IJCRR - 6(11), June, 2014
Pages: 01-07
GARCINIA KOLA: A REVIEW OF ITS ETHNOMEDICINAL, CHEMICAL AND PHARMACOLOGICAL PROPERTIES
Author: Ekene E. N., Erhirhie Earnest O.
Category: Healthcare
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Abstract:
Plants still remain the basis for development of modern drugs for the preservation of health in the rural and urban communities worldwide in this present technological era. Garcinia kola (bitter kola) is referred to as a “wonder plant” because every part of it has been found to be of medicinal importance. Research carried out using different in vitro and in vivo techniques of biological evaluation supports most of its folkloric claims. This review compiled the ethno botanical/medicinal, phytochemistry, pharmacological, clinical and toxicological studies carried on this plant using references from various database.
Keywords: Garcinia kola, phytochemistry, Ethno medicine, Bioactivities.
Citation:
Ekene E. N., Erhirhie Earnest O.. GARCINIA KOLA: A REVIEW OF ITS ETHNOMEDICINAL, CHEMICAL AND PHARMACOLOGICAL PROPERTIES International Journal of Current Research and Review. 6(11), June, 01-07
References:
REFERENCES
1. Adaramoye, OA. and Adeyemi, EO. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats. J Pharm Pharmacol. 2006; 58(1):121-8.
2. Adebukunola, O. A, Bernice O. A., Adebayo, K. A., Olayinka, O. A., Elsie, S., and Kehinde, O. Efficacy of Garcinia kola 0.5% Aqueous Eye Drops in Patients with Primary OpenAngle Glaucoma or Ocular Hypertension. Middle East Afr J Ophthalmol. 2010; 17(1): 88–93.
3. Adegboye, M. F., Akinpelu, D. A. and Okoh, A. I. The bioactive and phytochemical properties of Garcinia kola (Heckel) seed extract on some pathogens. African Journal of Biotechnology 2008; 7 (21): pp. 3934-3938.
4. Adesina, SK, Gbile, ZO. and Odukoya, OA. Survey of indigenous plants of West Africa with special emphasis on medicinal plants and issues associated with management. The United Nations Programme on Natural Resources in Africa; 1995; 2nd edition. 84–5.
5. Akinyemi, K.O., Coker, A.O., Bayabgon, C., Oyefolu, A.O.B., Akinsinde, K.A. and Omonigbehin E.U. Antibacterial screening of five Nigerian medical plants against S. styphi and S. paratyphi. J. Nig. Inf. Cont. 2000; 3(1): 19-27.
6. Akpantah, AO., Oremosu, A A., Noronha, C C., Ekanem, TB. and Okanlawon, A O. Effects of Garcinia kola seed extract on ovulation, oestrous cycle and foetal development in cyclic female sprague - Dawley rats. Nigerian Journal of Physiological Sciences 2005; 20(1ande 2): 58-62.
7. Alade, A. and Ani, R. E. Protective effects of Garcinia kola seed extract against paracetamol-induced hepatotoxicity in rats. Journal of ethnopharmacology 1990; 29 (2): 207–211.
8. Ayensu, ES. Medicinal Plants of West Africa, Reference Publ. Inc; Algonac, Michigan. 1978; 162.
9. Brisibe, E.A., Uyoh, E.A. Brisibe, F. Magalhaes, P.M. and Ferreira, J.F.S. Building a golden triangle for the production and use of artemisinin derivatives against falciparum malaria in Africa. Afr. J. Biotechnol., 2008; 7: 4884-4896.
10. Charity, U. O., Uwaifoh, A., Charlse, I. I., Williams, A. A. and Kerry, E. A. The effect of chronic ingestion of crude Garcinia kola on the histology of the liver. Pelagia Research Library European Journal of Experimental Biology, 2012; 2 (2):404-409.
11. Christinah T. S. and Roland N. N. Identification and Antibacterial Evaluation of Bioactive Compounds from Garcinia kola (Heckel) Seeds Molecules. 2012; 17: 6569- 6584.
12. Collise N., Anthony, J. A., Anna, M. C. and Roland, N. N. Crude Ethanolic Extracts of Garcinia kola Seeds Heckel (Guttiferae) Prolong the Lag Phase of Helicobacter pylori: Inhibitory and Bactericidal Potential. Journal of Medicinal Food. 2011; 14(7-8): 822-827.
13. Dalziel, JM. The Useful Plants of West Tropical Africa. Crown Agents for the Colonies, London. 1937.
14. Ebana, RU., Madunagu, BE., Ekpe, ED. and Otung, IN. Microbiological exploitation of cardiac glycosides and alkaloids from Garcinia kola, Borreria ocymoides, Kola nitida and Citrus auratifolia. J. Appl. Bacteriol. 1991; 71(5): 398-401.
15. Esimone, C. O., Nwafor, S. V., Okoli, C. O., Chah, K. .F., Uzuegbu, D.B., Chibundu, C., Eche, M. A., and Adikwu, M. U. In Vivo Evaluation of Interaction Between Aqueous Seed Extract of Garcinia kola Heckel and Ciprofloxacin Hydrochloride. American Journal of Therapeutics. 2002; 9 (4): pp 275- 280. '
16. Esomonu, UG., El-Taalu, AB., Anuka, JA., Ndodo, ND., Salim, MA and Atiku, MK. Effect of ingestion of ethanol extract of Garcinia kola seed on erythrocytes in wistar rats. Nigerian Journal of Physiological Sciences 2005; 20(1and 2): 30-32.
17. Farnsworth, N.R. Screening Plants for Medicine. In: Wilson, E.O. (Ed). Biodiversity. Part II. National Academy Press, Washington. 1989; pp. 83-97.
18. Gabriel, F. I. and Emmanuel, O. O. Pharmacological evaluation of Garcinia kola nut for antitrichomonal activity. International Journal of Pharma and Bio Sciences 2011; 2, (2): 264-269.
19. Iwu MM. Food for medicine (Ed.) M. Iwu. In: Dietary Plants and Masticatories as Sources of Biologically Active Substances. University of Ife, Nigeria. Ife Press. 1989; 303–10.
20. Iwu, M. Handbook of African medicinal plants.CRC Press, Boca Raton, FL., 1993; 12: 32-38.
21. Iwu, M.M., O.A. Igboko, C.O. Okunji and M.S. Tempesta. Antidiabetic and aldose reductase activities of Biflavanones of Garcinia kola. J. Pharm. Pharmacol. 1990; 42: 290-292. '
22. Iwuji, T. C. and Herbert, U. Semen characteristics and libido of rabbit bucks fed diets containing Garcinia kola seed meal. Rabbit Genetics 2012; 2(1):10-14.
23. Juliana, A., Moctar, S. and Christophe, K. Garcinia kola Heckel. Forest and Landscape Denmark. 2006.
24. Kakjing, D. F., Mary, O. U. and Nkoli, L. N. (2014). Anti-pyretic Activity of Garcinia kola Seed Extract. European Journal of Medicinal Plants .4(5). 511-521.
25. Mathew, O. W. and Blessing C. D. Hepatoprotective effects of Garcinia kola seed against hepatotoxicity induced by carbon tetrachloride in rats. BIOKEMISTRI 2007; 19(1):17-21.
26. Mesembe, O. E., Asuquo, O. R., Fischer, V. A., Udoaffah, G. U., Mfem, C. C and Kalu, N. N. Influence of Long-term Ingestion of Garcinia Kola Seed Diet on Sperm Count, Sperm Motility, and Fertility in the Wistar Rat. Journal of Health, Medicine and Nursing 2013; 1.20-22.
27. Morabandza, C.J., Ongoka, R.P., Matini, L., Epa, C., Nkounkou, L.C. and Abena, A.A.Chemical Composition of the Mesocarp of Garcinia kola Heckel (Clusiaceae) Fruit. Research Journal of Recent Sciences. 2013; 2(1): 53-58.
28. Nwangwa, E. K. Effects of Garcinia kola on the Lipid Profile of Alloxan-Induced Diabetic Wistar Rats. British Journal of Pharmacology and Toxicology. 2012; 3(2): 39-42.
29. Nwokochaa, CR., Owua, DU., Ufearob, CS. and Iwualac, M.O.E. Comparative study on the efficacy of Garcinia kola in reducing some heavy metal accumulation in liver of Wistar rats. Journal of Ethnopharmacology. 201; 135 (2): Pages 488–491.
30. Ofokansi, KC., Mbanefo, AN., Ofokansi, MN and Esimone, CO. Antibacterial Interaction of Crude Methanol Extract of Garcinia kola Seed with Gatifloxacin. Tropical Journal of Pharmaceutical Research 2008; 7(4): pp1159- 1165.
31. Okoko, T. and Ndoni, S. The effect of Garcinia kola extract on lipopolysaccha-rideinduced tissue damage in rats. Tropical Journal of Pharmaceutical Research 2009; 8 (1): pp. 27-31.
32. Onasanwo, S. A., Singh, N., Olaleye, S. B. and Palit, G. Anti-ulcerogenic and proton pump (H+, K+ ATPase) inhibitory activity ofKolaviron from Garcinia kola Heckel in rodents. Indian Journal of Experimental Biology. 2011; 49(6): 461-468.
33. Otor, J. U., Abdulkadir, U. and Abu, M. A. Some biological activities of Garcinia kola in growing rats. Vet. arhiv 2001; 71 (5): 287- 297.
34. Penduka, D., Okoh, OO. and Okoh, AI. InVitro Antagonistic Characteristics of Crude Aqueous and Methanolic Extracts of Garcinia kola (Heckel) Seeds against Some Vibrio Bacteria. Molecules. 2011; 16(4):2754-2765.
35. Tebekeme, O. In vitro antioxidant and free radical scavenging activities of Garcinia kola seeds. Food and Chemical Toxicology.2009; 47 (10): 2620–2623.
36. Terashima, K., Y. Takaya and M. Niwa. Powerful antioxidative agents based on garcinoic acid from Garcinia kola. Bioorganic Med. Chem., 2002; 10(5): 1619-1625.
37. Udenze, E.C.C. Braide, V.B. Okwesilieze, C.N. and Akuodor, G.C. Pharmacological Effects of Garcinia kola Seed Powder on Blood Sugar, Lipid Profile and Atherogenic Index of Alloxan-induced Diabetes in Rats. Pharmacologia, 2012; 3 (12): 693-699.
38. Unigwe, C.R. and Nwakpu, P.E. Effect of ingestion of Garcinia kola seed on erythrocytes in rabbits. Continental J. Veterinary Sciences 2009; 3: 7 – 10.
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