International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 08 Issue 13, July, 2016

Pages: 17-23

Date of Publication: 12-Jul-2016


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ASSOCIATION OF SERUM MAGNESIUM WITH GLYCEMIC CONTROL AND INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Author: A. Velayutharaj, R. Saraswathi, R. Shivakumar, S. Saha, G. Niranjan, R. Ramesh, AR. Sreenivasan

Category: Healthcare

Abstract:Background - Context: Magnesium is an essential intracellular cation involved in many carbohydrate oxidation enzyme reactions and in glucose transporting mechanisms besides its involvement in insulin secretion, binding and activity. Body concentrations of Mg++ lowered by poor glycemic control and may predispose for diabetic complications.
Objective: To compare the levels of serum magnesium in type 2 diabetes patients with glycemic control, insulin resistance and lipid profile.
Design, setting and patients: 90 type 2 Diabetes patients who are undergoing treatment protocol were followed by a tertiary care hospital and the correlation of serum magnesium levels assessed against indicators of glycemic control and insulin resistance.
Main outcome: Since hypomagnesemia is a prime risk factor for the development of micro and macro vascular complications, this study was undertaken to find out the association, if any, between hypomagnesemia, glycemic control, lipid profile and insulin resistance.
The results: A plasma Magnesium concentration of 40 (out of 90) type 2 diabetes patients in our study were below the reference range (mean 1.4\?0.22 mg %). In patients with hypomagnesemia, the mean Glycated hemoglobin was 9.1\?1.4%, which was 130% higher than the mean Glycated hemoglobin value in normomagnesemic patients (6.98\?1%) and found significant inverse correlationship between GlycatedHb levels and Serum Magnesium levels at a value of -0.713 with a p value less than 0.01 and also showed significant correlationship with HOM Air values, Fasting blood glucose, and HDL-C levels and TAG levels.
Conclusions: There was a high prevalence of hypomagnesemia in patients with T2DM reduces insulin sensitivity and may increase the risk of secondary complications. And there was a direct correlation between HDL-C and Magnesium levels; hence it is advisable to periodically monitor plasma Mg++ concentrations in diabetic patients, especially those with other risk factors such as alcoholism, familial history of CVD, etc. to reduce future complications.

Keywords: Serum magnesium, Insulin resistance, Glucose transporting mechanism, International diabetes association

Full Text:

INTRODUCTION
Diabetes mellitus (DM) is one among the major endocrine disorders that affects South Asians in general and Indians in particular because of the sedentary lifestyle, socio -economic status, ethnicity and the acquired changes in food habits of the Indians. Magnesium is the fourth most abundant cation in the body and plays an important physiological role as a cofactor in various enzymatic reactions involving energy metabolism includes carbohydrate oxidation , glucose transporting mechanism of the cell membrane and also involved in insulin secretion, binding, and activity. Chronic magnesium deficiency has been associated with the development of insulin resistance 1 Homeostatic model assessment for insulin resistance (HOMA-IR) may constitute a useful method for diagnosing insulin resistance as well as to aid the follow-up during the treatment of patients with T2DM and as an indicator of insulin resistance in diabetic patients has been the focus of attention in recent years2 . Glycosylated hemoglobin (HbA1c) measurements are the standard criteria for monitoring longterm glycemic control and reflect control for the previous 3 months. The American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD), and the International Diabetes Association (IDF) recommend the use of HbA1c assay in the diagnosis of T1DM and T2DM 3 . Hitherto, very few reports are available from South India and more specifically in the region of Trichirapalli, Tamilnadu implicating magnesium levels (in serum) glycemic control, lipid profile and insulin resistance hence we conducted this study. Aim and Objectives: The study aims to estimate the levels of magnesium in serum in patients with type 2 DM and find out any correlation, if any, between magnesium levels in serum, glycemic control and Insulin resistance and lipid profile. Materials and Methods: Patients with Type 2 DM were the subjects for the study. A detailed history of the patient was taken and the duration of the disorder documented. Co morbid status and complications of Type 2 DM were also noted. The patients were divided into three groups based on their glycemic control (Glycated hemoglobin), viz., good control, fair control and poor control (n=30 each). Total number of Cases (n) = 90. After informed consent blood sample for fasting plasma glucose (FPG) and insulin (FPI) serum magnesium, lipid profile and HbA1c (EDTA sample). Biochemical parameters are analyzed in BS380 auto analyzer and HbA1c analyzed by NGSP approved method. HOMA-IR calculated by = Fasting plasma glucose (mmol/l) x Fasting plasma insulin (mlU/l) / 22.5. Inclusion criteria: 90 diabetic patients (Type 2) in three groups (n=30 each) undergoing rationale drug therapy as per the established protocol followed in a tertiary care hospital diabetic clinic. Exclusion criteria: Type 1 DM , gestational Diabetes, specific types of diabetes , patients receiving magnesium therapy, diagnosed cases of osteomalacia, patients who are on diuretic therapy, chronic alcoholics and patients with clinically diagnosed / known micro or macrovascular complications . Results: Basic demographics - The present study included 90 patients, 60 males (66.7%) and 30 females (33.3%). The mean patient’s age was 50 years. The youngest patient was 28 years old and the oldest, 82 years old (Fig.1). The sample population had normal distribution of ages.

The normal serum magnesium level was considered to be between 1.7 to 2.7 mg/dl. Serum magnesium levels below 1.7 mg/dl were considered to be hypomagnesemia. In the present study, hypomagnesemia was detected in 40 patients out of 90 (44.4%) which is consistent with earlier reports of the prevalence of hypomagnesemia in diabetic patients (Fig.2). Pham et al had reported hypomagnesemia in 47.7% of non-hospitalized patients with diabetes mellitus4 . Most other studies had reported anywhere from 22 to as high as 43% prevalence.

We subjected the data obtained from our study to a vigorous .spearson correlation analysis using SPSS version 19 (IBM, Chicago, 2010) and found significant and very significant correlations between serum magnesium and other studied parameters. A p Value of less than 0.05 is considered significant and P values less than 0.01 were considered very significant. The low serum magnesium value recorded was 0.9 mg%, while the highest value was 2.40 mg%. The mean serum Mg++ value obtained was 1.77 (±0.38) mg%. Frequency of serum magnesium levels with gender (Fig.3). Glycated Hemoglobin levels measured in the whole study population ranged from 4.8 to 13.3% with a mean of 7.9±1.6 In patients with hypomagnesemia, the mean Glycated Hb was 9.1±1.4%, which was 130% higher than the mean Glycated Hb value in Normomagnesemic patients (6.98±1%). Except for one patient, all the rest had elevated Glycated Hb values above 5% of HbA1c (Fig.4). The mean fasting blood glucose was 156.4±53.7mg% and had a normal distribution over the study sample population (Fig.5). Plasma Insulin levels among patients showed a wide variation in our study with a mean of 14.5 and a standard deviation of as high as 13.57. The insulin levels were used to calculate the homeostatic model assessment (HOMA) indices that quantify Insulin resistance and beta cell function using the following formula: HOMA IR = Fasting Plasma Glucose (mg/dl) X Fasting Plasma Insulin (mu/L) / 22.5 A mean HOMA IR value of 5.4±5.1 mg/dL was obtained from our results (Fig.6) When Plasma Insulin was taken into consideration along with Glycated Hb and Serum Mg++, the correlation was strengthened by a factor of 12%). When HDL levels were correlated with Serum Magnesium, significant direct correlationship was obtained (Fig.10)

DISCUSSION
Hypomagnesemia is an important electrolyte abnormality observed in patients with type2diabetes mellitus. Magnesium depletion is described as the most under diagnosed electrolyte abnormality in current medical practice5 . In fact, the intracellular magnesium deficiency appears to be associated with an impaired function of several enzymes involved in glucose metabolism, which need high energy phosphate bonds and thus require Mg as a cofactor6 and this may lead to an impairment in insulin action and worsening of insulin resistance in diabetic and hypertensive patients 7 . A decreased magnesium status contributes to the development of insulin resistance, which in turn attenuates magnesium uptake in insulin-sensitive tissues. Moreover, low serum magnesium is a strong, independent predictor of the development of type 2 diabetes. In the USA, it has been established that 25 to 39 % of outpatient diabetics have low concentrations of serum Magnesium and several studies have shown lower serum concentrations in type 2 diabetics as compared to healthy controls. The results from the Atherosclerosis Risk in Communities (ARIC) study indicate low serum Magnesium to be a strong, independent predictor of the development of type 2 diabetes8 . Similar to findings from other countries in Europe, Asia and North America 9,10, the mean plasma Magnesium concentration was significantly lower ( overall ) in our study population of overt diabetes. In the present study, the significant correlation between HOMA IR and serum magnesium levels confirms the strong relationship with Insulin resistance (p< 0.05). The striking finding in this population was the high correlation of low plasma magnesium concentrations with high glycated Hb levels among the diabetic subjects. A plasma magnesium concentration of 40 (out of 90) diabetics in our study were below the reference range (mean 1.4±0.22 mg %), a prevalence of low magnesium status that is similar to that reported in type 2 diabetics from outpatient clinics elsewhere11. Senthil et al observed that hypomagnesemia was present in both controlled and uncontrolled diabetic patients12. Magnesium depletion has a negative impact on glucose homeostasis and insulin sensitivity in diabetics as well as on the evolution of complications such as retinopathy, thrombosis and hypertension13. Studies have shown that oral supplementation of magnesium chloride improves insulin sensitivity and glucose homeostasis 14 In human type 2 diabetics, Sheehan (1991) 15 found a significant inverse correlation between serum Mg and hypertriglyceridemia. In our study, there has been a strong positive correlationship between serum Mg++ levels and HDL levels and negative correlation with triacylglycerol levels when taken together attests to the importance of hypomagnesaemia in overall development of metabolic syndrome and future complications. And studies have shown that there is a direct and significant correlation between HbA1c and cholesterol, triglycerides, LDL-C & VLDL-C and inverse correlation with HDL-C16,17. Increased levels of total cholesterol, triglycerides with Hypomagnesemia are responsible for micro- and macrovascular complications in diabetes 18. And in diabetic patients with micro vascular complications had poorer glycemic control than patients without micro vascular complications19. And it is important to note that dietary intake of magnesium from food plus supplements has been associated with a decreased risk for metabolic syndrome, obesity or overweight, elevated blood pressure, and reduced HDL-cholesterol and with lower odds ratios with dietary supplements for elevated HbA1c, increased waist circumference & C-reactive protein.20

CONCLUSIONS
There was a high prevalence of hypomagnesaemia in patients with T2DM in our study population. Hypomagnesemia had shown a significant correlation with age, gender, Glycemic control, HOMA IR, triglycerides and HDL cholesterol in our study. Because of a decrease in magnesium levels reduces insulin sensitivity and may influence the risk of secondary complications, it is advisable in clinical practice to periodically monitor plasma magnesium in diabetic patients, especially those with other associated risk factors such as alcoholism, familial history of CVD, etc. If plasma Magnesium is low, an intervention to increase dietary intakes may be advisable in patients with DM and therapeutic for the prevention of future sequelae due to T2DM.

ACKNOWLEDGEMENT
Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. And authors here by declared that no conflict of interest.


References:

1. Chaudhary DP, Sharma R, Bansal DD. Implications of magnesium deficiency in Type 2 Diabetes. Biol Trace Elem Res 2010; May: 119 – 29.

2. Akira Katsuki, MD Yasuhiro Sumida, MD Esteban C. Gabazza, Shuichi Murashima Masahiko Furuta, Rika Araki-Sasaki, Yasuko Hori, Yutaka Yano. Homeostasis Model Assessment Is a Reliable Indicator of Insulin Resistance During Follow-up of Patients With Type 2 Diabetes; Diabetes Care February 2001 vol. 24 no. 2 362-65.

3. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care. Jul 2009; 32(7):1327-34.

4. Pham, P.C., P.M. Pham, P.A. Pham, S.V. Pham, H.V. Pham and J.M. Miller, 2005. Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2. Clin. Nephrol., 63(6): 429-36.

5. Paul Marino: Fluid and electrolyte disorders– Magnesium. The ICU Book, 2nd ed., Philadelphia, Lippincott, Williams and Wilkins 2004; 660-72.

6. Rosolova H, Mayer O, Jr. and Reaven G (1997) Effect of variations in plasma magnesium concentration on resistance to insulin-mediated glucose disposal in nondiabetic subjects. J Clin Endocrinol Metab 82, 3783-85.

7. Paolisso G and Barbagallo M (1997) Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hypertens 10, 346-55.

8. Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL and Brancati FL (1999) Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study. Arch Intern Med 159, 2151-59.

9. Nadler JL, Malayan S, Luong H, Shaw S, Natarajan RD, Rude RK. Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus. Diabetes Care 1992;15:835–41

10. Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, et al. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study. J Clin Epidemiol 1995; 48:927–40.

11. Nadler JL, Rude RK. Disorders of magnesium metabolism. Endocrinol Metab Clin North Am 1995; 24:623–41.

12. Senthil Manikandan Thirumanilayur Jayaraman, Kannan Rajendran, Prasanna Karthik Suthakaran, Lal Devayani Vasudevan Nair, Lokesh Rajaram, Rajiv Gnanasekar, Rajendran Karuthodiyil.Study on serum magnesium levels and glycemic status in newly detected type 2 diabetes patients. Int J Adv Med. 2016; 3(1): 11-14

13. Mather HM, Levin GE, Nisbet JA. Hypomagnesemia and ischemic-heart-disease in diabetes. Diabetes Care 1982; 5:452–3.

14. Martha Rodriguez Moran, Fernando Guerrero –Romero .Diabetes care vol.26:4.April 2003 15. Sheehan JP (1991) Magnesium deficiency and diabetes mellitus. Magnes Trace Elem 10, 215-19.

16. Jain Meenu , Jadeja Jayendrasinh M , Mehta Neeta. Correlation between HbA1c Values And Lipid Profile In Type 2 Diabetes Mellitus. International Journal of Basic and Applied Physiology . 2013;Vol. 2 Issue 1;47-50

17. Netravathi Sajjan et al. A study of serum magnesium and dyslipidemia in type 2 diabetes mellitus patients. International Journal of Clinical Biochemistry and Research 2016;3(1):36-41.

18. Asha S Khubchandani*, Hiren Sanghani**Study of Serum Magnesium and HbA1C in Diabetic Patients along with Changes in their Lipid Profiles. Indian Journal of Clinical Practice, Vol. 23, No. 11, April 2013

19. Ramachandra Prabhu .H .D1 , Sruthi Kunche2 . Study of Serum Magnesium and HbA1c in Type 2 Diabetes Mellitus Patients .International Journal of Science and Research (IJSR).2013; Volume 4 Issue 6, June 2015 (2521-24).

20. Papanikolaou Y, Brooks J, Reider C, Fulgoni VL (2014) Dietary Magnesium Usual Intake is Associated with Favorable Diabetes-Related Physiological Outcomes and Reduced Risk of Metabolic Syndrome: An NHANES 2001-2010 Analysis. J Hum Nutr Food Sci 2(3): 1038.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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