International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 05 Issue 18, September, 2013

Pages: 35-40

Date of Publication: 25-Sep-2013


Print Article   Download XML  Download PDF

COMPARATIVE STUDY OF OXIDANT AND DIETARY ANTIOXIDANTS IN BENIGN AND MALIGNANT BREAST TUMORS- A PILOT STUDY

Author: Shinde Atul, Abhang Subodhini A, Shelgikar Prachi J.

Category: Healthcare

Abstract:Background: The incidence of breast cancer has been increasing in India in the past few years. Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In normal conditions, a balance between the oxidants and their destruction by the cellular antioxidant system in the human body is maintained. However, any imbalance between the levels of oxidants and antioxidants might cause DNA damage and may lead to tumor development. Though a large number of women are affected with breast tumors, very few studies have been undertaken in India to compare oxidant/ antioxidant status in benign and malignant breast tumors. Therefore the present study was undertaken with following aim. Aim: To compare the oxidative stress and dietary antioxidants in benign and malignant breast tumors. Material and Methods: This study included clinically diagnosed and histopathologically proven 30 each benign and malignant breast tumor patients of stage III and IV as per inclusion criteria. Fresh tumor and fibro adenoma tissues were obtained from patients immediately after surgery. Adjacent normal tissue served as control. The levels of malondialdehyde [MDA]) as a marker of oxidative damage and dietary antioxidants (Vitamin A, E and C) were estimated from the benign, malignant and normal tissues. Results: Significantly increased levels of MDA and decreased levels of dietary antioxidants (Vit E, C, A) were observed in benign and malignant breast tissue as compared to control tissue. A strong negative correlation in MDA Vs all vitamins were found. Conclusion: The results of our study indicate that the imbalance between oxidants and antioxidants leads to oxidative stress which might be playing an important role in tumorogenesis.

Keywords: Oxidative stress, dietary antioxidants, breast tumors

Full Text:

INTRODUCTION

In India, breast cancer is the most common cancer with an estimated 115,251 new diagnoses and 53,592 breast cancer deaths in 2008 according to breast cancer factsheet.[1] Carcinoma of breast continues to be one of the most frequent cancers in women all over the world. Cancer begins in cells, the building blocks that make up all tissues and organs of the body, including the breast. The buildup of extra cells often forms a mass of tissue called a lump or tumor. Breast tumors can be benign (not cancer) or malignant (cancer).

The etiology of breast tumors is multifactorial. Risk factors are early menarche, late menopause, first pregnancy at late age, obesity, oral contraception, hormone replacement therapy, dietary factors, genetic history, nulliparity etc. [2] Apart from these factors, there are some environmental factors that are behind the process of tumorogenesis. One of the most accepted factors is oxidative stress. Cells in tissues and organs are continuously being subjected to oxidative stress and free radicals on a daily basis. Oxidative stress caused by increased free radical generation and/or decreased antioxidant level in the target cells and tissues have been suggested to play an important role in carcinogenesis. Prime targets of free radicals are polyunsaturated fatty acids in cell membrane and their interaction results in lipid peroxidation. As Breast tissue is loaded with lipids they are more susceptible to oxidative insults. Normally, the free radical is counter acted by the cells’ antioxidant system without damage to the cellular DNA. As a woman ages, cellular protection may become less effective and DNA damage is wrought faster than the free radicals can be controlled and damage repaired. [3]

The levels of free radical molecules are controlled by various cellular defense mechanisms, consisting of enzymatic (catalase, glutathione peroxidase, superoxide dismutase) and non-enzymatic (glutathione and dietary vitamins E and C) antioxidants. Antioxidant vitamins can protect against a number of degenerative diseases including cancer. The main antioxidant vitamins are Vitamin C, E and β-carotene. Dietary antioxidant vitamins and retinol have been proposed to be protective against breast cancer on the basis of their ability to inhibit mutagenesis and cell transformation by reducing oxidative DNA damage. [4, 5, 6]

Thus, it is necessary to determine the role of free radicals and dietary antioxidants in tumorogenesis. We therefore undertook this study to examine the extent of lipid peroxidation in terms of MDA and the status of dietary antioxidant vitamins A, E and C in the tissue of benign and malignant breast tumor patients.

MATERIAL AND METHODS

Thirty each clinically diagnosed and histopathologically confirmed benign and malignant breast tumor cases of stage III and IV were selected. The mean age of patients in the study group was 46 years (range 30-55 years). The patients were not using hormones, oral contraceptives and were nonsmokers. Exclusion criteria includes conditions such as diabetes mellitus, liver disease, rheumatoid arthritis or any other prolonged illness, which could have caused conflict with the results of this study. This study was approved by our Internal review Board.

Fresh tumor and fibro adenoma tissues obtained from patients immediately after surgery were blotted on filter paper, weighed (1gm) and placed in cold 0.9% NaCl solution. Adjacent normal tissue (histopathologically proven) from benign and malignant tumors serves as control.  The tissues were homogenized under standardized conditions in saline and 20% tissue homogenate was prepared. The supernatant was kept in an ice cold condition until assayed. Lipid peroxidation was estimated by thiobarbituric acid (TBA) reactivity.[7] Malondialdehyde (MDA) an end product of fatty acid peroxidation reacts with TBA to form a colored complex having maximum absorbance at 532 nm. Vitamin E was measured using the spectrophotometric method of Baker and Frank. [8] Vitamin E from tissue was extracted into n-heptane, which reacts with ferric chloride and reduces ferric to ferrous ions. Ferrous ions then forms a red colored complex with 2, 2 dipyridyl which was read at 520 nm. A correction for ß carotene was made after reading vit E at 520 nm. ß carotene was determined in mg% by multiplying absorbance at 460nm by 856 factor. This is the modified method of Quaife et al. [9] Vitamin C was determined by the method of Ayekyaw. [10] Vitamin C from serum reacts with phosphotungstate to give a blue color that has maximum absorbance at 600 nm.

Statistical analysis

After estimation of sample and control for different assay, the data for the biochemical analysis is expressed as mean ± SD. Statistical comparisons were performed by analysis of variance (ANOVA) followed by Duncan’s multiple range tests.

RESULTS

Malondialdehyde (MDA) is a marker of oxidative stress. The levels of MDA in benign tumor were found to be significantly increased (p < 0.001) than control tissue. When MDA levels of control tissue were compared with malignant tissue the rise was still higher    (p< 0.001) than the rise observed in benign tissue [Table1].

Levels of Vitamin E in benign tumor tissue were significantly lower (p < 0.001) than control tissue whereas vitamin E status of control tissue when compared with malignant tissue was further decreased as compared to benign tissue [Table1].

There was significant decline (p < 0.001) in the levels of vitamin C in both benign and malignant tissues as compared to normal tissue [Table1].

Highly significant (p < 0.001) decrease in malignant and benign tissues as compared to control tissue were seen in the levels of vitamin A [Table1].

DISCUSSION

Breast cancer is a leading cause of morbidity and mortality in women’s lives and its incidence is on the rise in metropolitan population. [11] Most of the population is ignorant about breast examination. Screening programme is also not very effective in India. This leads to late detection and poor prognosis. This led us to select the cases of stage III and IV. Though a large number of women are affected with breast cancer, very few studies have been undertaken in India on relation between oxidants and dietary antioxidant status among women with the risk of breast cancer.

We studied the correlation between oxidative stress and dietary antioxidants in both type of tumors by studying MDA levels and Vit E, C, A levels. A strong negative correlation has been observed between oxidant (MDA) and antioxidants (dietary vitamins) in control, benign and malignant tumor tissue [Table 2].

Development of breast tumor is through damage to the breast epithelium by reactive oxygen species which lead to fibroblast proliferation, epithelial hyperplasia, cellular atypia and breast tumor. [12] The reactive oxygen species (ROS) play an important role in tumor initiation and may influence breast cancer by altering gene expression or by promoting oxidative DNA damage. [13, 14]  Oxidative stress caused by increased free radical generation and/or decreased antioxidant level in the target cells and tissues have been suggested to play an important role in carcinogenesis.

The evidence for increased action of oxidants in breast cancer is related with the increase in the level of oxidative damage. In our study, it was observed that there was a higher production of oxygen free radicals in benign and malignant tumors as evidenced by high MDA levels. In malignant tissue this rise is more than benign tissue [Table 1].

Similar results were obtained by Tas et al (2005), Sinha RJ et al (2009) in tissues of benign and malignant breast cancer patients. [15, 11] Even Rajneesh CP et al (2008), Seema Khanna (2012) reported same results in serum sample of breast cancer patients.[12, 16] On the contrary Gonenc et al (2006) reported that serum sample of malignant breast disease had lower MDA levels than benign breast disease but both test groups showed prominent rise than controls. [2]

In healthy persons balance between oxidants and antioxidants is always maintained. But this balance is disturbed in diseased conditions. The probable reason for the elevated level of tissue lipid peroxides observed in breast carcinoma may be due to less availability of antioxidants than required, which leads to the accumulation of lipid peroxides in cancer tissue. Recent reports suggest that there is disturbance of the pro-oxidant/antioxidant balance, resulting from increased free radical production, antioxidant enzyme inactivation or excessive antioxidant consumption, is a causative factor in oxidative damage. [2, 11, 16]  

Dietary vitamins are involved in direct elimination of reactive oxygen metabolites in association with antioxidant enzymes. They also act as anti-carcinogens and inhibitors at initiation and promotion/transformation stage in carcinogenesis. [5] In this study we estimated the levels of dietary vitamins in breast tumors as less work was carried out about them by researchers.

In our study we found decreased levels of vitamin E, C and A [Table 1] as compared to controls. This decrease may be due to the overutilization of these antioxidant vitamins in order to quench the free radicals. Vitamin E is used up in eliminating lipid peroxide radicals. This utilized vitamin E is regenerated again by vitamin C. This could also be the cause of reduced vitamin levels observed. [17]

Our results are in good correlation with the results obtained by Singh P (2005) about vitamin E and C in serum of breast cancer patients. [18] Ramaswamy (1996) noted fall in serum vitamin A and C levels in benign breast disease than in controls while in cancer patients, there was a significant trend of lower serum vitamin levels with increasing stage of the disease. [19] While Hou MF (1998) found that, the serum vitamin A levels were not decreased in early breast cancer patients but the serum vitamin A levels were significantly decreased in the metastatic breast cancer group. [20]

Thus, it has been hypothesized that the increased production of ROS along with decreased dietary antioxidant vitamin level might be characteristic of tumour cells [Table2].

CONCLUSION

Oxidative stress is in the foreground of both benign and malignant tumor, but its level is more in malignant as compared to benign tumour. The additional oxidative stress produced in case of malignant tumor may contribute to malignancy.  Thus, in conclusion oxidative stress plays an important role in tumorogenesis and its intensity decides the nature of tumor i.e. malignant or benign. The results of our study provide strong evidence regarding the definitive role of dietary vitamins in breast tumours. To prove the role of antioxidant vitamins further study is needed with their supplementation in both study groups.

ACKNOWLEDGEMENT

The authors are grateful to all the subjects for actively participating in this study. Our thanks are also to all laboratory managers and staff for their support during our investigations.

Authors acknowledge the great help received from the scholars whose articles cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. Authors are grateful to IJCRR editorial board members and IJCRR team of reviewers who have helped to bring quality to this manuscript.

References:

  1. Breast Cancer Factsheet By Dhillon PK. South Asia Network for Chronic Disease, Public Health Foundation of India.  
  2. Gonenc A, Erten D, Aslan S, Akinci M, Simsek B, Torun M. Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease. Cell Biol Int 2006; 30:376-80.
  3. Heinz G. Breast cancer: the role of free radicals. The Lancet Oncol 2001; 2:196.
  4. Kasapovi? J, Peji? S, Todorovi? A, Stojiljkovi? V, Pajovi? SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. Cell Biochemistry and Function 2008; 26: 723-730.
  5. Borek C. Dietary Antioxidants and Human Cancer. Integrative Cancer Therapies 2004; 3:333-341.
  6. Sivakumar S, Devaraj N. Enzymatic and nonenzymatic antioxidant status of breast cancer patients in Tamilnadu. IJPBS 2011;2(4):B46- 53.
  7. Buege and Aust. Microsomal lipid peroxidation. Methods in Enzymol 1978; 105: 302 - 310.
  8. Baker H, Frank O. Determination of serum ?-tocopherol. In: Gowenlock, McMurry. Varley’s Practical Clinical Biochem; London. 6th ed. 1968: 902-903
  9. Quaife et al. Determination of serum ß carotene. In: Gowenlock, McMurry. Varley’s Practical Clinical Biochem; London. 6th ed. 1968: 903-903.
  10. Ayeqaw. A simple colorimetric method for ascorbic acid determination. Clinica Chem Acta 1978; 86: 153-157.
  11. Sinha RJ, Singh R, Mehrotra S, Singh RK.  Implications of free radicals and antioxidant levels in carcinoma of the breast: A never-ending battle for survival. Indian J cancer 2009; 46: 146-50.
  12. Rajneesh C P, Manimaran A, Sasikala K R, Adaikappan P. Lipid peroxidation and antioxidant status in patients with breast cancer. Singapore Med J 2008; 49: 640-643.
  13. Halliwell B, Gutteridge JMC Free Radicals in Biology and Medicine. 2007; 4th edition. Oxford: Oxford University Press,UK.
  14. Feng JF, Lu L, Zeng P, Yang YH, Luo J. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. Int J Clin Oncol 2011 Oct 5.
  15. Tas F, Hansel H, Belce A, Ilvan S, Argon A. Oxidative Stress in Breast Cancer. Medical Oncology 2005; 22: 11–15.
  16. Khanna S, Pande D, Negi R, Karki K. Oxidative stress induced damage in benign and malignant breast diseases: histopathological and biochemical aspects. Journal of Stress Physiology and Biochemistry 2012; 8: 209-214.
  17. Kline K, Yu W, Sanders B. Vitamin E and Breast Cancer. J Nutr 2004; 134: 3458S–3462S.
  18. Singh P, Kapil U, Shukla NK, Deo S, Dwivedi SN. Association between breast cancer and vitamin C, vitamin E and selenium levels: results of a case-control study in India. Asian Pac J Cancer Prev 2005; 6: 177-80.
  19. Ramaswamy G, Krishnamoorthy L. Serum carotene, vitamin A, and vitamin C levels in breast cancer and cancer of the uterine cervix. Nutr Cancer 1996; 25: 173-7.
  20. Hou MF, Tsai LY, Huang CJ, Huang YS. Serum vitamin A level in breast cancer patients. Kaohsiung J Med Sci 1998; 14:673-8.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2023 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions