International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 04 Issue 23, December, 2012

Pages: 104-110

Date of Publication: 15-Dec-2012


Print Article   Download XML  Download PDF

VISUAL OUTCOME AFTER MICROCOAXIAL PHACOEMULSIFICATION WITH MICRIOL PLUS LENS IMPLANTATION

Author: Mohd Dilawar Mir, Tufela Shafi, Manzoor Qadir Keng, Asifa Jehan, Tasneem Muzaffar, Raashid MaqboolWani

Category: Healthcare

Abstract:Background: Study carried out in a tertiary care eye institute in North India with the aim of evaluating the visual outcome after Microcoaxial Phacoemulsification with MICRIOL PLUS lens implantation as well as to study the intraoperative and postoperative complications associated with the procedure. Methods: Prospective study conducted in one hundred cases over a period of one year. Patients with grade 1 to 3 nuclear and corticonuclear cataracts were included in the study after undergoing complete ophthalmic evaluation. Each patient underwent Microcoaxial Phacoemulsification using incision size of 2.2 mm and MICRIOL PLUS lens was implanted in each case using 'D' cartridge. Patients were followed up for a period of 6 months and visual acuity, slit lamp biomicroscopy, IOL centration, capsule opacification were noted during follow up. Results: Microcoaxial Phacoemulsification was successfully performed in all 100 eyes. 93 % patients achieved a BCVA of 6/9 or better over a 6 month followup, the procedure being associated with low intraoperative and postoperative complications. Conclusions: Microcoaxial Phacoemulsification with MICRIOL PLUS lens is a safe and cost effective alternative surgical procedure for management of cataracts with excellent postoperative visual acuity and few intraoperative and postoperative complications.

Keywords: Cataract, Visual Outcome, Microcoaxial Phacoemulsification, Bimanual Phacoemulsification, MICRIOL PLUS lens, D cartridge.

Full Text:

INTRODUCTION
Cataract surgery has undergone remarkable technical refinement, with simplified postoperative care and faster visual recovery as consequences.1,2 . With improved instrumentation, small incision Phacoemulsification became possible in the late 1980s, leading to the current state of the art of sutureless phacoemulsification surgery with foldable intraocular lens implantation3,4 . Phacoemulsification introduced by Dr. Charles Kelman in 1967, utilizes a small incision. The incision size for routine phacoemulsification is approximately 3 to 3.5mm in width. This small 3.5 mm incision required for standard phacoemulsification is self sealing and generally does not require any suturing, as it is watertight. The smaller the incision, the less the pressure changes, the more stable the anterior chamber, the more the control during capsulorrhexis and hydrodissection. Smaller wounds heal more rapidly, with less risk of leakage and endophthalmitis. Besides, the surgically induced astigmatism is also much less with a smaller incision. However at present, the incision size is limited not only by the diameter of the phacoemulsification tip but also by the irrigation sleeve around the phacotip, which provides irrigation fluid into the anterior chamber besides adequate fluid to cool the phacoemulsification needle5 . If a rigid intraocular lens implant is used, the incision has to be enlarged upto 5.0mm to 5.5mm. If the lens implant that can be folded is used, this may not have to be enlarged. With the introduction of microincisional cataract surgery, phacoemulsification can be done through incisions of 2.2 mm or less, using either the Bimanual or Microcoaxial technique. Surgeons who perform bimanual phacoemulsification, create two 1.5mm to 1.2 mm incisions, one to insert an irrigation hand piece and the other to introduce a sleeveless phaco tip to remove the cataract. Apart from the various advantages of a small incision, microincisions further reduce surgically induced astigmatism. However, smaller incisions come with their own problems. Generally sleeveless phacotips need to be used through these incisions,with fluid inflow into the anterior chamber being maintained separately through the irrigation handpiece . The low flow rates from the small irrigating tips placed through these incisions may compromise anterior chamber stability. Besides once the inflow into the anterior chamber is reduced, the aspiration rate also gets limited6 . In such a situation, high vacuum levels and post occlusion surge potentially can threaten the safety of the procedure. In addition, the sleeveless phaco tips can overheat, thereby raising the risk of thermal damage to the cornea. Microcoaxial Phacoemulsification Microcoaxial phacoemulsification also known as coaxial micro-incision cataract surgery (C-MICS) requires an incision less than or equal to 2.2mm and accommodates a sleeve over the phacotip. Therefore aspiration and irrigation can be carried through the same incision and implantation of a foldable IOL can be done without enlarging the incision3 . The instrument and surgical technique is the same, only the incision size is variable. The machine parameters need to be reset and higher vacuum (400-450 vaccum) needs to be used and the surgeon needs to get used to the more controlled procedure7 . For C-MICS a microincision sleeve, micro-coaxial phaco needle, an appropriate keratome and micro-coaxial irrigation / aspiration are needed. A standard sleeve has a 1.8mm diameter, whereas a coaxial sleeve has a smaller diameter of 1.6mm which tapers to 1mm at the tip8. With bimanual micro phacoemulsification, unsleeved rigid round tips are used which induce distortion of the small slit incisions and at times result in the fish mouthing of these incisions. In contrast, the sleeve around the phacotip in CMICS acts as a buffer and does not distort or ‘fish mouth’ the incision. These microincisions are snug fitting, self seal and do not leak post or intraoperatively. There is at times poor chamber control with bimanual microphacoemusification due to imbalance between aspiration and irrigation flow, particularly if aspiration is continued when there are no nuclear particles which need to be captured by the aspiration port 9 ; however, with the coaxial microphacoemulsification, the fluidics are basically the same as those seen with standard phaco. Surge testing has also demonstrated that there is less surge and greater chamber stability during coaxial microphacoemulsification using the thin sleeve than during the bare tip bimanual technique10 . The attractive feature of coaxial microphaco is that the phaco tip is covered with a sleeve and yet it is sub 2mm, therefore all the above mentioned disadvantages of bimanual microphaco are obviated. Standard technique of coaxial phaco is used and no extra instrumentation or steep learning curve is required. The whole procedure can be performed through sub 2mm wound size and the IOL can be introduced through the same using wound assisted insertion without the need to enlarge the wound. However, there is a limited availability of the small size IOLS which can be implanted through these microincisions and most of them are quite expensive, limiting the population in which this procedure can be carried out. Cost factor plays a major role in deciding the type of lens and hence the type of surgery which can be carried out in the majority of the patient groups from developing countries like ours. MICRIOL PLUS lens from Care Group meets all the needs of the lenses required for microincisions besides being low in cost, hence we selected this for our study with the view of popularizing this surgical procedure to all sections of the society particularly to the patients from low socioeconomic strata.

RESEARCH METHODOLOGY
Patients in the age group between 10 years to 70 years, having Grade 1 to 3 nuclear and corticonuclear cataracts (LOCS-III classification system), a transparent central cornea, pupil dilatation at the preoperative examination of at least 6 mm, absence of Bio-microscopical signs of pseudoexfoliation and with no active fundus pathology were included in the study. Patients with high density lens opacity (LOCS-III : NO5- NO6, C4-C5, P4-P5), relevant corneal opacities, Pseudoexfoliation syndrome, pupil anomalies, synechia, zonulolysis or defective zonules, abnormal fundus, history of ocular trauma, intra ocular surgery as well as history of serious coexistent ocular diseases such as uveitis, glaucoma, optic atrophy or ocular tumors, Diabetes Mellitus or other metabolic diseases were excluded from the study. Only 100 patients who fulfilled the criteria and completed the followup schedule were included in the study. Preoperative assessment included Visual acuity, complete slitlamp and fundus examination, keratometry and A- Scan.

Procedure and Instrumentation (Fig 1&2)
Microcoaxial phacoemulsification.
In all patients, maximum mydriasis was achieved with 1 drop each of a combination of tropicamide (0.8%) and phenylephrine (5%) and cyclopentolate (1%) applied 4 times 1 hour before surgery. Peribulbar block was used to achieve anesthesia and akinesia. All the cases were operated upon by a single surgeon. Following disinfection and draping, a clear corneal stab incision was created at 12 O’clock position using a 2.0 mm keratome. Two side port stab incisions (1mm) were made at 10 O’clock and 2 O’clock position. An air bubble was then injected through the side port, followed by application of 0.1 to 0.2ml of trypan blue solution over the anterior capsule for capsular staining. After 20 seconds, the trypan blue solution was aspirated. The anterior chamber was then filled with viscoelastic fluid. Continuous curvilinear capsulorhexis was then performed with a bent 26 gauge disposable needle mounted on a syringe. In case of difficulty in completing the CCC it was completed using the micro CCC forceps. Hydrodissection was performed and rotation of nucleus done followed by reformation of anterior chamber with a viscoelastic agent. Endocapsular phacoemulsification and aspiration of nucleus was done using the divide and conquer technique. The machine parameters were varied according to the hardness of the cataract. The infusion bottle height was adjusted according to the anterior chamber stability. The residual cortex was removed using the bimanual irrigation and aspiration handpiece. The capsular bag was then filled with a dispersive ophthalmic visco-surgical device. The incision size was enlarged to 2.2mm to fit the outer diameter of the cartridge tip (D cartridge) of microincision IOL injectors. The 360 degree square edge acrylic lens (MICRIOL PLUS Lens) was taken from its container and loaded into the IOL injector with D cartridge and inserted into the main incision and the IOL was delivered inside the eye. MICRIOL PLUS lens is a single piece ultrathin lens with 4 haptics which are designed to provide wider angle of equatorial contact and more reliable centration. The ophthalmic viscosurgical device was aspirated using irrigation / aspiration cannula through the same incisions and at the end of the procedure the internal diameter of the main incision was measured using the 2.2mm measuring guage. Stromal hydration of the corneal wound and side ports were performed postoperatively. The operating surgeon did not report any difficulty in negotiating the phaco probe or any other instrument through the incision. Post operative pad and bandage was done. On next day slit lamp examination was performed. The patients received topical antibiotic steroid drops for 6 weeks and cycloplegics for 2 weeks. Examinations were done at 1 and 7 days and at the end of 1, 3 and 6 months postoperatively. Observations were done with pupil fully dilated. At every visit, slit lamp biomicroscopy, capsule opacification, and IOL centration were evaluated. Visual acuity, IOP measurements and fundus evaluation was also done.

RESULTS
The major outcomes measured were the postoperative visual acuity as well as intraoperative and postoperative complications. There were 55 males (55%) and 45 females (45%). Patients were included irrespective of sex. The age of the patients varied between 10 to 70 years. Maximum patients (72%) were in the 51- 70 years age group. Lowest number of patients (7%) were in the age group of 10-30 years. The mean age in our study was 54.47 years (Table 1). Combined cataract was the most frequent type of cataract encountered (26%) in our study followed by nuclear cataracts (25%) and posterior subcapsular cataracts (21%).(Table 2). Preoperative visual acuity ranged between 6/24 and hand movements with a median value of 6/60. The most common operative complication that we encountered was striate keratopathy in 21 patients (21%) but that was not seen to interfere with the final visual outcome. 2 patients who had posterior capsular rent with vitreous loss had persistent macular edema with visual status of 6/36 and 6/60 at follow up. Residual superior cortex was seen in 2 patients (2%) but both had good visual outcome since the pupillary axis remained clear. 2 patients (2%) had corneal oedema, 1 patient (1%) had extension of capsulorrhexis, and 1 patient (1%) had IOL decentration but the final visual acuity was 6/9 or better in all the four cases. Only 2 patients had a visual acuity less than 6/60 (1 each due to persistent macular edema and CNVM). (Table 3). Post operatively, at 6 months, majority i.e. 93 patients (93%) had best corrected visual acuity of 6/9 or better, whereas 7 patients had visual acuity of 6/12 or less. (Table 4). The causes of decreased visual acuity (less than 6/12) were posterior capsular opacification in 4%, persistent macular edema in 2 % and CNVM in 1% patient who had soft drusens preoperatively.(Table 5).

DISCUSSION
The major advantage of microcoaxial phacoemulsification is an improvement in control of most endocapsular surgery steps. Because visocoelastic material does not leave the eye easily through these small incisions, the anterior chamber is more stable during capsulorrhexis construction and there is a less likelihood for an errant capsulorrhexis to develop. Hydrodelineation and hydrodissection can be performed more efficiently because of a higher level of pressure buildup in the anterior chamber before eventual prolapse of viscoelastic material through the microincisions. Stable anterior chamber is also advantageous when weak zonules are present. The surgical technique for C-MICS is the basically the same as for conventional phacoemulsification , hence no learning curve is required . Besides with the availability of IOLs in the market to suit these microincisions ,the surgeon does not need to compromise on the quality of IOL nor is there any need to enlarge the incision, rendering the procedure a truly microincision procedure.

In our study the visual outcome after microcoaxial phacoemulsification was evaluated by recording the visual acuity of the patients operated for cataracts in the follow up period.72% patients in our study belonged to the age group of 51 to 70 years (72%), lowest being in the age group of 10 to 30 years (7%). The mean age in our study was 54.47 years. In the study done by Abhay Vasavada et al11, the mean age group was 54.23 years (range 39 to 73 years) and in the study done by Arup Chakraborti12 , mean age group was 62 years (range 46 years to 72 years). This is because most common types of cataracts are age related. Combined cataract was the most frequent type of cataract encountered (26%) in our study. Nuclear cataracts and posterior subcapsular cataracts were the next commonest types. In our study endocapsular phacoemulsification using the divide and conquer technique was used to emulsify the nucleus. The endocapsular phacoemulsification technique decreases the endothelial cell loss and postoperative corneal oedema which is more common when the phacoemulsification is performed in the anterior chamber. This finding is supported by the study conducted by Victoria W. Y. Wong et al13 . Striate keratopathy was the most frequent complication encountered in our study (21%) followed by residual cortex (3%) and posterior capsular rent (PCR) with vitreous loss (2%). The findings were consistent with other studies done earlier. In the study done by Amar Agarwal et al14, 18 patients (5.9%) developed corneal oedema, 5 patients (1.6%) developed posterior capsule rupture, 3 patients (0.9%) developed cystoid macular oedema and 1 patient developed age related macular degeneration. Because the anterior chamber is stable during MICS, management of PCR becomes much easier. Best corrected visual acuity at 6 months follow up was 6/9 or better in 93% of cases. Posterior capsular opacification (4%) was the most common cause of vision less than 6/9 (target vision) followed by persistent macular oedema (2%). These findings are consistent with the other studies conducted by Amar Agarwal et al14, Arup Chakraborti et al12, Jorge L. Alio15 et al and Victoria W. Y. Wong et al13. Rapid visual rehabilitation is considered to be one of the advantages of this procedure. The information available to date on results from surgery with the coaxial microphacoemulsification procedure shows that it is a relatively safe and effective operation. All reported cases reflect decreasing complications, better visual outcome and early rehabilitation. With this method comparison of the complications with those of standard phacoemulsification technique is difficult due to relative paucity of reported data, the lack of standard techniques and the fact that improved surgical technique and instrumentation have apparently decreased complications in all types of cataract surgery.

CONCLUSION
The ability of coaxial microphacoemulsification to:
1) To allow the surgery using the same technique as that of conventional phacoemulsification, without warranting the need for a learning curve.
2) Limit the hospital stay to 24 hours and therefore reduce the expenses.
3) Permit the patient unrestricted activity after discharge and
4) Reduce the intra operative time as well as postoperative recuperative times gives it distinctive advantages.

It should definitely be the procedure of choice for both patients as well as surgeons for the removal of cataracts .With the change in the trend from small incision (>2.0mm) to minimal incision (<2.0mm) surgery, microcoaxial phacoemulsification offers a new modality in the management of cataracts of all densities. Though still in its early years, with improved and specific  instrumentation and manoeuvers, increasing experience and newer IOL materials, it may fast become the preferred choice of all cataract surgeons.

ACKNOWLEDGEMENT
Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

1. Jaffe NS (1996) History of cataract surgery. Ophthalmology ; 103: S5-16.

2. Olson RJ, Mamalis N, Werner L, Apple DJ (2003) Cataract treatment in the beginning of the 21st century. Am J Ophthalmol ; 136: 146-154.

3. Leaming DV (2005) Practice styles and preferences of ASCRS members – 2003 survey. J Cataract Refract Surg; 30: 892- 8900.

4. Leaming DV (2003 ) Practice styles and preferences of ASCRS members – 2002 survey. J Cataract Refract Surg; 29: 1412- 1420.

5. From the Editor (2003) Is smaller better. J Cataract Refract Surg ; 29: 1049-1050.

6. Vasavada V, Vasavada V, Raj SM, Vasavada AR (2007) Intraoperative performance and postoperative outcome of microcoaxial phacoemulsification. J Cataract Refract Surg ; 33: 1019-1024.

7. Singh MS (2008) Coaxial MICS: sub 2mm made easy. Ophthalmology World Report; July: 17-22

8. Barrett G (2007) Minimizing incision size without compromise. Ophthalmology World Report ; December Supplement: 3-5.

9. Tsuneoka H, Takahama M (2003) Ultra small incision bimanual phacoemulsification and AcroSof SA30AL implantation through a 2.2mm incision. J Cataract Refract Surg; 29: 1070-1076.

10. Kapur KB, Sud S (2008) C-MICS the future is here to stay. DOS Times; 13: 23-27.

11. Vasavada A, Singh R, Desai J (1998) Phacoemulsification of white cataracts. J Refract Surg ; 24:270-277.

12. Chakrabarti A, Stephen V, Chakrabarti M (2006) Microincision cataract surgery in white mature/ hypermature cataracts in South India. AIOC Proceedings.

13. Wong VW, Lai TY, Lee GK, Lam PT, Lam DS (2007) Safety and efficacy of microincisional cataract surgery with bimanual phacoemulsification for white mature cataract. Ophthalmologica; 221: 24- 28.

14. Agarwal A, Agarwal A, Agarwal S, Narang P, Narang S (2001) Phakonit: Phacoemulsification through a 0.9 mm corneal incision. J Cataract Refract Surg; 27:1548-1552.

15. Alio JL, Rodriguez-Prats JL, Vianello A, Galal A (2005) Visual outcome of microincision cataract surgery with implantation of an Acri.Smart lens. J Cataract Refract Surg ; 31:1549-1556.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2022 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions


Fatal error: Uncaught Error: Function name must be a string in /home/u845032518/domains/ijcrr.com/public_html/footer-bottom.php:487 Stack trace: #0 /home/u845032518/domains/ijcrr.com/public_html/article_html.php(51): include() #1 {main} thrown in /home/u845032518/domains/ijcrr.com/public_html/footer-bottom.php on line 487