International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 9(20), October, 2017

Pages: 01-04

Print Article   Download XML  Download PDF

A Brief Review on Medicinal Plants from South India, Endophytes and their Antidiabetic Properties

Author: Aditi Makarand Ranade, Arjun Vignesh, Gayathri M.

Category: General Sciences

Abstract:This paper seeks to review the potential treatment of diabetes with a focus on novel therapeutic effects produced by endophytic fungi that are associated with certain plants. Diabetes is a growing concern among the Indian population, and as a result, there has been an increasing amount of research done to discover new drugs and remedies. South India, with its unique geographical terrain is conducive for the growth of several indigenous plants that have medicinal properties. These plants are known to also be associated with some fungal strains that have metabolites with potentially anti-diabetic properties. This review looks at such plants, and how best to grow endophytic fungi accordingly.

Keywords: Diabetes mellitus, Endophytic fungi, Medicinal plants, South India

Full Text:

INTRODUCTION

There is currently a growing need for compounds of high potency and low toxicity with therapeutic properties for various medicinal applications. This, along with the search for microbial drug resistance has led to great interest in the research of endophytic fungi. Endophytes collectively refer to those fungi and certain bacterial strains exhibiting a mutualistic relationship with a host organism, thereby preventing the entry of a variety of pathogens into the host. As a result of years of co-evolution coupled with some degree of genetic recombination, endophytic fungi possess biosynthetic capabilities greater than that of the host organism.(1) This manifests as them being a source of novel organic compounds with unique biological activities- including anitbiotics, antimycotics, immunosuppresants, anticancer and antidiabetic ones.

 

Endophytes -

Endophytes describe those microorganisms which inhabit healthy tissues of living plants, but do not result in any apparent symptoms of diseases. They are found loaded in some part or the other of every plant. Studies have shown that there exists a balance between the host’s defence mechanism and the virulent nature of the endophyte. Although they usually do not cause any disease, if there is any disturbance in this balance, a disease condition can develop.(2) Endophytes often produce various metabolites, and the properties of these metabolites vary according to the source. Secondary metabolites produced by the endophytes are similar to those produced by the host, as a consequence of genetic exchange.

 

Diabetes Mellitus: Type II Diabetes -

Diabetes mellitus is a group of metabolic disorders that is most commonly associated with one common manifestation in the form of hyperglycaemia- a condition in which there is excessive amounts of glucose circulating in the blood plasma. Chronic hyperglycaemia may damage the eyes, kidneys, nerves, heart and blood vessels.(3) An inherited or acquired deficiency of insulin produced by the pancreas, or the ineffectiveness of the insulin which is produced causes this condition.

The WHO has recently released records of 30 million people who were diagnosed with diabetes in 1985. Since then, the number has increased to more than 171 million in 2000. It is estimated that over 367 million people will suffer from diabetes by the year 2030.(4) Highest incidences of diabetes are predicted to take place in developing countries, between the age groups of 45 and 65.

 

Traditional treatment for Diabetes Mellitus -

There is a lot of ongoing research to determine methods of chemical treatment and discovering biological drugs in order to treat this condition. Traditionally, metabolites from plants have been used to treat many disorders. India is famous for Ayurveda- a system that stresses the use of plant based herbs and pastes to help cure disorders that are common, helping people maintain a healthy lifestyle.(5)

Technology and an increasing pool of knowledge have led to research being carried out into potential use of drugs from plants.(6) Indian tribes have used various plant species specifically to treat diabetes, as detailed in the literature on traditional phytotherapy of Indian Medicinal Plants. These include- Asparagus racemosus, Butea monosperma, Cathanranthus roseus, Coccinia indica, Gymnema sylvestre, Syzygium cumini and Momordica charantia. They are also currently being used in modern medicine.(7)

Endophytes from potential medicinal plants are subject to bioprospecting during isolation as the choice of the plant is important. Metabolites which are produced and screened are usually composed of compounds such as steroids, quinones, coumarins and phenols. Since the early ages, substances that have been harvested from plants have aided towards the treatment of various bacterial and viral infections. With the advent of more research, there is an increasing focus on the endophytes associated the plants as opposed to the plant itself. Medicinal plants are used by 80% of the world to help cure diseases.(8)

Ancient Indian literature such as the Ayurveda has a mention of medicinal plants that possess endophytesto treat various ailments. A few plants that have been specifically reviewed for possessing anti-diabetic activity include Allium sativum, Allium cepa, Aloe vera, Cajanus cajan, Coccinia indica, Caesalpinia bonducella, Ficus bengalenesis, Gymnema sylvestre, Momordica charantia, Ocimum sanctum, Pterocarpus marsupium, Syzigium cumini, Swertia chirayita, Tinospora cordifolia and Trigonella foenum graecum.(5) Apart from these, there are about 400 species that have been identified to possess anti- diabetic effects. These plants have antihyperglycemic effects that can help control diabetes mellitus. These effects are due to their ability to alter pancreatic tissue function. This is achieved by either decreasing the absorption of glucose in the intestine or increasing the insulin output or by even facilitating metabolites in processes that heavily depend on insulin.(9)

Novel bioactive compounds extracted from these plants have hypoglycemic effects that are equal to the known oral agents that are used presently. These plants can be further exploited for endophytes and these endophytes can then be tested for production of substances with hypoglycemic activity.(10)

 

South Indian plants with anti-diabetic properties -

Annona squamosa Linn. (Annonaceae), is a plant grown throughout India, and is known as Custard Apple more commonly. The active pharmacological components can be found in the seeds and leaves of the plants. They show both hypoglemic and antidiabetic properties, by increasing the level of insulin from the pancreatic islets. This result in more glucose being utilized in the muscle and output of glucose from the liver being inhibited. Leaves are additionally used to maintain cholesterol levels. Extracts from this plant have a high margin of safety.(11)

Bougainvillea spectabilis Linn. (Nyctaginaceae), is a widely used ornamental plant in India. It traditionally has shown to possess antidiabetic activity, with a potential to lower the blood glucose level. The effect has been reported on streptozotocin-induced type 1 diabetic albino rats.(12) An ethanolic extract of the leaf increases glucose uptake by enhancing the glycogenesis process in the liver as well as the insulin sensitivity. This is an example of antihyperglycemic activity.

Casearia esculenta Roxb. (Flacourtiaceae), is a shrub in South India more widely known as wild cowrie fruit. The root extract of this plant has shown to lower blood sugar levels by influencing metabolism of certain proteins as well as important enzymes. C. esculenta root extract has the hypoglycemic and antihyperglycemic effect. However, it may elevate liver and renal damage.(13)

Cassia kleinii (Caesalpiniaceae), is used by the common folk as a remedy, as well as by some medical practitioners. Phytomedicines have been shown to develop from this plant, as they show antihyperglycemic activity on the glucose feed. It has use in insulin dependent diabetes, while the action that the drug does is similar to that of insulin on glucose metabolism.

Terminalia catappa Linn. (Combretaceae), is the Indian almond plant and is found growing in warmer parts of India. The fruit of this plant with petroleum ether and a methanolic extract has an effect on blood glucose levels. The plant acts via β-cells regeneration. The effect may be due to β-carotine in preventing complications such as glycosylation in diabetic rats.(14)

 

 

Plant Name

Common name/ Herbal Formulation

Anti-Diabetic and other beneficial effects

Annona squamosal

Sugar apple

Ethanolic leaf extract has antihyperglycemic effect

Artemesia pallens

Davana

Reabsorption of glucose is inhibited

Areca catechu

Supari

Utilization of peripheral glucose increases

Beta vulgaris

Chukkandar

Enhances glucose tolerance

Boerhavia diffusa

Punarnava

Antioxidant, plasma insulin level increases, activity of hexokinase increases

Bombax ceiba

Semul

Hypoglycemic

Camellia sinensis

Tea

Antioxidant and antihyperglycemic

Capparis decidua

Pinju

Hypolipidemic, antioxidant and hypoglycemic

Coccinia indica

Bimb or Kanturi

Hypoglycemic and insulin secretogogue

Emblica

Amla

Hypoglycemic and decreases lipid peroxidation

Ficus bengalensis

Bur

Hypoglycemic

Gymnema sylvestre

Gudmar or Merasingi

Antihyperglycemic and hypolipidemic

Hemidesmus indicus

Anantamul

Anti-snake venom activity and anti-inflammatory

Hibiscus rosa-sinesis

Gudhal or Jasson

Triggers insulin release from pancreatic beta cells

Ipomoea batata

Sakkargand

Insulin resistance is decreased

Momordica cymbalaria

Kadavanchi

Hypoglycemic

Murraya koenigii

Curry patta

Enhances glycogenesis and inhibits gluconeogenesis

Musa sapientum

Banana

Antihyperglycemic, antioxidant

Phaseolus vulgaris

White kidney bean

Inhibits alpha amylase activity

Punica granatum

Anar

Antihyerglycemic

Salacia reticulata

Vairi

Alpha glucosidase inhibitor

 

Table 1: List of notable South Indian plants and their anti-diabetic properties.(7)

Optimization of growth of endophytic fungi -

If we wish to investigate the endophytic fungi and their benefits, it is important to cultivate them under the appropriate laboratory conditions. In this regard, isolation is the first step.(15,16) Surface sterilization followed by crushing plant tissues and plating on to a nutrient medium is a commonly used protocol. Sodium hypochlorite, Hydrogen peroxide and ethanol have all been used for this purpose. The plant tissues are usually submersed into sodium hypochlorite and then rinsed with distilled water. If done well, there will be high amounts of growth as there is no damage to the endophytic colonies from sterilization. An efficient surface sterilization results in high amounts of endophytic growth on agar plates which indicates that there is no damage from the sterilization to the endophytic population.

Next, the choice of nutrient medium also could influence the efficiency of the isolation process. For endophytes, there are two types of media used most commonly- one that is complex and rich containing high amounts of undetermined nutrients and another that is minimal, containing much lesser but precise amounts of nutrients. The number of colonies as well as the diversity of endophytes grown is determined by the choice of nutrient media.(17) Studies show that less than 1% of the endophytes are usually cultivable, and some that are grown initially cannot be recultivated later. This is mostly because residual compounds and metabolites specific to certain plants are not present at all stages. Tissues contain some compounds that are not present in the media for growth, but are nonetheless important for their growth.

Both types of media contain elements that are vital for non-selective growth of endophytes. Complex media contains water, carbon sources, salts and a source of amino acids from fungal, plant or animal origin (yeast extract, tryptone, peptone, etc). These are undefined because the composition of the source of the amino acid is unknown. These media are called undefined because the exact composition of the amino acid source is not known.(18) Trypticase Soy Agar (TSA) and Caesin Starch are examples. They have high quantities of nutrients, and hence many dominant strains grow fast and grow over those strains that take longer. Minimal media however provides a precise amount of nutrients leading to selective growth. This mimics the actual conditions of the plant and as a result, might allow the endophytes to adapt easier.(19)

As a gelling agent, Agar is commonly used. However, it might be the case that some fungal strains are unable to grow. To overcome this, gellan gum has been used, as it is a bacterial polysaccharide that is used for human tissue culture. This is produced by Sphingomonas sp. Literature reviews have shown a higher amount of endophytic growth on complex media.(20)

 

DISCUSSION

While there have been several attempts to come up with commercially viable drugs and methods of treatment for diabetes, each of them come with their own set of hurdles and challenges. However, the use of endophytes from natural plant sources as prospective anti-diabetic agents confers various advantages that are otherwise lacking in our conventional approaches to treating the disease. South India’s ambient geographic conditions, both in terms of weather as well as terrain, make it conducive for the growth of innumerable varieties of plants, and as a result- an even larger number of endophytes associated with them. It is imperative that our research focus shifts to the use of these plant sources, as it may be possible to scale up their pharmaceutical activity as anti-diabetic agents into sustainable drugs by optimizing the conditions for their growth, cultivation and isolation.

 

CONCLUSION

A lot of medicinal plants have been under research for treatment of various disorders, be it common flu, HIV or diabetes. But due to the risk of increasing microbial resistance to the already existing drugs, there has been shift from plant metabolites to endophytic metabolites for treatment of different kinds of disorders. The easy availability of endophytes throughout the plant is a major advantage. Extraction and isolation of specific endophytes thus becomes a relatively simple process. Another important thing to note is the relation between the source of the endophyte and endophyte itself. The plants that are known to have specific pharmaceutical importance will definitely possess endophytes with similar properties. Therefore, the main area of focus is the endophytes collected from medicinal plants known to possess anti-diabetic properties. South India is a rich source of medicinal plants and there have been various literatures and manuscripts that talk about the same.

ACKNOWLEDGEMENT

Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

 

SOURCE OF FUNDING

This review article has been prepared without funding and as independent study under the guidance of Dr. Gayathri M.

 

CONFLICT OF INTEREST

The authors express no conflict of interest.

 

ABBREVIATIONS USED

WHO: World Health Organization.

HIV: Human Immunodeficiency Virus.

 

 

 

References:

REFERENCES

1. Mujesh R, Namita P. Medicinal Plants with Antidiabetic Potential - A Review. Am J Agric Environ Sci. 2013;13(1):81-94.

2. Divya VC, Sathasivasubramanian S. Submandibular sialolithiasis - A report of two cases. Biomed. 2013;33(2):279-83.

3. Dey A. Alstonia scholaris R.Br. (Apocynaceae): Phytochemistry and pharmacology: A concise review. J Appl Pharm Sci. 2011;1(6):51-7.

4. Publishers BS. Current Medicinal Chemistry. Curr Med Chem. 2010;14(15):2011.

5. Eldeen IMS, Effendy MAW. Antimicrobial agents from mangrove plants and their endophytes. 2013;872-82.

6. a JB, V RR, Samaga P V. Evaluation of the antimicrobial activity of three medicinal plants of South India. 2011;7(1):14-8.

7. Modak M, Dixit P, Londhe J, Ghaskadbi S, Paul a DT. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007;40(3):163-73.

8. Chitravadivu C, Manian S, Kalaichelvi K. Qualitative analysis of selected medicinal plants, Tamilnadu, India. Middle-East J Sci Res. 2009;4(3):144-6.

9. Rai MK. A review on some antidiabetic plants of India. Anc Sci Life. 1995;14(3):168-80.

10. Mary Shoba Das C, Gayathri Devi S. In vitro glucose binding activity of Terminalia bellirica. Asian J Pharm Clin Res. 2015;8(2):320-3.

11. Miller KI, Qing C, Sze DMY, Roufogalis BD, Neilan BA. Culturable Endophytes of Medicinal Plants and the Genetic Basis for Their Bioactivity. Microb Ecol. 2012;64(2):431-49.

12. Kaul S, Gupta S, Ahmed M, Dhar MK. Endophytic fungi from medicinal plants: A treasure hunt for bioactive metabolites. Phytochem Rev. 2012;11(4):487-505.

13. Sharma D, Pramanik A, Agrawal PK. Evaluation of bioactive secondary metabolites from endophytic fungus Pestalotiopsis neglecta BAB-5510 isolated from leaves of Cupressus torulosa D.Don. 3 Biotech. Springer Berlin Heidelberg; 2016;6(2):1-14.

14. Wang J, Quan C, Wang X, Zhao P, Fan S. Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. Microb Biotechnol. 2011;4(4):479-90.

15. Jalgaonwala RE, Mohite B V, Mahajan RT. Evaluation of Endophytes for their Antimicrobial activity from Indigenous Medicinal Plants belonging to North Maharashtra region India. Int J Pharm Biomed Res. 2010;1(5):136-41.

16. Tan RX, Zou WX. Endophytes: a rich source of functional metabolites. Nat Prod Rep. 2001;18(March):448-59.

17. Isolation and Identification of Endophytic Fungi in Trigonella foenum-graceum L . and their Antibacterial Activity. 2016;(9):516-21.

18. Value SJRI, Roy S, Majumdar P. Available online http://www.ijddr.in Covered in Official Product of Elsevier , The Netherlands Hydro-Gel Swelling Study and Modelling Full Length Research Manuscript Full Length Research Manuscript. Int J Drug Dev Res. 2013;5(2):145-50.

19. Sandhya B, Thomas S, Isabel W, Shenbagarathai R. Ethnomedical plants used by the Valaiyan community of Piranmalai Hills (reserved forest), Tamilnadu, India - A pilot study. African J Tradit Complement Altern Med. 2006;3(1):101-14.

20. Ayyanar M, Sankarasivaraman K, Ignacimuthu S. Traditional Herbal Medicines Used for the Treatment of Diabetes among Two Major Tribal Groups in South Tamil Nadu , India. Ethonobotanical Leafl. 2008;12:276-80.

 

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions