International Journal of Current Research and Review
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IJCRR - 3(9), September, 2011

Pages: 52-61

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EFFECT OF FOLIAR APPLICATIONS OF PLANT GROWTH REGULATORS ON YIELD PARAMETERS AND
SENNOSIDE CONTENTS OF CASSIA ANGUSTIFOLIA VAHL.

Author: Shilpa Mohan Shitole1, K. N. Dhumal

Category: General Sciences

Abstract:The uses of plant growth regulators have emerged as an important tool in improving agricultural production. The study was conducted to compare the effects of three PGRs on the yield parameters and sennoside (a and b) contents from leaves and pods of medicinal plant Cassia angustifolia.The PGRs viz., Gibberellic acid (GA3), Indole acetic acid (IAA) and the growth retardant Abscisic acid (ABA) were applied at the concentrations of 25, 50 and 100mg/l as foliar spray. Performances of different PGRs in C. angustifolia indicated that all the PGRs used have caused statistically significant increase in yield attributes and sennoside contents over control. Amongst the different treatments of PGRs, IAA and ABA (100mg/l) had shown maximum positive influence on yield parameters in C angustifolia. While for enhancing sennoside a and b contents from leaves and pods, IAA and ABA (50mg/l) emerged best treatments over control.

Keywords: senna, foliar spray, plant growth regulators, HPLC.

Full Text:

INTRODUCTION

Different strategies like, use of dormancy breaking agrochemicals, proper irrigation and fertilizers, hybrid seeds, plant growth regulators (PGRs) etc. are generally used to achieve vigorous growth and to enhance the flowering, fruiting, yield and production of commercially important secondary metabolites. Amongst these, use of PGRs is proven and widely used technique for different crops including medicinal plant to achieve these objectives. The term plant growth regulating substances (PGRS) include both naturally occurring and synthetic growth substances, and include both growth promoters and growth retardants. They control and regulate the growth, metabolic processes and developments in plants by physiological manipulation. The use of PGRs have emerged as an important tool in improving agricultural production and to help in removing many of the barriers imposed by heredity and/or environmental stress. The major types of plant bio-regulators are auxins, gibberellins, cytokinins, abscisic acid, and ethylene. Auxins is the first hormone to be discovered in plants, which regulate polar translocation, apical bud dominance, root initiation, delay in abscission, vascular differentiation, floral bud formation and fruit development. Gibberellins (GAs) are commonly used as growth enhancers because they stimulate cell division, cell growth or increase wall plasticity and the transcription of genes for α-amylase synthesis (Jones and Mac.

Millan, 1984). Gibberellins stimulate stem growth by promoting both cell elongation and cell division. Growth retardants are also used in crop improvement programs. These induce variety of morphological and biochemical responses in plants, including retarded shoot elongation, stimulated rooting and protection from various environmental stresses. Hence the study was conducted to compare the effects of three PGRs on the yield parameters and sennoside (a and b) contents from leaves and pods of medicinal plant Cassia angustifolia under natural condition. Cassia angustifolia (Family: Caesalpiniaceae), popularly known as senna, is a valuable plant drug in ayurvedic and modern system of medicine for the treatment of constipation and is used to cure a large number of intestinal diseases (Aktar et al. 2008). Sennoside A and B are the two anthraquinone glycosides that are responsible for purgative action of senna. However, the performance of this plant in salinity stress environments, and the effect of these stresses on its sennoside production have not been studied well. The objective of this research was to evaluate the effect of foliar application of PGRs yield parameters and sennoside contents of senna.

MATERIAL AND METHOD

Plant material Authentic seeds of Cassia angustifolia Vahl were obtained from National Research Centre for Medicinal and Aromatic Plants, Boriavi, Gujarat. Field culture experiments were conducted in the research field of Department of Botany, University of Pune, from October 2008 to May 2009 to determine the effect of foliar application of PGRs on the, yield parameters and secondary metabolites content i.e. sennoside a and b in senna.

Field Experimental

All experiments were conducted in a complete randomized design. The pre-soaked seeds of senna were sown in ridges and furrows cover with thin layer of soil. The distance between two plants was 30 cm and the distance between two rows was 40 cm. Each treatment had 3 replications and each replication had 10 seedlings. Light irrigation was immediately given after seed sowing. Standard inter cultivation practices were used throughout the experiment. Temperatures during the experiment were in the range of 28-300C during day and 19- 210C at night.

PGRs treatments

The plants were sprayed four times at 45, 60, 75 and 90 days after sowing with freshly prepared solutions of Gibberellic acid (GA3 ), Indole acetic acid (IAA) and the growth retardant abscisic acid (ABA) in the concentration of 25, 50 and 100mg/l using 1.5, 2.5 and 3.5 litter of solution respectively for each experimental plot. PGRs were dissolved in 95% ethanol and then brought to final concentration using distilled water. The treatment was continued up to flowering stage (90DS) at the interval of 15 days. DW spread plants were considered as control.

Yield parameters analysis

Yield attributes like number of flowers per plant, number of pods per plant, pods fresh and dry weight, 100 seed weight were measured. Pod formation began at 90 DAS and therefore sampling of pods was done at 105 and 120 DAS. The fresh and dry weight of the whole plant was measured at post flowering stage (120DAS). For this randomly selected healthy plants were uprooted from each treatment and control at the stages mentioned above. After cleaning the roots fresh weight of ten plants was measured immediately with the help of electronic top pan balance and expressed in gram per plant and from this average fresh weight of each plant was determined. This plant after taking the fresh weight was kept in oven at 400C still the constant weight was obtained. The constant weight was recorded as dry weight of each plant.

For analysis of sennoside a and b contents ten randomly selected third leaf from top of each plants from control and treatment was selected at 60 DAS and green pods at 120 DAS while, kept in oven at 600C for 48 h and used for HPLC analysis.

HPLC analysis of Sennoside content

 HPLC analysis was done at 60DAS from leaves and 120DAS from pods. All the chemicals used were of AR grade. Methanol and water were obtained from Merck (Mumbai). The standard for the experiment was obtained from Mehta Pharmaceuticals Pvt. Ltd. (Mumbai).The dried leaves (1.0 gm.) were finely powered and extracted with hexane (3 X 25 mL). The hexane extract was discarded and 25 ml of methanol:water (70:30, v/v) was added to mark, the suspension left overnight at room temperature (250C) and then extracted with the methanol:water mixture (2 X 25 mL). The extract was made up to 100mL with methanol: water and 10 µL samples were subjected to HPLC analysis. The extraction of pods was performed exactly as described above for leaf sample. The solution containing known concentration of range 10-100 µg/ml of sennoside was prepared in methanol, and used as standard for HPLC analysis. HPLC analysis was performed using a Water modular system consisting of two model 501 pumps, an automated gradient controller, a model U6K injector, an in-line solvent degasser, a model 996 photodiode array detector and Millennium 2010 chromatography management software. A Symmetry C18 column (150 X 406mm) was used for analysis, and spectral acquisition was performed at 285nm after scanning the standards. The solvent system consist of (A) methanol: water: acetic acid (80:20:0.1v/v/v; pH 4.0). The flow rate was maintained at 0.6ml/min for the first 20 min, while at 30 min it was 1.0ml/min. The HPLC data including height and area of the sennoside peak at particular retention time, of standard sennoside sample (with known concentration) was recorded. This data of standard sennoside sample was compared with the data obtained from plant samples and content of sennoside in the respective plant samples was calculated.

Statistical analysis

The data was presented as arithmetic means of three replicates ±standard deviation. The significance of the mean differences was explored through one-way-ANOVA statistics followed by DMRT (Duncan‘s multiple range test) at p=0.05 as a post hoc test. SPSS for Windows ver. 11.5 and Microsoft Excel 2003 were used to carry out statistical analyses and graphical data presentations.

RESULTS

Number of flowers

The influence of different PGRs on various yield parameters in Cassia angustifolia clearly indicated that the yield parameters had shown positive increase over control. The increase in number of flowers per plant was maximum in IAA 100mg/l (23.59%) recorded in Fig1. The next better treatment was GA3 100mg/l (20.53%). However the treatment of ABA 100mg/l was comparatively less effective (18.53%).

Number of pods

The impact of various growth regulators on number of pods per plant recorded in Fig 1, illustrated that all the treatments had favoured the positive increase in number of pods per plant over control. The percentage increase was ranging from 21.78% to 41.26%. The impact of ABA (100mg/l) was highly significant, as it has caused maximum increase in number of pods per plant by 41.26%. Amongst the remaining treatments IAA and GA3 with 100mg/l were following the previous one. They have caused 32.56% and 25.56% increase in number of pods per plant over control.

Pods fresh weight

The results on pods fresh weight per plant recorded in Fig 2 revealed that GA3, IAA and ABA had positively influenced the pods fresh weight per plant over control. The percentage increase over control was in the range of 24.53% to 41.56%. The maximum increase in pods fresh weight was 41.56% in ABA 100mg/l. The next better treatment was IAA 100mg/l, which had caused 37.59% increase in pod fresh weight. The GA3 100mg/g had caused 32.56% increase over control.

Pods dry weight

The impact of various growth regulators on dry weight of pods per plant recorded in Fig 2 revealed that all growth hormones used in the present studies had increased the fresh as well as dry weight of pods per plant. However the increase in yield was more significant in dry weight of pods. The increase in dry weight during field experiment was 43.26% in ABA 100mg/l. It was the highest increase over control and other treatments. While IAA 100 mg/l has caused 42.53% increase in pod dry weight and emerged as second better treatment. Even the performance of GA3 (100mg/l) was very promising over control, because it has also caused the positive increase in pods dry weight by 36.15% over control.

Dry weight of seeds

The influence of various plant growth regulators on 100 seeds‘ dry weight presented in Fig 3 revealed that the 100 seeds dry weight was positively increased by all the treatments of PGRs over the control. The percentage increase in dry weight of seeds was in the range of 11.53% to 34.26%. The treatment of IAA emerged as the best treatment for enhancing dry weight of seeds (34.26%). It was followed by ABA 100 mg/l (29.42%). The GA3 treatment had not shown so promising effect on dry weight of seeds.

Fresh weight per plant

The effects of PGRs treatment on fresh weight per plant for field grown plants of Cassia angustifolia are presented in Fig 4. From the results it was clearly seen that all the PGRs used in the present investigation had significantly and positively caused the enhancement in fresh biomass of treated plants over control. The highest increase in fresh weight per plant was recorded in ABA 100mg/g. (50.23 %). The next best treatment was GA3 100 mg/l (40.23 %). The remaining treatment i.e., IAA (100mg/l) registered 23.56 % increase over control

Dry weight per plant

The results on dry weight per plant influenced by various PGRs treatments during field experiments in Cassia angustifolia presented in Fig 4 revealed that dry weight per plant was increased in the range of 24.26% to 76.23% in field experiment. ABA 100mg/l was more effective than other treatments and control for causing the accumulation of dry matter (76.23%); it was followed by GA3 50 mg/g (51.26%). The IAA (100mg/g) treatment was less effective as compared to other treatments (30.21%).

Sennoside content

From the figure 5 and 6; it is seen that all the plant growth regulator treatments resulted in to increased sennoside content as compared to control. Amongst all the treatments, IAA (50mg/l) had a pronounced effect on the sennoside content from leaves and pods which was followed by ABA (50mg/l). The treatments of GA3 were also quite effective over control for enhancing the sennoside content (Figure No.5 and 6). The impact of GA3 on sennoside content might be due to enhanced biosynthetic pathway of sennoside. The treatments of IAA (50mg/l) emerged as best treatments for enhancing the sennoside content from leaves and pods by 37.15 % and 51.23% respectively over control. The overall results on various yield parameters such as number of flowers per plant, number of pods per plant, fresh and dry weight of pods and even dry weight of seeds were positively influenced by the treatments of GA3, IAA and ABA. Amongst the different treatments of PGRs, IAA and ABA (100mg/l) had shown maximum positive influence on yield parameters in Cassia angustifolia. While for enhancing sennoside content from leaves and pods, IAA and ABA (50mg/l) emerged best treatments over control.

DISCUSSION

Total number of flowers present on a plant is one of the important yields contributing character in various plants. The correlation between number of flowers per plant and economic yield has been well established. Singh et al. (2003) noted early flowering with IAA (100ppm) and maximum number of flowers with GA3 (100ppm) in Tagetes patula. Choudhuri and Chatterjee (1979) reported that the GA3 was responsible for inducing increase in number of flowers per plant in Solanum khasianum. Farooqui et al. (1999) had recorded the significant increase in number of flowers in GA3 treated Chrysanthymum cinerariae. The work of Gowda et al. (1986) in S. viarum treated with GA3 (1000 ppm) reported enhanced and earlier flowering. Flower induction with GA3 was observed by Warm (1980) in Hyoscyamus niger. The earliest flowering in Coriandrum sativum due to GA3 (50 ppm) was noted by Verma and Sen (2003). Similarly Verma et al. (2003) had also reported maximum number of flowers in Prunus salicina with GA3 (100 ppm) treatment. Prasad et al. (2003) registered maximum number of flowers heads due to GA3 (300 ppm) in Artemisia pallens. The positive effect of growth retardant cycocel for improving the fruit number was recorded in Solanum khasianum (Hazarika, 1985; Haleem and Thimmaraju 1983), Trichosanthes dioica (Singh et al. 2003). Most of the workers like Chakarvarty and Basu (1973), Chaudhary and Chatterjee (1979), Borse and Dhumal (2001), Barua and Hazarika (1982) have reported that growth retardant CCC was more superior than GA3, auxin and kinetin for increase in fresh and dry weight of fruits in S. khasianum. Several investigators also reported an increase in yield of different plants by application of auxins (Mandurah, 1984; Rao and Narayanan, 1997 ). Foliar spray of IAA increased number and weight of pods as well as number and weight of seeds in cowpea (Saeid et al. 2010). Similarly Kumar and Singh (2003) recorded maximum seed weight due to IAA (50mg/l) in Linum usitatissimum. The maximum grain weight per plant was recorded in chickpea (Zarrin et al. Several investigators also reported an increase in yield of different plants by application of 2008) with ABA (foliar spray). The enhanced fresh and dry weight due to growth retardants was reported by various workers in different plants like Morus alba (Mishra et al. 2001), potato (Prakash et al. 2001), Solanum khasianum (Shobhane et al. 2003), Datura metal (Gupta and Madan 1976), Sida acuta (Seal and Gupta 2001). The results of the present investigation in conformity with above results, indicating the suitability of PGRs for enhancing the fresh as well as dry weight of plants, which directly or indirectly caused the improvement in yield and productivity. Sharma et al. (2001) claimed improved growth, biomass, chlorophylls, photosynthetic rate, leaf area are responsible to enhance the production of various secondary metabolites. The results of present investigation are in agreement with the above findings. Similar results have reported an improvement in secondary metabolites through treatment of auxins in different medicinal plants. In Solanum nigrum, the positive influence of IAA on alkaloid production was recorded by Bhatt et al. (1983). Reports in Solanum jaminoides (Sahoo et al. 1999), Hyoscyamus muticus (Gamasy et al. 1978) Solanum khasianum (Borse et al. 2000),

Artemisia annua (Yaseen and Tajuddin 1998), Andrographis paniculata (Gudhate and Dhumal 2008) showed positive influence of IAA on secondary metabolite production. The influence of GA3 on biosynthesis and accumulation of alkaloid content was recorded by various workers in Solanum khasianum (Borse et al. 2000, Borse and Dhumal, 2001; Gowda, 1986). In the present studies the treatment of growth retardant ABA found to be the second best treatment for enhancing the sennoside content. Several investigators also reported an increase in secondary metabolites content by application of plant growth retardants in Solanum khasianum (Gowda et al. 1986), S. laciniatum (Antably et al. 1975; Eid et al. 1974), Datura metal (Gupta and Madan 1976), turmeric (Jirali et al. 2001), Catharanthus roseus (Choudhary and Gupta 1996).

CONCLUSION

The comparative account regarding the performance of different PGRs in C. angustifolia indicated that all the PGRs used have caused statistically significant increase in yield and sennoside content over control, but the effect of IAA and ABA was more significant and hence use of these PGRs can be recommended for commercial purpose after studying the cost benefit ratio. All the results on yield parameters and sennoside content were showing positive and significant correlations.

ACKNOWLEDGEMENT

The first author is thankful to UGC for awarding meritorious student fellowship. The authors sincerely thank Head, Department of Botany, University of Pune, Pune- 411007, Maharashtra, India for providing facilities in the Department.

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A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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