IJCRR - 6(7), April, 2014
Pages: 65-73
ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS AMONG NEWBORNS IN RELATION TO MODE OF DELIVERY
Author: Soumika Biswas, Swati Bhattacharyya, Chinmoy Ghosh, Sayari Banerjee, Kasturi Mukherjee, Arghya Basu
Category: Healthcare
[Download PDF]
Abstract:
Oxidative stress results from an imbalance between reducing agents and enzymes involved in the removal of free radicals (FR) and/or reactive oxygen species (ROS). Objective of the study was to compare oxidative stress between newborns delivered by normal vaginal delivery and elective caesarean section by estimation of cord blood ischemia modified albumin (IMA) and to compare antioxidant status between them by measuring activity of super oxide dismutase and tocopherol in their cord blood. Cord blood was collected from 50 newborns delivered by uncomplicated normal vaginal delivery and 50 newborns delivered by elective caesarean section. Mean serum ischemia modified albumin level in cord blood of newborns born by normal vaginal delivery (35.34+-3.4U/ml, mean+-2SD) was higher than serum IMA values in cord blood of newborns born by caesarean section(24.89+-2.86U/ml, mean+-2SD)( by albumin cobalt binding assay method). Mean serum tocopherol in cord blood of newborns born by normal vaginal delivery was found to be lower (1.99+-0.62mg/lit, mean+-2SD), than that of cord blood of newborns born by caesarean section (4.21+-1.04mg/lit, mean+-2SD) in this study( by Baker and Frank method). Mean cord blood plasma super oxide dismutase values were found to be lower in cord blood of normal delivery born babies (3.54+-0.60U/ml, mean+-1SD), than that of caesarean section born babies (5.82+-0.45U/ml, mean+-1SD) (by Kakkar’s method). So, there is increased antioxidant status in cord blood of caesarean section born babies and increased oxidative stress (which is indicated by raised ischemia modified albumin) in cord blood of normal delivery born newborns. Antioxidant supplementation to mothers and newborns may be considered.
Keywords: Oxidative stress, Normal vaginal delivery, Elective caesarean section, Antioxidants
Citation:
Soumika Biswas, Swati Bhattacharyya, Chinmoy Ghosh, Sayari Banerjee, Kasturi Mukherjee, Arghya Basu. ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS AMONG NEWBORNS IN RELATION TO MODE OF DELIVERY International Journal of Current Research and Review. 6(7), April, 65-73
References:
REFERENCES
1. Buonocore G,Perrone S.Biomarkers of oxidative stress in the fetus and newborn.[haematological reports] 2006; 2(10):103-107,
2. Casanova E, Viteri FE.Iron and oxidative stress in pregnancy. J Nutr 2003 May; 133(5 suppl 2):1700S-1708S,
3. Gitto E, Pellegrino S, D’Arrigo S, Barberi I, Reiter RJ.Oxidative stress in resuscitation and in ventilation of newborns. Eur Respir J 2009Dec; 34(6):1461-9.
4. Wagenaar GT, Horst SA, Van Gastelen MA,Leijser LM,Maunad T,Van der Velden PA et al .Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress. Free Radical Biol Med 2004;36:782-801.
5. Halliwell B, Free radicals, antioxidants and human disease:curiosity,cause or consequence? Lancet 1994; 344:721-24.
6. Saugstad OD.Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease.Acta Paediatr1996;85:1-4.
7. Halliwell B,Gutteridge JMC,1999.Free radicals in biology and medicine,3rd ed. Oxford university press Inc.New York.
8. Bar-Or D, Curtis G, Rao N. Characterization of the Co2+ and Ni2+ binding amino-acid residues of the N terminus of human albumin: an insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem.2001;268:42-47.
9. Haga P,Kran S. Ceruloplasmin levels and RBC SOD activity in small preterm infants during the early anaemia of prematurity. Acta Peadiatrica(1981);70:861-64.
10. Soumitra Chakravarty,Alka N. Sontakke.A correlation of antioxidants and lipid peroxidation between maternal and cord blood in full term and preterm deliveries.Curr Pediatr Res 2012 ;16(2):167-174.
11. Guven S,Alver A,Mentese A,Ilhan F.C.,Calapoglu,M, Unsal A.The novel ischaemia marker Ischaemia modified albumin is increased in normal pregnancies. Acta Obstet Gynaecol Scand 2009;88(4):479- 82.
12. Kumral A,Okyay E,Guclu S,Gencpinar P, Islekel GH,SS oguz,Kant M,Demirel G,Duman N,Ozkan Het al. Cord blood IMA:Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?. Journal of obstetrics and gynaecology research 2012(Dec.):1-4.
13. Gugliucci A,Hermo R,Monroy C,Numaguchi M,Kimura S. Ischaemia modified albumin levels in cord blood: a case control study in uncomplicated and complicated deliveries. Clinica chimica acta international journal of clinical chemistry(2005);362:155-160.
14. Sazzad Y,Leonard M,Doyle M.Antioxidant levels in the cord blood of term fetus.Journal of obstetrics and gynaecology.2000;(20)No.5:468-471.
15. Inanc F,Kilinc M,Kiran G,Guven A,Kurutas EB,Cikim IG,Akyol O.Relationship between oxidative stress in cord blood and route of delivery. Fetal Diagn Ther.2005 SepOct;20(5):450-3.
16. Vakilian K,Ranjbar A,Zarganjfard A,Mortazavi M,Vosough-Ghanbari S,Mashaiee S,Abdollahi M.On the relation of oxidative stress in delivery mode in pregnant women;a toxicological concern. Toxicol Mech Methods 2009 Feb;19(2):94-9.
17. Gulbayzar S, Arica V,Hatipoglu S,Kaya A,Arica S,Karatekin G. Malondialdehyde level in cord blood of newborn infants. Iran J Paediatr 2011 September;21(3):313-319.
18. Greco A,Minghetti L,Puopolo M,Pietrobon B,Franzoi M,Chiandetti L,Suppiej A.Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery. Clin Biochem 2007 Dec;40(18):p.1420-22.
19. Pence S,Kocoglu H,Balat O,Balat A.The effect of delivery on umbilical arterial cord blood gases and lipid peroxides :comparison of vaginal delivery and caesarean section. Clin exp obstet gynaecol 2002;29(3):p.212-4.
20. M. T. M. Raijmakers , E. M. Roes , E. A. P. Steegers , B. van der Wildt , W. H. M. Peters.Umbilical glutathione levels are higher after vaginal birth than after cesarean section. Journal of Perinatal Medicine; Volume 31, Issue 6: Pages 520–522.
21. Watanabe K , Iwasaki A , Mori T, Kimura C, Matsushita H, Shinohara K, Wakatsuki A. Differences in levels of oxidative stress in mothers and neonate: the impact of mode of delivery. J Matern Fetal Neonatal Med. 2013 Jun 20. [Epub ahead of print]
22. Üdris Mehmetoúlu (Akkuþ),Ali Kart,Osman .Aúlayan,Metin.Apar,Recep G.K.E. Oxidative Stress in Mothers and Their Newborns in Different Types of Labour. Turk J Med Sci (2002);32: 427-429.
23. Z.Hracsko,Z.Safar,H.Orvos,Z.Novak,A.Pal,I S Varga.Evaluation of oxidative stress markers after vaginal delivery or caesarean section. in vivo 2007; 21 :703-706.
24. Saphire O,Schneid-Kofman N,Silberstein E,Silberstein T. Does mode of delivery affect neonate oxidative stress in parturition?.Arch gynaecol obstet 2013 Mar;287(3):403-6.
25. Gitto E,Pellegrino S,Gitto P,Barberi I,Reiter RJ .Oxidative stress of the newborn in the pre and postnatal period and the clinical utility of melatonin.J Pineal Res 2009 Mar;46(2):128- 39.
26. Kakkar P,Das B, Vishwanathan PN. A modified spectrophotometric assay of super oxide dismutase.Ind J Biochem Biophys1984;21:130-132.
27. Gowenlock AH,Mc Murray JR,Mc Lauchlan DM. Determination of serum tocopherol ,Baker and Frank,1968.Varley’s Clinical Biochemistry 1988:902.
28. Robert H. Christenson, Show Hong Duh. Characteristics of an Albumin Cobalt Binding Test for Assessment of Acute Coronary Syndrome Patients: A Multicenter study. Clinical Chemistry 2001;47:464-470.
|