International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 03 Issue 05, May, 2011

Pages: 04-09

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STUDY ON THE EFFECT OF GLYCEROL, PROPYLENE GLYCOL AND POLYSORBATE 80 ON
THE LIPOPHILIC BEHAVIOUR OF TRANDOLAPRIL

Author: Mbah, C. J, Enwereji, P.O

Category: Healthcare

Abstract:The present study examines the lipophilic behaviour of trandolapril by partitioning the drug in a
chloroform-water system at room temperature. The aqueous vehicles investigated are glycerolwater,
propylene glycol-water and polysorbate 80-water systems. The results show that both the
binary combinations and the surfactant solution decreased the lipophilicity of trandolapril. The
order of decrease is: polysorbate 80> propylene glycol> glycerol. The findings suggest that
none of the vehicles investigated, has the potential of enhancing the vehicle-skin partition
coefficient and therefore might not be considered as potential dermal enhancers for trandolapril.

Keywords: Trandolapril, partition coefficient, spectrophotometry.

Full Text:

INTRODUCTION
The desire to use transdermal routes for potent drugs or to avoid certain unsuitable characteristics of oral administered drugs has empowered formulation scientists to employ various formulation approaches with the view of enhancing transdermal drug absorptions. Some of such approaches involve the use of ethosomes, liposomes, microemulsions, nanoemulsions, solid-lipid nanoparticles and transferosomes1,2,3,4 . These nanotechnology-based solutions are lipid-based systems employed to improve drug solubility and bioavailability of poorly soluble compounds. The formulations could contain glycerol, propylene glycol and polysorbate 80 either as co-vehicles or dermal permeation enhancers. For example, propylene glycol has been reported to enhance the dermal permeability of diazepam and midazolam maleate5 , estradiol6 and naloxone7 . Trandolapril (2S,3aR,7As)-1-[(2S)-2-{[(1S)-1- (Ethoxycarbonyl)-3-phenylpropyl]amino}- 1-oxopropyl]octahydro-1H-indole-2- carboxylic acid is a potent nonsulphydryl angiotensin converting enzyme inhibitor. Clinically, it used in the treatment of patients with congestive heart failure, hypertension and myocardial infarction8,9 . Commercially, trandolapril exists only in pharmaceutical solid dosage forms (tablets or capsules), however, the potential of formulating it into transdermal pharmaceutical products exists, if appropriate vehicles (or co-vehicles) and chemical dermal enhancers could be selected. The purpose of this investigation therefore, was to examine the lipophilic behaviour of trandolapril in these vehicles (or co-vehicles) by partitioning the drug between them and chloroform. It is hoped that such information, could provide an insight into its potential dermal absorption. Previous studies10,11.12 have shown that linear correlation exists between permeability coefficient and partition coefficient. Another report13 has also shown dermal permeability coefficient to depend on the partition coefficient and molecular weight of chemical compounds. However, as literature survey has shown little or no study on the lipophilicity of trandolapril in the studied vehicles (or covehicles), in this paper, we report the partitioning of the drug between these vehicles (or co-vehicles) and chloroform

MATERIALS AND METHODS

Materials

Trandolapril (Abbot Laboratories, USA), glycerol, propylene glycol and polysorbate 80 were purchased from Sigma-Aldrich (USA). Chloroform was purchased from Fisher Scientific (USA).

Standard solution

Stock solution of trandolapril (100 g/ml) was prepared in methanol. Aliquots (10.0- 50.0 g/m) of the standard stock solution were pipetted into a 10 ml volumetric flask, diluted to volume with methanol.

Partition coefficient determination.

The partition coefficient of trandolapril was determined in a chloroform-water system. To 5 ml of saturated chloroform solution containing 1 mg of trandolapril, 10 ml of saturated aqueous solution of different concentrations of glycerol, propylene glycol and polysorbate 80 were added. The flasks were stoppered and agitated at room temperature for 2 h to achieve complete equilibration. The aqueous phase was analyzed by a spectrophotometric method for trandolapril content at a maximum wavelength of 210 nm and its concentration was calculated from a pre-constructed graph. The partition coefficient of trandolapril was calculated using the following equation14: P = (C1-Cw)Vw CwVo where, P = partition coefficient, C1 = total concentration of trandolapril, Cw = concentration of trandolapril in the aqueous phase, Vw = volume of the aqueous phase, Vo = volume of the organic phase.

RESULTS AND DISCUSSION

The regression analysis of the calibration graph of trandolapril gave correlation coefficient of 0.9997. The results of the partition coefficient and estimated permeability parameters are presented in Table 1. The results show that all the vehicles or (co-vehicles) decreased the partition coefficient of trandolapril. The decreasing effect was observed with increasing concentration of each vehicle (or co-vehicle). Polysorbate 80-water system was noted to show the highest decreasing effect on the partition coefficient of the drug. The difference between the effect of glycerol and propylene glycol on the partition coefficient of trandolapril could be attributed to decrease in the ability of water molecules to squeeze out the drug molecules from the aqueous environment, resulting in less drug molecules moving into the organic phase. This phenomenon is applicable more to propylene glycol-water system than glycerol-water system. Furthermore, differences in the dielectric constant of the binary systems could also have contributed to the observed difference in the partition coefficient. However, with polysorbate 80-water system, the decrease in the partition coefficient could be as a result of micellar complexation or  entrapment of trandolapril in micelles. A plot of logarithm of the observed partition coefficient versus the concentration of vehicle (or co-vehicle) gave linear relationships with correlation coefficients of –0.9501, –0.9498 for glycerol-water and propylene-water systems respectively and – 0.9399 polysorbate 80-water system. The graphs are shown in figure1 for the binary systems and figure 2 for polysorbate 80- water system. As an earlier report15 has shown that permeability coefficient is a useful parameter in evaluating percutaneous absorption, the potential permeability coefficient of trandolapril through the skin was estimated using the observed partition coefficient. The estimation was done by the application of previously reported dermal permeability equation13: log kp (cm/h) = -2.7 + 0.71 log P – 0.0061 MW, where kp is the dermal permeability coefficient, P is the observed partition coefficient of trandolapril, MW is the molecular weight of trandolapril. The estimated permeability coefficients were used to calculate the potential fluxes at steady-state using the following equation16: kp = Jss/C, where Jss is the flux at steadystate, C is the concentration (μg / ml) of the test compound. A comparison of the kp values of trandolapril in glycerol-water; propylene glycol-water system and polysorbate 80-water systems at a concentration level of 5 % w/v, showed glycerol-water system (1.3527 10-4 cm/h) with factors of about 1.2 and 3.9 much greater than propylene glycol-water system (11.460 10-5 cm/h) and polysorbate 80-water system (3.5070 10-5

CONCLUSION

The investigation shows that the studied vehicles (or co-vehicles) decreased the partition coefficient of trandolapril. Polysorbate 80-water system was observed to produce the highest decrease in the lipophilicity (defined by the partition coefficient) of trandolapril. As permeability through the skin depends partly on the partition coefficient of the drug, the study suggests that none of the vehicles (or covehicles) could enhance the transdermal absorption of trandolapril through vehicle/skin partition coefficient mechanism.

 

References:

REFERENCES

1. Touitou E, Godin B, Dayan N, Weiss C, Piliponky A, Levi-Schaffer F. Intracellular delivery mediated by an ethosomal carrier. Biomaterials 2001; 22:3053-59.

2. Baboota S, Alazaki A, Kehl K, Ali J, Dixit N, Shakael F. Development and evaluation of a microemulsion formulation for transdermal delivery of terbenafine. PDA J. Pharm. Sci. Technol. 2007; 61: 276-85.

3. Shakael F, Baboota S, Ahuja A, Shafq S, Faisal S, Ali J. Enhanced transdermal delivery of aceclofenac using nanoemulsion technique. J Pharm Pharmacol 2007; 93: 31-7.

4. Shafiq S, Shakael F, Telegaankar S, Ahmad FJ, Khar RK, Ali M. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm. 2007; 66: 227-42.

5. Toniton E. Transdermal delivery of anxiolytics. In vitro skin permeation of midazolam maleate and diazepam. Int J Pharm 1986; 33: 37-43.

6. Mollsaard B, Hoelgaard A. Permeation of estradiol through the skin. Effect of vehicles. Int J Pharm 1983;15: 185-97. 

7. Panchagnula R, Salve PS, Thomas NS, Jain AK, Ramarao P. Transdermal delivery of naloxone: effect of water, propylene glycol, ethanol and their binary combinations on permeation through rat skin. Int J Pharm 2001; 219:95-105.

8. Peters DC, Noble S, Plosker GL. Trandolapril: An update on its pharmacology and therapeutic use in cardiovascular disorders. Drugs 1998; 56: 871-893.

9. Pederson OD, Bagger H, Kober L, Pederson C. Trandolapril reduces the incidence atrial fibrillation after acute myocardial infarction in patients with left ventricular dysfunction. Circulation 1999; 100: 376-80.

10. Hatanaka T, Inuma M, Sugibayashi K, Marimoto Y. Prediction of skin permeability of drugs 1: Comparison with artificial membrane. Chem Pharm Bull 1990; 38:3452-59.

11. Bunge AL, Cleck RL. A new method for estimating dermal absorption from chemical exposure 2, Effect of molecular weight and octanol-water partitioning. Pharm Res 1995; 12:88- 95.

12. Wagner H, Kosita K, Lehr C, Shaefer U. Correlation between stratum corneum/water partition coefficient and the amounts of flufenamic acid penetrated into the stratum corneum. J. Pharm. Sci. 2002; 91: 1915-21.

13. Potts RV, Guy RH. Predicting skin permeability. Pharm Res 1992; 9: 663-669.

14. Johnansen M, Bundgaard H Prodrugs as drug delivery systems XII. Solubility, dissolution and partition behaviour of N-mannich bases and N-hydroxymethyl derivatives. Arch Pharm Chem Sci Edu 1980a; 8:141-45.

15. Korinth S, Schaller KH, Drexler H. Is permeability coefficient (Kp) a reliable tool in percutaneous absorption studies. Arch Toxicol 2005; 79:155-59.

16. Julreht K, Keith AP, James AW. Development of a transdermal delivery device for melatoin in vitro studies. Drug Dev Ind Pharm 1998; 21; 1377-87.

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Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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