International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 5(15), August, 2013

Pages: 42-45

Date of Publication: 17-Aug-2013


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ROLE OF FINE NEEDLE ASPIRATION CYTOLOGY IN DIAGNOSING THYROID LESIONS - A RETROSPECTIVE STUDY

Author: Pratibha Vyas, Sulabh Bansal, Tarun Ojha, Amit Singhal, Suresh Kumar

Category: Healthcare

Abstract:Background: One of the most common problems among patients attending ENT OPD (particularly female patients) is the thyroid enlargement. Though Thyroid cancer is not common; incidence of Thyroid nodule (Simulating thyroid cancer in appearance) is high. This study was conducted to evaluate efficacy of Fine Needle Aspiration Cytology (FNAC) at Mahatma Gandhi Medical College & Hospital, Jaipur in diagnosing thyroid lesions (benign or malignant) and to compare its advantages & results with histopathology. Method: This retrospective study was conducted in Department of ENT and Head-Neck surgery at Mahatma Gandhi Medical College and Hospital, Jaipur during the period January 2008 to January 2013. In all 282 cases were evaluated by detailed history, thorough clinical examination, ultrasonography (USG) of neck, complete thyroid profile (Serum T3, Serum T4 & Serum TSH) and histopathology of thyroid lesion. Results: In our study, sensitivity and specificity of FNAC was 70.2% and 97.3% respectively (in diagnosing thyroid lesions as benign and malignant). Conclusion: FNAC is safe, less expensive, less invasive and cost effective diagnostic tool in diagnosing thyroid lesions and distinguishing benign from malignant ones.

Keywords: Thyroid, FNAC, Malignant, Cytology

Full Text:

INTRODUCTION

Thyroid lesions are quite prevalent and globally thyroid enlargement affects 15% of the population.1But incidence of thyroid cancer is very low i.e. 3.6 per 100,000 population (.0036 percent)2

The most common indication for thyroid surgery is presence of Thyroid nodule which may be benign or malignant. Prevalence of thyroid nodule is about 4-7%.3 Because of very low incidence of thyroid cancer; thyroid nodules must be identified as benign or malignant; as treatment options in both the conditions are different.  Thyroid cancers are treated surgically, while benign lesions must be followed strictly.4

FNAC was first reported in 1930 by Martin and Ellis.5 Since then, it has become reliable and cost effective method to distinguish benign from malignant lesion in neck. 6

FNAC is technically easy to perform, safe and inexpensive diagnostic tool.  Sensitivity of FNAC in detecting malignancy in thyroid lesions is high.7 Any solitary or dominant nodule larger than 1 cm should be subjected for FNAC as smaller nodules carry very low risk of morbidity.8

Many studies show accuracy rate of FNAC more than 80%.9 Pitfalls of FNAC include false negative and false positive results, inadequate aspirate and suspicious results.10

Present retrospective study was conducted to evaluate efficacy of FNAC in diagnosis of thyroid lesions and to compare the results with histopathology after surgery. 

MATERIAL AND METHODS

This study was conducted at Mahatma Gandhi Hospital and Medical College, Jaipur in the Departments of ENT and Head-Neck Surgery during the period between January 2008 and January 2013. Patients with features of hyperthyroidism, Hot and toxic nodule were excluded from the study. Patients with systemic diseases for example hypertension or hepatic or renal failure were also excluded from the study. A detailed history was taken followed by thorough clinical examination, thyroid profile, USG neck, and FNAC. 

CT scan was advised in patients in whom malignancy was suspected to see the extent of tumour.  After surgery the specimen was sent for HPE in 10% formaldehyde.  The specimen was properly labeled.

RESULTS

In our series of 282 patients, 31 were male and 251 were females with male to female ratio being 1:9.  Duration of thyroid swelling in the present study was from 4 months to 5 years.  The average size of Goiter was 2-3 cm.  The highest incidence of thyroid lesion was found in the age group of 20-40 years.  On FNAC, 250 (87.6%) cases were benign as compared to 10 (6.1%) malignant cases. 

DISCUSSION

To evaluate a thyroid nodule, a battery of investigations is needed including USG neck, thyroid profile, thyroid imaging, complimented by thorough clinical evaluation. 

In diagnosing thyroid neoplasms, the highest rate of sensitivity and specificity is achieved by FNAC.2              

A complication rate for FNAC is low. 2Complications include hematoma, tracheal puncture and transient laryngeal palsy.11 Tumour implantation following FNAC is reported only once.12

In our study, sensitivity and specificity of FNAC in diagnosing thyroid lesions is 70.2% and 97.3% respectively.  Humberger reported sensitivity at 65.53% and specificity at 72-100%.13  In a study by Safirullah 94.2% sensitivity and 94% specificity in diagnosis of Malignant thyroid diseases was reported.

Results of this study are comparable with other data. Agrawal et. al. (1995)14 in Tata Memorial Hospital, Mumbai found accuracy of FNAC to be 90.9% in evaluating thyroid nodules, Kumar et.al. (2008) 15 reported accuracy of 97.7%. Both these findings are comparable with our study.

Reported sensitivity, specificity, and accuracy of Thyroid FNAC in detecting malignancies are between 65 – 98%, 72 – 100%, 65 – 95% respectively. 16, 17, 18

CT guided and US guided FNAC have a higher probability of accuracy along with any wet stain.8

FNAC has some very distinct advantages. It requires no preprocedural investigations or hospitalization.  As a result, it is very easy to convince patients to give consent to it.  Patients were also very willing as it reduced their expenditure, which otherwise they would have had to incur; had they opted for open biopsy. Post procedure complications are also very rare. 

CONCLUSION

This study conclusively shows that FNAC could be first line diagnostic test in any case of thyroid swelling.  FNAC of thyroid swelling is very safe, accurate, much less expensive, relatively simple and five minute OPD procedure.  FNAC being much less expensive and quite painless is very well accepted by patients. With all these advantages, FNAC is very effective tool in diagnosis of thyroid pathology. Though FNAC is not the substitute for conventional open biopsy and subsequent histopathology, particularly in old patients but definitely should be first choice in diagnostic modalities in any case of thyroid swelling.

References:

  1. JA Franklyn, J Daykin, J Young, et.al.: Fine needle aspiration cytalogy in diffuse or multinodular goitre compared with solitary thyroid nodule, BMJ 1993; 307: 240
  2. Theodar R. Miller, MD; John S., et.al.: Fine-Needle Aspiration Biopsy in the management of thyroid Nodules : West J Med 134: 198-205, Mar 1981
  3. Wienke JR, Chong WK, Fielding JR, et.al.: Sonographic features of benign thyroid nodules.  J Ultrasound Med 2003; 22:1027-31
  4. Polyzos SA, Kita M, Avarmindis A. Thyroid nodules-stepwise diagnosis and management.  Hormones (Athens) 2007; 6: 101-9
  5. Martin HE, Ellis EB; Biopsy by needle puncture and aspiration.  Ann Surg. 1930; 92: 169-81
  6. Lowhagen T, Gargberg P.O., Ludell G, et.al.: Aspiration biopsy cytology (ABC) in nodules of the thyroid gland suspected to be malignant.  Surg. Clin N Am 59: 3-18, 1979.
  7. Mahar SA, Hussain A, Islam N. Fine needle aspiration cytology of thyroid nodule; diagnostic accuracy and pitfalls.  J Ayub Med Coll Abbottabad 2006: 18 (4): 26-9
  8. Arup Sengupta, Ranbir Pal, Sumit Kar, et.al. J. Natural Science, Biology, Medicine. 2011; 2(1) 113-118
  9. Gharib H. Diffuse nontoxic and Multinodular goitre.  Curr Ther Endocrinal Metab 1944; 5: 99-101
  10. Baloch MN, Ali S, Ansari MA, et.al.. Contribution of Fine needle apsiration cytology in the diagnosis of malignant thyroid nodules Pak J. Surg 2008; 24(1) : 19-21
  11. Wang C, Vickery A, Maloog F: Needle biopsy of thyroid.  Surg Gynocol obs 143: 365-368, 1976
  12. Sinner WN, Zajicek J; Implantation metastasis after percutaneous transthoracic needle aspiration biopsy.  Acta Radial [Diagn] (Stockh) 17: 473-479, 1976
  13. Humberger JI.  Diagnosis of Thyroid nodule by fine needle aspiration cytology of thyroid nodules.  J Clin Endorcinal metab 1994, 79:335-9
  14. Agrawal A, Mishra SK. Completion total thyroidectomy in the management of differentiated thyroid carcinoma. Aust N Z J Surg 1996;66:358-60.
  15. Kumar S, Aqil S, Dahar A. Role of fine needle aspiration cytology in thyroid disease. J Surg Pak 2008;13:22-5.
  16. Gharib H. Fine needle aspiration biopsy of thyroid nodules: advantages, limitations and effects. Mayo Clinic Proc 1994;69:44-9.
  17. Hamburger JI. Diagnosis of thyroid nodules by fine needle biopsy: Use and Abuse. J Clin Endocrinal Metab 1994;79:335-9.
  18. Ali K. Ageep. Efficacy of Fine needle aspiration cytology in the diagnosis of thyroid swelling in Red Sea State, Sudan. Sudan JMS Vol 8 Issue 1, March 2013.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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