IJCRR - 6(6), March, 2014
ASSOCIATION OF HbA1c WITH SERUM LIPID PROFILE AND LIPOPROTEIN (a) IN TYPE 2 DIABETES MELLITUS
Author: Mahantesh Patil, Nirmal Kumar, Aliya Nusrath, Shubha Jayaram, Rajeshwari A.
Background: Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism. Also it is proposed thatunderutilization of glucose is associated with changes in lipid profile. Lipoprotein (a) [Lp (a)] is regarded as an independent indicator of risk development of vascular disease which is also a diabetic complication. Changes in lipid profile are also well related with severity of DM as adjudged by glycated Hb (HbA1c). Objectives: The study intends to find the association between Lipid profile, Lp (a) and HbA1c levels in type 2 diabetic patients. Methods: A case-control study was conducted in Adichunchanagiri Institute of Medical Sciences, B.G.Nagara, Karnataka from 1st Jan to 15th June 2012. Study involved 80 participants of which 40 were patients admitted with diagnosis of DM and other 40 were healthy controls. Blood samples were collected in fasting state and analyzed for FBS, PPBS, HbA1c, TAG, VLDL, HDL, LDL and Lp(a) and values were tabulated for statistical evaluation. Results: In DM patientssignificant changes in the following parameters were observedcompared to controls. FBS, PPBS, HbA1c &Lp (a) levels increased significantly (P<0.001), HbA1c/HDL, HbA1c/LDL & HbA1c/Chol ratios also increased significantly (P<0.001). Also the levels of TAG, VLDL &Chol/HDL were significantly increased with P<0.008, P<0.011 & P<0.003 respectively. The levels of HDL were significantly reduced in patients with DM compared to controls with P<0.002. There is no significant change observed in Cholesterol, LDL & HbA1c/Lp (a) levels. Conclusions: Along with lipid profile and Chol/HDL ratio, study of HbA1c/HDL, HbA1c/LDL & HbA1c/Chol ratios may be helpful in risk assessment of coronary heart disease in DM and association between Lp (a) and HbA1c needs to be further evaluated.
Keywords: Diabetes Mellitus, Glycated hemoglobin (HbA1c), Lp (a)
Mahantesh Patil, Nirmal Kumar, Aliya Nusrath, Shubha Jayaram, Rajeshwari A.. ASSOCIATION OF HbA1c WITH SERUM LIPID PROFILE AND LIPOPROTEIN (a) IN TYPE 2 DIABETES MELLITUS International Journal of Current Research and Review. 6(6), March, 20-25
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