International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 03 Issue 03, March, 2011

Pages: 81-87

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ANTIBACTERIAL PROPERTIES OF EXTRACTS IN CYANOBATERIA ISOLATED FROM COASTAL
REGION OF ORISSA

Author: Indira Priyadarshani, Hrudaynath Thatoi, Biswajit Rath

Category: General Sciences

Abstract:Biologically active substances were reported from cyanobacteria. Many strains of cyanobacteria
(blue green algae) are known to produce intracellular and extracellular secondary metabolites
with diverse biological activity such as antibacterial, antifungal, antiviral and antineoplastic
properties. In the present study attempt has been made to asses the antibacterial effect of aqueous
and methanol extracts of six marine cyanobacteria belonging to the genus Phormidium and
Lyngbya isolated from coastal region of Orissa against some Gram positive and Gram negative
human pathogenic bacteria following Disc diffusion assay method. The results showed that all the
test species of cyanobacteria exhibited antibacterial activity on aqueous and methanolic extracts.
However the intensity of antibacterial properties varied among the pathogenic strains of bacteria
used for the experimental purpose. Among the six cyanobacterial species the antibacterial effect
was found to be significant in Phormidium tenue and Lyngbya maintensiana as compared to other
test species. This shows greater biotechnological potential of these two species which needs
further studies.

Keywords: Aqueous, Cyanobacteria, Orissa coast, Secondary metobolites.

Full Text:

INTRODUCTION

Cyanobacteria are very old group of prokaryotic organism and relics of the oldest photoautotrophic vegetation in the World that occurs in fresh water, marine and terrestrial habitats. They vary from small single celled forms to complex multicellular forms. Cyanobacteria have drawn much attention as prospective and rich sources of biologically active constituent and have been identified as one of the most promising groups of organism to be able to produce bioactive compounds. Cyanobacteria occur in varied habitats ranging from marine to fresh water, from desert sand to hot springs and from snow field to ice caps. There are several reports of cyanobacterial compounds possessing a wide range of biological activity such as antibacterial, antiviral, antineoplastic effect ( Finical and Paul 1984, Hodgson 1984, Ballesteros et al., 1992, Bhosale et al., 2002). However the production capacity of antimicrobial substances by some species varies (Pesando, 1990). Screening of cyanobacteria for antibiotics and other pharmacologically active compound has received increasing interest as potential sources of new drugs ( Fish and Codd 1994, Borowitzka 1995, Ostensvik et al., 1998, Schlegel et al., 1999). The purpose of the present work was to evaluate the antibacterial activity of six strains of cyanobacteria viz. Phormidium tenue, Phormidium mole, Phormidium angustissium, Phormidium bohneri, Lyngbya maintensiana, Lyngbya chaetomorphae, against Gram positive bacteria, Staphylococcus epidermidis, Staphylococcus aureus, Bacillus brevis, Bacillus subtilis, Streptococcus aureus and Gram negative bacteria Escherichia coli and Shigella fleximinia. So far studies on biologically active substances from cyanobacteria isolates from Orissa coast has not been attempted. Hence the present study my provide valuable information for biological exploitation of cyanobacteria from Orissa coast for industrial applications.

 

MATERIALS AND METHODS

Algal samples were collected from different locations along Orissa coast during the month of March to June 2004 ( fig-1). Epiphytic and extraneous matters were removed by washing first in sea water and then in the fresh water. The samples were transported to the laboratory in the sterile polythene bags at ice temperature. The algal samples were separated into unialgal condition by repeated subculturing in enrichment media in both liquid and agar slants and were maintained at 26 ± 10C and 4000 lux light intensity with a photoperiod of 16h. light and 8h dark. Identification was done using morphological variation studies and taxonomical approaches according to Desikachary (1959). Altogether six species so far identified were taken as test organisms such as Phormidium tenue (Menegh) Gomont; Lyngbya maintensiana (Menegh) Gomont; Phormidium mole (Kutz) Gomont; Phormidium angustissium (W. et. G. S. West); Phormidium bohneri (Schmidle); Lyngbya chaetomorphae ( Iyengar et. Desikachary). The algal samples were shade dried, cut into small pieces and powdered in a mixture grinder. The extractions were carried out in solvents such as methanol and water (aqueous). These two extracts were tested for antimicrobial property on five Gram positive bacteria, Staphylococcus epidermidis (MTCC1114); Staphylococcus aureus (MTCC 25923); Bacillus bravis (MTCC 6853); Bacillus subtilis (MTCC 6633); Streptococcus aureus (MTCC3542), and two Gram negative bacteria, Escherichia coli (MTCC 11230) and Shigella fleximinia ( MTCC23223). The antibacterial assay was done following disc diffusion assay method (Casida 1986). 500µg of each extracts (50µl) dissolved in sterile filter paper disc (6mm) was used. After evapouration of the solvent the disc were placed in nutrient agar containing test pathogens. The plates were then incubated overnight at 370C and observations were made after 48h of incubation.

 

RESULTS AND DISCUSSION

The results of antibacterial activity of six marine cyanobacteria isolated from coastal region of Orissa to different pathogenic strains of bacteria are represented in table-1. The result showed that all the test organisms possesses antibacterial property against all the strains of bacteria in both aqueous and methanolic extracts. However their intensity varies among strains basing on type of pathogenic bacteria and the extracts type. In this study it was observed that the test species of marine cyanobacteria Phormidium tenue and Lyngbya maintensiana showed significant antibacterial activity as compared to other four species. It is evident from the study that aqueous extracts of Phormidium tenue showed prominent antibacterial activity with inhibition zone size of 18.8mm diameter against Staphylococcus epidermis followed by inhibition zone of 17.6mm against E.coli. For other pathogenic strains of bacteria the size of inhibition zone ranges from 9 – 14mm. Compared to aqueous extracts, methanolic extracts showed size of inhibition zone ranging from 8-15mm against the test pathogenic Gram positive and Gram negative bacteria. Similarly Lyngbya maintensiana showed maximum size of inhibition zone i.e. 14.1mm against Staphylococcus aureus and minimum 9.2mm against E. coli in aqueous extracts. So far in Lyngbya maintensiana there was not much variations of antibacterial property between aqueous and methanolic extracts was observed. Among the test four species Phormidium mole and Phormidium angustissium showed moderate antibacterial activity in both aqueous and methanolic extracts which ranges from 3-9mm and 4- 12mm diameter size of zone of inhibition in these two species respectively. In other two species Phormidium bohneri and Lyngbya chaetomorphae the antibacterial property as expressed in zone of inhibition ranges between 3-5.3mm and 3- 6.7mm respectively. However in these four species the antibacterial property was not detected against few pathogenic test species of bacteria in aqueous and methanolic extracts as mentioned in the table-1. The results so far obtained was encouraging as all the strains of maine cyanobacteria isolated from coastal region of Orissa showed antibacterial activity, although the degree of antibacterial activity varies with species. Among the test species of cyanobacteria Phormidium tenue and Lyngbya maintensiana showed promising antibacterial activity against multiple strains of pathogenic bacteria in varied pattern in the aqueous and methanolic extracts. This variation might be due to masking of antibacterial activity by the presence of some inhibitory compounds or factors in the extracts as observed by Sastry and Rao, (1994). The antibacterial activity was found to be higher in aqueous extracts than the methanolic extracts, this is probably because of polar nature of active compounds. The differential antibacterial response of the test cyanobacteria to Gram positive and Gram negative group of bacteria may be attributed to the production of active compounds. The result of this work indicates that?s the marine cyanobacteria of Orissa coast which displays potential source of bioactive compounds which can be biotechnologically exploited for industrial application. Orissa coast extends over 480km along Bay of Bengal from Chandipur in the north to Gopalpur in the south with Puri coast at the centre. The samples were collected in these regions which are quite apart in their physiographic and environmental conditions and harbours different cyanobacterial strins suitable for growth in such habitats which needs further periodical study at different locations along the coastal region in this direction to reach at a conclusion.

 

CONCLUSION

Results from the present work indicate that the species of marine cyanobacteria from orissa coast examined showed a variety of antimicrobial activities and presence of bioactive molecules. Further isolation and identification of the active ingredients need to be done in order to understand their bioprospects. Since different activities were observed in extracts obtained with organic solvent and extracts obtained with water we can suggest that compounds with different polarities are involved. Thus the present work will contribute to an understanding that these bioactive compounds will need further studies to identify the chemical structure of these compounds and to examine their beneficial effect for inhibition of some pathogenic bacteria as antimicrobial metabolites of marine cyanobacteria are of special interest now in the development of new environment harmless.

ACKNOWLEDGEMENT

The authors thank Dr. N. Thajuddin, Dept. of Microbiology, Bharathidasan University, Tiruchirappalli (India) for identifying the cyanobacteria strains isolated from Orissa coast.

 

 

References:

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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