International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 10 Issue 14, July, 2018

Pages: 16-21

Date of Publication: 18-Jul-2018


Print Article   Download XML  Download PDF

Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti

Author: Mithun Kumar Patel, Aishwarya Tiwari, Vijay Laxmi Saxena

Category: Life Sciences

Abstract:Mosquitoes are the most vital single gathering of creepy crawlies as far as general wellbeing. They transmit various illnesses, for example, jungle fever, dengue fever, chikungunya, filariasis, Japanese encephalitis, West Nile infection and yellow fever and so on prompts a large number of passings consistently. The aim of this study is to investigate the impacts of various parts of Solanum nigrum unrefined concentrate tried against fourth instars hatchlings of dengue vector, Aedes-aegypti, under the research facility conditions. New Solanum nigrum plants were gathered from professional flower bed D.G.P.G College in Kanpur, U.P. India, and washed completely 2-3 times with running faucet water. 20 gm of new leaves and 10-10gm green and dark berries was gathered and quickly ground utilizing a pestle and mortar independently. All ground material was sifted through a Buchner pipe with What-man number 1 channel paper and independently put away in glass bottle till additionally utilize. Research centre raised fourth instars hatchlings of Aedes-aegypti were treated with various centralization of fluid arrangements all things considered. The tests were directed at room temperature (24\?C-29\?C). Fixations (1-5%) of the all concentrate were set up in de-chlorinated water. At each the given fixation, 100 hatchlings were uncovered. Mortality was watched for 24, 48 and 72 hours. Leaves and dark berries extricate displayed most noteworthy larvicidal movement with a LC50 estimation of 2.47, 1.67, 0.98 and 1.54, 1.14 0.99% following 24, 48 and 72 hours individually. No mortality was seen in the control gathering. This is another eco-accommodating methodology for the control of Aedes-aegypti mosquito as target species. The present outcomes propose that the viable rough leaf extricates can possibly be utilized as a perfect eco-accommodating methodology for the control of mosquito vectors.

Keywords: Aedes-aegypti, Solanum nigrum, Larval mortality, Dengue vector

Full Text:

Introduction:

There are many forms of mosquito living in the tropical and sub-tropical regions of the world, we can roughly them divide into two groups Culex and Aedes, but perhaps one of the most important is Aedes-aegypti. According to the World Health Organization, the virus for Dengue fever is the most important arbovirus to man in the world, and since Aedes has been found to transmit this virus, it has been widely studied and blamed as the vector. The males of all species of mosquitoes do not bite humans or animals of any species, they live on fruit. Only the female bites for blood because she requirements to mature her eggs. The eggs of most species are laid together in a raft form, but Aedes lays her eggs separately thus allowing them to spread over large surfaces of water if conditions permit, this way the eggs stand a better chance of survival. When freshly laid the eggs are white but soon turn black in color. The young larvae feed on bacteria in the water and soon cast their skins as they rapidly grow. Here, I must point out the fact that most species lay their eggs in any type of water, mainly dirty or even polluted. Not Aedes, she only lays her eggs in clean water which contains no other living species1.

This mosquito is small in comparison to others, usually between 4-5mm in length discounting leg length. It is totally black apart from white 'spots' on the body and head regions and white rings on the legs. The thorax is decorated with a white 'Lyre' shape of which the 'chords' are two dull yellow lines (Fig 1-E). Its wings are translucent and bordered with scales2. Aedes-aegypti bites primarily during the day. This species is most active for approximately two hours after sunrise and several hours before sunset, but it can bite at night as well. This mosquito can bite people without being observed because it approaches from behind and bites on the ankles and elbows. Aedes aegypti prefers biting people but it also bites dogs and other domestic animals, mostly mammals3. To find a host, Aedes-aegypti is fascinated to chemical compounds that are discharged by mammals. These compounds include ammonia, carbonlactic acid, and octanol. Scientists at the Agricultural Research Service have studied the specific chemical structure of octenol in order to better understand why this chemical attracts the mosquito to its host4. One primary vector of yellow fever, chikungunya fever, dengue fever, dengue hemorrhagic fever (DHF) and dengue shock syndrome, is Aedes-aegypti5. However, Dengue fever has become an important public health problem as the number of reported cases continues to increase, especially with more severe forms of the disease, dengue hemorrhagic fever, and dengue shock syndrome, or with unusual manifestations such as central nervous system involvement6. Mosquito control, in view of their medical importance, assumes global importance. In the context of ever increasing trend to use more powerful synthetic insecticides to achieve immediate results in the control of mosquitoes, an alarming increase of physiological resistance in the vectors, its increased toxicity to non-target organism and high costs are noteworthy7. Most of synthetic chemicals are expensive and destructive to the environment and also toxic to humans, animals and other non-target organisms. Besides, they are no selective and harmful to other beneficial organisms. Some of the insecticides act as carcinogenic agents and are even carried through food chain which in turn affects the non-target organism. Therefore alternative vector control strategies, especially effective and low cost are extremely imperative8, 9, 10. The plant based herbal insecticides are found to more efficient, safe and best substitute for chemicalInsecticides11. Natural products of plant origin are safe to use than the synthetic insecticides12. Therefore biological and eco-friendly natural resources are broad search area for the control of vector of medical importance13. In recent years use of environment-friendly and easily biodegradable natural insecticides of plant origin has received renewed importance for disease vector control. Interest in this field has increased more so, as they are least phytotoxic and do not accumulate chemical residues in flora, fauna andsoil14. The present communication deals with the laboratory studies carried out to ascertain the larvicidal properties of different parts of Solanum nigrum (Figure 1) in Aedes-aegypti. This plant is widely distributed in the wild in many parts of India. Taxonomic position of this plant is as follows: Division – Embryophyta; Sub-division – Angiospermae; Class –Dicotyledoneae; Order – Tubeflorae; Sub-order – Solanales; Family – Solanaceae; Genera – Solanum. The local names in some important vernacular languages are: Hindi – Makoi15. S. nigrum L. subsp. Nigrum- glabrous to slightly hairy with appressed non-glandular hairs. This species is reported to have many medicinal properties and is used mainly as antidysenteric, diuretic, antipyretic, anti-in?ammatory, hepatoprotective, laxative and antispasmodic16.

Materials and Methods

Selection of Plant:

The whole plant of Solanum nigrum were collected from 2 months old mature plants growing in the Home garden of swarup nagar, Kanpur, India. The plants were identified as per method17 [S.K. Jain, A handbook of field and herbarium methods, New Delhi] and the plant was submitted to Department of Botany, D.G.P.G College, Kanpur, for taxonomic identification and confirmation of the species.

Preparation of leaf extract of Solanum nigrum:

50gm fresh leaves were washed with tap water and cleaned thoroughly with a cloth. The leaves were cut into small pieces and immediately ground using a pestle and mortar. The ground material was filtered by cloth and then passing the filtered material through What-man No. 1 filter paper and filtrate of the crude leaf extract was stored in a clean brown bottle till further use.

Preparation of berries extract of Solanum nigrum:

Collect 40gm berries, 20gm black and 20gm green colour washed with tap water and dried on a paper towel. Both berries extract was prepared separately by grinding in a mortar and pestle and ground material was filtered by cloth and then passing the filtered material through Buchner funnel (Borosil, Mumbai, India) with What-man No. 1 filter paper.

Selection of mosquito species:

The eggs of Aedes-aegypti(Fig. 1-A)were procured from stagnant water of pools with the help of hand net from an around area of civil lines, Kanpur city, UP, India.  The egg rafts of Aedes-aegypti were kept in the tray containing tap water (culture medium) and maintained at 24 ± 20C temperature,  70 ± 30C relative humidity under 14 h light (L): 10 h dark (D) photo period cycle. After 24-36 hrs of incubation, the eggs were observed to hatch out into first instar larvae. Appropriate amount of nutrient (sterilized yeast powder and dog biscuit in 1:1 ratio) were added to enhance the growth of larvae. The 4th instar larvae(Fig. 1-B) were used in the study. The treated larva was mounted on a slide and examined under a microscope (Zoomstar III, Trinocular Stereozoom microscope-Dewinter Technologies, Italy) for image capture on a Dewinter digital Microscope camera (Dewinter Technologies, Italy). All stages of Aedes-aegypti were identified and take the pictures of main characters: Larval abdomen have pitch fork shaped comb scale with distinct larger median spine(Fig. 1-C), strong black hooks on side of larval thorax (Fig. 1-D), adult- scutum black or brown with a pair of submedian-longitudinal white stripes and lyre-shaped silvery-white scales (Fig. 1-E), mesepimeron with two well separated white scale patches(Fig. 1-F), clypeus has white scales (Fig. 1-G).

img

Larvicidal bioassay

A laboratory reared colony of Aedes-aegypti larvae was used for the larvicidal activity. Each of the previously made concentration of 1,2,3,4 and 5% each crude extracts of Solanum nigrum(leaf and berries extract) was transferred into a sterilized glass beakers (250 ml capacity). Hundred larvae of 4th instar per concentration were used for all larvae experiment with 100ml of tap water (8pH, checked by indicator papers-S D fine chem. Ltd., Mumbai). Larval food (sterilized yeast powder and dog biscuit in 1:1 ratio) was added in each beaker. The treatments were replicated three times, and each replicate set contained one control. Mortalities were reported after 24hr, 48hr, and 72hr of the exposure period. Laboratory room temperature was maintained at 24-+20C during the experiment period. The dead larvae in three replicates were combined and expressed as percentage mortality for each concentration. Dead larvae were acknowledged when they failed to move after probing with a needle and brush.

Result

Larvicidal properties of extracts from different part of Solanum nigrum:

The crude extracts from different parts of Solanum nigrum were respectively prepared into five different concentrations of each part; and the mortality of the Aedes-aegypti larvae was observed. All extracts showed considerable larvicidal activity when tested against Aedes-aegypti. The effects of the leaf and berries extracts of Solanum nigrum were tested at 1,2,3,4 and 5% each extract and showed activity against the fourth instar larvae of Aedes-aegypti (Table 1). All plant extracts showed moderate larvicidal effects after 24 h; however, the highest larval mortality was found in leaf and black berries extract of 5% concentration.

Larvicidal activity of crude Leaf extracts:

The effects of the plant leaf crude extracts of

Different concentrations (1, 2, 3, 4 and 5%) were shown in Fig. 2, respectively. At concentration of 5%showed highest mortality (100%) after 48 h, followed by extract 1, 2, 3 and 4%. The LC50 values2.47, 1.67, 0.98% and LC90 values 4.15, 3.49 and 2.64% after 24, 48 and 72h, respectively.

Larvicidal activity of crude berries extracts:

The larvicidal activity of different concentrations of green and black berries extracts were shown in Fig. 3 and 4, respectively. After 24 h and concentration of 5%, black berries extracts showed 86.66 % mortality and green berries extracts showed 22.33% mortality of larvae. The LC50 value in green berries extract, 8.92, 7.47, 5.14 %, LC90 values 23.21, 26.96, 45.98% and LC50 value in black berries extract, 1.54, 1.14, 0.99%, LC90 values 11.64, 7.67, 5.61% after 24, 48 and 72h, respectively.

img

imgimg

img

Statistical analysis:

The percentage mean mortality (%) was calculated by statistic calculator and probit analysis (calculating LC50 and LC90 values) calculated by StatsDirect3 software using logit model.

Discussion

The transmission of mosquito-borne diseases can be interrupted by the potential insecticides of herbal origin at the individual as well as at the communitylevel18. Recently the natural insecticides of plant origin have been given importance due to their eco-friendly nature and biodegradability as a substitute of synthetic. Insecticides for the control of vectors of public health importance19. Many approaches have been developed to control the mosquito menace. One such approach to prevent mosquito-borne disease is by killing mosquito at the larval stage. The current mosquito control approach is based on synthetic insecticides. Even though they are effective, they created many problems, such as insecticide resistance20, pollution, and toxic side effects on humans21. The present study evaluatebio-control efficacy of crude extract of Solanum nigrum (different part) against Aedes-aegypti. Highest mortality was recorded after 24h in5% concentration of crude leaves extract against 4th instar larvae. In the present study, at a very low concentration of 1%, extract of leaves and black berries of S. nigrum resulted in 61.66and 55.66 per cent mortality of 4thinstar larvae after 72 h of exposure which indicates its bio-control potentiality.

Conclusion:

In the present study, Solanum nigrum crude extract showed larvicidal activities against mosquito probably due to the presence of active compounds such as eugenol and (E)-6-hydroxy-4,6-dimethyl-3-heptene-2-one (Kelm and Nair, 1998) which either in single form or in combination with other responsible compounds for larval death. There is no any abnormal behaviour of non-target organisms when they exposed to LC50 value so it is safe to use in natural condition. The present investigation revealed that the leaves of Solanum nigrum have a potential source of useful drugs due to the presence of phytochemicals and can be utilized in the treatment of many diseases. However further studies required to isolate the active principle from the crude extract for proper drug development.

Acknowledgements: Authors thanks Ankita Sethia, Swati Srivastava, Khushboo Arya, Dolly Chauhan, Mohit Kashyap and Anjali Katiyar for their critical inputs in this manuscript.

References:

  1. Centers for disease control. (2007). Chikungunya fever fact sheet. Division for Vector-borne infectious disease: Centers for disease control. 

  2. Roland Mortimer, Rio de Janeiro. Aedes-aegypti and Dengue fever.Onview.net Ltd, Microscopy-UK. Retrieved 2010-08-27.

  3. "Travelers' Health Outbreak Notice". Centers for Disease Control and Prevention. June 2002, 2010. Archived from the original on 26 August 2010. Retrieved 2010-08-27.

  4. Dennis O'Brien (March 9, 2010). "ARS Study Provides a Better Understanding of How Mosquitoes Find a Host". U.S. Department of Agriculture. Archived from the original on 8 October 2010.Retrieved 2010-08-27.

  5. Grantz, G.N. (1993) .What must we do to effectively control Aedes aegypti. Journal of Tropical Medicine, 35, 243-251.

  6. Pancharoen, C., Kulwichit, et al., 2002. Dengue infection: a global concern. J. Med. Assoc. Thai. 85, 25–33.

  7.  World Health Organization, 1975. Manual on Practical Entomology in Malaria Part I. Who division of malaria and other parasitic diseases, pp. 160.

  8. Piyarat, S.W.K., Freed, M., Roy, S., 1974. Biologically active plant extract for the control of mosquito larvae. Mosq. News 34, 398.

  9. Kalyanasundaram, M., Das, P.K., 1985. Larvicidal and synergistic activity of plant extracts for mosquito control. Indian J. Med. Res. 82, 19–23.

  10. Jayapal Subramaniam, Kalimuthu Kovendan, et.al.(2012). Mosquito larvicidal activity of Aloe vera (Family:Liliaceae) leaf extract and Bacillus sphaericus, against Chikungunya vector, Aedes aegypti. Saudi Journal of Biological Sciences,

  11. Ghosh A., Chowdhury N., Chandra G., 2012, Plant extracts as potential mosquito larvicide, Indian J. Med. Res, 135: 581-598.

  12. Kishore N., Mishra B.B., Tiwari V.K. and Tripathi V., 2011, A review on natural products with mosquitosidal potentials, In: Tiwari VK, editor, Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry, Kerala: Research Signpost, pp.335-65.

  13. Singha S., Adhikari U., Ghosh A., Chandra G., 2012, Mosquito larvicidal potentiality of Holoptelea integrifolia leaf extract against Japanese encephalitis vector, Culex vishuni group, Journal of Mosquito Research, 2(4): 25-31.

  14. Thomas, T. G., Sharma, S. K., Jalees, S. and Rahman, S. J., J. Basic Appl. Biomed., 1994, 2, 53–55.)

  15. Chopra, R. N., Nayar, S. L. and Chopra, I. C., Glossary of Indian Medicinal Plants, PID, New Delhi, 1956, p. 229.

  16. Jain, R, Sharma, A, Gupta, S, Sarethy, I.P., Gabrani, R., "Solanum nigrum: current perspectives on therapeutic properties." Altern Med Rev. 2011 Mar;16(1):78-85. 

  17. S.K. Jain and R.R Rao, A handbook of field and herbarium methods, (New Delhi: Today and Tomorrow Printers and Publishers-1976).

  18. Campbell F.L., Sullivan W.W. and Smith L.N., 1993, The relative toxicity of nicotine, nabasine, methylanaba sine and lupinine for Culicine mosquito larvae, J. Econo. Entomol., 26: 505-509.

  19. Mousumi Kundu ; Anjali Rawani ; Goutam Chandra 2013, Evaluation of Mosquito Larvicidal Activities of Seed Coat Extract of Cassia sophera L. Journal of Mosquito Research, Vol.3, No.11, 76-81.

  20. Liu H., Xu Q., Zhang L., Liu N., 2005 -Chlorpyrifos resistance in Mosquito Culex aegypti and Culex pipiens pallens.  - J.Med. Ent. 42: 815-820.

  21. Lixin S., Huiquin D., Chongxia G., et al., 2006 Larvicidal activity of extracts of Ginko biloba Exocarp for three different strains of Culex pipiens pallens. - J.Med. Ent. 43: 258-261.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2022 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions


Fatal error: Uncaught Error: Function name must be a string in /home/u845032518/domains/ijcrr.com/public_html/footer-bottom.php:487 Stack trace: #0 /home/u845032518/domains/ijcrr.com/public_html/article_html.php(51): include() #1 {main} thrown in /home/u845032518/domains/ijcrr.com/public_html/footer-bottom.php on line 487