IJCRR - 9(2), January, 2017
The Prevalence of Philadelphia Chromosome in BCR-ABL Positive Chronic Myelogenous Leukemia Cases in North Indian Population
Author: Fatima Bhopalwala Ali1, R.K. Verma2, Mustafa Ali3, Navneet Kumar4
Aim: The aim of my study was to identify the prevalence of Philadelphia chromosome in BCR-ABL positive CML cases in North Indian population. Philadelphia (Ph) chromosome is a specific cytogenetic marker, essentially required for the diagnosis, clinical management and follow up of patients of chronic myelogenous leukemia (CML), which is a myeloproliferative neoplasm of hematopoietic cell. It results from a reciprocal translocation, t (9; 22) (q34; q11.2) in the hematopoietic stem cells. The molecular consequence is the formation of the chimeric BCR ABL1 gene which plays a central role in the development of CML.
Methods: Bone marrow and peripheral blood sample from 66 CML cases were collected from Dept. of Clinical Hematology, KGMU. The samples culture and cytogenetic analysis was done in the Dept. of Anatomy, KGMU.
Results: Out of the total 66 cases, karyograms of 52 cases (78.8%) were obtained. 49 cases (94.2%) showed the presence of Philadelphia chromosome, while 5.8% cases showed normal karyogram. Most common age group showing the presence of Ph+ve CML was 41-50 years (28.6%) followed by patients in 51-60 years group. Majority of cases were males (59.2%). Compared with stage of CML 81.6% of Ph+ve cases were in chronic phase.
Conclusion: Majority of the CML cases were Philadelphia positive, with males more commonly involved. Ph+ve CML was seen commonly above 40 years of age with maximum patients presenting in chronic phase of CML. Our results are at par with research reports published around the world on the Philadelphia chromosome prevalence in CML.
Keywords: Chronic myelogenous leukemia, Philadelphia chromosome, BCR-ABL
Fatima Bhopalwala Ali1, R.K. Verma2, Mustafa Ali3, Navneet Kumar4. The Prevalence of Philadelphia Chromosome in BCR-ABL Positive Chronic Myelogenous Leukemia Cases in North Indian Population International Journal of Current Research and Review. 9(2), January, 14-19
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