International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 11(5), March, 2019

Pages: 06-09

Date of Publication: 14-Mar-2019


Print Article   Download XML  Download PDF

The Myelogram: Its Contribution to the Diagnosis of Hemopathies

Author: Boufrioua El Ghali, Belkhair jihane, Allali Asma, Mouamin Maryam, Mohamed Chakour

Category: Healthcare

Abstract:Background: The myelogram is the collection of elements provided by microscopic examination of a hematopoietic bone marrow smears collected by puncture-suction. It is considered one of the most valuable diagnostic tools for assessing hematological abnormalities.
Methods: We conducted the present retrospective study of 305 patients collected over a 3 year period, from February 2015 through June 2018, performed in the hematology laboratory of the Avicenna military hospital in Marrakech to expose the main bone marrow indications, review its diagnostic contribution, evaluate the practice of the myelogram in our context, and propose recommendations to improve the practice of this examination.
Results: The myelogram study allowed to make the diagnosis of 53 (17, 4%) megaloblastosis cases, fifty five (18%) cases of medullary plasmocytosis. Acute myeloblastic leukemia was found in 27 patients (8.8%) followed by chronic lymphocytic leukemia in 11 patients (3.6%), comes after chronic myeloid leukemia in 11 cases (4.3%), while acute lymphoblastic leukemia is in 16 cases (5.2%). The myelogram was normal in 60 cases (19.6%). It objectified a reactional marrow in 49 cases (16%). The myelogram was impossible to interpret in 21 cases (7%), in which the sample was diluted.
Conclusion: This general review of haemopathies has highlighted the importance of the myelogram as an indispensable tool for diagnosis. In our study it was possible to know the contribution of this examination, which is linked to its good interpretation.

Full Text:

Introduction 

The myelogram is the collection of elements provided by microscopic examination of a hematopoietic bone marrow smears collected by puncture-suction. It includes the assessment of the smear richness in nucleated cells (megakaryocyte lineage included), the percentage of each cell category and their morphology [1]. It also detects the presence of parasites, infectious agents and tumour cells of spinal and extraspinal cord origin. Thus, it is a cytological examination which allows the qualitative and quantitative analysis of cells belonging to the hematopoietic medullary precursor compartment [2]. It is considered one of the most valuable diagnostic tools for assessing hematological abnormalities.

Its indications include diagnosis, classification and therapeutic follow-up of hematological diseases [3]. We conducted the present retrospective study to expose the main bone marrow indications, review its diagnostic contribution, evaluate the practice of the myelogram in our context, and propose recommendations to improve the practice of this examination.

Patients and Methods

This is a retrospective study of a representative series of 305 patients collected over a 3 year period, from February 2015 through June 2018, performed in the hematology laboratory of the Avicenna military hospital in Marrakech.

The data collection was conducted using a farm return by excluding extensions assessment and non-hematological spinal disorders. In this study, all patients of both sexes regardless of age or socio-economic level were concerned.

All medullary punctures were performed in the departments with the doctors at the bedside of the patient. The location of the sampling was variable, the sternum facing the 2nd intercostal space was the site of choice for adults, the anterior superior and posterior superior iliac spines were for the children.

The punctures were made with Mallarmé trocar and colored with May Grunwald Giemsa which is the reference color in hematology, it consists of applying two neutral dyes; the May-Grünwald’s alcoholic solution, and Giemsa’s 10% diluted alcoholic solution. As for the coloration Perls it is performed on spinal cord smears as part of the primary classification of myelodysplastic syndromes, this coloring highlights insoluble cellular complexes containing iron: hemosiderin, Pappenheimer granules (fine iron-rich granules) = overloaded iron mitochondria. Determining Myeloperoxydase activity by testing (MPO) is routinely used for acute leukemia diagnosis. Its positivity represents a strong marker of myeloid differentiation.

Data entry and analysis were performed using the Microsoft Office Excel 2016 software for Windows version 10.0.

Results

The mean age of patients was 42 years, with minimum age of 1 year and maximum age being 70 years. Children of less than 18 years represent 10% of our patients. A light male predominance was noted with a sex-ratio of 1, 2.

Fifty three percent of bone marrow smears performed on hospitalized patients in different services, mainly in the service of internal medicine with a rate of 43% and 47% was conducted on not hospitalised patients.

Hemogram disturbance was the first indication of myelogram, that is to say 53% of cases, followed by tumor syndrome in 23% of cases, then the suspicion of monoclonal gammapathy 17% of the cases (Table I). Among the disturbances in blood count (CBC) listed, Macrocytic anemia was the most common abnormality with a rate exceeding 19%, followed by normochromic normochromic anemia found in 14% of the cases. Bicytopenia and pancytopenia respectively represent 12% and 6% of all disturbances.

Among the 57 of macrocytic anemia cases found in the hemograms performed, 47 had megaloblastosis. Myelograms done within the framework of thrombocytopenia turned out to be normal, except for one patient who was in coma and suffers from thrombocytopenia and leukocytosis and in whom the myelogram showed acute myeloid leukemia. 18 myelograms were conducted on patients suffering from a pancytopenia: 15 had tumor associated syndrome, and their myelograms showed acute myeloid leukemia. Two cases of megaloblastosis, and one showed a dystrophic plasmocytosis.

Myelograms of 51 patients showed a bone syndrome with suspicion of gammopathy, had revealed; a multiple myeloma in 42 patients, chronic lymphocytic leukemia (CML) in three patients, 5 cases of reactive plasma cells, and 1 case of plasma leukemia.

In the case of splenomegaly; the myelogram objectified three medullary megaloblastosis and chronic lymphocytic leukemia.

Four myelograms were made for suspicion of medicinal side effects: two patients showed rheumatoid arthritis under methotrexate, following the discovery of a hemogram pancytopenia, and for which the myelogram revealed a case of megaloblastosis, and a normal marrow in the other case. Two patients with diabetes under sulfonamide who had thrombocytopenia, and for which the myelogram did not objectify abnormalities.

Ten myelograms were performed as part of a nephropathy assessment. Medullary plasmocytosis was found in seven cases, a CML in a case and a dystrophic pith in a patient with chronic kidney failure and a pancytopenia.

In total, the myelogram study allowed to make the diagnosis of 53 (17, 4%) megaloblastosis case, fifty five (18%) cases of medullary plasmocytosis. Acute myeloblastic leukemia was found in 27 patients (8.8%) followed by chronic lymphocytic leukemia in 11 patients (3.6%), comes after chronic myeloid leukemia in 11 cases (4.3%), while acute lymphoblastic leukemia is in 16 cases (5.2%). The myelogram was normal in 60 cases (19.6%). It objectified a reactional marrow in 49 cases (16%). The myelogram was impossible to interpret in 21 cases (7%), in which the sample was diluted (Table II).

Discussion

This work focuses on the contribution of the myelogram in the diagnosis of blood diseases, in the hematology laboratory at the Avicenna Marrakech military hospital has retrospectively noted an average prevalence of 101 myelogram / year. This average result is attributed to the participation of the hematology laboratory of the Mohammed VI University Hospital Centre of Marrakech, which supports a significant number of preformed myelograms. The sampling of this exam at University Hospital Centre of Treichville is 275 myelograms per year [1], and 1100 myelograms / year at the central hematology laboratory at Ibn Sina Hospital in Rabat in 2016 [2]. Compared to the hemogram, the myelogram is a relatively infrequent examination. This is due to the speed and ease of the conduct of the hemogram: thanks to automation. As for the myelogram, it also represents a major examination of major utility, but it has few indications compared to hemogram.

The average age of patients in our series was 43 years, close to the average ages found in studies in Burkina Faso (42 years old) [4], of Cameroon (44,27) [5]. While the study conducted in Rabat [2] showed an average age of 14 years, this is explained by the predominance of the pediatric population in this series, which is 61%.

The male predominance found in our study is comparable to the results reported in the studies of Casablanca (1, 4) [6], Bass-Normandy (1, 13) [7], in Senegal (1, 6) [8], Mali (1, 9) [9] in the Democratic Republic of Congo (1, 7) [10]. Men are more exposed to environmental factors than women because of their professional activity (use of herbicides and pesticides) [11, 12].

The most affected age group was 30 to 40 years old, whereas the study conducted in Rabat [2] found a high prevalence of malignant hemopathies (MH) in the age group 10 to 19, this difference being explained by the fact that that our population was essentially an adult population (90% of the patients were at least 18 years old).

We identified 11 main indications of the myelogram in our study; disturbances of the hemogram were the main indication, followed by tumor syndrome, these are the classic indications of the myelogram; Hugard [3], Ouattara [1] found similar results, concerning the frequency of a hemogram anomalies with predominance of pancytopenia in their series.

The blood count generally showed bicytopenia (anemia and thrombocytopenia) associated with variable leukocytosis. Anemia and thrombocytopenia were generally associated with leukocytosis in patients with MH in a series in Burkina Faso [13]. These biological signs have also been observed in Tunisia [12] and Cote d'Ivoire [14, 15]. Pancytopenia was also noted in 6% of patients. In fact, the circumstances of discovery of MH, especially leukaemias, are generally signs of bone marrow failure more or less associated with a tumor syndrome [13].

Among the 57 macrocytic anemias, 47 had megaloblastosis with myelogram. This aspect is compatible with vitamin deficiency [16, 17], which have been confirmed by the corresponding vitamin dosages (folic acid and vitamin B12).

Lymphoproliferative syndromes are ranked first in the MH study in 24.5% of cases. A prevalence of lymphoproliferative syndromes of 67, 3% was found in Ivory Coast [18]. Multiple myeloma represents 15.5% of the cases in our study, which was close to the 12.2% reported in Abidjan [19], but above the 7% average rates found in Mali and Senegal [9, 8]. The CLL occupied 5.2% of the cases, unlike in Niger where it occupied 33.3%. [20].

Acute leukaemias represent 13.1% (40 cases) of MH. They occupied the third position as nosological group in our study while in Ivory Coast study; they were in second with 21.3% of cases [21]. In the study by Seiter et al [22], acute myeloid leukemia (AML) represents 80% of acute leukemia (AL) in adults and 20% of acute children leukemia.

Myeloproliferative syndromes came fourth with 4.5% (14 cases); in comparison with a Cameroonian study [21]. In our study, CML represents 4.2% of cases while other authors found higher proportions: 18.9 in Niger [20] and 9.3 in Ivory Coast [19].

In our series, we had only one patient in whom there was an appearance of hemophagocytosis in the myelogram. Confronted with other clinico-paraclinical data described in the literature [23], the diagnosis of macrophage activation syndrome (MAS) was retained.

We have 4 cases presenting different medicinal side effects: Two patients followed for rheumatoid arthritis under methotrexate that had pancytopenia. Pancytopenia under methotrexate at low doses is a rare but serious complication [24]. Its prevention is based on the close supervision of elderly patients, especially in cases of polypharmacy and hypoalbuminemia. The results of myelogram in these patients showed normal marrow in one and megaloblastosis in the other. This effect has been mentioned by several authors [24]. The other two patients with type 2 sulfamide diabetes had thrombopenia: known side effect of this treatment [25]. The myelogram in our 2 patients showed a normal aspect of the marrow which favors the immunological origin [25].

Reaction marrows were noted in 16% of patients in our series. This medullary reaction is not specific and is observed in a large number of pathological states (toxic, viral, parasitic) [25].

Diluted myelogram represented 7% of cases in our series. The most frequent causes of dilution were the technical errors during the sampling, the other causes of diluted marrow being: fibroses and medullary aplasias [26].

Conclusion 

On a going back 3 years at Avicenna Military Hospital, this study allowed us to take stock of the hematological conditions diagnosed within our service. This general review of hemopathies has highlighted the importance of the myelogram as an indispensable tool for diagnosis. In our study it was possible to know the contribution of this examination, which is linked to its good interpretation, which is in turn directly related to the rigor of its performance. Highlight the various technical errors, and make recommendations to improve its implementation.

Conflict of Interest:

The authors declare no potential conflicts of interest, financial or otherwise.

References:

  1. Ouattara S, Danho B, Kone M, Tea D. La pratique du myélogramme au CHU de Treichville : bilan de 19 années d’activité. Médecine d'Afrique Noire; 2000:47(5)

  2. Omar El hamdaoui. L’apport du myélogramme dans le diagnostic des hémopathies: expérience du laboratoire central d’hématologie de l’hôpital Ibn Sina. Thèse de médecine. universite Mohammed V – rabat. Faculté de médecine et de pharmacie Rabat;2018,22 p.

  3. HugardL, Bon J.C, Force -barge P, Porte J, RODIER J. Contribution à l’étude de la prévalence de l’anémie chez l’enfant en milieu tropical. CMS ELF-Congo - Pointe Noire. Méd. Afr. Noire 1997; 44 (1): 40-44.

  4. Ouédraogo SM, Hien F, Bazié W, Millogo A, Drabo YJ. Place des hémopathies malignes en service de Médecine interne du CHU SouroSanou (Burkina Faso). Mali Médical 2011 ; XXVI : 17-21.

  5. Moueleu N, Ngouadjeu D, Ngo S, Luma H. Épidémiologie des hémopathies malignes recensées en milieu hospitalier au Cameroun. Médecine et Santé Tropicales, Vol. 28, N8 1 - janvier-février-mars 2018

  6. M. Harif, A. Benider, M. Bennani Othmani et al. Registre des cancers de la région du Grand Casablanca. Année 2005, 2006,2007, édition 2012. 

  7. www.orsbn.org/publication/bulletin_11.pdf.  Mortalité par hémopathies malignes en Basse-Normandie. Le Bulletin de l’observatoire régional de la santé de Basse-Normandie numéro 11, Décembre 1997.

  8. Thiam D, Diop TM, Tallarmin F, Toure AO, Diakhate L. Epidemiology and therapy of malignant hemopathies in Senegal. Hematol Cell Ther 1996 ; 38 : 187-91.

  9. Diallo DA, Cissoko LS, Cissoko Y, et al. Epidémiologie actuelle des hémopathies malignes dans les services d’hématologie oncologie médicale et de médecine interne de l’hôpital du Point G, Bamako, Mali. Mali Medical 2005 ; 4 : 1-8.

  10. Mufuta NJP, Mbayo K, Kayembe NZ, Gini EK, Mbuyi M. Cytologie des hémopathies malignes dans deux formations médicales de Kinshasa. Ann AfrMed 2013 ; 6.

  11. Henry K. Neoplastic disorders of lympho-reticular tissue in Henry K. and Symmers, W St C : Systemic Pathology : thymus, lymph node, node spleen  and lymphatics.3 rd Edition. London : Churchill Livingtone, 1992; p. 611960.

  12. Elloumi M, Hafsia R, Omri EL, et al. Caractéristiques épidémiologiques, cliniques et cytohématologiques des leucémies aigués lymphoblastiques de l’adulte en Tunisie. Tunis Me ´dical 2002 ; 80 : 199-202

  13. Ouédraogo SM, Hien F, Bazie W, Millogo A, Drabo YJ. Place des hémopathies malignes en service de Médecine interne du CHU Souro Sanou (Burkina Faso). Mali Médical 2011 ; XXVI : 17-21.

  14. Sangaré M, Kassi HY, N’Dogom M, Yayo-Ayé ME, Inwoley AK, Sawadogo D. Pro?l biologique des leucémies aigues non myéloides en Co ˆte d’Ivoire. Rev Int ScMéd 2013 ; 15 : 49-53.

  15. Sawadogo D, Lartey MT, Kouassi D, et al. Impact de la chimiothérapie sur les pro?ls hématologiques et biochimiques au cours des hémopathies malignes à Abidjan. Cahier Santé2002 ; 12 : 229-32.

  16. Sebahoun G, Sainty D, Horschowski N. Ponction médullaire et biopsie médullaire. Editions techniques. Encycl. Méd. Chir. (Paris, France), Hématologie 13000, A30,1991,7p.                                                

  17.  Zittoun J, Zittoun R. Les anémies macrocytaires. Encycl. Méd. Chir. (Paris, France), Sang, 13002,A10,1985,14 p.

  18. N’Dhatz Comoe E, Kof? KG, Ayemou R, et al. Prévalence et incidence des hémopathies malignes au CHU de Yopougon. Revintscme ´d 2012 ; 14 : 205-8.

 

  1. Téa D, Yao T, Abissey A, Anoh J, Rain JD. Panorama des hémopathies diagnostiquées au laboratoire central du CHU de Treichville bilan de 10 années d’activité. Médecine d'Afrique Noire : 39-43.

  2. Mounkaila B, Touré I, Gragnic G, MounkailaI. Hémopathies malignes à Niamey   à propos  de 90 observations sur 6ans. Méd Afr Noire 1996; 43: 472-5.

  3. N’Dhatz Comoe E, Koffi KG, Ayemou R, et al. Prévalence et incidence des hémopathies malignes au CHU de Yopougon. Rev int sc méd 2012 ; 14 : 205-8.

  4. Seiter K, Harris J. E. Myeloid leukemia staging.  N Engl J Acute Med 1999; 341(11):807-813

  5. Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, et al. Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007; 48:124-131. 

  6. Sallah S, Hanrahan L R,  Phillips D L. Intrathecal methotrexate induced megaloblastic anemia in patients with acute leukemia. Arch Pathol Lab Med. 1999 Sep; 123(9):774-7

  7. Dearden C. Wade R. Else M. Richards S. Milligan D. Hamblin T.  UK National Cancer Research Institute (NCRI), Haematological Oncology Clinical Studies Group, NCRI CLL Working Group. Blood 2008; 111:1820-1826.

  8. Goldberg C et al. Bone marrow aspiration and biopsy transfusion. http://emedicine.medscape.com/article/207575, consulté le 24 oct. 2017.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions