IJCRR - Vol 06 Issue 10, May, 2014
MALIGNANT PHYLLODES TUMOUR OF BREAST WITH LIPOSARCOMATOUS DIFFERENTIATION PRESENTING CLINICALLY AS FIBROADENOMA - REPORT OF A RARE CASE
Author: Vimal Chander R., Sonti Sulochana, Madhavan M., Karuna Kumar K., Chitra S.
Introduction: Malignant phyllodes tumor accounts for less than 1% of breast tumors and 2 to 3% of fibroepithelial tumors of the breast. They are derived from intralobular or periductal stroma and most of them are benign. The stromal component of phyllodes tumor has the potential to undergo metaplasia to cartilage, bone, smooth muscle and striated muscle as well as their respective malignant neoplasms. The liposarcomatous differentiation of the stromal elements of phyllodes tumor is extremely rare. Case Report: We report a 27 year old female with a history of a mobile lump in the left breast presenting clinically and cytologically similar to a fibroadenoma. Histopathological examination revealed features of Malignant phyllodes tumour with liposarcomatous differentiation. Conclusion: Malignant phyllodes tumour is very rare and represents less than 1% of breast malignancies. It presents in females more than 40 years of age as a large mass. Malignant transformation is rare and heterologous liposarcomatous differentiation is unusual. This case is presented to illustrate that in a small mobile nodule of the breast presenting in young women clinically as a fibroadenoma, the possibility of a malignant phyllodes tumour should also be considered. Hence a thorough histopathological examination is necessary to rule out a malignant component. A regular follow up is needed in such cases to monitor for recurrence.
Keywords: Phyllodes tumour, Malignant, Breast tumour, Liposarcomatous
Vimal Chander R., Sonti Sulochana, Madhavan M., Karuna Kumar K., Chitra S.. MALIGNANT PHYLLODES TUMOUR OF BREAST WITH LIPOSARCOMATOUS DIFFERENTIATION PRESENTING CLINICALLY AS FIBROADENOMA - REPORT OF A RARE CASE International Journal of Current Research and Review. Vol 06 Issue 10, May, 120-125
1. Argáez Cimé NL, Gutiérrez Vega P, López Cruz J. Malignant phyllodes tumor with differentiation to liposarcoma. A report of a case and bibliographic review. Ginecol Obstet Mex 2005;73:145-50.
2. Taira N, Takabatake D, Aogi K, Ohsumi S, Takashima S, Nishimura R, Teramoto N. Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin. Jpn J Clin Oncol 2007;37:730-6.
3. Guerrero MA, Ballard BR, Grau AM. Malignant phyllodes tumor of the breast: review of the literature and case report ofstromal overgrowth. Surg Oncol 2003;12:27- 37.
4. Mohammed Al-Zoubaidi, Suimin Qiu, Mark Bonnen, Melissa Joyner, Kendall Roehl, Colleen Silva and Celia Chao. Malignant Phyllodes Tumor of the Breast: A Case Report. The Open Breast Cancer Journal 2011;3:45-48.
5. Mohammed Al-Zoubaidi, Suimin Qiu, Mark Bonnen, Melissa Joyner, Kendall Roehl, Colleen Silva and Celia Chao. Malignant Phyllodes Tumor of the Breast: A Case Report. The Open Breast Cancer Journal 2011;3:45-48.
6. Tan PH, Jayabaskar T, Chuan KL et al. Phyllodes tumors of the breast: the role of pathologic parameters. Am J Clin Pathol 2005;123:529-40.
7. Isotalo PA, George RL, Walker R, Sengupta SK. Malignant Phyllodes Tumor With Liposarcomatous Differentiation. Arch Pathol Lab Med 2005;129:421-2.
8. Uriev L, Maslovsky I, Vainshtein P, Yoffe B, Ben-Dor D. Malignant phyllodes tumor with heterologous liposarcomatous differentiation and tubular adenoma-like epithelial component. Int J Med Sci 2006;3:130-4.
9. Abdul Aziz M, Sullivan F, Kerin MJ, Callagy G. Malignant phyllodes tumour with liposarcomatous differentiation, invasive tubular carcinoma, and ductal and lobular carcinoma in situ: case report and review of the literature. Patholog Res Int 2010:501274.
10. Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, Liu TP. Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases. J Surg Oncol 2005;91:185-94.