International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 2(10), October, 2010

Pages: 27-33

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SPECTROPHOTOMETRIC DETERMINATION OF SPARFLOXACIN IN BULK AND DOSAGE FORMS

Author: Okorie HN, Mbah CJ

Category: Healthcare

Abstract:A spectrophotometric study of sparfloxacin is described. The method is based on the charge-transfer complexation between sparfloxacin as n-electron donor with chloranilic acid as -acceptor to form a violet-coloured complex having absorption maximum at 530 nm. Beer?s plot is obeyed in the concentration range of 5-30 g/ml. Results of theanalysis of this method were validated statistically by recovery studies. The proposed
method is simple, accurate and precise for the quantitative determination of sparfloxacin in bulk and tablet formulations.

Keywords: Sparfloxacin, spectrophotometry, chloranilic acid.

Full Text:

INTRODUCTION

Sparfloxacin, 5-amino-1-cyclopropyl-7- (cis-3, 5-dimethyl-1-piperazinyl)-6,8- difluoro-1, 4-dihydro-4-oxo-3- quinolinecarboxylic acid is a difluoroquinolone antibacterial agent belonging to the third generation quinolones. Clinically, it is very effective in the treatment of streptococci infections. Its mechanism of action involves the inhibition of DNA synthesis by promoting cleavage of bacterial DNA in the DNA-enzyme complexes of DNA gyrase and type iv topoisomerase, resulting in rapid bacterial death1 . The drug is not official in any pharmacopoeia, hence no official method is available for the estimation of the drug in formulations. A number of analytical methods used for the determination of sparfloxacin in pure and dosage forms include electrochemistry2-5 ; UV-Visible spectrophotometry6-9 ; HPLC 10-13 . Chloranilic acid, 2,5-dichloro-3,6- dihydroxy-p-benzoquinone has been used largely as a spectrophotometric reagent for the determination of some organic compounds containing lone pair of electrons14-18, but not hitherto in the assay of sparfloxacin. The present work describes the spectrophotometric determination of sparfloxacin in bulk and pharmaceutical formulations using chloranilic acid as a chromogenic reagent.

MATERIALS AND METHODS

Materials: Sparfloxacin (Micro Labs Limited.92, Sipcot, Hosur. India), all other chemicals were of analytical grade. Freshly prepared 0.5 % (w/v) chloranilic acid solution in dioxan. A Hitachi UV/VIS spectrophotometer, model 2000 (Japan) was used for absorbance measurements.

Standard solution: A stock solution of sparfloxacin (50 g/ml) was prepared by dissolving the required amount in methanol. Standard solutions of the analyte (5-30 g/ml) were prepared by serial dilution of the stock solution.

Proposed procedure: An aliquot of the standard solution containing sparfloxacin was transferred into a 10 ml volumetric flask. A 1-ml volume of chloranilic acid solution (500 g/ ml) was added and the contents were mixed thoroughly. After 30 min standing, the volume was made up with dioxan and the absorbance of the solution was measured at 530 nm against reagent blank.

Procedure for assay of dosage forms: Ten tablets of the drug were weighed and ground to a fine powder. An adequate amount of the powder was transferred into a beaker. The powder was dissolved in methanol by stirring for 15 min. The mixture was filtered to a volumetric flask (100 ml) through Whatman filter paper No.41. The filtrate and washings were diluted to volume with methanol. A suitable volume of this solution was treated as described under proposed procedure and the drug content was evaluated. The results are given in Table 2

Procedure for recovery of sparfloxacin: To study the recovery of sparfloxacin, samples were prepared by mixing known amounts of pure sparfloxacin with portions of commercial preparation. The mixtures obtained were assayed by proposed method and the results are presented in Table 3.

RESULTS AND DISCUSSION Spectrophotometric characteristic of the sparfloxacin-chloranilic acid system: A violet-coloured complex with a ratio of sparfloxacin to reagent of 1:1 was formed when chloranilic acid solution was added to sparfloxacin solution. The complex exhibited a max at 530 nm while the reagent showed a max at 434 nm. An absorbance of the complex using an aliquot of the standard solution was measured at 530 nm at 30 min interval over a period of 2h. No change in the initial absorbance was observed indicating that the colour of the complex is fairly stable. Beer?s law was obeyed in the range of 5-30 g/ml. Beer?s law range, molar absorptivity, slope, linear least-square analysis are given in Table 1.

Optimization of reaction conditions: Effect of chloranilic acid concentration: The effect of chloranilic acid concentration on the colour development was studied. It was observed that 1 ml of 0.5 % (w/v) chloranilic acid solution produced maximum colour intensity (Fig. 1).

Effect of reacting time: The colour product developed rapidly after addition of the reagent attaining maximum intensity after 30 min at room temperature (Fig. 2). The colour was stable for over 2 h.

Stoichiometric relationship: In order to establish the composition of the charge-transfer complex, the molar ratio method and Job?s method of continuous variation using equimolar solutions of the drug (0.004 M) and reagent (0.004 M) were studied. In the molar ratio method, the concentration of the drug was kept constant while varying the concentration of the reagent in the series of solutions prepared. In the Job?s method, equimolar solutions of the drug and the reagent were mixed in complimentary proportions to a fixed total volume. The results obtained indicate that the composition of chargetransfer complex was (1:1) drug to reagent (Fig. 3). In conclusion, the proposed spectrophotometric method was applied in the determination of sparfloxacin in bulk and pharmaceutical formulations. The method is simple, accurate, reproducible and the statistical analysis has good agreement with reported methods. The optimum conditions for the proposed method have been established and the method has shown a reasonable tolerance towards excipients. Finally, due to the minimum time required for the complexation to be complete, the proposed method can be employed for the routine analysis of sparfloxacin from bulk and tablet dosage form in quality control laboratories.

References:

1. Hooper DC. Mode of action of fluoroquinolones. Drugs 1999;58(2): 6-10.

2. Abdel-Ghana NT, EL-Shall MA, El-s MA. Validated polarographic method for the determination of certain antibacterial drugs. Anal Sci 2007;23:1053-57.

3. Kumar KG, Augustine P, Poduval R, John S. Voltammetric studies of sparfloxacin and application to its determination in pharmaceuticals. Pharmazie 2006;61:291-92.

4. Jains NK, Pitre KS. Electrochemical analysis of sparfloxacin in pharmaceutical formulations and biochemical screening of Co (II) complex. J Pharm Biomed Anal 2002;29:795-801.

5. Reedy TM, Sreedhar M, Reedy J. Electrochemical determination of sparfloxacin in pharmaceutical formulations and urine samples using -cyclodextrin modified carbon electrode. Anal Lett 2003;36:1365-79.

6. Akram M, EL-Didamony AM. Spectrophotometric determination of sparfloxacin in pharmaceutical preparations by ternary complex formulation with Pd (II) and eosin. Anal Lett 2007;40:2708-20.

7. Kuchekar BS, Thakkar SV, Chothe PP, Herimathm MR, Shinda DB. Spectrophotometric estimation of sparfloxacin in tablets. Indian J Pharm Sci 2002;64: 496-7.

8. Herida RN, Marona HRN, Elfrides ES, Schapoval EES. Spectrophotometric determination of sparfloxacin in pharmaceutical formulations using bromothymol blue. J Pharm Biomed Anal 2001;26:501-4.

9. Marona HRN, Schapoval EES. Spectrophotometric determination of sparfloxacin in tablets. J Antimicob Chemother 1999;44:136-7.

10. Nahar NR, Shahabuddin A. Development of quantitative analysis of sparfloxacin by high performance liquid chromatography. J Pharm Pharmaceut Sci 2007;6:21-7.

11. Marona HRN, Schapoval EES. A high performance liquid chromatographic assay of sparfloxacin. J Pharm Biomed Anal 1999;20:413-7.

12. El-Sayed YM. A simple high performance liquid chromatographic assay for sparfloxacin in human plasma. Anal Lett 1995;28:279-93.

13. Borner KE, Lode H. Determination of sparfloxacin in serum and urine by high performance liquid chromatography. J Chromatogr Biomed Appl 1992;579:285-9.

14. Walash MEM, Sharaf EM, Meturalli M, Redashabara M. Spectrophotometric determination of nizatidine and ranitidine through charge-transfer complex formation. J Arch Pharm Res 2007;27:720-6.

15. Attama AA, Nnamani PO, Adikwu MU, Akidi FO. Spetrophotometric determination of haloperidol by charge-transfer interaction with chloranilic acid. STP Pharm Sci 2003;13:419-21.

16. Adikwu MU, Oforkansi KC. Spectrophotometric determination of moclobemide by charge-transfer complexation. J Pharm Biomed Anal 1997;16:527-32.

17. El-Sayed MA, Barary M, AbdelSalam MA, Mohamed YA. Spectrophotometric assay of cardiovascular drugs through charge-transfer. Ana Lett 1984;22:1651-84.

18. El-Sayed MA, Agarwal SP. Spectrophotometric determination of atropine, pilocarpine and strychnine with chloranilic acid. Talanta 1982;29:535-7.

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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