.C.K.W. Kho et.al [13]. The same results were also reported in another study done by Florian B Mayr [4] that severe sepsis is more likely to occur in individuals with diabetes mellitus, Chronic kidney disease and liver disease.

Among the blood isolated organisms, current study reported that gram positive organisms and gram negative were found as causing sepsis. Organisms isolated were categorized according to their species. Among the blood isolates Klebsiella spp. (21.4%) was the predominant cause of sepsis in adults. The second isolated gram negative organism was Acinetobacter spp. (18.1%) followed by other organism E.coli (16.4%) Pseudomonas aeruginosa (9.6%). This finding was similar to other studies reported where Gram negative organism were the common isolated organism than Gram positive such as in Jalandhar (India) (58.46 % and 38.46 %) done by Kumar et al. [14]

In our study imipenem was found to resistant to Klebsiella spp.  (51.40%). This similar result was found in the study done by Nidhi Pal and Ramamurthy Sujatha that resistance to imipenem seen approximately in 60% with the same organism. [15]

CONCLUSION

Our study found that gram negative and gram positive bacteria were responsible for adult sepsis while gram negative found to be predominant. Among that, Klebsiella species and Acinetobacter species were found to be common. It was found that the antibiotic Piperacillin/tazobactam was prescribed the most and the same is lacking sensitive to the Acinetobacter species and Klebsiella species. Which gives an alarming conclusion that sensitivity of antibiotics towards the species are going down.  From our study it can be anticipated that routine culturing and sensitivity testing should be performed to detect the appearance of resistance.

Acknowledgement

Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

  1. Kumalo A, Kassa T, Mariam ZS, Daka D, and Tadesse AH. Bacterial Profile of Adult Sepsis and their Antimicrobial Susceptibility Pattern at Jimma University Specialized Hospital, South West Ethiopia. Health Science Journal. 2016; 10(2):3.

  2. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003; 31:1250-6

  3. Malmir J, Bolvardi E, Afzal Aghaee M. Serum lactate is a useful predictor of death in severe sepsis and septic shock. Reviews in clinical medicine. 2014;1(3):97-104.

  4. Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence.2014;5(1):4–11

  5. Mendu ML, Zager S, Gibbons FK, Christopher KB. Relationship between neighbourhood poverty rate and bloodstream infections in the critically ill. Crit Care Med. 2012 May 1;40(5):1427-36.

  6. Pradipta IS, Sandiana AT, Halimah E, Diantini A, Lestari K, et al. Microbial and Resistance Profile in Isolate from Adult Sepsis Patients: An Observational Study at an Indonesian Private Hospital during 2009-2012. Int Jour of Pharm Sci Rev and Res 19: 24 -9.

  7. Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72.

  8. Garnacho-Montero J, Ortiz-Leyba C, Herrera-Melero I, Aldabo-Pallas T, Cayuela-Dominguez A, Marquez-Vacaro JA, Carbajal-Guerrero J, Garcia-Garmendia JL. Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. Journal of Antimicrobial Chemotherapy. 2007 Dec 3;61(2):436-41.

  9. Schröder J, Kahlke V, Staubach KH, Zabel P, Stüber F. Gender differences in human sepsis. Arcz1998 1; 133(11):1200-5.

  10. Berkowitz DM, Martin GS. Sepsis and sex: can we look beyond our hormones? Chest. 2007 1; 132(6):1725-7.

  11. Bodmann KF. Current guidelines for the treatment of severe pneumonia and sepsis. Chemotherapy. 2005; 51(5):227-33.

  12. Bone RC. Sepsis and its complications: the clinical problem. Crit care med.1994;22(7):S8-11.

  13. C.K.W.K. Koh, S.J.P Peacock, T.Van Der Poll. The Impact of diabetes on the pathogenesis of sepsis, Eur J Clin Microbiol Infect Dis. 2012, (4):379-88.

  14. Kumar A, Zarychanski R, Light B et al (2010) Early combination antibiotic therapy yields improved survival compared with monotherapy: a propensity- matched analysis. Crit Care Med 38:1773–85.

  15. Pal N, Sujatha R. Antimicrobial Resistant Pattern of  Blood Culture Isolates, Among Septicaemia Suspected Patients. National Journal of Laboratory Medicine.2016;5(1):17-21.V

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Awards, Research and Publication incentive Schemes by IJCRR

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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Best Article Award

A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by situs slot and Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh et al. situs slot "Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma situs slot entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by situs slot et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
Late to bed everyday? You may die early, get depression situs slot
Egg a day tied to lower risk of heart disease situs slot
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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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