International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 05 Issue 18, September, 2013

Pages: 15-21

Date of Publication: 25-Sep-2013

Print Article   Download XML  Download PDF


Author: Anita M. Raut, A.N. Suryakar, Dilip Mhaisekar

Category: Healthcare

Abstract:Lipid peroxide plays an important role in smokers. Increased epithelial permeability produced by cigarette smoke is likely to be mediated through depletion of sulphydryl proteins (-SH) and antioxidant capacity. The oxidant burden in the lungs is enhanced in smokers by the release of ROS from macrophages and neutrophils. Oxidants present in cigarette smoke can stimulate alveolar macrophages to produce ROS some of which attack neutrophils and other inflammatory cells into lungs. 60 smokers with smoking history 20 pkts /year were included in the study.100 healthy non-smokers' were served as controls. Their base line clinical examination, malondialdehyde (MDA), sulphydryl proteins (-SH), superoxide dismutase (SOD) and total antioxidant capacity (TAC) were measured. The mean malondialdehyde levels in the patients at base line were high (P< 0.001) than Controls. The sulphydryl proteins, superoxide dismutase and total antioxidant capacity were low (P< 0.001) in the smokers compared to controls. We found decreased levels of sulphydryl proteins and increased levels of lipid peroxide (MDA) in smokers. Thus the present study confirmed the existence of oxidative stress and alteration in enzymatic and nonenzymatic antioxidant (-SH Proteins) status.

Keywords: Sulphydryl proteins, Malondialdehyde, Antioxidant status, Superoxide Dismutase, Smokers’, Reactive Oxygen Species (ROS).

Full Text:


The lungs are a pair of sponge like organs in the chest which are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and the blood. (1). It is a unique organ in terms of its direct exposure to high levels of oxygen and reactive compounds (2) .Inhaled ozone induces toxic processes that impair lung function. The oxidant burden in the lungs is enhanced in smokers’ by the release of ROS from macrophages and neutophiles. Oxidants present in cigarette smoke can stimulate alveolar macrophages to produce reactive oxygen species (ROS). Some are weakly attack neutophiles and other inflammatory cells into the lungs (3) .A number of abnormalities and measurement of biomarkers have suggested that increased oxidative stress is occurring and is detrimental in cigarette smokers’. The most convincing way to determine the involvement of oxidative stress in smokers’ is to directly measure oxygen radicals. However direct measurement is difficult. The alternative has been to measure damage by oxygen radicals upon various lung biomolecules usually lipids (4). Lipid peroxidation can be defined as a chain of reaction of oxidative deterioration of polyunsaturated fatty acids, initiated by free radicals(5). Exposure to cigarette smoke has been shown to increase the oxidative metabolism of macrophages and appear to be more prevalent in he lungs of smokers’ and are responsible for the increased O2? production by smokers’ macrophages. Sulphydryl proteins (-SH) and redox states of intracellular and extracellular compartments is critical in the determination of protein structure, regulation of enzyme activity and control of transcription factor activity and binding of-SH / disulfide redox buffer as metal chelators, as radical quencher and as specific reductants  of individual protein disulfate’s bonds. Thus the increased level of –SH proteins have been associated with increased tolerance to oxidant stresses in all these systems. Sulphydryl proteins (-SH) groups are essential in the protection against the deleterious effect of reactive species (6) Cigarette smoking increases oxidation of plasma proteins. Exposure to gas phase cigarette smoke caused increased, lipidperoxidation. It is likely that α - ß unsaturated aldehyde, which are abundantly present in cigarette smoke, may react with sulphydryl (-SH) groups leading to the formation of a protein bound aldehyde functional group (7).

To minimize oxidant damage to biologic molecules the human lung is endowed with an integrated antioxidant system of enzymatic and expendable soluble non enzymatic antioxidants.  This system includes several antioxidant defense mechanisms that detoxify reactive products and convert them to products that are quenched by other antioxidants. If the oxidant burden is sufficiently great, the reactive species may overwhelm or inactive the antioxidant system. The resulting excess oxygen species can damage major cellular components, including membrane lipids, proteins and DNA etc. The pathophysiological consequences of this injury are inflammation and widespread tissue damage. Thus overall alters the antioxidant status (8).          


1-The present work was planned to study -SH proteins as well as oxidant/antioxidant balance in smokers.

Following parameters were studied-

  1. To explore the existence of possible peroxidative damage in smokers by estimating the   level of serum malondialdehyde as an index of lipid peroxide.                                                                                         
  2. To evaluate alteration in enzymatic antioxidant such as erythocytic superoxide dismutase (SOD).
  3. To study possible alteration in antioxidant status in smokers by estimating concentration of non enzymatic antioxidant sulphydryl proteins.                                                                                                                                           
  4. To make global assessment of antioxidant defense by measuring total antioxidant capacity in smoker’.


1. The level of serum total lipid peroxide in terms of Malondiadehyde (MDA) was determined by Kei Satoh method.(9)

2. Serum sulphydryl proteins (-SH) was determined by A.F.S.A.method(10).

3. RBC – Superoxide dismutase activity was estimated by Najwa Cortas and Nabil Wakid method (11)

4. Total antioxidant capacity in plasma (TAC) was assayed by FRAP analysis. (12)


The present study was conducted in the Department of Biochemistry Dr. Vikhe Patil Medical College and Hospital Ahmednagar. Smokers’ with Hypertension, Malignancy, overt cardiac failure, recent surgery, severe endocrine hepatic or renal diseases and use of anticoagulant medicine and the lung disorders were excluded. All smokers’ were active smokers’ without any disease. Smokers’ with smoking history of >20 pkts /year in the age group of 25-60 years of age were included in the study and 100 healthy controls were also included in the study . Informed consent was obtained from each participant in the study.         


Distribution of these subjects was as follows.

Sr. No.



No. of Subjects



Healthy subjects




Smoking history > 20 pkts/years







The control subjects were completely healthy non smokers and showed no abnormality on clinical examinations and were completely symptom less. The study was cleared by institutional ethics committee.

10 ml blood was collected from each patient. 5ml of it was collected in EDTA bulb and 5ml was collected in plain bulb. Plasma and serum were separated from respective bulbs by centrifugation at 3000 rpm for 10 minutes at room temperature. All the samples were analyzed on the same day of collection.

Serum MDA levels were measured reacting than with thiobarbituric acid at high temperature to form pink colored complex which was measured at 530 mn(9). Erythrocyte SOD activity was measured by Kajari Das method (10) which is based on the ability of SOD to inhibit nitrite formation. Plasma -SH protein were measured at 412 nm using A.F.S.A.method (11). And total antioxidant capacity was measured at 593 nm by using FRAP analysis. (12)

The statistical analysis was performed by using student t test and P values < 0.001 were interpreted as statistically significant. The values were expressed as mean ± SD.


Table No. 1 Illustrate the levels of MDA, SOD,-SH, TAC in the healthy controls and smokers

Sr No.


Healthy controls  n=100

Smokers’ n=60





4.5±2.76 *



(U/mg of Hb )


0.40±0.1 *


Sr. –SH Proteins



8.1±1.15 *



(umol /L)



 n = number of cases

All values are expressed in mean ± SD                       

* = Significant when compared with control group                                                                                                                                                                         DISCUSSION

Table No. 1 display serum total lipid peroxide (MDA) levels in healthy controls and smokers’    

Significantly higher levels of serum total lipid peroxide (MDA) (P<0.001) were observed in smokers’ as compared to healthy controls .The elevated MDA levels observed in the present study suggest increased ROS production and thereby lipid peroxidation in smokers’.

Reactive oxygen species (ROS), such as the superoxide anion liberated by phagocytes recruited to sites of inflammation, are proposed to be a major cause of the cell and tissue damage, including apoptosis, associated with many chronic inflammatory diseases Lung cells, in particular alveolar epithelial type II cells, are susceptible to the injurious effects of oxidants. Lungs are continuously exposed to oxidants, either generated endogenously by metabolic reactions or exogenously, such as air pollutants or cigarette smoke.

Cigarette smoking a environmental hazard, also delivers oxidants and free radicals to the lungs. Cigarette smoke contains many oxidants and free radicals, both in the gas and the tar phase (13) and causes sequestration of neutrophils into the pulmonary microcirculation and accumulation of macrophages in respiratory bronchioles (14).  Once recruited, these cells become activated and generate ROS in response to a sufficient level of stimulus (threshold concentration). The mechanism for this may involve neutrophil adhesion to endothelium and upregulation of CD18 integrins (15,16), which is known to upregulate the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, hydrogen peroxide-generating system.

Activation of macrophages, neutrophils and eosinophils generates superoxide anion, which is rapidly converted to H2O2 by superoxide dismutase (SOD), and hydroxyl radicals, formed nonenzymatically in the presence of Fe2+ as a secondary reaction. In neutrophils, myeloperoxidase also catalyses the formation of the potent oxidant hypochlorous acid from H2O2 in the presence of chloride ions. ROS, which may also be released by lung epithelial cells, may also stimulate inflammatory cells directly, thereby amplifying lung Inflammatory and oxidant events. Changes induced by reactive oxygen species may result in inactivation of antiproteases, epithelial cell injury, apoptotic and necrotic cell death, mitochondrial dysfunction, disturbance of extracellular matrix repair and maintenance of airway inflammation (17).

Thus, smokers’ are clearly subjected to oxidative stress as indicated by increased lipid peroxidation.

To prevent free radical formation or limit their damaging effects, cells have developed a comprehensive array of defenses i.e. antioxidants. Table No. 1 show superoxide dismutase activity in healthy controls and smokers’ significantly diminished SOD activity (P<0.001) was observed in smokers’.         

In smokers’ the excessive production of superoxide anions, by polymorphonuclear leukocytes, macrophages and monocytes disturb the oxidant and antioxidant balance. To scavenge these superoxide anions more amount of SOD gets utilized.

Cu-Zn-SOD has two identical subunits of about 32 kDa, each containing a active site constituted by a copper and a zinc atom bridged by a common ligand histidine ( 18).

It has been reported that Cu-Zn SOD is irreversibly inactivated by its product H2O2, and it is well known that mature erythrocytes are unable to synthesize de novo SOD (or other proteins). Under normal circumstances a minor loss of SOD due to oxidative inactivation may not be of physiological significance. During exposure to oxidative stress, however, substantial SOD inactivation may occur, thus seriously compromising the antioxidant defenses of the RBC (19).

SOD inactivation by H2O2 has been shown to involve oxidative modification of a histidine residue which is important in the binding of the copper moiety to the active site of the enzyme. H2O2-dependent structural changes in the active site region of SOD lead to a conformational change which is susceptible to proteolysis. Such modified SOD undergoes

further reactions to form protein fragments, which are rapidly degraded by intracellular peptidase. The low SOD activity could contribute to a failure in plasma antioxidant defense.

Table No.1depicts the levels -SH proteins in healthy controls and smokers’ significantly lower levels of -SH proteins (P<0.001) were observed in smokers’ as compared to healthy controls.

Protein sulphydryl groups contribute physiologically to overall redox balance and modulate oxidative stress by generating reversible semi-oxidized species (mixed disulphides with non-protein low molecular weight thiols). Protein sulphydryl groups are also responsible for antioxidant action in plasma because they can react with several oxidant radicals (20).

In smokers’, oxidative stress oxidize thiols of various proteins and glutathione. Two series of oxidized species arise depending on the starting target, oxidation / nitration leads to the formation of protein thiolates (cys–S-), can be readily oxidized to a sulphenic acid (cys-SOH), which is a relatively reactive form that can quickly form a disulphide with a nearby -SH. Strong oxidants will oxidize either cys–S- or cys–SH to sulphinic (cys–SO2H) and /or sulphonic (cyss–SO3 H) acid derivatives. This difference in the generation of a particular cysteine -SH species provides a basis for distinguishing redox signaling from oxidative stress. While oxidative stress generally involves nonspecific oxidation of those cysteines which are located in an environment promoting dissociation of -SH. The higher oxidation states in the form of sulphinic and sulphonic derivatives have essentially been considered as irreversible modification under biologically relevant condition and associated with oxidative injury thus lowering the -SH levels in smokers’(21).

It has been hypothesized that cigarette smokers were found to have 20 % more oxidized proteins in their plasma compared with non smokers’. Therefore -SH proteins measurement may be used as a prognostic marker test for cigarette smoke dependent lung diseases.

Total antioxidant capacity and smokers- The total antioxidative potential of the plasma reflects the ability of an individual to resist the oxidative stress. Ferric reducing ability of plasma (FRAP) evaluates plasma total antioxidant capacity due to known and unknown antioxidants in the plasma (22).

Table No. 1 describe total antioxidant capacity in healthy controls and smokers. As compared to healthy controls total antioxidant capacity of smokers was significantly decreased (p<0.001).



  1. ORT, Oncology Research Therapeutics lung structure and function.  Amherst, NY, 14228.
  2. Dominici S, Valentini M, Maellaro E, et. al. Redox modulation of cell surface protein thiols in U937 lymphoma cells the role of gamma – glutamyl turns peptidase- dependent H2O2 production and S. thiolation .Free Radic Biol.Med. 1999, 27, 623 – 635.
  3. I Rahman and I. M. Adcock. Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respair J. 2006, 28; 219-242.
  4. Dekhuijzen P.N. Aben KK, Dekker I, Aarts L.P. Wielders PL, Van Herwaarden CL, Bast A.  Increased exhalation of hydrogen peroxide inpatients with stable and unstable chronic obstructive pulmonary disease. Am J.Respir. Crit. Care   Med. 1996   Sept.  154, 813-6.
  5. Chesseman K.H. Slater T.F. An introduction to free radical biochemistry. British Medical Bulletin 1993: 49: 481 – 493.
  6. Di Simplicio P; Franconi F, Frosali S, Giuseppe D. Thiolation and nitrosatin of cysteines in biological fluids and cells. Amino acids    2003, 25, 323-339.
  7. Brown D.M. Drost E, Donaldsonk, MacNec W. Deformability and CD11/ CD18 expression of sequestered neutrophils in normal and inflamed lungs.  Am. J. Respir, Cell. Mol. Biol 1995: B-531-53.
  8. Suzy A.A. Comhair and Serpel C, Erzurum .Antioxidant responses to oxidant – mediated lung diseases. Am J Physiol lung Cell Mol physiol 2002 283: L246 – L255.
  9. Estimation of lipid peroxide (MDA) by Kei Satoh method .Clinica chemical Acta 1998, 0:37- 43.                                                                                                                                      
  10. Kajari Das, Luna Samanta and GBN chainy A modified spectrophotometric assay of superoxide dismutase using nitrite formation b superoxide radicals. Indian Journal of Biochem and Biophysics Vol 37, June 2000, 201-204.
  11. Habeeb, A F.C.A (1972), Estimation of protein sulphydryl (-SH) groups with Ellman’s reagent. Methods Enzymol: 34:457-464.
  12. Iris F.F. Benzic and J.J. Strain. The Ferric Reducing Ability of plasma (FRAP) as a Measure of “Antioxidant Power”.  The FRAP Assay Article No. 0292 analytical Biochem. 239, 1996, 70-76
  13. Thurbleck W.M., pathology of chronic airflow obstruction.  In Cherniack NS (ed) chronic obstructive pulmonary Disease.  Philadelphia   WB. Saunders 1991: P-3.
  14. Suinder G.L. et. al. The definition of emphysema, Report of the National Heart, Lung and Blood Institute Division of lung Diseases Workshop Am. Rev. Respir Dis, 1985 132:  182.
  15. Weibel E.R. Physiological Anatomy of respiratory system. Text book of physiology vol –I, 3rd e. p. 410.
  16. K. Jain Physiological anatomy of respiratory system. Textbook of physiology vol I, 3rd ed.p428-429.
  17. 38.Paul Kirkham and Irfan Rahman .Oxidative Stress in asthma and COPD: Antioxidants as a therapeutic strategy pharmacology and Therapeutics volume 1: issue 2: August 2006: 476-494.
  18. Irwin Fridovich, Superoxide radical and superoxide dismutase. Ann. Rev. Biochem. 1995: 64-97-112.
  19. Salo DC, Pacifici RE, Lin SW, Giulivi C Davies KJ. Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation. J. Biol Chem. 1990: 265:11919-27.
  20. Fridovich I. Superoxide radical and superoxide dismutase Ann. Rev: Biochem 1995: 64: 97- 112.
  21. R Permanand. P.H.Santosh Kumar and Alladi Mohan. Study of thiobarbituric reactive substances and total reduced glutathione as indices of oxidative stress in chronic smokers with and without chronic obstructive pulmonary disease. Indian J. Chest Dis. Allied Sci. 2007: Jan –Mar: 49( 1 ): 9- 12.   
  22. Iris F.F. Benzic and J.J. Strain. The Ferric Reducing Ability of plasma (FRAP) as a Measure of “Antioxidant Power”.  The FRAP assay Article No. 0292 Analytical Biochem. 239: 1996: 70-76.




Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to for more details.

Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

RSS feed

Indexed and Abstracted in

Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

Copyright © 2023 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions