International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 5(6), March, 2013

Pages: 16-21

Date of Publication: 30-Mar-2013


Print Article   Download XML  Download PDF

HEPATOPROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF ADHATODA VASICA IN SWISS ALBINO RATS

Author: Rayese Ahmad, Vaseem Raja, Manik Sharma

Category: Healthcare

Abstract:The hepatoprotective activity of Ethyl acetate extract of Adhatoda vasica was investigated against CCl4 induced liver damage in Swiss albino rats. At the dose of 1ml/kg, CCl4 induced liver damage in rats as manifested by statistically significant increase in serum Alanine aminotransferase, (ALT), Aspartate aminotransfrase (AST), Alkaline Phosphatase (ALP) and also in serum Bilirubin. Pre-treatment of rats with the ethyl acetate Extract of Adhatoda Vasica (100mg/kg and 200mg/kg) prior to the CCl4 dose at 1ml/kg statistically lowered the three serum level enzymes and also Bilirubin. Histopathlogical observations also coincided with the above results, however 200mg/kg dose was found to be more active. Current results suggest that Ethyl acetate extract of Adhatoda vasica has potent hepatoprotective effect against CCl4 - induced liver damage.

Keywords: Adhatoda vasica, CCl4, silymarin and DMSO.

Full Text:

INTRODUCTION
Liver is one of the largest organs in the human body and the chief site for intense metabolism and excretion. So it has the surprising role in the maintenance, performance and regulating the homeostasis of body. It is involved in almost all biochemical path ways to growth, to fight against infections, diseases, nutrient supply, energy provision etc. The major functions of liver are carbohydrate, protein and fat metabolism, detoxification, storage of vitamin and formation of bile. Unfortunately, conventional or synthetic drugs used in the treatment of liver diseases are inadequate and some times can have serious side effects. Drug induced liver injury is a major health problem that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies.1 The rate of hepatotoxicity has been reported to be much higher in developing countries like India(8-30%) comp aired to that in advanced countries(2-3%) with a smaller dose schedule2 . The use of medical plants to treat human diseases has been performed for millenniums. Now days it is known that 80% of the world populations have already taken medicinal plants and 30% are prescribed by physicians. To prove the traditional claims, the hepatoprotective activity of Adhatoda vasica was evaluated. Adhatoda vasica (common name- Malabar nut, Family- Acanthacea) is a small ever green plant (1-1.25m) with broad lanceolate leaves. The flowers are white, pink or purple. The plant grows through out the Indian pensula up to an altitude of 1300m3 . The biological work performed so for on this plant showed poultice on rheumatic joints as counter-resistance on inflammatory swelling on fresh wounds, urticaria and in neuralgia4 . The present investigation has been designed to study the hepatoprotective activity of Ethyl acetate extract of the whole plant of Adhatoda vasica in carbon tetrachloride induced hepatic damage in rats.

MATERIAL AND METHODS
Plant material
The plant of Adhatoda vasica was collected from remote areas of Bhopal district, during Dec. 2010. Identification of plant was carried out at department of Botany Bhoj Mahavidhyalya Bhopal. A voucher specimen has been deposited at the Herbarium located at postgraduate department of zoology Bhoj Mahavidhyalya Bhopal. Preparation of plant extract The whole plant of Adhatoda vasica was washed thoroughly with tap water, sun dried and powdered. The powder (100gm) was successively extracted with 90% ethyl acetate in soxhlet apparatus for 48 hours duration. The filtrate was then concentrated and the solvent was evaporated under reduced pressure in a Rotatory evaporator. The yield of the extract was found to be 25.89%. This crude extract was referred to as AV. For administration the crude extract was dissolved in DMSO and used for the experiments. Experimental animals Swiss albino male rats (150-175gms) obtained from the animal house of PBRI. They were housed under the standard laboratory conditions and were feed commercial rat feed (Lipton India Ltd, Mumbai, India) and water, ad libitum. All animal experiments were carried out according to NIH guide lines after getting approval of the institute’ s Animal Ethics Committee (Regd No.1283/c/09 CPCSEA). Carbon tetrachloride induced hepatotoxicity CCl4 was suspended in olive oil and administered p.o, at a dose of 1ml/kg. Healthy rats were divided into five groups (six per group). Group 1, the normal control group received a single dose of DMSO (3ml/kg p.o) for 7 days. Group 2, the CCl4 intoxicated control group received a single dose (1ml/kg bw,p.o). Group 3 received drug silymarin (50mg/kg,bw) for 7 days and a single dose CCl4 (1ml/kg,p.o.) on seventh day. Group 4 and 5 received AV (100and 200mg/kg, bw, p.o) and a single dose of CCl4 (1ml/kg) on the seventh day. The animals were scarified after 24 hours of last treatment. The blood samples from all groups were collected separately by retro orbital puncture and allowed to coagulate for 30 min at 37 oC, the clear serum was separated at 8000 rpm for 10min and subjected to the liver function tests. Liver function tests Biochemical parameters like serum glutamate pyruvate transaminase5 (SGPT), serum gultimate oxaloacetate transaminase5 (SGOT), serum alkaline phosphatase6 (SALP) and serum Bilirubin7 (SB) were assayed according to the standard methods. Histopathological studies After blood draining liver samples were excised from the control and treated groups of animals and washed with normal saline separately. They were suspended in 10% formalin for 24 hours. The formalin-fixed liver samples were stained with haemtoxylin-eosin for photo microscopic observations of the liver histological architecture.

STATISTICAL ANALYSIS
Statistical comparison between control and treated groups was made, Analysis of variance, followed by multiple comparisons 8 .

RESULTS
Administration of the CCl4 (1ml/kg p.o) caused a significant increase in serum enzymes namely SGOT, SGPT, ALP and SB in rats, as compared to normal rats. However pretreatment with plant extract AV, prior to CCl4 administration caused a significant reduction in the values of SGOT, SGPT, SALP and SB, however 200mg/kg dose brought reduction almost comparable to silymarin(50mg/kg) treated groups (table-1) The hepatoprotective of AV was further confirmed by histopathological examinations of the liver samples from respective groups. Histological architecture of CCl4 treated liver sections showed degeneration of hepatic cells with centrilobular necrosis. Sinusoids were observed to be inflamed and flooded with inflammatory cells. However, administration of AV (200mg/kg) almost normalized these defects in the histological architecture of the liver resembling that of silymarin treated groups, showing its potent hepatoprotective effects (Fig 1-5).

DISCUSSION
Herbal based therapeutics for liver disorders has been in use in India for a long time and has been popularized world over by leading pharmaceuticals. Despite the significant popularity of several herbal medicines in general, and for liver diseases in particular, they are still unacceptable modalities for liver disease. The efficacy of any hepatoprotective drug is essentially dependent on its capability to either reduce harmful effects or to maintain the normal hepatic physiological mechanism that have been un balanced by the hepatotoxin9 . The result of the present study reveal that the Ethyl acetate extract of Adhatoda vasica possess significant hepatoprotective activities against CCl4 induced liver damage in Swiss albino rat. It has been observed that the CCl4 is bio-transformed by the cytochrome p-450 system to the trichloronethyl free radical; this free radical may react again with oxygen to form a trichloromethyl per oxygen radical which may attack lipids on the membrane of endoplasmic reticulum10. Trichloromethyl per oxygen free radical leads to lipid per oxidation, the disruption of ca++ homeostasis and finally results in cell death11-12. Therefore the leakage of large quantities of enzymes into the blood stream is often associated with massive necrosis of the liver. Administration of CCl4 results in the rapid increase in the serum GOT, GPT and ALP (table1) .Serum GOT can be found in the liver, cardiac muscles, kidney , brain , lungs, skeletal muscles ,leukocytes and erythrocytes (in decreasing concentrations)13 . Whereas the highest concentration of serum GPT is found in liver tissues, serum GPT occurs in two locations, the cytosol and mitochondria. Serum GPT appears to be more sensitive and specific test for hepatocellular damage than serum GOT. Although the serum enzyme levels are not the direct measure of hepatic injury, they show the status of the liver. The elevated levels of enzymes are indicative of cellular leakage and loss of functional integrity of cell membranes in the liver14. Thus lowering of enzyme content in serum is a definite indication of hepatoprotective action of a drug. Serum ALP and Bilirubin levels are also related to the status and function of hepatic cells. In the present study Ethyl acetate extract of Adhatoda vasica has been found to reduce the serum level enzymes and Bilirubin in the treated groups compared to untreated ones in dose dependent manner (Table-1). The liver sections treated with AV also showed the normal hepatic cell architecture and portal triad coincides with serum levels. The serum and histopathological results confirm the hepatoprotective activity of Adhatoda vasica. Thus may be the best remedy for treatment of liver disease in developed as well as in developing countries. The results coincided with our investigations that200mg/kg b.w showed the best protective effect against the carbon tetrachloride induced liver injuries, therefore the possible hepatoprotective mechanisms of extract of Adhatoda vasica may be due to preventing process of lipid per oxidation, inhabiting the cytochrome p-450 activity, stabilizing the hepatocellular membrane and enhancing the protein synthesis. Preliminary phytochemical studies have indicated the presence of flavonoids in Adhatoda vasica. Flavonoids consumed in large amounts in diet, are known to protect liver15. Hence the anti hepatic toxicity of Adhatoda vasica may due to presence of flavonoids.

CONCLUSION
On the basis of the present investigations it can be concluded that the ethyle acetate extract of Adhatoda vasica seem to poessess hepataprotective activity in rats, it is further demonstrated that 200mg/kg b.w. dose has prominent hepatoprotective activity as is evident from the biochemical and histopathological parameters. Further studies are needed to elaborate whether some compounds present in extract responsible for hepatoprotection I CCl4 induced hepatotoxicity and the molecular basis of their mode of action.



 

References:

1. Sobiya R., Vennila, J .J., Aiyavu, C. and Selvam, K.P. (2009). The hepatoprotective effects D of ancholic extract of Annona squamosa leaves on experimentally induced liver injury in Swiss albino mice.international Journal of Integrative Biology, 5 ( 3): 182- 190.

2. Shama, S.K. (2004). Antituberculosis drugs and hepatotoxicity . Infect Genet Evol. 4 : 167-170.

3. Claeson, U.P., Malmfors, T., Wikman, G. and Bruhn, J.G. (2000). Journal of Ethnophamacology, 72, 1-20.

4. Wealth of India, Raw Materials(1985). CSIR New Delhi, 1, 76.

5. Reitman, S. and Frankel, S. (1957). A colorimatric method for the determination of serum gultimate oxaloacetate and glutamic pyruvic acid transaminase. Amr J. Clinic. Pathol, 28: 56-62.

6. Kind, P.R.N. and King, E.J. (1954). Determination of serum alkaline phosphatase. J Clin Pathol, 7: 132-136.

7. Jendrassikl. and Grof, P. (1938). Verenfachte photometrishe method zur bestimmung des blubilirubins. Biochem Z, 297: 81-89

8. Armitage, P. and Berry, G. (1985). Statistical methods in Medical Research, 2ndEdn, Black Well Scientific publications, Edinburgh, UK, 186

9. AL – Howring, T.A., AL – Sohaibani, M.O., AL – Said., M.S., AL – Yahya, M.A., AL – Tahir, K.H. and Rafatullah, S. (2004). Hepatoprotective properties of Commiphora opobalsamum (Balessan), a traditional medicinal plant of Saudi Arabia. Drugs Exptl. Clin. Res, 5 (06): 213-220

10. Manokarn, S., Jaswanth, A., Sengotuvelus., Nandha, K.J., Duraisamy, R., Karthikeyan, D. and Mallegaswari, R. (2008). Hepatoprotective activity of Avera lanata against paracetamol induced liver damage in rats. Research of Pharm and Tech, 1(4): 398- 400.

11. Clawson, G.A. (1989). Mechanism of Carbon tetrachloride hepatotoxicity. Pthol ImmunoPathol Res, 8: 104-115.

12. Reknagel, R.O., Glande, E.A., Dholak, J.A. and Walter, M.A. (1989). Mechanism of carbon tetrachloride toxicity. Pharmacol Ther, 43, 135-140.

13. Rafatullah, S., Moosa, J.S., Ageel, A.M., Alyahya, M.A. and Tariq, M. (1991). Hepatoprotective and Safety evaluation studies on Sarsaparilla. Int J Phamacognosy, 29, 4: 296-301.

14. Susanta, S.K., Goutam, C., Malya, G. and Upal, K.M. (2005). Hepatoprotective activity of Diospyros malabarica Bark in carbon tetrachloride intoxicated rats. Europian Bulletin of Drug Research, 13, (1): 25-30

15. Di Garlo G, Mascolo N, Izzo AA and capasso F(1999). Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci., 65,(4): 337-353

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions