International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 3(10), October, 2011

Pages: 177-180

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A STUDY OF LONG TERM PROGNOSIS IN CEREBRAL VENOUS THROMBOSIS

Author: Navendra Kumar Gupta, Lalit Shrimali, Suchi Gupta

Category: Healthcare

Abstract:Background and Purpose: Very little is known about the long-term outcome of patients with cerebral venous thrombosis (CVT), particularly regarding the risk of residual epilepsy and further thrombotic
events.
Methods : We retrospectively studied 35 patients with age range between 18 \? 37 years who were diagnosed CVT by clinical findings and confirmed by CT scan were followed up for mean of 21.8
months. Information on death, neurological status, seizures, recurrent CVT, other thrombotic events, and
subsequent pregnancies was obtained from direct observation and mail.
Results :
26 patients (74.28%) had no neurological sequelae while 9 patients ( 25.71%) had neurological deficit with 1 of these 9 patients initially presented with isolated intracranial hypertension had blindness
due to optic atrophy ,while remaining 8 patients who had focal signs at presentation were left with various
cognitive or focal deficits . Conclusion:
CVT has an essentially good long term prognosis . The
frequency of long term epilepsy is low , suggesting that long-term
anticonvulsant treatment is not necessary in the majority of cases. A second
CVT or another thrombotic episode occurred in 12% of patients, stressing the need in a minority of cases
for long-term anticoagulation

Keywords: Cerebral venous thrombosis , neurological deficit , prognosis, pregnancy .

Full Text:

INTRODUCTION

Cerebral venous sinus thrombosis (CVT) is a disease with potentially serious consequences, which usually affects young to middle aged people. Bouser 1 and Einhäupl 2 studied the outcome of patients with cerebral venous sinus thrombosis and showed that it may vary from complete recovery to permanent neurological deficits, as a natural course of the disease. Cerebral venous thrombosis for many years has been diagnosed mainly at autopsy. This has led to the description of a very rare and lethal disease characterized clinically by headache, papilledema, seizures, focal deficits, coma, death and pathologically by haemorrhagic infarction contraindicating the use of anti-coagulants according to Kalbag and Woolf 3 , Krayenbuhl 4 . The introduction and widespread use of cerebral angiography, CT of the brain and more recently MRI 5 has made early diagnosis of CVT possible and had completely modified knowledge of this condition 6, 7. Einhäupl2 and Brujin8 shown that treatment with anticoagulant drugs leads to a moderate benefit for patients with CVT compared with placebo treatment, but the mortality after treatment with anticoagulant drugs isstill 5% to 10%. Little is known about the long-term outcome of patients with CVT, since there is no study specifically dedicated to the subject. We report the long-term prognosis of 35 patients with CVT.

 

MATERIAL AND METHODS

Patients who had been diagnosed CVT by detailed history including obstetric history, mode of delivery, onset of symptoms, clinical findings, neurological examination and by CT scan after their discharge from the hospital was followed up. They were specifically asked for presence of any of the following; headache, seizures, sensorimotor and visual disturbances. Data was also collected regarding recurrence of CVT, deep vein thrombosis, pulmonary embolism and any other health problem and hospitalization and subsequent pregnancies. Other relevant information regarding socio-economic status, use of oral contraceptives and other medications was also collected.

RESULTS The main characteristics along with suspected etiology are summarized in table 1. 20 (57.1%) patients received anticoagulants, initially heparin for few days (5 to 7 days) followed by oral anticoagulants for 3 to 4 months unless there was any contraindication for anticoagulation. These patients had haemorrhagic infarcts before treatment, however no worsening was observed after anticoagulation therapy. Anticonvulsant was used only in 20patients who had seizures in the acute stage; anticonvulsants were tapered off gradually after 3 to 4 months unless attacks persisted. The majority of the patients 26 of 35 had no neurological sequelae during follow up. 9 patients continued to suffer from various degrees of neurological impairment as summarized in table 2. Seizures were observed only in few patients (6 out of 20) who had seizures and focal signs in the acute stage. These seizures appeared in the first year after CVT. Regarding the thrombotic risk, 4 patients had recurrence of CVT within 12 months of the first episode. None of the 4 patients with recurrence was on long term anticoagulation.

 

DISCUSSION

The interval between delivery and onset of symptoms varied with about 90% of them developed symptoms within 7 to 10 days of delivery. This has been attributed to increased platelet adhesiveness during pregnancy and puerperium with peak increase by 10th postpartum day when the incidence of CVT is highest. Focal deficits such as hemiparesis and hemisensory disturbance, seizures, impairment of level of consciousness occur in one third to three quarters of cases. Predominant CT scan finding in all the patients was haemorhagic infarction. 60% of these patients had superior sagittal sinus thrombosis and other 40% had deep venous system and cortical veins involvement .Haemorrhagic infarction occurred in nearly all patients principally affecting the cortex and adjacent white matter . Viilringer9 observed that this is thought to be primarily due to elevated venous and capillary pressure caused by persistence of thrombosis. Haemoglobin was found to be less than 6.6 gm % in most of the patients, significantly low haemoglobin and packed cell volume are seen in most patients. 26 of 35 patients with CVT recovered with no permanent neurological impairment and 9 patients were left with neurological damage .This confirms that these two main modes of presentation carry a different prognosis regarding the risk of sequelae, as seen by International Journal of Current Research and Review www.ijcrr.com Vol. 03 issue 10 October 2011 179 Bouser1 , Ameri6 , and Barinagarrementeria10. No worsening was observed in patients who received anticoagulant agents in the acute stage, as this was not controlled study it was difficult to conclude that the low rate of sequelae observed in the present study is related to the wide use of anticoagulants. The frequency of epilepsy beyond the acute attack was low in contrast to those in Nagpal RD11 study. However, the low risk of recurrent seizures and the very low risk of late recurrences, it is appropriate to maintain anticonvulsant therapy for a year and to taper off gradually thereafter. If seizure recurs, anticonvulsant should be given on a long term basis. Heparin is considered the treatment of first choice in patients with CVT by most experts, because it is safe and probably beneficial as also seen in Frey JL12 study. Nevertheless, it is clear that a substantial number of patients with CVT may recover completely without any treatment 1, 12.Thrombotic events occurred in 9 patients during follow up. When no cause is found, long term anticoagulation is not indicated after the initial CVT. However, if there is a recurrent CVT or another venous thromboembolic event, then long term anticoagulation is preferred. The systemic heparin treatment is not warranted unless there is an underlying thrombophillia or a known cause of venous thrombosis.

 

CONCLUSION

In conclusion, the long term prognosis of CVT in the study was essentially good. The risk of long standing epilepsy and of CVT recurrence were low in most cases, there is no need for long term anticoagulant or anticonvulsant treatment. In the absence of known thrombophillia, heparin treatment during further pregnancies does not seem to be required. It should, however be emphasized that this is a retrospective study and that prospective studies need to better assess the long term prognosis of patients with CVT.

 

 

References:

1. Bousser M, Russell RR. Cerebral venous thrombosis. London: WB Saunders, 1997.

2. Einhäupl KM, Villringer A, Haberl RL, et al. Clinical spectrum of sinus venous thrombosis. In: Einhäupl KM, Kempski O, Baethmann A, eds. Cerebral sinus thrombosis Experimental and clinical aspects. New York: Plenum Press, 1990; 149-156.

3. Kalbag RM, Woolf AL. Cerebral venous thrombosis. London, UK; Oxford University Press; 1967.

4. Krayenbuhl HA. Cerebral venous and sinus thrombosis. Clin Neurosurg; 1967; 14; 1 – 24.

5. Thron A, Wessel K, Linden D Scroth G. Superior sagittal sinus thrombosis; neuroradiological evaluation and clinical findings. J Neurol; 1986; 162; 779 – 785.

6. Ameri A, Bousser MG. Cerebral venous thrombosis .Neurol Clin; 1992; 10; 87 – 111.

7. Preter M . Langzietprognose bei Hirnvenen und Sinusthrombosen. Eine Katamnese von 77 patienten. Munich , Grrmany ; Ludwig – Maximillians –university ; 1995 . Doctoral thesis.

8. Bruijn de SFTM, Stam J, for the Cerebral Venous Sinus Thrombosis Study Group. Randomised placebo-controlled trial of anticoagulant treatment with low-molecularweight heparin for cerebral sinus thrombosis. Stroke 1999; 30: 484-488.

9. Viilringer A, Mehraen S. Pathophysiological aspects of cerebral sinus venous thrombosis. J Neuroradiol; 1994; 21; 72 – 80.

10. Barinagarrementeria F, Cantu C, Arredondo H. Aseptic cerebral venous thrombosis; International Journal of Current Research and Review www.ijcrr.com Vol. 03 issue 10 October 2011 180 proposed prognostic scale. J Stroke Cerebrovasc Dis; 1992; 2; 34 –39.

11. Nagpal RD. Dural sinus and cerebral venous thrombosis. Neurosurg Rev; 1983; 6; 155 – 160.

12. Frey JL, Muro GJ, McDougall CG, et al. Cerebral venous thrombosis: combined intrathrombus rtPA and intravenous heparin. Stroke 1999; 30:489-494.

 

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
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A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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