International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 5(23), December, 2013

Pages: 31-36

Date of Publication: 16-Dec-2013

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Author: Partha S. Saha

Category: Healthcare

Abstract:Cerebrovascular attack (CVA) or stroke is one of the leading causes of adult disability in world. The current treatments of the stroke are preventive treatment, acute-phase stroke treatment and post-stroke rehabilitation. But the need of more sophisticated therapies and the drawbacks of the existing therapies in their usages call for the new therapies to replace them or develop them. This essay summarizes some of the major new therapeutic approaches, such as the use of statin agents, ACE-I, vitamins, minocycline, edaravone, other neuroprotective agents, stem cell therapy and hyperbaric oxygen therapy. It also describes new methods of implanting of Penumbra system for prevention of the stroke.

Keywords: Stroke, penumbra system, minocycline in stroke, edaravone in stroke, ReN001 stem cell therapy, hyperbaric oxygen therapy.

Full Text:


Stroke, also known as a cerebrovascular attack (CVA), is the rapid loss of brain function(s) due to disturbance in blood supply to brain. This can be due to ischemia (lack of blood flow) caused by blockage (thrombosis, arterial embolism), or a hemorrhage (leakage of blood) [1]. As a result, the affected areas of brain cannot function, which might result in an inability to move one or more limbs on one side of the body, to understand or formulate speech, or to see one side of a visual field [2].

 A stroke is a medical emergency that can cause permanent neurological damage, complications, and even death. It is the leading cause of adult disability in the United States and Europe and the second leading cause of death worldwide [3]. Risk factors for stroke include old age, hypertension (high blood pressure), previous stroke or transient ischemic attack (TIA), diabetes, high cholesterol, cigarette smoking and atrial fibrillation. High blood pressure is the most important risk factor of stroke [2].


Stroke is a major public health problem throughout the world. Stroke is usually considered as a disease of the elderly, but strokes can occur at any age and their consequences in terms of lost productivity are even greater in younger patients than that of older ones. Stroke is regarded as the third leading cause of death after heart disease and cancer, and it is a leading cause of disability as well. In addition, stroke is the single largest cause of adult disability in developed world. Over 150,000 people suffer a stroke each year in the UK, and over 700,000 people in the US.  The annual health and social costs of caring for disabled stroke patients is estimated to be in excess of £5 billion in the UK, with stroke patients occupying 25 per cent of long term hospital beds [3].

Current Therapies

Strokes can be classified into two major categories: ischemic and hemorrhagic, and the treatment of the stroke can be classified into three 

major categories - preventive treatment, acute-phase stroke treatment and the post-stroke rehabilitation.

The preventive treatment is aimed in reduction of associated risks of stroke earlier than its occurrence.  There are several ways by which preventive treatment can be done. Some of the treatment includes the use of the drugs, such as anticoagulants or antiplatelets, surgical procedures like Carotid Endarterectomy, Hemicraniectomy, Angioplasty, etc. Among these techniques, the most prevalent treatment therapy is through use of anticoagulants and antiplatelets. Several antiplatelet agents and anticoagulants interfere with the blood's clotting ability and thereby play a significant role in preventing stroke.

The acute-phase stroke treatment aims at arresting a stroke when it takes place. This therapy is done by using thrombolytics or clot-busting drugs, such as tissue plasminogen activator (tPA). Therefore, it is also known as thrombolytic therapy. This is the most promising treatment for the ischemic stroke till today.

Lastly, post-stroke rehabilitation therapies are effective for improving both functional and cognitive recoveries in a patient some weeks or months after the event of stroke. Transcranial infrared laser therapy, for example, reduces the infarct area and improves the intra-cerebral microcirculation.
Drawbacks of the current therapies

Among the preventive therapies, use of antiplatelet drugs or anticoagulant drugs involves increasing the incidence of the drug interaction in patients. On the other hand, the surgical preventive treatments are very costly and life-threatening.

The acute-phase treatment with thrombolytic drugs is more complex as it needs to be done in hospitals with professional intervention. In addition to that, to ensure best therapeutic effect of the dose, the thrombolytic drugs should be administered within a three-hour interval from the onset of symptoms. But in this short interval of time, only 3 to 5% of the patient can reach hospitals. Therefore, the disadvantage of this therapy can alone keep out patients to harvest maximum benefits out of this so-called ‘most promising’ treatment of ischemic stroke.

Like acute-phase therapy, the post-stroke rehabilitation therapies also need the professional intervention of physicians, rehabilitation nurses, vocational therapists, and mental health professionals. Moreover, they are involved with the use of sophisticated instrument which is never a cost-effective way. Moreover, patients do not get cured fully.

Therefore, the existing therapies have several drawbacks of their usage which call for the new therapies to replace them or develop them.

New Therapeutic Approaches

Use of Statin agents, ACE-I, vitamins for prevention of the stroke

Atherosclerosis, a major risk factor for stroke, was first realized as an inflammatory disease. This insight helped to make suggestion regarding its therapeutic agents, such as statins, vitamins and angiotensin-converting enzyme inhibitors (ACE-I) as they have certain anti-inflammatory activities. These agents reduce inflammation by stabilising atherosclerotic plaque or by other protective mechanism. Here, the statins like atorvastatin lower the risk factor of stroke. ACE-I, on the other hand, lowers the risk of vascular outcomes and related complications in high-risk patients, especially those with diabetic and non-diabetic renal diseases. In addition to that, vitamin C, beta carotene and vitamin E are the sources of the antioxidant nutrients. These antioxidants reduce the atheroma formation by inhibiting oxidation of LDL, which is an important step for atherosclerotic process [4].

The Penumbra System

To prevent the damage caused in the penumbral region, timely revascularization and the establishment of the reperfusion are mostly essential. The Penumbra System is an embolectomy device which is designed for removing thrombus in acute ischemic stroke. The  

device functions through 2 mechanisms - aspiration and extraction. The device is composed of three parts: a reperfusion separator, catheter, and thrombus removal ring. For aspiration, the reperfusion catheter is used along with the separator and an aspiration source to separate the thrombus and aspirate it from the occluded vessel. If residual thrombus still remains after revascularization with aspiration, the thrombus removal ring is used to directly removal of the thrombus. Overall, it is an effective device to reduce the neurologic deficit, stroke-related mortality and morbidity, and also to improve clinical outcomes [5]. It was approved by FDA in 2007 [6].

On July, 2013, Penumbra Inc. has launched a next-generation clot-extraction device, namely 5MAX™ ACE. This device uses aspiration technology as a primary tool to revascularize the clots more effectively than any other devices which use aspiration approach [7]. A Direct Aspiration First-Pass Technique (ADAPT) - a simple and effective technique using a large bore aspiration catheter to recanalize the vessel in AIS- when optimized with 5MAX™ ACE showed superior clinical outcomes as a first-line approach. In this way, it is now possible to remove complete thrombus without causing distal embolism- which is regarded as the highest state-of–art in reperfusion technology [7, 8].

Use of Minocycline for the treatment of the stroke

Minocycline is a protease inhibitor which was found to be useful in treatment of stroke in preclinical state of a preclinical stroke model. Being a promising anti-inflammatory, it has shown its effectiveness as a potential vascular-protective agent.  Moreover, it has also shown a significant success in dropping bleeding effects during tissue plasminogen activator (tPA) trial. Overall, this drug has already shown a great success to be used as an adjunctive therapy to tPA in stroke. It is to be noted here that since it shows no adverse effect in the fibrinolytic activity of tPA, the impact of reperfusion homorrhage is highly reduced; however, it was observed in some other experimental models [9].

Significance of Neuroprotection in Ischemic Stroke treatment

Neuroprotection is regarded as “any strategy, or combination of strategies, that antagonizes, interrupts, or slows the sequence of injurious biochemical and molecular events that, if left unchecked, would eventuate in irreversible ischemic injury” [10].

It is considered that some of the important mechanisms, such as activity of the excitotoxic neurotransmitters, production of the free radicals in neurons and apoptotic signalling of them can give a complete picture to draw conclusion about the mechanisms of the neuronal cell death in the brain even in the stroke condition [11]. In the preclinical condition, the neuroprotective agents have their own merits and demerits. Some of these types of the neuroprotective agents are the glutamate antagonists, GABA agonists, nitric oxide signal regulators, glutamate antagonists, etc. Use of the neuroprotective agents for the use of inhibiting neuronal cell death is a matter of recent concern and some of these protective therapies, which are considered to be used shortly, are the therapeutic hypothermia, hyperacute magnesium therapy, high-dose human albumin therapy, etc. The effectiveness of these therapies, even in their combinations, is also being studied [12].

Use of Edaravone for Acute of the stroke

Since 2001, in Japan, the edaravone has been marketed by Mitsubishi Pharma. This was being used an antioxidant. But later on, it was found to have effectiveness in treating acute brain ischemia and cerebral infraction, along with different mechanism of the neurological recovery. The mechanism that is involved with the activity of the edaravone in causing the neurological recovery is the ability to take away the hydroxyl radicals and thus inhibiting the hydroxyl dependent and independent lipid peroxidation. This is the reason that it can act as a potent antioxidant in protecting 

against oxidative stresses and neuronal cell deaths [12].

The edaravone is effective for both acute ischemic stroke (AIS) and acute haemorrhage stoke (AHS). According to an investigator, “a clinical trial has shown that the administration of edaravone alone within 72h of the onset of AIS significantly reduced the infarct volume and produced sustained benefits during a 3-month follow-up period”. He observed the effects of edaravone on AHS and found that “in an AHS model, rats treated with edaravone immediately after a hemorrhage showed a stronger reduction in brain water content and quicker functional recovery compared with rats treated with edaravone at 2h or 6h after hemorrhage” [13]. Most recently, Kono et al. has concluded through a clinical research on ischemic stroke patients older than 80 years of age that edaravone may be used as a partner for combination therapy with tPA; this may enhance recanalization and reduce hemorrhagic transformation [14]. On the other hand, safety and efficacy of multi-doses Edaravone injection is being trailed at phase II level [15].

ReN001 Stem cell therapy

Recently, stem cell therapy has proven effective to address the rehabilitation of post-stroke patients. ReN001 is a standardised, clinical and commercial-grade cell therapy product which is capable of treating all eligible patients. In short, it involves a neural cell line (CTX), cell selection technologies, cell-expansion procedures for selected cells and quality testing procedure. An extensive pre-clinical testing has shown to improve functional deficits associated with stroke disability, and it also indicated that the therapy is safe, with no adverse effects. A ground-breaking first-in-man clinical trial with ReN001 is proceeding in the UK under the name of PISCES (Pilot Investigation of Stem Cells in Stroke) study, which is being coordinated by ReNeuron Group. This is the world's first fully regulated clinical trial with neural stem cell. Based on the results already shown by the on-going study, the authority has already submitted an application for commencing a multi-site Phase II clinical trial to inspect the efficacy of ReN001 stem cell therapy on patients disabled by an ischaemic stroke [16]. Undoubtedly, the report of PISCES study indicates so far that ReN001 stem cell therapy is an effective treatment, but it is only useful for the patients who are in third treatment stage, not for any other two classifications [16].

Hyperbaric oxygen therapy (HBO2T)

Hyperbaric oxygen (HBO) has proved itself effective in treating acute and sub-acute focal cerebral ischemia in several animal models [reviewed in 17]. Observing its apparent promise in treating different diseases, the scientists have been practising hyperbaric oxygen therapy or HBO2T to cure or treat several diseases. This therapy involves placing one or more patients in an enclosed chamber and supplying with 100% oxygen in a pressure-regulated manner for respiration for a stipulated period of time, once or twice daily. In 2010, a clinical trial was organized by Bennett et al. to assess the effectiveness and safety of HBO2T. Due to adoption of less number of randomized controlled trials, the study could not show consistent evidence of its efficacy [18]. However, in this year, FDA has already warned on the potential health risks that are associated with the HBO2T.

Yet, certain groups of medical practitioners are still hopeful over the value. In tune with this, again in this year itself, Lim et al. observed the neuroprotective effect of HBO in attenuating microgliosis and pro-inflammatory cytokinine TNF-α expression [19]. This suggests again the need of performing a well set-up clinical trial to find its true effectiveness in treating stroke, at least as a rear-liner in stoke treatment.


Many substances or agents are still in pipeline for the treatment of the stroke. With the advancement of molecular biology and bio-therapeutics, newer agents are emerging day to day with strong promises to treat stroke. The days are not far when the patients from each phase of stroke will be able to get full range of effective treatments to come round all in all.


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  5. Bose  A, Henkes H, Alfke K, Reith W, Mayer TE, Berlis A, Branca VS. The penumbra system: a mechanical device for the treatment of acute stroke due to thromboembolism.  American Journal of Neuroradiology. 2008; 29:1409- 1413.
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  7. Penumbra, Inc. (2013). Penumbra, Inc. launches 5MAX™ ACE—the newest clot extraction device to treat acute ischemic stroke patients. Available: [Last accessed 26th Oct. 2013].

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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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SCOPUS indexing: 2014, 2019 to 2021

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to for more details.

Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


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