IJCRR - Vol 06 Issue 11, June, 2014
MATURE CYSTIC TERATOMA HARBOURING SQUAMOUS CELL CARCINOMA - A CASE REPORT
Author: Krishnendu Das, Arindam Karmakar, Debanjan Bhattacharjee
Aim: Squamous cell carcinoma arising in a mature cystic teratoma is an extremely rare event. This effort aims at adding authors’ experience to the pool of knowledge of this very rare but ominous tumour. Case Report: Herein, we report a case of squamous cell carcinoma in mature cystic teratoma of right ovary in a 45-year-old woman presenting with abdominal mass which was diagnosed after surgery. The tumour was large and cystic. An exhaustive search was made to rule out the possibility of metastasis into the ovary. Discussion: Benign or malignant tumours that arise in a benign cystic teratoma are rare. Malignant transformation occurs in only 1-3% of benign cystic teratomas1, 2, 3. Preoperative diagnosis is difficult because of the lack of specific symptoms and signs to suggest malignancy 4. Factors such as age, tumour size, tumour markers and tumour imaging characteristics help in preoperative risk assessment. Better understanding of the pathology and prognostic factors of this group of tumours is required for early and proper management. Conclusion: This report emphasizes on the sinister nature of malignant transformation of mature teratoma and the importance of comprehensive investigations for early diagnosis and treatment.
Keywords: mature cystic teratoma, squamous cell carcinoma, ovary
Krishnendu Das, Arindam Karmakar, Debanjan Bhattacharjee. MATURE CYSTIC TERATOMA HARBOURING SQUAMOUS CELL CARCINOMA - A CASE REPORT International Journal of Current Research and Review. Vol 06 Issue 11, June, 14-17
1. Genadry R, Parmley T, Woodruff J D. Secondary malignancies in benign cystic teratoma. Gynecoloncol 1979;8:246-51.
2. Stamp G W H, McConnell E M. malignancy arising in cystic ovarian teratomas. A report of 24 cases. Br J ObstetGynaecol1983;90:671- 75.
3. Hirakawa T, Tsuneyoshi M, Enjoji M. Squamous cell carcinoma arising in mature cystic teratoma of the ovary. Clinicopathologic and topographic analysis. Am J Surg Pathol 1989;13:397-405.
4. Hurwitz JL, Fenton A, McCluggage WG, McKenn S. Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series. BJOG 2007 Oct; 114(10):1283-7.
5. Itoh H, Wada T, Michitaka K et al. Ovarian teratoma showing a predominant haemangiomatous element with stromal lutenization: report of a case and review of literature. Pathol Int 2004;54:279-84.
6. Tseng C J, Chou H H, Huang K G et al. Squamous cell carcinoma arising in mature cystic teratoma of the ovary. Gynecol oncol 1996;63:364-70.
7. Vartanian R K, McRae B, Hessler R B. Sebaceous carcinoma arising in a mature cystic teratoma of the ovary. Int J Gynecol Pathol 2002;21:418-21.
8. Ronnett B M, Seidman J D. Mucinous tumours arising in ovarian mature cystic teratomas: relationship to the clinical syndrome of pseudomyxomaperitonei. Am J Surg Pathol 2003;27:650-57.
9. Kikkawa F, Nawa A, Tamakoshi K, et al. Diagnosis of Squamous cell carcinoma arising from mature cystic teratoma of the ovary. Cancer 1998 ; 82(11):2249-55.
10. Mori Y, Nishii H, Takabe K, et al. Preoperative diagnosis of malignant transformation arising from mature cystic teratoma of the ovary. Gynecol Oncol 2003; 90(2):338-41.
11. Lai PF, Hsieh SC, Chien JC, Fang CL, Chan WP, Yu C. Malignant transformation of ovarian mature cystic teratoma: Computerized tomography findings. Arch Gynecol Obstet 2005;271(4):355-57.
12. Kido A, Togashi K, Konoshi I, et al. Dermoid cysts of the ovary with malignant transformation: MR appearance. Am J Roentgenol 1999;172(2):445-49.