International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 4(19), October, 2012

Pages: 128-132

Date of Publication: 15-Oct-2012


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STUDY OF C - REACTIVE PROTEIN, MALONDIALDEHYDE AND URIC ACID LEVELS IN PREDICTING OUTCOME IN ACUTE MYOCARDIAL INFARCTION

Author: Mriganka Baruah, Chandan Nath, Sapna Goyal, Bobby Das, Runi Devi

Category: Healthcare

Abstract:Acute Myocardial Infarction (AMI) is an important health problem with poor outcome despite impressive advancement in diagnosis and management. Objective: The purpose of this study is to investigate the role of C-reactive protein (CRP), Malondialdehyde (MDA) and serum Uric Acid as a predictor of outcome in Acute Myocardial Infarction (AMI). Materials and Method: A study was conducted in 72 subjects; 42 patients with AMI (35 years to 81 years), of which 6 patients expired during the study (4 Males, 2 Females) and 30 age and sex matched healthy control. These subjects are divided into among 3 groups, Group I- 6 AMI patients who expired after 7th day, Group II -36 patients with AMI; and Group III- 30 control group. Serum CRP, Uric acid and MDA readings were taken on day 1, 3 and 7 from the onset of symptoms. Result: Group I and II readings are found statistically significant (p< 0.01) on all days as compared to the control (Group III). All the parameters in Group I showed an increasing trend and remained significantly elevated on day 1, 3 and 7 compared to Group II and controls. Conclusion: Our results suggest that inflammation and oxidative stress play important role in AMI and can be used in predicting outcome in AMI.

Keywords: Death, Acute Myocardial Infarction (AMI), C-reactive protein (CRP), Malondialdehyde (MDA), Uric acid, Lipid Peroxidation, Oxidative Stress.

Full Text:

INTRODUCTION
AMI an interruption of blood supply to a part of the heart which causes damage and potential death of heart tissue become an important health problem despite of advancement in management of this disease over the last few decades. This disease is often premature and severe, with serious complication and increase morbidity and mortality irrespective of age. CRP is labelled as a predictor of outcome in AMI and correlated with infarct size and host (immune) response factors [1,2] i.e the total circulating Creactive protein levels in the setting of acute myocardial infarction is likely represents a marker of chronic vascular inflammation as well as the inflammatory response to acute myocardial injury. Studies have shown that uric acid is an important independent risk factor for cardiovascular mortality [3]. Under ischaemic conditions, Xanthine oxidase activity [4] and uric acid synthesis [5] are increased invivo and therefore elevated serum uric acid may act as a marker of underlying tissue ischaemia. The three carbon dialdehyde Malondialdehyde (MDA) is a highly reactive marker of lipid peroxidation due to production of free radical. Any imbalance between prooxidant and antioxidant defences in which the former dominates defined as ?oxidative stress? of which lipid peroxidation is one important manifestation [6]. Oxidative stress in relation with ROS is involved in LDL oxidation, platelet aggregation, thrombus formation and thereby atherosclerosis and AMI [7,8].

MATERIALS AND METHODS
The study is conducted in a group of 72 subjects; 42 patients with cases of Acute Myocardial Infarction (35 years to 81 years) of which 6 patients expired during the study (4 Males, 2 Females) and 30 age and sex matched healthy control, irrespective of age and sex taken randomly from the admitted patients of Cardiology department of Gauhati Medical College (GMC), Assam. All procedures for the study is followed and Informed consent was obtained from all patients and control subjects participating in this study. Inclusion criteria- history of Squeezing or Crushing central chest pain, characteristic electrocardiogram (ECG) changes and elevated creatine kinase isoenzyme MB (CK-MB) and troponin-t within 12 hrs of onset of pain [9]. Exclusion criteria - Renal failure, Rheumatic fever, Rheumatoid Arthritis, Inflammatory Bowel disease, Gout, Neoplastic disease and Bacterial Infection.. Antioxidant, vitamin supplements, probucol, quinidine, disopyramide, or other drugs were not given to the Patients or controls group which may affect the study. Beta blockers, oral ACE inhibitors, antiplatelet therapy (aspirin or clopidogrel), unfractionated heparin, and GP (Glycoprotein) IIb/IIIa inhibitors, were used in treating the AMI Patients. Blood samples for estimation of Serum C-Reactive Protein, Uric acid and Malondialdehyde were collected on day1 and day3 from the onset of the symptoms. 3 ml of blood is drawn from the Ante cubital vein under aseptic precautions. Biochemical estimations were done based on colorimetric principles. ? Serum C - reactive protein was estimated by using the Turbidimetric Immunoassay method [10]. ? Serum Malondialdehyde (MDA) was measured as thiobarbituric acid reactive substance by colorimetric method by modified procedure of Yagi‘s and Satoh‘s methods [11]. ? Serum uric acid is estimated by Uricase method [12] using the Crest Biosystems kits. SPSS 16.0 statistical package were used. The results obtained were presented in Mean± SD and then compared between different groups of the study by applying students?t‘ test, probability (p) less than 0.05 is considered significant.

OBSERVATIONS AND RESULTS
The test group comprises of 72 subjects; 42 patients with cases of Acute Myocardial Infarction (35 years to 81 years), of which 6 patients expired during the study (4 Males, 2 Females with a mean of 56.5 years) and 30 age and sex matched healthy control (25 males and 5 females, age ranging from 38 years to 77 years) with a mean of 53.4 years comprises of the control group. Serum C - reactive protein, Malondialdehyde and Uric acid readings were taken on Day 1, 3 and 7 from the onset of symptoms. Table 1 shows statistically significant value of Serum C - reactive protein, Malondialdehyde and Uric acid on days 1, 3and 7 in Death and AMI compared to Controls group. Figure I show mean CRP values in Death, AMI and Control. Figure II shows a mean MDA values in Death, AMI and Control, Figure III shows a mean Uric acid levels in Death, AMI and Control on Day 1, 3and 7. CRP, MDA and Uric acid peaks around 3rd day with subsequent decline but Group I showed an increased trend in all the parameters.

DISCUSSION
An inflammatory risk marker of acute phase protein is C-reactive protein. Studies have interpreted that an elevated levels of CRP to be a predictor of outcome in AMI [1, 13, 14]. Our results are also comparable with them. Our results showed elevated levels of C-reactive protein in Death patients (group I) on day 1,3,7 as compared to the AMI (group II) and control group (group III). Castelli P et al, 1995 has labelled elevated Uric acid as a marker of tissue ischemia. Studies also reveal that uric acid level as a risk factor for AMI [15] and also increases in cardiac failure [16]. In the present study, there is a statistically significant high level of serum uric acid concentration in death patients as compared to AMI and control subjects on day 1, 3and 7 . Lipid peroxidation marker (MDA), has significantly higher values in death patients (group I) on all days compared to Group II and III. Our study showed that MDA has a definite pattern in AMI and its level continues to rise and peaks around 3rd which matches with the result obtained by Justo aznar et al 1983 [17]. CRP, MDA and Uric acid reading remain significantly elevated in Death patients (group I) with an increasing trend without subsequent decline as compared to other AMI subjects (group II) as seen in figure I,II and III respectively. Markedly elevated levels of CRP, MDA and Uric acid in death and AMI patients should be cautiously taken and considerably importance in the serial measurement of these parameters should be given to patients admitted with AMI. Thus the increasing rise of these parameters should be taken as alarming signs in management of AMI. CONCLUSION All the 6 patients who died had very high CRP, MDA and Uric acid at presentation and remained highly elevated during the course compared to other AMI patients who had gradual elevation of all three parameters and subsequent decline in AMI. As a result of this we conclude that CRP, Uric acid and MDA at presentation may be considered as alarming and should be taken as a serious marker in predicting outcome including death of the patients, as the line of treatment and lab diagnosis can go hand in hand to increase the life expectancy of the individuals.

ACKNOWLEDGMENTS
The authors wish to express their acknowledgement to the Principal GMC and the Department of Biochemistry Department of Medicine, Department of Cardiology of GMC, Guwahati, Assam for their kind support throughout the study. Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed

References:

1. Sabatine MS, Morrow DA, De Lemos JA. Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, Creactive protein, and B-type natriuretic peptide. Circulation. 2002; 105:1760–1763.

2. Nijmeijer R, Lagrand WK, Lubbers YT. Creactive protein activates complement in infarcted human myocardium. Am J Pathol. 2003;163:269–275

3. Niskanen LK, Laaksonen DE, Nyyssonen K, Alfthan G, Lakka HM, Lakka TA et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med. 2004; 164: 1546–1551.

4. Castelli P, Condemi AM, Brambillasca C, et al. Improvement of cardiac function by allopurinol in patients undergoing cardiac surgery. J Cardiovasc Pharmacol 1995; 25:119–25.

5. Kogure K, Ishizaki M, Nemoto M, et al. Evaluation of serum uric acid changes in different forms of hepatic vascular inflow occlusion in human liver surgeries. Life Sci 1999;64:305–13.

6. Kappus H, Lipid peroxidation : Mechanisms, analysis , enzymalogy and biological relevance.In : Sies H, ed.Oxidative stress .London , England: Academic press, 1985;273-310.

7. Loeper, J., Goy, J., Rozenstajin, L., Bedu, O., and Moisson, P. ?Lipid peroxidation and protective enzymes during myocardial infarction?. Clin Chim Acta. 1991;15; 196(2- 3): 119-125.

8. Loscalzo J. Oxidaive stress: a key determinant of atherothrombosis. Biochem Soc Trans .2003;21:1059-61.

9. Alpert Js. Thygesen K, Antman E, Bassand JP. Myocardial Infarction redefined-a consensus document of The joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000; 36:959.

10. Chenillot O, Henny J, Steinmetz J. Clin Chem Lab Med. 2000;38(10):1003-1011

11. Satoh K. Serum lipid peroxide in cerbrovascular disorders determined by new colorimetric method. Clin Chim Acta. 1978; 90:37—43.

12. Tietz Textbook of Clinical Chemistry. 4th edition, Edited by CA Burtis, ER Ashwood, WS Bruns. W.B. Saunders Company, Philadelphia, 2006;24:803-807.

13. Mriganka Baruah, Chandan Kr. Nath, Bikash Chaudhury, Runi Devi. A Study of Serum Uric Acid and C-Reactive Protein in Acute Myocardial Infarction. IJBMSP 2012; Vol. 2(1): 21-24.

14. Kushner I, Broder ML, Karp D. Control of the acute phase response. Serum C-reactive protein kinetics after acute myocardial infarction. J Clin Invest. 1998; 61:235–242.

15. Michiel J. Bos, MD, MSc; Peter J. Koudstaal, MD, PhD; Albert Hofman, MD, PhD; Jacqueline C.M. Witteman, PhD Monique M.B. Breteler, MD, PhD . Uric Acid Is a Risk Factor for Myocardial Infarction and Stroke-The Rotterdam Study: Stroke. 2006; 37:1503-1507.

16. Zebrack JS, Anderson JL, Maycock CA, Horne BD, Bair TL, Muhlestein JB. Usefulness of highsensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. Am J Cardiol. 2002; 89:145–149.

17. Justo Aznar,m Teresa santos,t Juana valles,t Jesus sala: J Clin Pathol 1983;36:712-715.

 

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
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A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
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A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
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A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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