IJCRR - 6(10), May, 2014
HONEY PHONOPHORESIS VERSUS LOW INTENSITY LASER THERAPY IN FEMALE GENITAL HERPES
Author: Intsar Salim Waked, Abdel Hamid N. Deghidi, Randa Shalaan
Objective: To compare the efficacy of honey phonophoresis versus low intensity laser therapy in female genital herpes simplex II. Research Methodology: Forty female patients suffering from genital herpes simplex type II assigned randomly into 2 groups; honey phonophoresis group (A) and low intensity laser group (B). Intensity of pain and serological response were recorded before and after 3 weeks of treatment. Results: The results of study showed that there were significant differences between both groups post-treatment as p value< 0.05. Percentage of improvement in VAS, IgG, IgM after intervention were 60%, 45%, 8%, respectively for group (A ) while for group (B) were 82%, 66%, 56%, Respectively. Conclusion: The study concluded that low intensity laser was more effective than Honey phonophoresis in the treatment of genital herpes type II.
Keywords: Low intensity laser, genital herpes, honey phonophoresis, serological response, polymerase chain reaction.
Intsar Salim Waked, Abdel Hamid N. Deghidi, Randa Shalaan. HONEY PHONOPHORESIS VERSUS LOW INTENSITY LASER THERAPY IN FEMALE GENITAL HERPES International Journal of Current Research and Review. 6(10), May, 08-15
1. Lavoie SR, Kaplowitz LG. Management of genital herpes infection. Semin Dermatol. 1994 Dec;13(4):248-55.
2. S Faro; A review of famciclovir in the management of genital herpes; Infect Dis Obstet Gynecol. 1998; 6(1): 38–43.
3. Siegel MA. Diagnosis and management of recurrent herpes simplex infections. J Am Dental Assoc 2002; 133:1245-1249.
4. Fiddian AP, Yeo JM and Stubbings RF, (2006) :“Successful treatment of herpes simplex with topical acyclovir”. Br. Med. . (Clin. Res. Ed.), 286:1699-1701.
5. Armon TT, (2009): "the use of honey in the treatment of infected wounds". Trop. Doct; 10:91.
6. Sanya AO and Oluseye KA (2000): Relative transmissivity of local substitutes for the manufacturer's ultrasonic transmission medium. J Nig Soc Phys 2000; 10(2): 23-25.
7. Ohta, A, Abergel, RP, Uitto, J: Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy. Lasers Surg Med 1987 7:199–201.
8. Yu, W, Chi, L, Naim, JO, Lanzafame, RJ: Improvement of host response to sepsis by photobiomodulation.Lasers Surg Med 1997b 21:262–268.
9. Schindl, A, Schindl, M, Schindl, L: Successful phototherapy with low intensity laser irradiation of a chronic radiation ulcer in a patient with lupus erythematosus and diabetes mellitus. Br J Dermatol 1997a 137:840–841.
10. Haichenberger-Wildner, I, Michels, H: Laserstrahlen bei Herpeserkrankungen. Med Cosmetol 1981 11:142–144,
11. Landthaler, M, Haina, D, Waidelich, W: Behandlung von Zoster, postzosterischen Schmerzen und Herpes simplex recidivans in loco mit Laser-Licht. Fortschritte Med 1983 101:1039–1041.
12. Cork RC, Isaacc IG and El-Sharydah AR, (2004): “A comparison of the verbal rating scale and the visual analog scale for pain assessment”. The Internet Journal of Anaesthesiology, 8(1):227-236.
13. Pfister WR and Hsieh DS, (2007): Permeation enhancers compatible with transdermal drugdelivery systems. Part II. System design considerations. Pharm Tech: 14(10):54-60.
14. Deissl LP and Frenkel NS, (2006): “Herpes simplex virus amplicon: Cleavage of concatameric DNA is linked to packaging and involves amplification of the terminally reiterated a sequence”. J. Virol., 57:933.
15. Fatahzadeh MS and Schwartz RA, (2007): “Human herpes simplex. ”. Clinical and Experimental Dermatology, (32):625-630.
16. Al-Waili NS, (2004): Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Medical Science Monitor, 10(8), 94-98
17. Molan PC (1992) The antibacterial activity of honey. The nature of the antibacterial activity. Bee World 73: 5–28.
18. Booth S (2004) Are honey and sugar paste alternatives to topical antiseptics? Journal of Wound Care 13(1): 31–3.
19. Kwakman PH, te Velde AA, de Boer L et al (2010) How honey kills bacteria FASEB J 24(7): 2576–82 20. Tunér, J., Hode, L.: Low Level Laser Therapy - clinical practice and scientificbackground, 1999, ISBN 91-630- 7616-0.
21. Donnarumma G, De Gregorio V, Fusco A, Farina E, Baroni A, Esposito V, Contaldo M, Petruzzi M, Pannone G , Serpico R. Inhibition of HSV-1 replication of laser diodeirradiation: possible mechanism of action. Int J Immunopathol Pharmacol. 2010 OctDec;23(4);1167-76.
22. Sanchez PJM, Femenias JLC, Tejeda AD, Tuner J. The Effect of 670-nm Low Laser Therapy on Herpes Simplex Type 1. Photomedicine and Laser Surgery. ahead of print. 0.1089/pho.2011.3076. Online Ahead of Print: November 2, 2011.
23. Schindl A, Neuman R. Low-intensity laser therapy is an effective treatment for recurrent herpes simplex infection. Results from a randomized double-blind placebocontrolled study. J Invest Dermatol. 1999: 113 (2): 221- 223
24. Marotti J, Aranha AC, Eduardo Cde P, Ribeiro MS.Photodynamic therapy can be effective as a treatment for herpes simplex labialis. Photomed Laser Surg. 2009;27(2): 357-63.
25. De Carvalho RR, de Paula Eduardo F, Ramalho KM, Antunes JL, Bezinelli LM, de Magalhães MH, et al. Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study. Lasers Med ScI 2010;25(3):397-402