IJCRR - Vol 06 Issue 09, May, 2014
ESTIMATION OF GLYCATED ALBUMIN LEVELS IN VARIOUS THYROID DISORDERS
Author: Suresh Babu Kondaveeti, Bhanu Prakash G., I. Anand Shaker
Background: Glycation is the linking of sugar molecule to various compounds such as glucose, lipid or protein. As albumin is one of major protein in our circulation, to which sugar has bonded to form Glycated albumin. Albumin is present not only in blood but also in major organs and body fluids and it serves to maintain cell shape and distribution of hormones. Objective: The present study was designed to compare the levels of GA in Various thyroid disorders group with Normal healthy control group. Materials and Methods:The present cross sectional study includes 200 cases, (n=50 in each group) newly diagnosed hyperthyroidism, hypothyroidism, subclinical hypothyroidism and normal controls between 30-55 years of both genders.serum samples obtained for the estimation of T3,T4,TSH and glycated albumin. Statistical analysis done by using SPSS, version16.0. One-way ANOVA was performed. All P-values which were ?0.05 were considered as stastically significant. Results: Glycated albumin values were found to be significantly correlated among the different groups (p=0.001). GA levels significantly increased in hypothyroidism, subclinical hypothyroidism and lowered in hyperthyroidism group compared to normal group. Significant correlation was found between T3, T4, TSH and GA levels. Conclusion: The present study showed increased levels of GA among experimental groups when compared with the normal control group. Hence It was concluded that estimation of serum GA will be useful as a noval parameterin thyroid disease cases.
Keywords: Glycated albumin, Hypothyroidism, subclinical hypothyroidism, Hyperthyroidism
Suresh Babu Kondaveeti, Bhanu Prakash G., I. Anand Shaker. ESTIMATION OF GLYCATED ALBUMIN LEVELS IN VARIOUS THYROID DISORDERS International Journal of Current Research and Review. Vol 06 Issue 09, May, 138-144
1. Pierce JC: Pituitary Thyrotropin: Chemistry in The Thyroid. 1998.fourthedition.
2. Muller MJ, Acheson KJ, Jequier E, Burger AG. Effect of thyroid hormones on oxidative and nonoxidative glucose metabolism in humans. Am J Physiol.1988;255:E146-52.
3. Canaris G,J, Manowitz NR, Mayor G, and Ridgway C: The Colorado Thyroid Disease Prevalance study. Arch Intern Med. 2000.160;526-534.
4. Boelaert K, Franklyn JA. Thyroid hormone in health and disease.J Endocrinol2005;187:1-15.
5. Wiersinga WM. Subclinical hypothyroidism and hyperthyroidism.I. Prevalence and clinical relevance. Neth J Med 1995;46:197-204.
6. Wilson GR: Subclinical Thyroid Disease: scientific review and guidelines for diagnosis and management. JAMA, 2008. 291:228-38.
7. Carl A. Burtis, Edward R. Ash wood, David R. Bruns. Tietz text book of Clinical Chemistry and Molecular Diagnostics. 4th ed. Philadelphia: W.B. Saunders Company publishers: 2008.
8. Rondeau, P.; Bourdon, E. The glycation of albumin: Structural and functional impacts. Biochimie. 2011, 93, 645–658.
9. Day, J.F.; Thorpe, S.R.; Baynes, J.W. Nonenzymaticallyglucosylated albumin. In vitropreparation and isolation from normal human serum. J. Biol. Chem. 1979, 254, 595– 597.
10. CirilloR,Balzano S, Cossu E, BartelenaL,Solinas MP, Falcone M, Balestrieri A, Martino E. The effect of altered thyroid function on serum fructosamine concentrations. Clin Biochem.1988 Jun; 21(3):179-81.
11. Larsen P, Davies T. Hypothyroidism andthyroiditis. In Williams Textbook of Endocrionology. 10th ed. Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, Eds. Maryland Heights, Missouri, Saunders Elsevier, 2002, p. 423–455
12. Masaaki Inaba, SenjiOkunoet al. Glycated Albumin Is a Better Glycemic Indicator thanGlycated Hemoglobin Values in Hemodialysis Patients withDiabetes: Effect of Anemia and Erythropoietin Injection J Am SocNephrol 18: 896 –903, 2007. doi: 10.1681/ASN.2006070772
13. Kouzuma T, Usami T, Yamakoshi M, et al. An enzymatic method for the measurement of glycated albumin in biological samples. ClinChimActa 2004; 324: 61-71.
14. Kouzuma T. Study of glycated amino acid elimination for an improved enzymatic glycated albumin measurement method. ClinChimActa 2004; 346: 135-143
15. Raboudi N, Arem R, Jones RH et al. Fasting and postabsorptive hepaticglucose and insulin metabolism in hyperthyroidism. Am J Physiol1989;256:E159-66.
16. Weinstein SP, O’Boyle E, Fisher M, Haber RS. Regulation of GLUT2 glucose transporter expression in liver by thyroid hormone: evidencefor hormonal regulation of the hepatic glucose transport system.Endocrinology 1994:135:649-54.
17. R ochon C, Tauveron I, Dejax C et al. Response of glucose disposal to hyperinsulinemia in human hypothyroidism and hyperthyroidism. ClinSci2003;104:7-15.
18. Maratou E, Hadjidakis DJ, KolliasAet al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol2009;160:785-90.
19. Meller J, Zappel H, Conrad M, Roth C, Emrich D, Becker W. Diagnostic value Q of 123 iodine scintigraphy and perchlorate discharge test in the diagnosis of congenital hypothyroidism. ExpClinEndocrinol Diabetes. 1997;105:24-27.
20. Nanda N, Bobby Z, Hamide A. Oxidative stress and protein glycation in primary hypothyroidism.Male/female difference.ClinExp Med 2008;8:101-108.
21. Weijers RN, Slaats EH, Kruijswijk H, Fructos amine values in hyperthyroidism, hypothyroidism and gammopathy WeinKlinWochenschr 1990; 18 0:Suppl21-24.
22. Ford HC, Lim WC, Crooke MJ, HemoglobinA 1c and serum fructosamine levels in hyperthyroidism ClinChemActa 1987; 166:31 7-21.
23. Mohan Kumar, Bobby Z, Selvaraj N, Kumard as A, Chandra KonerB, Sen SK, Possible link between glycated hemoglobin and lipid peroxidation in hyperthyroidism ClinChemActa. 2004; 342:1 87-92.
24. Kim HB, Han KH, Lee BW, Kim H, Lee MH, Chung ES, HbA1c and serum fructosamine levels in hyperthyroidism J KorSocEndocrinol 1992; 7:46-51