International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 5(15), August, 2013

Pages: 82-86

Date of Publication: 17-Aug-2013


Print Article   Download XML  Download PDF

STUDY OF SERUM LEVELS OF URIC ACID IN CORONARY ARTERY DISEASE AND DIABETES MELLITUS

Author: Suvarna T. Jadhav, Ajit V. Sontakke, Bipin M. Tiwale

Category: Healthcare

Abstract:Coronary Artery Disease (CAD) leads to Angina and Myocardial Infarction (MI). Premature mortality on Coronary Heart Disease (CHD) is more common in diabetic atherosclerosis. In the present study serum Uric Acid level was estimated in patients of CAD with DM, CAD without DM, DM without CAD and CAD with DM and other risk factors compared to healthy normal subjects. The level of Uric Acid was significantly increased in all four groups of patients as compared to control group. Conclusion: On the basis of our results we conclude that high circulating uric acid levels may be indicator that the body is trying to protect itself from harmful effects of free radicals by increasing the production of endogenous antioxidants like uric acid. Hence uric acid may act as non conventional marker to predict the risk of Coronary Vascular Disease (CVD) complication in Diabetes Mellitus (DM).

Keywords: Coronary Artery Disease, Diabetes Mellitus, and Uric Acid.

Full Text:

INTRODUCTION

Coronary Artery Disease (CAD) leads to Angina and Myocardial Infarction (MI). Premature mortality on Coronary Heart Disease (CHD) is more common in diabetic atherosclerosis (1).

Cardiovascular diseases (CVD), comprising coronary heart disease (CHD) are currently the leading cause of death globally, accounting for 21.9 per cent of total deaths, and are projected to increase to 26.3 per cent by 2030. The factors that coalesce to increase the risk of developing atherosclerotic Coronary Heart Diseases were demonstrated in Framingham in the mid - 20th century and have subsequently been shown to be pervasive across ethnicities and regions of the world. These are not new risks, but the ubiquity of smoking, dyslipidaemia, obesity, diabetes, and hypertension has been gradually escalating, and is thought to be the driving influence behind the epidemic of heart disease faced today (2).

Of the risk factors, diabetes, and its predominant form, type 2 diabetes mellitus (T2DM), has a distinctive association with Coronary Heart Disease. Those with diabetes have two- to four-fold higher risk of developing coronary disease than people without diabetes, and cardiovascular diseases accounts for an overwhelming 65-75 per cent of deaths in people with diabetes. More significantly, however, the age- and sex-adjusted mortality risk in diabetic patients without pre-existing coronary artery disease was found to be equal to that of non-diabetic individuals with prior myocardial infarction (MI). These remarkable findings regarding higher risk of mortality have led to suspicion that common precursors predispose to diabetes and Coronary Heart Disease, with subsequent implications that insulin resistance, visceral adiposity, and excess inflammation (2).

However, a great controversy arose as to whether elevated uric acid was an independent risk factor for  Coronary Artery Disease or it was merely a marker of co-existing conditions such as hypertension, abdominal obesity, diabetes mellitus, hyperlipidaemia, inflammation, impaired renal function and diuretic treatment (3).

The contradictory data obtained in the studies have been analysed and reviewed by independent research groups. Although different potential mechanisms explaining the associations between high serum uric acid and CAD have been proposed, a well- established pathophysiological link is still missing (4-6).The concentration of uric acid, as well as other risk factors for the development of CAD, is strongly influenced by different genetic factors and lifestyle habits. Traditionally, elevated serum uric acid (SUA) is linked to gout. Recent investigations have shown that there may be a relationship between hyperuricemia, ischemic heart disease and metabolic syndrome, which is characterized by obesity, dyslipidaemia, diabetes and hypertension. Although a direct relationship between Serum uric acid and cardiovascular disease is difficult to prove due to confounding factors like hypertension and diabetes, Strasak et al have recently demonstrated that Serum uric acid is an independent predictor of mortality due to congestive heart failure and stroke( 7).

MATERIALS AND METHODS

The present study was carried out in the Department of Biochemistry, Dr. D. Y. Patil Education Society’s Medical College and Hospital, Kolhapur. This study was approved by Institutional ethical committee.

In this study a total number of 200 subjects between age 40 yrs to 60 yrs matched with age and sex were included. They were distributed in controls and four study groups.

 

Controls

Normal Healthy controls- 100 cases

Group- I

Patients with CAD and DM- 25 cases

Group- II

Patients with CAD – 25 cases

Group- III

Patients with DM – 25 cases

Group- IV

Patients with CAD and DM + Other risk factors- 25 cases

 

All controls were from the same age groups as patients, not showing any clinical signs and symptoms suggestive of CAD. They were having normal blood pressure (BP), ECG, blood sugar level and apparently no other cardiac risk factors. Group-I contained patients diagnosed to have CAD (based on angiography) with confirmed DM and were receiving treatment for the same. Group- II contained patients with CAD but no DM. Group-III  contained Type II DM patients receiving treatment for DM, and were not showing any complications of DM, and had normal ECG and BP. Group- IV contained patients with CAD and DM along  with other risk factors  (such as smoking, hypertension, family history of Coronary Artery Diseases, obesity etc.)

Sample collection-3ml of venous blood sample was collected in plain bulb and was allowed to clot. Serum was separated by taking necessary precautions to avoid haemolysis. This serum was   

Used for the estimation of uric acid. Uric acid was estimated of Dynamic extended stability with lipid clearing agent modified Trinder method, End point (8).

Inclusion Criteria: A) Control group: 100 age matched healthy subjects were included in the control group. The subjects were selected after screening for any prior history of cardiovascular disease or any other disease. B) Coronary Artery Disease Patients: Angiographically proven patients by the cardiologists with relevant coronary artery disease showing greater than 50% stenoses in at least one major coronary artery at the time of diagnostic catheterization were enrolled in this study. Each subject was screened by a complete history, physical examination and laboratory analysis. C) Diabetic Patients with Coronary Artery Disease: Clinically diagnosed patients whose fasting blood   glucose level was above 125 mg/dl.  

Exclusion Criteria:-The patients with hemodynamically significant valvular heart disease undergoing catheterization, surgery or trauma, known cardiomyopathy, known cancer, abnormal hepatic and renal function, past or concurrent history of any disease and taking any medication that could influence the oxidant and antioxidant status and endothelial functions were excluded from the study group.

RESULT-

Showing the levels of Uric Acid in (mg/dl) in control subjects and different study groups

Groups

Uric Acid (mg/dl)

Control

4.6 + 2.43

Group I (CAD with DM )

6.0 + 2.7 #

Group II  (CAD with out DM )

6.4 + 3.06 #

Group III (DM with out CAD )

5.2 + 3.04 ♣ ♦

Group IV  (CAD with DM with other risk factors)

6.8 + 2.62 * ♠ $

 

Values are expressed as mean + SD

* P<0.001 Group IV as compared to control

# P<0.05   Group I and II as compared to control

♣ P<0.05 Group III compared to control

♠ P< 0.05 Group IV as compared to Group I

♦ P< 0.05 Group III as compared to Group II

$ P< 0.001 Group IV as compared to Group III

 The level of Uric Acid was significantly increased in all four groups of patients as compared to control group.  Similarly significant rise in the serum uric acid level was observed when Gr. III was compared with Gr. II and Gr. IV was compared with Gr. I and III

DISCUSSION

Serum uric acid (or more correctly, its mono anion uric acid at physiological pH values) has been thought to be, in humans, a metabolically inert end product of purine metabolism without physiological significance (except gouty diathesis). However, serum uric acid has been recently associated with insulin resistance (9, 10). Furthermore, in non diabetic subjects an elevated level of uric acid has been shown to be an independent predictor of coronary heart disease and total mortality (11-14). Elevated serum uric acid has been found to be closely associated with dyslipidaemia, obesity, hypertension, diabetes, smoking and inflammation (15).

The topical role of uric acid and its relation to cardiovascular disease, renal disease, and hypertension is rapidly evolving. Its important role both historically and currently in the clinical clustering phenomenon of the metabolic syndrome, type 2 diabetes mellitus (T2 DM), atheroscleropathy, and non-diabetic atherosclerosis is of great importance.

The association between high serum uric acid and incidence of was Coronary Artery Disease reported more than 50 year ago (16). Since then numerous clinical and epidemiological studies have explored the association more precisely. Such studies confirmed that elevated uric acid was predictor of cardiovascular disease. However, a great controversy arose as to whether elevated uric acid was an independent risk factor for Coronary Artery Disease.

In the present study the level of uric acid was significantly increased in all four groups of patients as compared to control group.

Similarly significant rise in the serum uric acid level was observed when Gr. III was compared with Gr. II and Gr. IV was compared with Gr. I and III. Hyperuricemia could play a role in the pathogenesis of atherosclerosis. Overwhelming evidence suggests that hyperuricemia is linked to obesity, hypertension, reduced HDL cholesterol, hypertriglyceridemia, hyperinsulinemia and reduced insulin sensitivity (9, 10 ).

Elevated levels of serum uric acid are due to either an increase in uric acid production or a decrease in its excretion.

The mechanism by which uric acid may cause Coronary Vascular Disease has been explored using cell culture and animal models. It appears that uric acid must enter the endothelial and vascular smooth muscle cells via a specific organic anion exchanger, where it activates a variety of intracellular signaling molecules involved in inflammation and proliferation. In the endothelial cells there is a decrease in nitric oxide levels and an inhibition of endothelial proliferation, whereas in vascular smooth muscle cells there is activation of proliferative and inflammatory pathways. Local activation of the rennin-angiotensin system has also been shown. Low nitric oxide may also have a central role in the induction of insulin resistance, as insulin requires nitric oxide for its action (by stimulating blood flow to the skeletal muscle) (17).

Despite the consensus that hyperuricemia is a significant Coronary Vascular Disease marker, there are controversies regarding a causative role for uric acid in Coronary Vascular Disease and/or metabolic syndrome. Prospective clinical studies are necessary to investigate whether a reduction in uric acid levels prevents Coronary Vascular Disease or metabolic syndrome (17).

Uric acid is one of the major endogenous water-soluble antioxidants of the body (18). There is accumulating evidence that increased oxidative stress is closely related to diabetes and its vascular complications (19). Thus, high circulating uric acid levels may be an indicator that the body is trying to protect itself from the deleterious effects of free radicals by increasing the production of endogenous antioxidants, eg. uric acid. Interestingly, uric acid prevents oxidative modification of endothelial enzymes and preserves the ability of endothelium to mediate  vascular dilatation in the face of oxidative stress.(18) There is also some evidence that uric acid may have the direct role in the atherosclerotic process, because human atheroscelerotic plaque contains more uric acid than do control arteries (20). Inflammation is one of the features of atheroscelerosis, (21) and uric acid crystals may induce inflammatory responses that are reduced by lipoproteins which have an ability to bind uric acid crystals (22). Hyperuricemia via purine metabolism may also promote thrombus formation (23, 24).

Increased level of Uric Acid in the current study might be responsible for the induction of inflammatory process of atherosclerosis as well as to promote thrombus formation. Increased uric acid production may also be an attempt by the body to overcome the oxidative stress associated with diabetes and its vascular complications.

CONCLUSION

In the present study the level of serum uric acid was significantly increased in all four groups of patients as compared to control groups.

High uric acids could be for marker of sodium retention coupled with impaired hemodynamic reserves and / or disturbed blood flow. Increased oxidative stress is closely related to diabetes and its vascular complications. Thus high circulating uric acid levels may be an indicator that the body is trying to protect itself from the deleterious effects of free radicals by increasing the production of endogenous antioxidants like uric acid. Hyperuricemia may also promote thrombosis.

References:

  1. V.K.Bali, Sandeep Seth. Management of coronary Artery Disease in patients with Diabetes Mellitus Department of Cardiology ‘All India Institute of Medical Sciences, New Delhi.  Indian Heart Journal.53:147; 2001, 157-162.
  2. Mohammed K Ali, K.M. Venket Narayan, Nikhil Tandon. Diabetes and Coronary Heart Disease: Current Perspectives. Indian J Med Res. 2010 November; 132(5): 584-597.
  3. Alderman, M. H. Uric acid and cardiovascular risk. Curr Opinion Pharmacol, 2002, 2, 126 – 130.
  4. Johnson, R. J., Kang, D. H, Feig, D. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease ?   Hypertension 2003, 41, 1183 – 1190.
  5. Barker J, Drishanan. E., Chen, L,  Schumacher, H. R. Serum uric acid and cardiovascular disease.Recent developments, and where do they leave us?  Am. J. Med., 2005, 118, 816 – 826.
  6. Hayden, M. R, Tyagi S. C. Uric acid;  A new look at an old risk marker for Cardiovascular disease, metabolic Syndrome, and type 2 diabetes mellitus: The Urate  redox shuttle.         Nutr. Metab  (Lond.), 2004, 1 – 10.
  7. Strasak A, Ruttmann E, Brant L. Serum Uric Acid Risk of  Cardiovascular Mortality: A Prospective Long –  Term study of 83 683austrian Men. (E pub. ahead of print).
  8. Shepard M.D, Mezzachi R.D, Clin Biochem Revs, 1983 ; 4; 61 – 7
  9. Mohan M, Halkin H, Karasik A, Lusky A. Elevated serum uric acid. Facet of hyperinsulinemia. Diabetologia, 1987; 30; 713 – 718.
  10. Facchini F, Chen YDI, Hollenbeek CB, Reaven G M. Relationship between resistances of insulin mediated glucose –uptake, urinary uric acid clearance and plasma uric acid concentration. JAMA, 1991; 266: 3008 – 3011.
  11. Brand F N, Mc Gee Dl, Kannel WB, Stokes J, Castgelli WB Hyperuricemia as a risk factor of coronary heart disease: The Framingham study. Am J Epidemiol 1985; 121, 11 – 18.
  12. Bengtsson C, Lapidus L, Stendahl C, Waldenstorm J. Hyperuricaemia and  risk of cardiovascular disease and overall death: a 12 year follow up of participants in the population study of wimeni Gothenburg, Sweden, Acta Med Scand 1988; 224: 549 – 555.
  13. Levine W, Dyer A.R, Shekelle R.B, Schoengerger J.A, Stamler J. Serum uric acid and 11.5 year mortality of middle – aged women: findings of the Chicago Hest Association Detection Project in Industry.Clin Epidmiol., 1989; 42 : 257 – 267.
  14. Zavaroni I, Bonora E, Pagliara M, Dall’ Aglio E, Luchetti L, Buonano G,  Bonati PA,  Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med., 1989; 320: 702 – 706.
  15. Lee J. Sparrow D, Vokonas P.S, Landsberg L, Weiss S.T. Uric acid and coronary heart disease risk: evidence for a role of uric acid I the obesity – insulin resistance syndrome: the Normative Aging Study. Am J Epidemiol. 1995; 142: 288 – 294.
  16. Gertler M. M., Garn S. M. and Levine S. A. Serum Uric acid in relation to age and hysique in health and in coronary heart disease.                                                                                                                                   Ann Intern. Med, 1951, 34, 1421 – 1431.
  17. Duk- Heekang.  Potential   Role of Uric Acid as a Risk Factor for Cardiovascular Disease. Korean J Intern med. 2010 March; 25(1): 18-20.
  18. Becker BF, Towards the physiological func, 1993; 14: 615 – 631.
  19. Baynes J W Role of oxidative stress in the development of complications in Diabetes  mellitus. Diabetes, 1991; 40: 405 – 412.
  20. Suvarna C, Dean RT, May J, Stocker R. Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha – tocopherol  and ascorbate. Arterioscler ThrombVasc Biol, 1995; 15: 1616 – 1624.
  21. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med, 1992; 326: 310 – 318.
  22. Feingold Kr, Grunfeld C. Role of cytokines in including hyperlipidaemia.Diabetes. 1992; 41(supp 2): 97 – 101.
  23. Visy J, Le – Coz P, Chadefaux B, fressinaud C, Woimant F, Marquet J.Homocystinuria due to ,10 – methylene tetrahydrofolate reductase  deficiency revealed by stroke in adult siblings. Neurology. 1991; 41: 1313 – 1315.
  24. Kuwano K, Ikeda H, Oda T, Nakayama H, Koga Y, Toshima H, Imazumi t.  Xanthine oxidase mediates cyclic flow variations in a canine model of coronary arterial thrombosis. Am J Physiol. 1996; 270 :  1993 – 1999.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions