International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 4(15), August, 2012

Pages: 37-42

Date of Publication: 15-Aug-2012


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UTERINE RUPTURE: 5 YEAR STUDY IN A TERTIARY CARE HOSPITAL OF WESTERN RAJASTHAN, INDIA

Author: Savitri Sharma, Ashok Sharma, Annapurna Mathur, MadhuSudan Swarnkar, D. S.Khangarot

Category: Healthcare

Abstract:Objective: To determine the frequency, predisposing, factors, maternal and fetal outcome in Uterine Rupture. Methods: This is a descriptive case series including all cases of uterine rupture who were either admitted with this complication or who developed it in the hospital were included in the study .Patients, who had rupture due to congenital abnormality were excluded from this study .Demographic data ,details of predisposing factors ,types of rupture ,the management ,maternal and fetal outcome were taken into consideration for analysis. Results: The total numbers of deliveries from Jan 2007 to Jan 2012 were28076.There were 22 cases of uterine rupture .Out of them most of the cases (55%) presented between age of 21 to 25 years. Majority of cases (54.54%) of uterine rupture occurred in 1 Para. All the cases were unbooked All cases had complete tear of anterior, lower part of uterus. Common cause (54.54%) of uterine rupture was previous caesarean section, second common because (22.72%) was prolonged obstructed labour .Sub total hysterectomy was performed in45 % cases and only repair was the management in remaining 55% cases. There was no maternal death in this study .live birth rate was 41%. There was still birth in 11(50%) and intra uterine death occurred 2(9%).3 cases had associated bladder injury with uterine rupture. Conclusion: This study showed that main cause of uterine rupture was previous caesarean section, followed by prolonged obstructed labour. Proper antenatal care and update training programme for health care providers is the need of time to prevent the catastrophic but avoidable complications.

Keywords: Uterine rupture, Caesarean section, Maternal and fetal outcome.

Full Text:

INTRODUCTION
Rupture of the gravid uterus is a grave obstetric complication. It is associated with high maternal and prenatal mortality rates. Even where the patient survives, their reproductive function is abruptly terminated, and recovery is often prolonged and turbulent1,2.Uterine rupture related with some instant hitches, such as shock, anaemia and a rupture of urinary bladder, may leave surviving patients with term complications like vesicovaginal fistula and inability to deliver children3 . The prevalence was found significantly high in underdeveloped countries of Asia and Africa in comparison to high income countries 4,5 . The incidence of uterine rupture has dropped significantly in developed countries and is most often encountered while attempting vaginal birth after caesarean section.6 The risk of experiencing uterine rupture during child birth is 50 times higher if the mother already had a caesarean 

section.6 Most cases of uterine rupture that occur in developing countries are due to ignorance, quackery, and maladministration or nonavailability of essential medical supplies. Causes of uterine rupture are: grand multiparity, injudicious use of oxytocin particularly when it is not medically indicated and administered, neglected labour, previous caesarean section and myomectomy, uterine instrumentation and manipulation, labour induction, congenital abnormalities of uterus and uterine distension due to polyhydroamnios, multiple pregnancy and foetal macrosomia. The sign and symptoms of uterine rupture largely depend on timing, site and extent of uterine defect, severe haemorrhage, palpable fetal parts, recession of presenting foetal parts, loss of uterine contractility, rarely blood stained urine, appearance of placenta at vulva and prolapsed loops of gut into vagina.7. Hysterectomy is considered the treatment of choice in patients with intractable haemorrhage or when uterine rupture sites are multiple. Repair of ruptured uterus with or without tubal ligation is done in young and stable patient. Repeat caesarean section is done at 36 weeks of gestation in patients with previous uterine repair 8,9 . This study was done with the view that there is paucity of studies related to uterine rupture in Rajasthan even in India.

MATERIAL AND METHOD
This is retrospective hospital based observational study and it was conducted from January 2007 to Jan 2012 at Heera kunwar Ba zanana Hospital Jhalawar which is a tertiary care hospital of Jhalawar Medical College and having 500 bed capacity in General including 150 beds in Zanana hospital. Two units are regularly being run in this institution in Obstetrics and Gynae department. The data collected from the maternity ward and operation theatre registers as well as from the patient‘s case file at the Hospital Medical Record office. 22 cases of uterine rupture were recorded in this period. Various parameters studied were age, parity, distance travelled by patients, maternal and fetal outcome, operative procedure done, blood transfusion and study of immediate complications. History of Previous caesarean section, other uterine surgery, and causes of prolonged labour were recorded. Management was done in the form of sub total hysterectomy, repair of ruptured uterus or bladder with or without tubal ligation. Maternal outcome in the form of recovery, death, also perinatal deaths were recorded and data analyzed. Most cases were referred from periphery and a few suffered uterine rupture in the hospital. Delay in starting definite treatment was found due to long distances travelled by patients from her place to the hospital.

RESULTS
From January 2007 to January 2012, 28076 deliveries conducted and 22 cases of uterine rupture were recorded. The overall incidence rate found 0.0783% or 1 in 1276 deliveries. The age of patients varied between 20 years to 40 years. The highest incidence(55%) of rupture seen in the age group of 21-25 years and 7cases (32%) from 26-30 years, 2 cases(9%) belonged to age group 31-35 years while lowest incidence was observed in 36 - 40 years. In 12(54.45) cases making majority, cause of rupture was previous caesarean section scar ,while second cause noted was obstructed labour 5(9%) ,third important cause came out as manipulation( internal podalic version) in 2 cases. One case refused for caesarean section and was given trial resulted in rupture uterus. Also there were two cases with IUD in which trial was given and uterine rupture occurred. Most of the patients (77%) travelled more then 30 to 45 Kilometers from periphery to hospital and had ruptured uterus at home or with traditional birth attendants or at the level of primary health centre while remaining patients (23%) suffered rupture uterus during management in hospital.

In this study it was observed that highest(59%) cases of rupture occurred in women having one parity, 2 cases (9%) were seen in 2 parity females, 3 cases(14%) of rupture occurred in 3 para ladies while only 3 (14%)cases were seen in 4 or more than 4 para. One case of rupture was seen in nuliparous woman. An analysis regarding fetal outcome revealed that in 41% (9 cases)females delivered live babies, while in 50% (11 cases) there was still birth delivery, 2 cases(9%) suffered from intra uterine death. Regarding maternal mortality no death was seen during management because of rupture uterus. Surgical management was the only choice for saving life of mothers. 10 cases (45%) were managed by subtotal hysterectomy, while a quite good number of cases 12(55%) were treated by repairing uterus for preserving reproductive function. A single case was managed by repair with tubal ligation.

 

DISCUSSION
Uterine Rupture is one of most dangerous obstetric situation carrying an increased risk of maternal and perinatal morbidity and mortality, which is associated with poorly managed labour10, 11 . The incidence of ruptured uterus (1:1276 deliveries) in this series is lower than 1:167 and 1:110 reported earlier in Nigeria 12 and Ethiopia 13 , respectively, but higher than 1:6331 deliveries reported by chen et al from Singapore 14 . 77% cases were reached this institute either from home directly or from peripheral health institutions. This reflects that these patients try to deliver at home by traditional birth attendants or at remote health centers by health service providers. The majority of patients in this series did receive care neither in antenatal period and/or nor in intrapartum period at primary health care centers. In spite of recognizable risk factors present in almost all of them in the antenatal period, they continued to be dependent either on traditional birth attendants or they remain quite unattended and proceeded to labour. All had prolonged labour and yet this was either not recognized or recognized and managed erroneously by the administration of enormous doses of oxytocin intramuscular which was noticed as a trend adopted by traditional birth attendants and even by trained ANMs (Auxiliary Nurse Midwife) in this area. As 12 cases of uterine rupture had history of previous LSCS cases. If these cases could have been attended at community health centre level equipped with blood bank and if Gynaecologist or Surgeons have attended it there it self providing surgical facility number of still born/IUDs could have been less. In 5 cases (22.72%) prolonged and obstructed labour was the cause for uterine rupture due to injudicious use of oxytocin and delay in transport of patients to tertiary care centre. The injudicious use of oxytocin was found to be a significant predisposing factor in this series unlike reports by Konje et al 12 but similar to reports by chen et al 14, Chen and Hsieh 15 . Majority (54.54%) of patients in this study had a rupture of scarred uterus, similar to a report from Singapore by chen et al 13 in which over two-third of cases occurred in women with scarred uterus.In a retrospective review of 93 cases,P.Veena et al found that maximum number of uterine rupture occurred in younger age group (20-30 years) and 77% cases in her series had previous caesarean section depicting strong association of uterine rupture with previous scarred uterus .These observations match with our study 16 . In our study 2 cases of previous LSCS had uterine rupture during trial for vaginal delivery. In these two case one patient refused for LSCS and in another trial was given under supervision both suffered uterine rupture. In 2 cases internal podalic version for vaginal delivery was the cause for uterine rupture. This calls for caution, especially when some of these patients were subjected to induction or augmentation of labour 14,2. In a trial of labour in patients with scarred uterus, It is important that health workers supervise the labour closely and exercise caution before considering augmentation of the labour 2 . Refusal for LSCS in 1 case with one previous LSCS and other multi gravid with cephalo pelvic disproportion shows that in Indian society still there is big craze for vaginal delivery even when patient was in high risk, constituting cause for uterine rupture. Most patients (45%) had sub total hysterectomy done while 55% had repaired (bilateral tubal ligation in one case). Therefore 45% of patients lost their reproductive and /or menstrual function. The rest could have reproductive and or/ menstrual function maintained. They could only reproduce at risk. Ruptured uterus therefore has grave sociocultural implications, especially in a society where these functions are considered the very essence of womanhood.

In our study there was no maternal mortality, all women with uterine rupture recovered fully and discharged which was due to the fact that they were timely attended and treated as soon as they reached hospital. Also This could happen because of good support from blood bank as in majority of cases 3 or more than 3 units of blood was transfused with no delay. One more reason for better survival in this study appears to be related with the incidence of uterine rupture in younger age group i.e. 21 to30 years (total 87%) who sustained haemorrhagic shock and surgical trauma efficiently. In this study live birth rate was 41% which was higher than that seen in other study (31%) 16 .But a number of still birth 50% is quite worrying in this study which calls for attention.

CONCLUSION
Ruptures uterus is only one of the many preventable obstetric problems with grave consequences. Ruptured uterus remains a problem in our set up, with primary health centers and deliveries by traditional birth attendant being identified as major contributors to this condition. They primarily fail in the reorganization of abnormalities in the antepartum and /or intrapartum periods, with delays in referral and injudicious use of oxytocin. We recommend prohibition of the unsafe prescription of oxytocin. This is presently an over -the -counter drug and has been shown in this study, a dangerous drug in the hands of the unskilled. Health education of women in the reproductive age is also required. We recommend utilizing pyramidal health structure that is primary health centers would be directly responsible to secondary health centers, which in turn would be directly responsible to tertiary health centers. Also there is need that referral health centers at subdivision, tehsil levels need to be well equipped with blood banks and availability of operating surgeon/gynaecologist so patient in such a grave situation may not have to rush for more then 35 Km distance to avail facility at district level/tertiary level centers as happened with them in this series of study, because it puts detrimental effects on maternal as well as foetal outcome in this rural population dominated country.

References:

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2. Prasad RN, Rantan SS. Uterine rupture after induction of labour for intrauterine death using the prostaglandin E2 analogue sulprostone Aus N Z J Obstet Gynaecol 1992:32:282-3.

3. Philpott RH- obstructed labour. Clin obstet Gynaecol 1982; 625-40.

4. Saglamtas M, Vicdan K, Yalcin H,et al.- Rupture of the uterus.Int J Gynaecol Obstet 1995;49:9-15.

5. Lema VM, Ojwang SB, Wanajala SHRupture of the gravid uterus: a review: East Afr Med J 1991;68:430-41

6. Rashmi, Kirshan, Vaid NB – Rupture uterus changing Indian scenario. J Indian Med Assoc 2001; 99:634-7.

7. Khanum Z, Lodhis K-emergency Obstetric Hysterectomy;a lifesaving procedure.Ann King Edvard Medical College 2004; 10:292- 4

8. Bashir A-maternal Mortality in Faisalabad city-A longitudinal study.The Gynaecologist 1993; 3:14-20

9. Lim AC,Kwee A ,Bruinse HW-Pregnancy after uterine rupture:A report of 5 cases and review of theliterature,Obstet Gynaecol Surv 2005;90;16-37

10. Kwast BE, Liff JM-Factors associated with maternal mortality in Addis Ababa, Ethiopia .Int J Epidemiol 1988; 17:115-21

11. Kadowa I- Ruptured uterus in rural Uganda;prevalence,predisposing factors and outcomes.Singapore Med J 2010;51:35-38.

12. Konje JC Odukya OA. Ladipo OA. Ruptured uterus in Ibadan- A twelve-year review Int J Gynecol Obstet 1990:32:207-13.

13. Gessessew A, Melese M. Ruptred uterus – eight year restrospective analysis of causes and management outcome in Adigrat Hospital.Tigray region. Ethiop J Health Dev 2002:16-241-5.

14. Chen LH, Tan KH. Yeo GS. A ten years review of uterine rupture in modern obstetric practice. Anm Acad Med J Singapore 1995:24:830-5.

15. Chen KC, Hsieh TT. Rupture of grand uterus: an eight-year clinical analysis and review of literature .Chang Keng I Hsueh- Chang Keng I Hsueh-Chang Gung Med J 1992; 15:15-22.

16. P.Veena, S Habeebullah, and L.ChaturvedulaA review of 93 cases of ruptured uterus over a period of 2 years in a Tertiary Care Hospital in South India; April 2012: Vol 32- No 3; pages 260-263

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
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A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
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A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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