International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 09 Issue 12, June, 2017

Pages: 39-48

Date of Publication: 24-Jun-2017


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To Mask the Bitter Taste of Rizatriptan Benzoate and Develop Water Dispersible Tablets

Author: Chilate Vikrant C., Godbole Mangesh D., Sonaye Harsha V., Doifode C.A.

Category: Healthcare

Abstract:Introduction: Rizatriptan benzoate is anti migraine drug. Report indicates that, it has very bitter taste, which deters its use in geriatrics patient thus not comply with prescription that results in high incidence of non-compliance and ineffective therapy.
Aim: To mask the bitter taste of Rizatriptan benzoate and develop water dispersible tablets.
Methodology: The sweetener like aspartame was use in variable ratio with drug. Physical mixture of Rizatriptan benzoate with Aspartame (1:5 ratio) were rated most effective (0.4) by the panel of tastes. The other used sweeteners did not prove to be very effective for masking of bitter taste as indicated by the high rating of bitterness score 2-3 and 3-4 by panel of human tastes. Water dispersible tablets of Rizatriptan benzoate was formulated by direct compression method using physical mixture of drug: aspartame with superdisintegrants viz. sodium starch glycolate, croscarmilose sodium and crospovidone in variable ratios.
Result: All the formulation batches passed the weight variation test, disintegration test and uniformity of dispersion test and offered good mechanical strength.
Discussion: The combination of sodium starch glycolate with crospovidone in the ratio of 1:2 given best result (disintegration time 19.18 sec), the disintegration time was decreased from 32 to 19 sec.
Conclusion: All formulation batches released more than 98% of drug within 30 min.

Keywords: Water dispersible tablet, Rizatriptan benzoate, Aspartame, Sodium starch glycolate, Cross povidone, Sodium carboxymethyl cellulose, Magnesium stearate, Aerosil

Full Text:

Introduction:

Since the development cost of a new drug molecule is very high, efforts are now being made to focus on the development of new drug dosage forms for existing drugs with improved safety and efficacy, bioavailability together with reduced dosing frequency and the production of more cost effective dosage forms. Drug dissolution and absorption as well as onset of clinical effect and drug bioavailability may be significantly greater than those observed from conventional dosage forms.2 The tablet is just one of the many forms that an oral drug can take such as syrups, elixirs, suspensions and emulsions. It consists of an active pharmaceutical ingredient (A.P.I.) with biologically inert excipients in a compressed  solid form.3 Dispersible tablets offer advantage for patients who have difficulty in swallowing. Patients for whom chewing is difficult or painful can use these new tablets easily. Dispersible tablets can be used easily for pediatric patients who have lost their primary teeth but do not have full use of their permanent teeth.4

Challenges to develop water dispersible tablets

  • Avoid increase in tablet size
  • Rapid disintegration of tablet
  • Have sufficient mechanical strength
  • Minimum or no residue in mouth
  • Protection from moisture
  • Good package design
  • Compatible with taste masking technology
  • Not affected by drug properties5

There is need for non-invasive delivery systems persists due to patients poor acceptance of and compliance with, existing delivery regimes, limited market size for drug companies and drug uses, coupled with high cost of disease management. 6

Materials and METHODS:

Rizatriptan benzoate was received as gift sample from Alkem Labs. Ltd. Mumbai. Kyron, Microcrystalline cellulose, Sodium starch glycolate, Cross povidone, Aspartame, Sodium carboxymethyl cellulose, Magnesium stearate, Aerosil were  gift samples from Alkem Labs. Ltd. Mumbai.

Characterization of drug and excipients

Characterization of Drug:

a) Appearance : Recorded by physical texture  of drug

b) Organoleptic Properties: Taste of sample was tested by panel of tastes following physical properties of drug were studied

c) Determination of melting point: Determined using glass capillary method by using thermometer10

d) Solubility analysis:

Excess quantities of drug were added in to the 5 ml of each of distilled water, phosphate buffer (pH 6.8) and 1.0 M HCl contained in 25 ml glass vials and were shaken at constant temperature 37 ±1oC over a period of 24 hr by recording absorbance using respective medium as blank15

e) Loss on Drying: Accurately about 1 gm Rizatriptan was weighed and the powder was kept in oven for 6 hr at 105oC. At interval of 2hr the moisture content was calculated15

Analytical Method

A validated Double Beam UV Spectrophotometer Model No. UV 1700 , Shimandzu using pH 6.8 phosphate buffer in the range of 400 nm to 200 nm for the estimation of drug

Characterization of Bulk Drug and Effect of Various Formulation Excipients

The infrared (IR) spectrum obtained FTIR Spectrophotometer Model -8300 (Shimadzu, Tokyo, Japan) was compared with that of the standard. To study the compatibility of various formulation excipients with Rizatriptan benzoate , solid admixtures were stored at 40 ± 20C temperature with relative humidity of  RH 75 ± 5 % for 30 days.

Determination of λmax in UV range

Solution of 50 μg/ml concentrations was scanned in the range of 400 nm to 200 nm using distilled water as blank and λmax was noted. Similarly, the λmax values for solutions of drug in 0.1M HCl and phosphate buffer pH 6.8 were determined using corresponding solution as blank.

Thermal behavior by differential scanning calorimetric

Heating at the rate of 100C/min in the range of 30 to 6000C. Air was purged at the rate 50 ml/min.

 X-ray diffraction:

X-ray scattering measurements on Rizatriptan benzoate was carried out at a voltage of 40 kV and current of 25 mA using Cr as a tube anode material. The solid were exposed to Cu –K radiation angles from 10°- 70°.63

Evaluation of taste of Rizatriptan benzoate and its taste modified forms by panel method

Healthy human volunteers of either sex in the age group of 20-30 yrs were selected. The procedure was carried out as follows.

  • Coding of drug and its taste modified forms was done using non-overlapping abbreviations.
  • About 5 ml dispersion of drug powder (equivalent to unit dose) in water was used.
  • Dispersion was held in oral cavity for 15 sec by the volunteers.
  • Content was split off from oral cavity by the volunteers into wash basin.
  • The oral cavity was rinsed with sufficiently large volume of purified water until the after taste of drug is completely ceased.
  • Same procedure was followed for all the taste modified form of Rizatriptan benzoate.
  •  The volunteers were asked to rate both pure drug as well as the individual modified drug samples i.e. resinates in the scale of 0 to 4 as follows,

0     - No bitter taste

            1     - Slightly bitter taste

            2     - Moderately bitter taste

            3     - Strong bitter taste

               4     - Very strong bitter taste

The scores from each volunteer were compared carefully and the most suitable approach (ratio 0-1) was judged.12

Formulation of water dispersible tablets using most suitable approach of taste masking

The ingredients were weighed, mixed in geometrical order and compressed by 8 mm size punch to get a tablet of 200 mg weight using 12 station single rotary Rimak tablet compression machine.

Manufacturing procedure: For Trial No. 01 and 18

  1. Dispense and weigh accurately all other ingredients as per batch formula and then mix well Rizatriptan Benzoate and Microcrystalline cellulose (PH101) sift  through #  mesh and other ingredients sift through # 40 mesh.

      2) Transfer the step 2 material for blending into the mortar pestle.

      3) Sift magnesium stearate through 60#.

     4) Compressed the above blend obtained in with their respective punch (punch No.7)

Evaluation of taste masked water dispersible tablets

Appearance: Tablets were examined for texture, any surface flaws like cracks and chips.

Weight variation: The average weight was calculated and individual tablet weight was then compared with average value and the deviation was recorded.

Friability: For this, weight of 10 tablets of each formulation type was recorded and these tablets were then subjected to combined effects of abrasion and shocks in a plastic chamber that revolved at 25 rpm for 4 min (100 revolutions) to make the impact from a height of six inches with each revolution. Test was carried out for 100 revolutions

F% = (Wo – W) / Wo x 100

 

                             

Where F = friability,  Wo = initial weight of the ten tablets = final weight of the ten tablets

Disintegration time (in vitro):

For this, 3 tablets of each formulation were used and the disintegration test was conducted at following test conditions,

Apparatus                                      : Disintegration test apparatus

Disintegration medium                  : Distilled water

Frequency of raising and lowering

of basket rack assembly                : 28 to 32 cycles.

Temperature of medium                 : 37±2oC

Wetting Time: A piece of tissue paper folded twice was placed in a small petridish (internal diameter = 6.5cm) containing 10 ml of distilled water. A tablet was placed on the paper and the time for complete wetting of the tablet was measured.

Water absorption ratio: A piece of tissue paper folded twice was placed in a small petridish containing 6ml of distilled water. A tablet was put on the paper and time required for complete wetting was measured. The wetted tablet was then weighed. Water absorption ratio, R, was determined using equation:

R= 100   ×   (Wa-Wb) / Wb

 

Where, Wa = weight of the tablet before water absorption, Wb = weight of the tablet after water absorption

Uniformity of dispersion: For this, two tablets of each formulation were used. The tablets were dropped into100 ml of water contained in a beaker. The dispersion was stirred to allow complete disintegration of tablets and was then passed through a sieve (sieve no. 22, #710μm).

In-Vitro drug release from dispersible tablets

i) In-Vitro release of Rizatriptan benzoate in 0.1 M HCl

The dispersible tablets of Rizatriptan benzoate were dropped in dissolution medium. Aliquots of solutions were withdrawn at predetermined intervals and were replaced with same volume of dissolution medium at each withdrawal. The aliquots were filtered through whatman filter paper (No.41) and diluted appropriately before recording the absorbances at previously reported λmax value.

ii) In-vitro drug release in distilled water

For this, 2 tablets from each formulation were crushed. A quantity of powder equivalent to 100 mg of Rizatriptan benzoate as well as unmodified Rizatriptan benzoate was accurately weighed and transferred to 10 ml of distilled water in different test tubes. The suspensions were shaken for 60 seconds. Absorbances of filtrates were measured at previously reported λmax value.   

Dimensions: Dimensions viz. diameter and thickness of the tablets were measured using digital vernier caliper.

Hardness: Tested using Monsanto hardness tester

Assay: A quantity of powder equivalent to 100 mg of  Rizatriptan benzoate was accurately weighed and transferred to 100 ml volumetric flask to which small volume of 0.1 M HCl was added to disperse the contents. Final volume was adjusted to 100 ml using 0.1 M HCl. The dispersion was stirred for 2 hrs using magnetic stirrer and then was allowed to settle. Then the solution was filtered through Whatman filter paper (No.41). Appropriate dilution of filtrate was made using 0.1M HC and the UV absorbance was recorded.

 Taste: Evaluation of taste of water dispersible Rizatriptan benzoate tablets by panel of tastes.

Stability testing of water dispersible tablets of taste masked Rizatriptan benzoate

For this, the dispersible tablets of Rizatriptan benzoate prepared using most suitable formulation for masking of bitter taste were selected and stored at the controlled environmental conditions (Temperature 40 ± 20 C and RH 75 ± 5 %) for 45 days. The tablets (in triplicate) were tested at the interval of     every 15 days

Results

Characterization for probable interaction of drug and excipients

Characterization of Rizatriptan Benzoate

a)Organoleptic Characteristic :

UV spectroscopy

Modified drug powders equivalent to 10 mg of Rizatriptan benzoate were dissolved separately in 0.1 M HCl and the final volume was made up to 100 ml. The solutions were appropriately diluted and were scanned in the UV range of 200-400 nm to note the shift in λmax value. However, in case of modified powders of drug resin complex, dried gels prepared with PEG 6000, the acidic solutions were stirred for about 2 hr and the solutions were filtered and the filtrates were appropriately diluted before scanning in the UV range.

Discussion:

Organoleptic Characteristic:

The Organoleptic characteristic of drug were matching with those reported in the USP

Melting range: From the result it was observed that the melting range of Rizatriptan benzoate has good agreement with those reported in the USP

Saturation Solubility: From the result of saturation solubility it was observed that Rizatriptan benzoate was more soluble in 0.1M HCl in water.

Loss on drying:  From the result it was observed that LOD was within specified limit

Spectrum analysis of Rizatriptan benzoate:

 

References:

  1. Shyamala B and Narmada G: Rapid dissolving tables; A novel dosage form. The Indian Phrmacist 2002; 13(8): 9-12
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  3. Remeington . The  Science and Practice of Pharmacy, Edition 21,vol. 1,1178-1198
  4. Mizumoto T, Masuda Y, Takeshi Y, Estuo Y and Katsuhide T: Formulation design of a novel fast   disintegrating tablet, Int. J. Pharm  2005; 306(12): 83–90.
  5. Thakur R and Kashi M: An unlimited scope for novel formulations as orally disintegrating  systems: : Present and futureprospects, Journal of Applied Pharmaceutical Science 2011;01 (01); 13-19
  6. Amin A F: Emerging Trends In the Development of orally Disintegrating Tablet Technology. Pharmaonfo. net,  2006; 4(1).
  7. Headache Classification Committee. The International Classification of Headache Disorders. Cephalalgia. 2004; 24(Suppl. 1): 9-160.
  8. Waugh A and Grant A. Anatomy and physiology in health and illness. Spain: Churchill living   stone, Elsvier: Edition 10. 2006. 287-288
  9. Suthar A M and  Patel M M: Development of taste masked liquid formulation of  Tinidazol using   ion exchange resin complexes. J of Pharmaceutical Sci and Tech 2010; 2(9):303-7.
  10. Indian Pharmacopoeia, Ministry of Health and Family Welfare. The Indian Pharmacopoeia Commission, Ghaziabad, India. Vol. I, 2010: 1947-1948.
  11. Stability testing of active pharmaceutical ingredients and finished pharmaceutical products, WHO Technical Report Series, No. 953, 2009
  12. Douglas S J and Bird F R, inventors: Glaxo group limited, assignee. Drug adsorbates. US patent 5219563. 1993 Jun 15.
  13. Bhagawati ST, Hiremath SM and Sreenivas SA: Formulation and Evaluation of Cefadroxil  Dispersible Tablets. The Pharma Review; 2006; 20(4): 136-39.                                                                                   
  14. Itoh A and Niwa T, inventors: Pfizer Inc., assignee. Rapidly releasing and taste masking pharmaceutical dosage form. US patent 6221402. 2001 Apr. 24.
  15. USP 32 , NF 27 , Vol. III, 2009: 2907-2912
  16.  Jadhav SB, Kudewar DR, Kaminwar GS,  Jadhav AB, Kshirsagar RVand Sakarkar DM: Formulation and evaluation of dispersible tablets of Diltiazem hydrochloride.  Int J  Pharm Tech Res 2011;3(3):1314-21.
  17. Sharma N and Telange D: Determination of the concentration blends of superdisintegrant for fast disintegrating tablets. IJPSR 2011; 1(11):2828-35.
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Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by situs slot and Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh et al. situs slot "Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma situs slot entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by situs slot et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
Late to bed everyday? You may die early, get depression situs slot
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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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